Motif ID: EVI1.p2

Z-value: 0.746


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_1688640660.472.4e-01Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_171060017 0.643 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr19_-_11564568 0.630 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr5_-_158526698 0.496 NM_024007
EBF1
early B-cell factor 1
chr17_-_66951381 0.425 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_+_20848288 0.371 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr12_-_15038724 0.326 NM_000900
NM_001190839
MGP

matrix Gla protein

chr6_-_31514620 0.314 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr2_-_224467095 0.311 SCG2
secretogranin II
chr5_-_158526428 0.294 EBF1
early B-cell factor 1
chr6_-_88854989 0.288 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr2_-_224467049 0.274 SCG2
secretogranin II
chr2_-_224467142 0.270 NM_003469
SCG2
secretogranin II
chr1_+_104292439 0.266 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr17_+_53344966 0.263 HLF
hepatic leukemia factor
chr7_-_100844192 0.262 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr1_-_161008733 0.239 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr8_+_97505895 0.236 SDC2
syndecan 2
chr8_+_97505876 0.235 NM_002998
SDC2
syndecan 2
chr9_-_95244750 0.228 NM_001193335
NM_017680
ASPN

asporin

chr4_+_41614725 0.224 LIMCH1
LIM and calponin homology domains 1
chr11_+_60989820 0.216 NM_001079808
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr4_+_62362838 0.213 NM_015236
LPHN3
latrophilin 3
chr3_-_114790221 0.213 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_140602914 0.208 NM_018934
PCDHB14
protocadherin beta 14
chr9_-_95244634 0.206 ASPN
asporin
chr20_+_15177503 0.202 NM_001033087
MACROD2
MACRO domain containing 2
chr9_-_107690526 0.201 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr15_+_34261088 0.200 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr1_-_161008710 0.199 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr2_+_37571752 0.193 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr4_+_70894129 0.190 NM_000200
HTN3
histatin 3
chr5_-_75919051 0.189 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr8_-_19460005 0.184 NM_001130518
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr13_+_31309644 0.181 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chrX_+_103031753 0.176 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr3_-_114478117 0.175 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chrX_+_86772714 0.171 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr2_+_189839113 0.171 COL3A1
collagen, type III, alpha 1
chr1_+_104198301 0.168 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr4_+_41614933 0.166 LIMCH1
LIM and calponin homology domains 1
chr8_+_134203281 0.165 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chrX_+_135730335 0.163 NM_000074
CD40LG
CD40 ligand
chr3_+_121774208 0.162 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr12_-_47219734 0.160 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr2_+_189839132 0.157 COL3A1
collagen, type III, alpha 1
chr10_-_29754478 0.155 SVIL
supervillin
chr1_-_238054221 0.154 NM_021186
ZP4
zona pellucida glycoprotein 4
chr7_+_106505696 0.153 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_+_81892257 0.151 NM_001012973
PLAC9
placenta-specific 9
chr6_-_53530505 0.149 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr9_+_34652125 0.148 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr4_+_55095263 0.147 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_-_145968819 0.147 PLSCR4
phospholipid scramblase 4
chr1_+_104159953 0.144 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr5_+_42549657 0.144 NM_001242404
GHR
growth hormone receptor
chr20_-_48099178 0.144 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr13_+_31309690 0.144 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr4_+_8951476 0.143 NM_001040071
LOC650293
seven transmembrane helix receptor
chr1_-_103496768 0.142 COL11A1
collagen, type XI, alpha 1
chr17_-_72542148 0.141 CD300C
CD300c molecule
chr5_+_140739589 0.140 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr3_-_112359277 0.139 CCDC80
coiled-coil domain containing 80
chr7_+_73275488 0.139 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr14_+_95078713 0.138 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_-_145968958 0.137 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr11_+_60970983 0.135 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr22_-_31688329 0.134 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr2_+_189839078 0.133 NM_000090
COL3A1
collagen, type III, alpha 1
chr6_+_52529157 0.132 LOC730101
uncharacterized LOC730101
chrX_+_103031797 0.131 PLP1
proteolipid protein 1
chr11_+_65266642 0.129


chr2_+_169929009 0.127 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_+_34087915 0.125 NM_145272
C17orf50
chromosome 17 open reading frame 50
chrX_+_103031433 0.125 NM_001128834
PLP1
proteolipid protein 1
chr11_-_5323174 0.125 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr9_-_8733893 0.124 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr16_+_28943259 0.124 NM_001178098
NM_001770
CD19

CD19 molecule

chr1_-_110933683 0.123 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr1_+_162602198 0.121 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chrX_-_11284094 0.120 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr12_+_13349716 0.120 EMP1
epithelial membrane protein 1
chr2_-_56151273 0.118 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chrX_+_85517970 0.118 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr18_-_53303129 0.118 NM_001243226
TCF4
transcription factor 4
chr1_+_215178884 0.117 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr1_-_110933635 0.117 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chrX_+_22291029 0.117 NM_152577
ZNF645
zinc finger protein 645
chr1_-_146697155 0.116 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr12_+_100750856 0.115 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr20_+_12989616 0.114 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr3_+_108541544 0.112 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr15_+_40643225 0.111 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr6_-_46293404 0.110 RCAN2
regulator of calcineurin 2
chr1_+_162602308 0.109 DDR2
discoidin domain receptor tyrosine kinase 2
chr9_+_118916069 0.109 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr4_+_86699858 0.108 ARHGAP24
Rho GTPase activating protein 24
chr9_-_27005649 0.108 NM_022901
LRRC19
leucine rich repeat containing 19
chr5_+_170289006 0.107 RANBP17
RAN binding protein 17
chr19_-_43709692 0.101 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr11_+_65193498 0.101 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr1_-_177939347 0.100 SEC16B
SEC16 homolog B (S. cerevisiae)
chr12_+_12223872 0.100 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr5_+_55147206 0.100 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr12_-_10151689 0.099 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr5_-_138862342 0.099 NM_198282
TMEM173
transmembrane protein 173
chr2_-_56150862 0.097 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr8_+_133879202 0.097 NM_003235
TG
thyroglobulin
chr11_+_22696318 0.096 NM_005256
GAS2
growth arrest-specific 2
chr3_-_57326709 0.096 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr14_+_64680858 0.095 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr20_+_29956420 0.094 NM_054112
DEFB118
defensin, beta 118
chr1_-_32281577 0.094 NM_144569
SPOCD1
SPOC domain containing 1
chr2_-_133429069 0.094 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr7_+_63773185 0.094 NM_001170905
ZNF736
zinc finger protein 736
chr4_-_88450243 0.093 SPARCL1
SPARC-like 1 (hevin)
chr6_+_26440699 0.092 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr18_+_61554938 0.091 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr12_-_54758228 0.091 NM_020370
GPR84
G protein-coupled receptor 84
chr11_-_8964579 0.090 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr5_+_170288863 0.090 NM_022897
RANBP17
RAN binding protein 17
chr1_+_117544371 0.089 NM_004258
CD101
CD101 molecule
chr19_-_49243836 0.089 NM_017805
RASIP1
Ras interacting protein 1
chr5_+_139876504 0.088 ANKHD1
ankyrin repeat and KH domain containing 1
chr2_+_33359607 0.086 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr12_+_1738411 0.086 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr4_+_153864134 0.085 NM_033393
FHDC1
FH2 domain containing 1
chr4_-_159094163 0.084 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr7_+_90893678 0.084 FZD1
frizzled family receptor 1
chrY_+_59330251 0.084 NM_002186
IL9R
interleukin 9 receptor
chr9_+_134378335 0.084 POMT1
protein-O-mannosyltransferase 1
chr4_+_41540187 0.083 LIMCH1
LIM and calponin homology domains 1
chr10_-_17171789 0.083 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr10_-_65028825 0.083 NM_004241
JMJD1C
jumonji domain containing 1C
chr8_-_93029864 0.082 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_24307529 0.082 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr1_+_79115476 0.081 NM_006417
IFI44
interferon-induced protein 44
chr9_-_73736513 0.081 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chrX_+_155227245 0.080 NM_002186
IL9R
interleukin 9 receptor
chr7_-_141646716 0.079 NM_013252
CLEC5A
C-type lectin domain family 5, member A
chr4_-_89744154 0.078 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr22_-_32555200 0.077 NM_001010859
C22orf42
chromosome 22 open reading frame 42
chr7_+_90893735 0.077 NM_003505
FZD1
frizzled family receptor 1
chr15_-_83240499 0.077 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr7_+_44040487 0.076 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr9_+_139871954 0.075 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr19_+_6135650 0.075 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr3_-_151102536 0.075 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr8_-_86253863 0.075 NM_001164830
CA1
carbonic anhydrase I
chr9_+_79115548 0.073 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr5_+_71403040 0.073 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_-_111358353 0.072 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr12_-_105322056 0.071 NM_032148
SLC41A2
solute carrier family 41, member 2
chr4_-_159093717 0.071 NM_016613
FAM198B
family with sequence similarity 198, member B
chr16_+_31539202 0.071 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr3_-_186079776 0.071 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr1_-_89591685 0.070 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr19_+_44764032 0.070 NM_001207005
NM_181756
ZNF233

zinc finger protein 233

chr11_+_65266980 0.070


chr6_-_154831788 0.070 CNKSR3
CNKSR family member 3
chr12_+_41831484 0.069 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr5_+_42565562 0.069 NM_001242406
GHR
growth hormone receptor
chr12_-_14132920 0.069 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr1_+_79086087 0.069 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_-_91576805 0.069 NM_001920
DCN
decorin
chr5_+_137203544 0.069 NM_001135940
NM_006790
MYOT

myotilin

chr6_-_99849266 0.069 PNISR
PNN-interacting serine/arginine-rich protein
chr16_+_2807490 0.068


chr2_+_158114109 0.068 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr9_+_82186846 0.067 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_+_34431219 0.067 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr3_-_109035239 0.067 NM_138815
DPPA2
developmental pluripotency associated 2
chr16_-_48644087 0.067 NM_153029
N4BP1
NEDD4 binding protein 1
chr1_-_9117554 0.066 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr5_+_156607847 0.066 NM_005546
ITK
IL2-inducible T-cell kinase
chr11_+_6897855 0.066 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr3_+_157154579 0.066 NM_002852
PTX3
pentraxin 3, long
chr19_-_52490050 0.066 NM_021632
ZNF350
zinc finger protein 350
chr2_+_115822246 0.065 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr4_-_5711274 0.065 NM_001166136
EVC2
Ellis van Creveld syndrome 2
chr4_+_186990308 0.064 NM_003265
TLR3
toll-like receptor 3
chr19_-_48547180 0.064 NM_019855
CABP5
calcium binding protein 5
chrX_-_55057408 0.064 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr16_+_2880172 0.064 NM_145252
ZG16B
zymogen granule protein 16 homolog B (rat)
chr19_-_43690558 0.064 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr6_-_154831704 0.064 NM_173515
CNKSR3
CNKSR family member 3
chr19_+_51760963 0.063 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr11_-_104916041 0.063 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr5_+_42550181 0.063 NM_001242405
GHR
growth hormone receptor
chr8_-_17942410 0.063 NM_001127505
NM_004315
ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

chr20_-_45985411 0.063 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr4_+_71200670 0.063 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr13_-_110802708 0.063 COL4A1
collagen, type IV, alpha 1
chr6_+_160327972 0.063 NM_002377
MAS1
MAS1 oncogene
chr3_-_112359251 0.063 CCDC80
coiled-coil domain containing 80
chr6_+_35200627 0.062 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr1_+_160160284 0.062 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr5_+_156820161 0.062 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_+_47694841 0.061 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr17_+_19990334 0.061 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr12_+_72079873 0.061 NM_018279
TMEM19
transmembrane protein 19

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.83 8.22e-05 GO:0009611 response to wounding
2.77 1.65e-02 GO:0002697 regulation of immune effector process
1.74 2.59e-02 GO:0002682 regulation of immune system process
3.55 3.31e-02 GO:0002699 positive regulation of immune effector process
1.66 4.57e-02 GO:0006952 defense response
8.86 4.77e-02 GO:0002825 regulation of T-helper 1 type immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 3.20e-10 GO:0005576 extracellular region
1.22 3.48e-05 GO:0044425 membrane part
1.25 3.88e-05 GO:0031224 intrinsic to membrane
1.25 4.12e-05 GO:0016021 integral to membrane
1.18 5.69e-05 GO:0016020 membrane
1.29 8.19e-05 GO:0005886 plasma membrane
1.44 9.03e-05 GO:0044459 plasma membrane part
1.28 2.09e-04 GO:0071944 cell periphery
1.67 2.20e-04 GO:0044421 extracellular region part
1.74 6.71e-04 GO:0005615 extracellular space
1.56 9.12e-04 GO:0005887 integral to plasma membrane
1.55 1.21e-03 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 5.33e-03 GO:0005509 calcium ion binding
2.65 8.59e-03 GO:0030414 peptidase inhibitor activity
2.95 1.59e-02 GO:0019955 cytokine binding
6.89 1.69e-02 GO:0004033 aldo-keto reductase activity
2.41 1.95e-02 GO:0061134 peptidase regulator activity