Motif ID: FOXD3.p2

Z-value: 0.652


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD3chr1_+_637887290.127.8e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_140247767 0.793 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr6_+_26501448 0.713 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr18_+_29027731 0.686 NM_001944
DSG3
desmoglein 3
chr16_+_68678150 0.674 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr4_+_40198526 0.644 NM_004310
RHOH
ras homolog gene family, member H
chr1_+_183155173 0.562 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr18_+_61254533 0.506 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr10_+_118187381 0.503 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr2_-_161056762 0.426 ITGB6
integrin, beta 6
chr2_-_215896809 0.425 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr19_-_5846465 0.402 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr11_-_108464344 0.398 NM_015065
EXPH5
exophilin 5
chr14_-_61748510 0.395 NM_001017970
TMEM30B
transmembrane protein 30B
chr5_-_24645084 0.394 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr19_+_6464259 0.393 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr1_+_44064509 0.383 PTPRF
protein tyrosine phosphatase, receptor type, F
chr6_+_150263120 0.381 NM_025217
ULBP2
UL16 binding protein 2
chr9_+_102677457 0.375 STX17
syntaxin 17
chr1_-_12677347 0.369 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr21_+_25801042 0.367 FLJ42200
FLJ42200 protein
chr9_-_117568292 0.366 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr22_+_45148437 0.353 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr12_+_13043955 0.343 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr6_-_136847609 0.330 MAP7
microtubule-associated protein 7
chr17_-_3599298 0.320 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr5_+_140220811 0.319 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr16_+_67001377 0.314 NM_001185176
CES3
carboxylesterase 3
chr18_-_47814691 0.314 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr9_+_127420690 0.308 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr17_-_3599359 0.304 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr11_-_88070840 0.303 CTSC
cathepsin C
chr2_-_165424993 0.297 GRB14
growth factor receptor-bound protein 14
chr12_+_105153258 0.294 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_+_136676706 0.294 NM_144717
IL20RB
interleukin 20 receptor beta
chr8_-_15095791 0.289 NM_139167
SGCZ
sarcoglycan, zeta
chr18_+_61554938 0.288 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr11_-_102651321 0.283 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr17_-_29641087 0.282 EVI2B
ecotropic viral integration site 2B
chr11_-_88070901 0.279 CTSC
cathepsin C
chr3_-_189838673 0.277 LEPREL1
leprecan-like 1
chr12_-_8815370 0.275 NM_003480
MFAP5
microfibrillar associated protein 5
chr9_+_93589704 0.273 NM_001174167
SYK
spleen tyrosine kinase
chr20_+_19870209 0.268 NM_018993
RIN2
Ras and Rab interactor 2
chr8_+_27631902 0.264 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr7_+_26400503 0.262 NM_001199837
SNX10
sorting nexin 10
chr17_-_29641094 0.259 NM_006495
EVI2B
ecotropic viral integration site 2B
chr21_-_27512668 0.256 NM_001136016
APP
amyloid beta (A4) precursor protein
chr7_+_89783688 0.253 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr7_-_122339186 0.248 NM_139175
RNF133
ring finger protein 133
chr5_+_173472737 0.244 HMP19
HMP19 protein
chr19_-_14785626 0.241 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr12_-_91452130 0.240 NM_007035
KERA
keratocan
chr4_+_69313166 0.240 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr4_-_187644983 0.238 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr4_-_139163222 0.238 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr5_+_140165875 0.238 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr19_+_11200037 0.236 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr3_-_189838907 0.236 NM_018192
LEPREL1
leprecan-like 1
chr19_+_9296269 0.232 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr7_+_86273219 0.232 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr14_+_23305816 0.230 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_-_39033981 0.227 NM_024943
TMEM156
transmembrane protein 156
chr13_+_21183940 0.227


chr22_+_29449877 0.226 ZNRF3
zinc and ring finger 3
chr5_+_68800003 0.226 NM_001205255
OCLN
occludin
chr22_+_37678519 0.226 CYTH4
cytohesin 4
chr1_-_160492982 0.224 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr1_+_220960038 0.222 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chr10_-_99161013 0.220 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr4_+_146031528 0.220 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr12_-_105322056 0.219 NM_032148
SLC41A2
solute carrier family 41, member 2
chr14_-_81405883 0.219 NM_152446
CEP128
centrosomal protein 128kDa
chr2_-_161056573 0.215 NM_000888
ITGB6
integrin, beta 6
chr16_+_68771192 0.214 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr11_+_124120422 0.213 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr9_+_105757592 0.213 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chrX_-_114252132 0.211 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr9_+_71944240 0.209 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr2_+_47596447 0.209 EPCAM
epithelial cell adhesion molecule
chr7_+_26331611 0.208 SNX10
sorting nexin 10
chr4_+_71062241 0.208 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr2_-_216003068 0.207 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_69435223 0.203 FRMD4B
FERM domain containing 4B
chr16_+_68771214 0.202 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr14_+_23305792 0.201 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr12_-_46633551 0.199 SLC38A1
solute carrier family 38, member 1
chr11_-_88070905 0.198 NM_001114173
NM_001814
NM_148170
CTSC


cathepsin C


chr12_-_28124915 0.197 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr19_-_33360641 0.196 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr3_+_122296432 0.195 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr7_+_89783789 0.194 STEAP1
six transmembrane epithelial antigen of the prostate 1
chr2_-_72374919 0.193 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr6_+_7541863 0.192 NM_001008844
NM_004415
DSP

desmoplakin

chr18_+_61420276 0.191 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr17_-_37322413 0.190 NM_001143968
ARL5C
ADP-ribosylation factor-like 5C
chr12_-_8815479 0.189 MFAP5
microfibrillar associated protein 5
chr4_-_103266577 0.189 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr19_-_11689765 0.188 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr21_+_39628869 0.187 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_8088629 0.185 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr6_+_7541837 0.184 DSP
desmoplakin
chr12_-_8815266 0.184 MFAP5
microfibrillar associated protein 5
chr4_-_153303663 0.183 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr19_-_23456964 0.182 LOC100132815
importin 5 pseudogene
chr3_-_149086884 0.182 TM4SF1
transmembrane 4 L six family member 1
chr22_+_23054862 0.182 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr16_+_68771304 0.182 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chrX_+_123234462 0.182 STAG2
stromal antigen 2
chr19_-_44174497 0.181 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr6_+_121756744 0.181 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_-_83824216 0.181 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_+_23842017 0.180 NM_172314
NM_022789
IL25

interleukin 25

chr1_+_84630374 0.179 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_219031646 0.178 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr15_-_55800431 0.178 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr1_-_156265395 0.178 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr18_-_13915534 0.177 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_+_74171610 0.177 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr12_+_95676175 0.176 VEZT
vezatin, adherens junctions transmembrane protein
chr6_+_7541892 0.175 DSP
desmoplakin
chr19_-_44174271 0.174 PLAUR
plasminogen activator, urokinase receptor
chr3_-_69435429 0.174 NM_015123
FRMD4B
FERM domain containing 4B
chr11_-_102745666 0.174 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr1_-_156265457 0.172 C1orf85
chromosome 1 open reading frame 85
chr4_-_103245468 0.172 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr9_-_33473919 0.172 NM_022917
NM_139235
NOL6

nucleolar protein family 6 (RNA-associated)

chr2_-_96150478 0.172 NM_001164464
TRIM43B
tripartite motif containing 43B
chr5_+_36608430 0.171 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_189507448 0.170 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr7_+_128312345 0.170 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr1_+_36748164 0.168 THRAP3
thyroid hormone receptor associated protein 3
chr4_+_71494460 0.168 NM_031889
ENAM
enamelin
chr4_-_130014405 0.168 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr14_-_99737821 0.164 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr19_+_14491920 0.163 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr12_+_101188373 0.162 NM_178826
ANO4
anoctamin 4
chr14_+_32798478 0.162 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr18_-_53089722 0.161 NM_001243233
TCF4
transcription factor 4
chr3_+_121774208 0.159 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr9_+_97136817 0.159 NM_032558
HIATL1
hippocampus abundant transcript-like 1
chr12_-_122018100 0.159 NM_001005366
KDM2B
lysine (K)-specific demethylase 2B
chr2_+_106432922 0.159 NCK2
NCK adaptor protein 2
chr4_+_108814419 0.159 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr1_+_220701547 0.159 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr20_-_14318200 0.158 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr7_-_22539795 0.158 NM_001164460
NM_207342
STEAP1B

STEAP family member 1B

chr13_-_86373328 0.158 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr14_+_23305913 0.157 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr20_+_58251715 0.157 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr10_+_71561643 0.157 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr20_+_19915716 0.156 RIN2
Ras and Rab interactor 2
chr13_-_75901897 0.155 TBC1D4
TBC1 domain family, member 4
chr7_-_16505292 0.154 NM_015464
SOSTDC1
sclerostin domain containing 1
chr5_+_147582338 0.151 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr15_-_63673918 0.150 CA12
carbonic anhydrase XII
chr6_-_31830551 0.149 NEU1
sialidase 1 (lysosomal sialidase)
chr1_-_223853359 0.149 CAPN8
calpain 8
chr1_+_150480486 0.148 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr9_-_117156684 0.147 NM_030767
AKNA
AT-hook transcription factor
chr11_+_6897855 0.147 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr4_+_72102249 0.146 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr15_-_63674074 0.146 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chrX_-_78623006 0.146 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr10_+_71561687 0.145 COL13A1
collagen, type XIII, alpha 1
chr19_+_3880675 0.145 ATCAY
ataxia, cerebellar, Cayman type
chr9_-_74675498 0.144 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr20_+_43990576 0.144 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr1_+_81771844 0.143 LPHN2
latrophilin 2
chr2_+_109384601 0.141 RANBP2
RAN binding protein 2
chr6_+_32132379 0.141 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr18_-_28681885 0.141 NM_004949
NM_024422
DSC2

desmocollin 2

chr3_+_142375738 0.140 NM_001172312
PLS1
plastin 1
chr1_+_35220647 0.139 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr17_-_56492938 0.139 RNF43
ring finger protein 43
chr7_-_112726143 0.139 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr14_-_23288912 0.138 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_+_32851469 0.138 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr2_-_170430312 0.136 NM_024622
FASTKD1
FAST kinase domains 1
chr9_-_88715024 0.136 NM_177937
GOLM1
golgi membrane protein 1
chr2_-_37297372 0.135 HEATR5B
HEAT repeat containing 5B
chr7_+_107110501 0.135 NM_005295
GPR22
G protein-coupled receptor 22
chr10_-_101841593 0.135 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_-_85108202 0.135 C2orf89
chromosome 2 open reading frame 89
chr4_+_88896838 0.135 SPP1
secreted phosphoprotein 1
chr19_+_15052298 0.135 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr12_+_20963637 0.135 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr3_+_172472246 0.134 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr12_-_67072881 0.134 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr1_-_77685076 0.134 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr11_+_73661363 0.134 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chrX_-_151877669 0.134 NM_001129826
NM_001129828
NM_001080848
NM_004909
CSAG3

CSAG2

CSAG family, member 3

CSAG family, member 2

chr9_-_139927291 0.133 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr5_+_140261792 0.133 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr19_-_48614013 0.133 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr9_+_139927515 0.132 C9orf139
chromosome 9 open reading frame 139
chrX_+_151927733 0.132 NM_001129828
NM_001129826
NM_001080848
NM_004909
CSAG3

CSAG2

CSAG family, member 3

CSAG family, member 2

chr4_+_88896801 0.132 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr17_+_7942351 0.132 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr20_+_55099784 0.130 NM_001012971
FAM209A
FAM209B
family with sequence similarity 209, member A
family with sequence similarity 209, member B
chr2_-_47134945 0.130 MCFD2
multiple coagulation factor deficiency 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.29 4.36e-03 GO:0009812 flavonoid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 7.79e-03 GO:0044459 plasma membrane part
1.10 1.53e-02 GO:0044425 membrane part
1.11 2.89e-02 GO:0016021 integral to membrane
1.11 3.69e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.72 1.02e-05 GO:0003823 antigen binding
2.14 3.35e-05 GO:0016758 transferase activity, transferring hexosyl groups
1.80 1.70e-03 GO:0016757 transferase activity, transferring glycosyl groups
3.54 6.25e-03 GO:0015020 glucuronosyltransferase activity
2.10 8.70e-03 GO:0008194 UDP-glycosyltransferase activity
2.65 1.07e-02 GO:0004896 cytokine receptor activity