Motif ID: GCUACAU

Z-value: 0.448


Mature miRNA associated with seed GCUACAU:

NamemiRBase Accession
hsa-miR-221 MIMAT0000278
hsa-miR-222 MIMAT0000279



Activity profile for motif GCUACAU.

activity profile for motif GCUACAU


Sorted Z-values histogram for motif GCUACAU

Sorted Z-values for motif GCUACAU



Network of associatons between targets according to the STRING database.



First level regulatory network of GCUACAU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_88324777 0.205 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr8_-_93115453 0.145 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_-_22487566 0.139 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr8_-_93107881 0.139 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr8_-_93111915 0.138 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_93107442 0.134 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr8_-_93029864 0.129 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_93075190 0.123 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_113739203 0.117 NM_001127493
ANK2
ankyrin 2, neuronal
chr4_+_113970784 0.107 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr8_+_32579350 0.104 NM_001159996
NRG1
neuregulin 1
chr1_-_62785067 0.096 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr4_-_42154894 0.088 NM_001159547
NM_207406
BEND4

BEN domain containing 4

chr4_+_55523906 0.083 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr10_+_120789227 0.070 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr6_-_82462374 0.070 NM_017633
FAM46A
family with sequence similarity 46, member A
chr1_-_44497132 0.067 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_-_16761600 0.062 NM_000332
NM_001128164
ATXN1

ataxin 1

chr1_-_44482996 0.061 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr8_-_116681103 0.059 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr9_-_123476578 0.055 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr6_-_52441815 0.052 NM_012288
TRAM2
translocation associated membrane protein 2
chr5_+_161275541 0.046 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_+_75736771 0.044 NM_015886
PI15
peptidase inhibitor 15
chr1_+_220701547 0.043 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr12_-_52685249 0.042 NM_002281
KRT81
keratin 81
chr5_+_161277391 0.041 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161274939 0.040 NM_001127644
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161274684 0.040 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_-_107957452 0.040 NM_014421
DKK2
dickkopf 2 homolog (Xenopus laevis)
chr1_+_215256559 0.040 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr12_-_121342050 0.039 NM_139015
SPPL3
signal peptide peptidase-like 3
chrX_-_83757398 0.038 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr8_+_28748030 0.038 NM_024567
HMBOX1
homeobox containing 1
chr13_+_111767586 0.037 NM_001113511
NM_001113512
NM_145735
ARHGEF7


Rho guanine nucleotide exchange factor (GEF) 7


chr8_+_32405727 0.037 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr1_+_215178884 0.036 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr5_+_161275897 0.036 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161274196 0.036 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_+_79257772 0.036 NM_001135805
SYT1
synaptotagmin I
chr5_+_76248679 0.035 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr13_-_67804432 0.035 NM_020403
NM_203487
PCDH9

protocadherin 9

chr12_+_79439432 0.034 NM_001135806
SYT1
synaptotagmin I
chr8_+_28747885 0.034 NM_001135726
HMBOX1
homeobox containing 1
chr18_-_25757351 0.034 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr7_-_27196163 0.034 NM_006896
HOXA7
homeobox A7
chr8_-_110657025 0.034 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr12_+_79258448 0.034 NM_005639
SYT1
synaptotagmin I
chr8_-_110704019 0.034 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr5_+_140220811 0.033 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr8_+_106331146 0.033 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr3_+_10183318 0.033 NM_000551
NM_198156
VHL

von Hippel-Lindau tumor suppressor

chr8_-_110661007 0.033 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr8_-_110693233 0.033 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chrX_-_142722869 0.032 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr3_-_124774735 0.032 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr18_-_53255734 0.031 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr7_+_20370724 0.031 NM_002214
ITGB8
integrin, beta 8
chr8_-_110657745 0.031 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr8_-_60031545 0.031 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr16_-_23521803 0.030 NM_015044
GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chrX_-_142722318 0.030 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr5_+_140186658 0.030 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr8_-_110655418 0.030 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr17_-_36762105 0.030 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr5_-_138211054 0.030 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr5_+_140254930 0.030 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr15_+_47476225 0.029 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr5_+_140213968 0.029 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr12_-_56652118 0.029 NM_173595
ANKRD52
ankyrin repeat domain 52
chr5_+_140207562 0.029 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr5_+_140247767 0.029 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr1_+_46806389 0.027 NM_199044
NSUN4
NOP2/Sun domain family, member 4
chr6_+_83073954 0.027 NM_001166392
TPBG
trophoblast glycoprotein
chr2_+_54952148 0.027 NM_001039753
EML6
echinoderm microtubule associated protein like 6
chr22_-_39152008 0.027 NM_001199579
NM_015374
SUN2

Sad1 and UNC84 domain containing 2

chr7_+_112090463 0.027 NM_001550
IFRD1
interferon-related developmental regulator 1
chr6_-_128841432 0.027 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr15_-_52970808 0.026 NM_019600
FAM214A
family with sequence similarity 214, member A
chr13_-_86373328 0.026 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr1_-_204380903 0.026 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr6_+_74104284 0.026 NM_018665
DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chrX_-_142723921 0.025 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr18_-_19284737 0.025 NM_138340
ABHD3
abhydrolase domain containing 3
chr8_-_11324184 0.024 NM_053279
FAM167A
family with sequence similarity 167, member A
chr6_+_106534188 0.024 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr1_-_242687997 0.023 NM_152666
PLD5
phospholipase D family, member 5
chr6_+_56819706 0.023 NM_152731
BEND6
BEN domain containing 6
chr15_-_65715385 0.022 NM_020962
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr3_+_36421944 0.022 NM_003149
STAC
SH3 and cysteine rich domain
chr15_+_89631380 0.022 NM_007011
NM_152924
ABHD2

abhydrolase domain containing 2

chr1_+_55505148 0.022 NM_174936
PCSK9
proprotein convertase subtilisin/kexin type 9
chr7_+_112092112 0.022 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr3_-_129612371 0.022 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chr1_-_242612757 0.021 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr3_+_154798078 0.021 NM_007289
MME
membrane metallo-endopeptidase
chr3_+_154797644 0.021 NM_007287
MME
membrane metallo-endopeptidase
chr22_-_39151457 0.021 NM_001199580
SUN2
Sad1 and UNC84 domain containing 2
chr5_+_140165875 0.021 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr16_+_54965110 0.021 NM_001252197
NM_005853
IRX5

iroquois homeobox 5

chr14_-_95623665 0.021 NM_177438
DICER1
dicer 1, ribonuclease type III
chr20_-_41818464 0.021 NM_007050
NM_133170
PTPRT

protein tyrosine phosphatase, receptor type, T

chr3_+_50304989 0.021 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr13_+_112721912 0.020 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr3_+_154797435 0.020 NM_000902
MME
membrane metallo-endopeptidase
chr3_+_154797910 0.020 NM_007288
MME
membrane metallo-endopeptidase
chr5_-_176057324 0.020 NM_001001502
NM_003085
SNCB

synuclein, beta

chr2_+_109335906 0.020 NM_006267
RANBP2
RAN binding protein 2
chr5_+_140235594 0.020 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr5_+_140345746 0.020 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr10_+_105036783 0.019 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chrX_+_105066531 0.019 NM_198465
NRK
Nik related kinase
chr8_+_61591239 0.019 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr17_-_2206811 0.019 NM_001170957
SMG6
smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr11_-_70507911 0.019 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr12_+_69864065 0.019 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr15_-_40401041 0.019 NM_001003940
BMF
Bcl2 modifying factor
chr6_+_106546736 0.019 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr8_-_142010987 0.019 NM_001199649
NM_005607
NM_153831
PTK2


PTK2 protein tyrosine kinase 2


chr16_-_18812691 0.018 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr11_-_16430425 0.018 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr2_+_201170795 0.018 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr14_+_72398816 0.018 NM_001204423
RGS6
regulator of G-protein signaling 6
chr11_-_70935807 0.018 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr5_+_161277702 0.018 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_106816593 0.018 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr2_+_201170603 0.018 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr9_+_36036900 0.018 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr2_+_70142152 0.018 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr22_+_33196801 0.017 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr18_+_43914186 0.017 NM_152470
RNF165-IT1
RNF165
RNF165 intronic transcript 1 (non-protein coding)
ring finger protein 165
chr6_-_161694992 0.017 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr14_+_72399149 0.017 NM_001204424
RGS6
regulator of G-protein signaling 6
chr3_+_169684549 0.017 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr7_+_130126035 0.017 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr4_+_52709165 0.017 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr2_+_5832778 0.017 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr10_-_128077072 0.017 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr11_-_16497917 0.016 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_+_28585959 0.016 NM_031459
SESN2
sestrin 2
chr7_+_130131921 0.016 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr15_-_40398573 0.016 NM_033503
BMF
Bcl2 modifying factor
chr5_+_79703792 0.016 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr1_-_224033673 0.016 NM_001031685
NM_005426
TP53BP2

tumor protein p53 binding protein, 2

chr8_-_62627167 0.016 NM_001164754
NM_001164755
NM_001164756
NM_004318
NM_032466
ASPH




aspartate beta-hydroxylase




chr10_-_73611050 0.016 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr20_+_33814538 0.016 NM_006690
MMP24
matrix metallopeptidase 24 (membrane-inserted)
chr10_+_114709963 0.016 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr14_+_73603140 0.016 NM_000021
NM_007318
PSEN1

presenilin 1

chr12_+_113229548 0.015 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr5_-_150948504 0.015 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr3_+_16926451 0.015 NM_001144382
PLCL2
phospholipase C-like 2
chr7_+_130131172 0.015 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr16_+_22019438 0.015 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr6_-_56112315 0.015 NM_030820
COL21A1
collagen, type XXI, alpha 1
chr2_-_38303307 0.015 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr3_-_129599220 0.015 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr6_-_88875766 0.014 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr4_-_100867868 0.014 NM_001031723
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr16_-_69419833 0.014 NM_005652
TERF2
telomeric repeat binding factor 2
chr6_+_83072922 0.014 NM_006670
TPBG
trophoblast glycoprotein
chr2_-_100106478 0.014 NM_001037872
NM_016316
REV1

REV1 homolog (S. cerevisiae)

chr3_-_157823815 0.014 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr4_+_56262051 0.014 NM_018475
TMEM165
transmembrane protein 165
chr12_+_41582167 0.013 NM_001164595
PDZRN4
PDZ domain containing ring finger 4
chr16_+_69599868 0.013 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr7_+_112063131 0.013 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr20_+_44330654 0.013 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr1_-_160617042 0.013 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_+_156887026 0.013 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr6_+_7107799 0.013 NM_001168344
RREB1
ras responsive element binding protein 1
chr17_-_3794036 0.013 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr6_+_36853639 0.013 NM_152734
C6orf89
chromosome 6 open reading frame 89
chr16_-_11350038 0.013 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr4_+_72204769 0.013 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr15_+_86220267 0.013 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr1_-_165738106 0.013 NM_019026
TMCO1
transmembrane and coiled-coil domains 1
chr15_-_65809603 0.013 NM_197960
DPP8
dipeptidyl-peptidase 8
chr11_-_16424391 0.013 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr6_+_7107986 0.013 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr1_-_33815498 0.013 NM_004427
PHC2
polyhomeotic homolog 2 (Drosophila)
chr2_-_27886443 0.012 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr1_-_33841142 0.012 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr3_-_184870727 0.012 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr10_+_74033676 0.012 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr6_+_90539569 0.012 NM_001137667
NM_001137668
NM_012115
CASP8AP2


caspase 8 associated protein 2


chr1_-_68697997 0.012 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chrX_-_148713400 0.012 NM_001174092
NM_032508
TMEM185A

transmembrane protein 185A

chr7_+_16793320 0.012 NM_014399
TSPAN13
tetraspanin 13
chr1_+_32645322 0.012 NM_175852
TXLNA
taxilin alpha
chr12_-_123594974 0.012 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr3_+_3841079 0.012 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr16_+_55542909 0.012 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chr9_+_103791030 0.012 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr8_-_27472298 0.012 NM_001831
CLU
clusterin
chr4_-_89744154 0.012 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr7_+_94285620 0.012 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr7_+_94285676 0.012 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr2_-_88926863 0.012 NM_004836
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr20_-_43438881 0.012 NM_001205317
NM_182970
RIMS4

regulating synaptic membrane exocytosis 4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.20 5.28e-07 GO:0007399 nervous system development
1.63 2.31e-06 GO:0032502 developmental process
1.73 1.08e-05 GO:0048731 system development
1.64 1.12e-05 GO:0007275 multicellular organismal development
5.48 1.74e-05 GO:0007156 homophilic cell adhesion
1.66 2.94e-05 GO:0048856 anatomical structure development
2.22 9.16e-03 GO:0007155 cell adhesion
2.22 9.16e-03 GO:0022610 biological adhesion
3.03 1.55e-02 GO:0016337 cell-cell adhesion
1.64 2.71e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 4.83e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
21.11 5.28e-04 GO:0045295 gamma-catenin binding
2.29 2.30e-03 GO:0005509 calcium ion binding
6.57 2.65e-02 GO:0008013 beta-catenin binding