Motif ID: GTF2A1,2.p2

Z-value: 0.921


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A2chr15_-_599495360.676.9e-02Click!
GTF2A1chr14_-_81687265,
chr14_-_81687574
0.314.5e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_203274646 0.742 NM_006763
BTG2
BTG family, member 2
chr17_+_17206626 0.350 NM_020201
NT5M
5',3'-nucleotidase, mitochondrial
chr11_+_5653484 0.324 NM_130390
TRIM34
tripartite motif containing 34
chr19_+_56153417 0.318 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr19_+_49468656 0.279 FTL
ferritin, light polypeptide
chr6_-_42713783 0.274 TBCC
tubulin folding cofactor C
chr12_-_7245048 0.265 C1R
complement component 1, r subcomponent
chr19_+_49468587 0.259 FTL
ferritin, light polypeptide
chrX_-_106960268 0.258 NM_004089
TSC22D3
TSC22 domain family, member 3
chr8_+_70378858 0.258 NM_001128204
NM_015170
SULF1

sulfatase 1

chr19_+_49468557 0.257 NM_000146
FTL
ferritin, light polypeptide
chr10_-_103543156 0.252 NM_006993
NPM3
nucleophosmin/nucleoplasmin 3
chr10_-_103543148 0.248 NPM3
nucleophosmin/nucleoplasmin 3
chr2_+_30369800 0.244 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30369749 0.241 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr12_-_7245006 0.234 NM_001733
C1R
complement component 1, r subcomponent
chr16_-_4562979 0.232 C16orf5
chromosome 16 open reading frame 5
chr2_+_95537177 0.230 NM_144705
TEKT4
tektin 4
chr10_+_101542460 0.229 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr17_-_39183453 0.228 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr11_-_111782447 0.222 NM_001885
CRYAB
crystallin, alpha B
chr11_+_59522905 0.219 STX3
syntaxin 3
chr7_+_97911023 0.213 BRI3
brain protein I3
chr2_+_27301434 0.212 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr2_+_28616346 0.211 FOSL2
FOS-like antigen 2
chr12_-_52715140 0.208 NM_002282
KRT83
keratin 83
chr18_+_616671 0.207 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr2_+_30369868 0.206 YPEL5
yippee-like 5 (Drosophila)
chr1_+_149822627 0.206 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr12_-_15038724 0.205 NM_000900
NM_001190839
MGP

matrix Gla protein

chr22_+_22786283 0.202


chr10_+_134351272 0.201 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr12_+_7341758 0.198 NM_001131026
PEX5
peroxisomal biogenesis factor 5
chr12_+_118814310 0.193 NM_022491
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr1_+_164818083 0.189 PBX1
pre-B-cell leukemia homeobox 1
chr12_+_12509947 0.188 NM_058169
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr17_+_54230835 0.188 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr2_+_28615695 0.186 FOSL2
FOS-like antigen 2
chr7_+_97910978 0.185 NM_001159491
NM_015379
BRI3

brain protein I3

chr16_+_691901 0.184 FAM195A
family with sequence similarity 195, member A
chr19_-_18654376 0.182 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr1_+_163038564 0.181 NM_005613
RGS4
regulator of G-protein signaling 4
chr1_+_163038934 0.181 NM_001113381
RGS4
regulator of G-protein signaling 4
chr22_-_30685485 0.177 NM_001037666
GATSL3
GATS protein-like 3
chr1_+_78470593 0.177 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr6_-_27799304 0.175 NM_003541
HIST1H4A
HIST1H4F
HIST1H4K
HIST1H4J
histone cluster 1, H4a
histone cluster 1, H4f
histone cluster 1, H4k
histone cluster 1, H4j
chr2_+_177028804 0.172 NM_006898
HOXD3
homeobox D3
chr7_-_105516923 0.168 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr6_-_24877453 0.168 NM_015864
FAM65B
family with sequence similarity 65, member B
chr16_+_691827 0.168 NM_138418
FAM195A
family with sequence similarity 195, member A
chr11_-_46867788 0.167 CKAP5
cytoskeleton associated protein 5
chr2_+_205410465 0.166 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr19_+_41082792 0.166 SHKBP1
SH3KBP1 binding protein 1
chr20_+_11898536 0.165 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr19_-_18654280 0.164 FKBP8
FK506 binding protein 8, 38kDa
chr1_-_57045214 0.163 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_+_111855406 0.162 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr17_+_45286713 0.160 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr5_-_175964223 0.159 NM_014901
RNF44
ring finger protein 44
chr17_-_21156577 0.158 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr7_+_73082320 0.157 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr20_+_35201854 0.156 NM_001199513
NM_001199514
TGIF2

TGFB-induced factor homeobox 2

chr17_+_1665233 0.156 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_+_84768333 0.155 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr5_-_95158365 0.155 GLRX
glutaredoxin (thioltransferase)
chr7_+_73082157 0.154 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr20_+_35201948 0.153 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr5_+_156696351 0.152 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_+_134555867 0.150 LINC00086
long intergenic non-protein coding RNA 86
chr3_-_99594915 0.150 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr17_+_1665342 0.149 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_67275549 0.148 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr19_-_39264144 0.147 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_-_63993562 0.146 NM_001033678
NM_001160389
NM_001160390
NM_001160392
NM_031472
TRPT1




tRNA phosphotransferase 1




chrX_+_12993224 0.146 NM_021109
TMSB4X
thymosin beta 4, X-linked
chrX_-_106960028 0.146 TSC22D3
TSC22 domain family, member 3
chr2_-_50574891 0.145 NM_138735
NRXN1
neurexin 1
chr19_-_5903991 0.144 NM_001193375
NM_175614
NDUFA11

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa

chr19_-_46417952 0.144 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr14_+_100531764 0.144 EVL
Enah/Vasp-like
chr2_+_28616360 0.143 FOSL2
FOS-like antigen 2
chr2_+_27301693 0.142 EMILIN1
elastin microfibril interfacer 1
chr19_-_1479176 0.141 C19orf25
chromosome 19 open reading frame 25
chr9_+_92219926 0.141 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr1_-_91487769 0.141 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr9_+_125273080 0.140 NM_054107
OR1J2
olfactory receptor, family 1, subfamily J, member 2
chr17_-_19651586 0.140 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_+_205410556 0.139 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr1_+_42928873 0.138 CCDC30
coiled-coil domain containing 30
chr1_-_57044980 0.138 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_74653338 0.137 NM_152635
OIT3
oncoprotein induced transcript 3
chr12_+_7342269 0.137 NM_001131023
NM_001131024
NM_001131025
PEX5


peroxisomal biogenesis factor 5


chr6_+_43139201 0.137 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr22_+_35777051 0.136 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr1_+_16693582 0.136 NM_001114600
NM_015609
C1orf144

chromosome 1 open reading frame 144

chr5_+_110407389 0.134 NM_033035
TSLP
thymic stromal lymphopoietin
chr5_-_95158465 0.134 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr22_-_24640850 0.132 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr10_+_101542554 0.132 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_-_35696359 0.131 NM_001145775
FKBP5
FK506 binding protein 5
chr9_-_5437825 0.131 NM_018465
C9orf46
chromosome 9 open reading frame 46
chr1_+_205473683 0.131 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr22_+_35777087 0.130 HMOX1
heme oxygenase (decycling) 1
chr1_+_205473768 0.129 CDK18
cyclin-dependent kinase 18
chr1_-_148176392 0.129


chr10_+_92980322 0.128 NM_032373
PCGF5
polycomb group ring finger 5
chr1_+_84864214 0.128 NM_021233
DNASE2B
deoxyribonuclease II beta
chr22_+_41347328 0.128 NM_014248
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr1_+_159141376 0.127 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr2_-_237172987 0.127 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr22_+_18893735 0.126 NM_005675
DGCR6
DiGeorge syndrome critical region gene 6
chr12_+_56618104 0.124 NM_024068
OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B
chr6_-_24583454 0.124 NM_001252328
KIAA0319
KIAA0319
chr1_-_151319674 0.124 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr19_+_41082729 0.123 NM_138392
SHKBP1
SH3KBP1 binding protein 1
chr8_+_42128821 0.122 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr6_+_149639435 0.121 NM_015093
TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr9_+_124043719 0.121 GSN
gelsolin
chr16_+_19079220 0.121 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr22_-_45608346 0.120 NM_015264
KIAA0930
KIAA0930
chr5_-_111312522 0.120 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr19_-_50316360 0.120 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr19_-_1479198 0.118 NM_152482
C19orf25
chromosome 19 open reading frame 25
chr19_+_41082786 0.117 SHKBP1
SH3KBP1 binding protein 1
chr17_+_79679299 0.117 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr5_+_87564729 0.117 LOC100505894
uncharacterized LOC100505894
chr5_+_137774632 0.114 NM_016606
REEP2
receptor accessory protein 2
chr14_+_75745480 0.114 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_+_14927305 0.114 H2AFJ
H2A histone family, member J
chr3_-_18480203 0.113 NM_001131010
SATB1
SATB homeobox 1
chr17_+_1665306 0.113 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_-_57045129 0.113 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_48213567 0.113 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr12_-_10324675 0.113 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr9_+_131580719 0.112 NM_004435
ENDOG
endonuclease G
chr2_+_28615771 0.111 NM_005253
FOSL2
FOS-like antigen 2
chr6_-_35765056 0.110 NM_001252597
NM_001252598
NM_001832
CLPS


colipase, pancreatic


chr19_-_1479194 0.110 C19orf25
chromosome 19 open reading frame 25
chrX_-_107334749 0.110 NM_002814
NM_170750
PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr10_-_13390018 0.110 SEPHS1
selenophosphate synthetase 1
chr12_+_56618150 0.109 OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B
chr12_-_54582588 0.109 NM_001243789
NM_001243790
NM_001243787
NM_001243788
NM_001243791
NM_014311
SMUG1





single-strand-selective monofunctional uracil-DNA glycosylase 1





chr20_+_47895178 0.108 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr20_+_23420321 0.107 NM_138283
CSTL1
cystatin-like 1
chr16_+_55515468 0.107 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr5_-_81046943 0.106 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr19_+_3572950 0.105 HMG20B
high mobility group 20B
chr11_-_63993340 0.105 NM_001160393
TRPT1
tRNA phosphotransferase 1
chr6_+_36644236 0.105 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chrX_-_134232663 0.105 LINC00087
long intergenic non-protein coding RNA 87
chr11_+_56949220 0.105 NM_001005210
LRRC55
leucine rich repeat containing 55
chr10_-_120355158 0.105 NM_004248
PRLHR
prolactin releasing hormone receptor
chr22_+_41347373 0.105 RBX1
ring-box 1, E3 ubiquitin protein ligase
chr11_+_313852 0.104 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr5_+_150020201 0.104 NM_001109974
NM_007286
SYNPO

synaptopodin

chr19_+_840963 0.104 PRTN3
proteinase 3
chr1_-_3816823 0.104 NM_207356
C1orf174
chromosome 1 open reading frame 174
chr4_-_26491888 0.104 NM_000730
CCKAR
cholecystokinin A receptor
chr1_-_57045235 0.104 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_42843217 0.103


chr16_-_66583587 0.103 TK2
thymidine kinase 2, mitochondrial
chr10_+_92980507 0.103 PCGF5
polycomb group ring finger 5
chr19_+_54606141 0.102 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr19_+_840970 0.102 NM_002777
PRTN3
proteinase 3
chr20_+_33146500 0.102 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr16_+_58283819 0.101 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr15_-_82338348 0.100 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr17_+_39240412 0.100 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr2_-_228244005 0.100 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr16_-_71264557 0.100 NM_032821
NM_017558
HYDIN

hydrocephalus inducing homolog (mouse)

chr19_+_3572903 0.100 NM_006339
HMG20B
high mobility group 20B
chr11_+_61008643 0.100 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr14_+_105953531 0.100 CRIP1
cysteine-rich protein 1 (intestinal)
chr3_+_29322802 0.099 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr1_-_11714396 0.099 FBXO2
F-box protein 2
chr19_-_41255827 0.098 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr3_+_141457035 0.098 NM_001201370
NM_014245
NM_183237
RNF7


ring finger protein 7


chr3_+_69985750 0.098 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chrX_-_92928566 0.098 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr19_-_49140569 0.097 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr11_-_72385411 0.097 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr10_-_82049178 0.097 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr19_+_35629727 0.097 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr4_-_82126200 0.096 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr6_+_26104103 0.096 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chr1_+_151253977 0.096 ZNF687
zinc finger protein 687
chr21_-_35987144 0.095 NM_004414
RCAN1
regulator of calcineurin 1
chr17_-_27916620 0.095 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr5_+_140566655 0.095 NM_019119
PCDHB9
protocadherin beta 9
chr4_+_142142044 0.094 NM_014487
ZNF330
zinc finger protein 330
chr19_-_1095380 0.094 NM_002695
POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr1_-_33116090 0.094 NM_178547
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr3_+_141457110 0.094 RNF7
ring finger protein 7
chr16_+_19078916 0.094 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr1_+_202976513 0.094 TMEM183A
transmembrane protein 183A
chr9_+_12693385 0.094 NM_000550
TYRP1
tyrosinase-related protein 1
chr12_-_56320895 0.093 NM_001143853
WIBG
within bgcn homolog (Drosophila)
chr19_-_39443326 0.093 NM_148169
FBXO17
F-box protein 17
chr1_-_151319717 0.093 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr15_-_83378488 0.092 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.74e-04 GO:0009987 cellular process
3.63 1.45e-02 GO:0031333 negative regulation of protein complex assembly
3.13 1.98e-02 GO:0051494 negative regulation of cytoskeleton organization
1.89 2.14e-02 GO:0030029 actin filament-based process
10.42 2.14e-02 GO:0042989 sequestering of actin monomers
1.45 2.88e-02 GO:0032774 RNA biosynthetic process
1.48 3.02e-02 GO:0006351 transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 1.79e-05 GO:0005829 cytosol
1.08 1.88e-05 GO:0005622 intracellular
1.08 1.46e-04 GO:0044424 intracellular part
1.15 3.16e-03 GO:0005634 nucleus
1.18 2.46e-02 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.61e-08 GO:0005515 protein binding
1.09 1.07e-06 GO:0005488 binding
1.41 1.92e-02 GO:0001071 nucleic acid binding transcription factor activity
1.41 1.92e-02 GO:0003700 sequence-specific DNA binding transcription factor activity