Motif ID: GUCAGUU

Z-value: 0.366


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223 MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_100027943 0.115 NM_032211
LOXL4
lysyl oxidase-like 4
chr5_+_71403040 0.104 NM_005909
MAP1B
microtubule-associated protein 1B
chr20_-_4982133 0.089 NM_005116
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr18_-_65183922 0.075 NM_032160
DSEL
dermatan sulfate epimerase-like
chr1_-_92371558 0.074 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr8_-_134584012 0.074 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr1_-_92351613 0.071 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr20_-_4990913 0.071 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr18_+_42260774 0.066 NM_015559
SETBP1
SET binding protein 1
chr13_-_24007822 0.063 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr9_-_16870719 0.061 NM_017637
BNC2
basonuclin 2
chr3_-_33260706 0.057 NM_015551
SUSD5
sushi domain containing 5
chr12_-_26985922 0.057 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chrX_+_77166178 0.056 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chrX_-_142722869 0.053 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr12_-_90049818 0.053 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr1_-_109969058 0.052 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr3_+_169755733 0.051 NM_014373
GPR160
G protein-coupled receptor 160
chr10_-_79397546 0.049 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr2_-_158300517 0.049 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_+_19437140 0.048 NM_018242
SLC47A1
solute carrier family 47, member 1
chrX_-_142722318 0.046 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr10_-_14372807 0.046 NM_018027
FRMD4A
FERM domain containing 4A
chr2_-_40657419 0.044 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chr20_+_45338125 0.043 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr10_+_31608097 0.043 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chrX_-_142723921 0.043 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr15_+_99192696 0.043 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr19_-_31840118 0.042 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr3_-_37034609 0.042 NM_014805
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr5_-_136834887 0.041 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_-_8534008 0.041 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr9_-_27005649 0.041 NM_022901
LRRC19
leucine rich repeat containing 19
chr1_+_116184573 0.040 NM_001172411
NM_138959
VANGL1

vang-like 1 (van gogh, Drosophila)

chr19_+_21264952 0.039 NM_182515
ZNF714
zinc finger protein 714
chr1_+_90098643 0.039 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr11_-_94134575 0.038 NM_016540
GPR83
G protein-coupled receptor 83
chr10_+_31610063 0.038 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr1_+_163038564 0.038 NM_005613
RGS4
regulator of G-protein signaling 4
chr1_+_163038395 0.038 NM_001102445
RGS4
regulator of G-protein signaling 4
chr14_-_75078669 0.038 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr16_-_73082169 0.037 NM_006885
ZFHX3
zinc finger homeobox 3
chr1_+_163038934 0.037 NM_001113381
RGS4
regulator of G-protein signaling 4
chr1_+_163041694 0.037 NM_001113380
RGS4
regulator of G-protein signaling 4
chr15_-_34681891 0.037 NM_181077
GOLGA8A
GOLGA8B
golgin A8 family, member A
golgin A8 family, member B
chr10_-_21463019 0.037 NM_001173484
NM_213569
NEBL

nebulette

chr2_-_40739570 0.036 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr16_+_14726667 0.035 NM_016561
BFAR
bifunctional apoptosis regulator
chr12_+_121837843 0.035 NM_025126
NM_194271
RNF34

ring finger protein 34

chr1_+_116185249 0.034 NM_001172412
VANGL1
vang-like 1 (van gogh, Drosophila)
chr7_+_72742154 0.034 NM_001135211
NM_003602
FKBP6

FK506 binding protein 6, 36kDa

chr1_+_78956727 0.034 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr17_-_35969401 0.034 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr20_-_32274154 0.033 NM_005225
E2F1
E2F transcription factor 1
chr11_-_61584451 0.033 NM_013402
FADS1
fatty acid desaturase 1
chr5_-_9546157 0.033 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chrX_+_57618268 0.033 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr10_-_21186530 0.033 NM_006393
NEBL
nebulette
chr5_-_172756505 0.033 NM_003714
STC2
stanniocalcin 2
chr1_+_118148506 0.033 NM_017709
FAM46C
family with sequence similarity 46, member C
chr2_+_20646831 0.033 NM_004040
RHOB
ras homolog gene family, member B
chr9_+_91606349 0.033 NM_005226
S1PR3
sphingosine-1-phosphate receptor 3
chr1_+_210111537 0.033 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr2_+_223725675 0.032 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr13_+_33160537 0.032 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr11_-_33744272 0.032 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr1_-_95007139 0.032 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr5_-_158636489 0.032 NM_001199383
RNF145
ring finger protein 145
chr13_+_108870713 0.032 NM_032859
ABHD13
abhydrolase domain containing 13
chr11_-_33744497 0.032 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr15_-_49338496 0.032 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr3_+_45927995 0.032 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr5_-_121414011 0.032 NM_002317
LOX
lysyl oxidase
chr6_+_47624222 0.032 NM_153839
GPR111
G protein-coupled receptor 111
chr10_+_54074037 0.032 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr16_+_2587951 0.032 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr2_+_109335906 0.031 NM_006267
RANBP2
RAN binding protein 2
chr22_-_29075708 0.031 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr5_-_121412805 0.031 NM_001178102
LOX
lysyl oxidase
chr17_-_34417386 0.031 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr4_-_103245468 0.031 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_33757872 0.031 NM_000611
NM_203329
NM_203330
NM_203331
CD59



CD59 molecule, complement regulatory protein



chr4_+_174089889 0.030 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr7_-_140098256 0.030 NM_032295
NM_207113
SLC37A3

solute carrier family 37 (glycerol-3-phosphate transporter), member 3

chr19_-_39368889 0.030 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr7_-_152133071 0.029 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr5_-_55290601 0.029 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr22_-_30642683 0.029 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_+_155054511 0.029 NM_014892
SCAF8
SR-related CTD-associated factor 8
chr15_-_34828112 0.029 NM_001023567
GOLGA8A
GOLGA8B
golgin A8 family, member A
golgin A8 family, member B
chrX_+_154997396 0.029 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr16_-_73092533 0.029 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_-_196230365 0.029 NM_152617
RNF168
ring finger protein 168
chr19_-_55954229 0.028 NM_001145176
SHISA7
shisa homolog 7 (Xenopus laevis)
chr7_-_82792127 0.028 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr1_+_171454636 0.027 NM_015172
PRRC2C
proline-rich coiled-coil 2C
chr2_+_26568900 0.027 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr7_-_139477437 0.027 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr12_+_1100352 0.027 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr5_+_140792507 0.027 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr2_-_175351755 0.027 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr1_-_72748147 0.027 NM_173808
NEGR1
neuronal growth regulator 1
chrX_+_37545008 0.026 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr5_+_140777603 0.026 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chrY_+_59100402 0.026 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr17_+_4981721 0.026 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr7_-_47621741 0.026 NM_022748
TNS3
tensin 3
chr11_-_74109417 0.025 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr9_-_14693459 0.025 NM_178566
ZDHHC21
zinc finger, DHHC-type containing 21
chr18_-_21166440 0.025 NM_000271
NPC1
Niemann-Pick disease, type C1
chr6_+_111580481 0.025 NM_153369
KIAA1919
KIAA1919
chr3_+_138066489 0.025 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr2_-_167232464 0.025 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr12_-_125348422 0.025 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr4_+_166248816 0.025 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr17_-_59940669 0.025 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr11_+_3876919 0.025 NM_003156
STIM1
stromal interaction molecule 1
chr2_-_178483677 0.024 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr8_+_17354562 0.024 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr8_+_27183062 0.024 NM_173175
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr7_-_98467663 0.023 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr17_+_53342320 0.023 NM_002126
HLF
hepatic leukemia factor
chr5_-_90679115 0.023 NM_020801
ARRDC3
arrestin domain containing 3
chr9_-_99801365 0.023 NM_001333
CTSL2
cathepsin L2
chr5_+_140743755 0.023 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr2_+_149632772 0.023 NM_004522
KIF5C
kinesin family member 5C
chr5_+_140718353 0.023 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr9_-_85678042 0.023 NM_152573
RASEF
RAS and EF-hand domain containing
chr11_-_85376159 0.022 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr5_+_139175385 0.022 NM_032289
PSD2
pleckstrin and Sec7 domain containing 2
chr8_+_27182995 0.022 NM_173176
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr4_-_119273874 0.022 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr2_-_145277879 0.022 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_89990396 0.022 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr12_-_31743822 0.022 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr12_-_51419923 0.022 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_194354009 0.021 NM_001011655
NM_001166305
NM_001166306
NM_138399
TMEM44



transmembrane protein 44



chr15_+_40886442 0.021 NM_144508
NM_170589
CASC5

cancer susceptibility candidate 5

chr11_-_17191287 0.021 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr4_-_99579540 0.021 NM_005723
TSPAN5
tetraspanin 5
chr6_-_46138584 0.021 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr3_+_138067444 0.021 NM_001085049
NM_001252093
MRAS

muscle RAS oncogene homolog

chr7_-_25164902 0.021 NM_018947
CYCS
cytochrome c, somatic
chr2_-_86565205 0.021 NM_001164730
REEP1
receptor accessory protein 1
chr5_+_140810126 0.021 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr10_-_65028825 0.021 NM_004241
JMJD1C
jumonji domain containing 1C
chr17_-_76921453 0.021 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr2_-_120980971 0.021 NM_024121
TMEM185B
transmembrane protein 185B
chr1_-_109940497 0.020 NM_002959
SORT1
sortilin 1
chr8_+_27168953 0.020 NM_173174
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr12_-_21654484 0.020 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr9_-_99801924 0.020 NM_001201575
CTSL2
cathepsin L2
chr17_+_48133331 0.020 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr5_+_140753480 0.020 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr16_-_87525317 0.020 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chrX_-_34675366 0.020 NM_031442
TMEM47
transmembrane protein 47
chr15_+_84322809 0.020 NM_207517
ADAMTSL3
ADAMTS-like 3
chr5_+_112043188 0.020 NM_001127511
APC
adenomatous polyposis coli
chr10_+_1102741 0.020 NM_014023
WDR37
WD repeat domain 37
chr5_+_112073555 0.019 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr5_+_150827138 0.019 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr12_-_51403028 0.019 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr20_-_39317875 0.019 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr17_+_70117154 0.019 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr1_-_109935869 0.019 NM_001205228
SORT1
sortilin 1
chr5_-_158637060 0.019 NM_001199380
RNF145
ring finger protein 145
chr5_-_88119604 0.019 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr3_+_63638343 0.019 NM_001080537
SNTN
sentan, cilia apical structure protein
chr1_-_77685076 0.019 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr4_-_76928601 0.019 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr4_-_103266577 0.019 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr3_-_57199402 0.019 NM_017563
IL17RD
interleukin 17 receptor D
chr2_+_24807345 0.019 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr3_+_170075449 0.019 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr20_+_48429249 0.018 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr1_+_90024271 0.018 NM_015350
LRRC8B
leucine rich repeat containing 8 family, member B
chr12_-_51422012 0.018 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr5_+_140710203 0.018 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr15_-_51057894 0.018 NM_032802
SPPL2A
signal peptide peptidase-like 2A
chr4_+_187112635 0.018 NM_207352
CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr4_-_103266286 0.018 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr5_+_96271345 0.018 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr8_+_27179918 0.018 NM_004103
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr9_-_127703294 0.018 NM_002077
GOLGA1
golgin A1
chr4_-_73434467 0.018 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr17_-_42907606 0.018 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr5_+_140767402 0.018 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr17_-_42908178 0.017 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr5_+_140739589 0.017 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr3_+_42642105 0.017 NM_005385
NKTR
natural killer-tumor recognition sequence
chr5_+_140723600 0.017 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr5_+_140749830 0.017 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr12_+_79258448 0.017 NM_005639
SYT1
synaptotagmin I
chr5_+_140729723 0.017 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr12_+_79439432 0.017 NM_001135806
SYT1
synaptotagmin I
chr6_-_79787939 0.017 NM_017934
PHIP
pleckstrin homology domain interacting protein
chr5_-_41510627 0.017 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr2_+_36583369 0.017 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr15_+_91643429 0.017 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr15_+_78857827 0.017 NM_000745
CHRNA5
cholinergic receptor, nicotinic, alpha 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.12 4.37e-14 GO:0007156 homophilic cell adhesion
3.05 8.99e-06 GO:0016337 cell-cell adhesion
2.13 5.49e-05 GO:0007155 cell adhesion
2.13 5.49e-05 GO:0022610 biological adhesion
1.74 1.33e-04 GO:0007399 nervous system development
1.88 7.94e-03 GO:0055085 transmembrane transport
1.97 4.95e-02 GO:0048666 neuron development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.32e-05 GO:0016021 integral to membrane
1.31 2.70e-05 GO:0031224 intrinsic to membrane
1.22 2.03e-04 GO:0016020 membrane
1.67 1.23e-03 GO:0031226 intrinsic to plasma membrane
2.22 3.07e-03 GO:0043005 neuron projection
1.23 3.15e-03 GO:0044425 membrane part
1.64 3.73e-03 GO:0005887 integral to plasma membrane
1.30 5.85e-03 GO:0071944 cell periphery
1.28 1.46e-02 GO:0005886 plasma membrane
1.50 2.05e-02 GO:0012505 endomembrane system

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.69e-06 GO:0005488 binding
2.17 2.20e-05 GO:0005509 calcium ion binding
1.33 2.08e-03 GO:0046872 metal ion binding
1.32 4.40e-03 GO:0043169 cation binding
3.14 4.58e-03 GO:0046873 metal ion transmembrane transporter activity
1.31 5.16e-03 GO:0043167 ion binding
4.86 3.46e-02 GO:0046332 SMAD binding