Motif ID: HAND1,2.p2

Z-value: 1.761


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_174451356-0.265.3e-01Click!
HAND1chr5_-_153857782,
chr5_-_153857820
-0.167.1e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_58296264 3.640 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr19_-_51456159 2.937 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr18_+_61420276 2.895 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_-_31146992 2.758 PRSS8
protease, serine, 8
chr5_+_36608430 2.594 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr16_-_31147062 2.512 NM_002773
PRSS8
protease, serine, 8
chr1_+_156030965 2.425 NM_020387
RAB25
RAB25, member RAS oncogene family
chr12_+_41086189 2.311 NM_001843
NM_175038
CNTN1

contactin 1

chr11_-_119999516 2.133 TRIM29
tripartite motif containing 29
chr2_-_113542970 2.092 NM_000575
IL1A
interleukin 1, alpha
chr7_+_26403944 1.995 NM_001199838
SNX10
sorting nexin 10
chr7_-_20256942 1.803 NM_182762
MACC1
metastasis associated in colon cancer 1
chr18_+_61254533 1.775 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_+_28261503 1.587 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr11_+_18287807 1.489 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr5_+_140220811 1.337 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr11_+_111411232 1.315 NM_178834
LAYN
layilin
chr1_+_95558072 1.314 NM_001199679
TMEM56
transmembrane protein 56
chr14_-_61748510 1.284 NM_001017970
TMEM30B
transmembrane protein 30B
chr11_+_124933197 1.277 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr6_+_80340971 1.266 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr14_+_96722546 1.239 NM_000710
BDKRB1
bradykinin receptor B1
chrX_-_33357725 1.235 NM_000109
DMD
dystrophin
chr19_+_55587220 1.198 NM_133180
EPS8L1
EPS8-like 1
chr2_-_165478357 1.192 NM_004490
GRB14
growth factor receptor-bound protein 14
chr17_+_73720775 1.174 NM_001005619
ITGB4
integrin, beta 4
chr15_+_40531236 1.174 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_-_31637598 1.166 NM_000379
XDH
xanthine dehydrogenase
chr6_-_133119625 1.133 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr6_+_30856462 1.120 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr2_-_69098502 1.100 NM_014482
BMP10
bone morphogenetic protein 10
chr11_+_111411419 1.078 LAYN
layilin
chrX_-_32173585 1.069 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr22_+_45072936 1.068 PRR5
proline rich 5 (renal)
chr11_+_69924407 1.056 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr17_-_27402626 1.054 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_+_46646199 1.048 TSPAN1
tetraspanin 1
chr19_+_35606731 1.034 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr19_-_51472003 1.018 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr2_-_31637553 1.015 XDH
xanthine dehydrogenase
chr19_-_51504799 1.005 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr1_+_26856259 0.997 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr20_+_9288446 0.975 NM_000933
PLCB4
phospholipase C, beta 4
chr1_-_209825673 0.953 NM_001127641
LAMB3
laminin, beta 3
chr5_-_176836488 0.888 F12
coagulation factor XII (Hageman factor)
chr20_-_1306512 0.848 NM_001199784
SDCBP2
syndecan binding protein (syntenin) 2
chr15_+_69606741 0.827 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr5_+_36606667 0.827 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_156123321 0.825 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr1_-_209825797 0.815 NM_000228
LAMB3
laminin, beta 3
chr4_+_76481257 0.812 NM_001206981
NM_178497
C4orf26

chromosome 4 open reading frame 26

chr22_+_45072687 0.805 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr10_-_104211244 0.793 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr11_+_45943171 0.766 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chrX_+_69672356 0.764 DLG3
discs, large homolog 3 (Drosophila)
chr5_-_176836535 0.758 NM_000505
F12
coagulation factor XII (Hageman factor)
chr6_-_47009992 0.750 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr2_+_68961912 0.745 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_+_44398991 0.739 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr8_-_125580745 0.735 MTSS1
metastasis suppressor 1
chr5_+_36606456 0.715 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr19_-_39264144 0.709 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr1_+_33231260 0.706 KIAA1522
KIAA1522
chr11_+_121461070 0.700 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr20_-_43883183 0.695 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr20_+_62795773 0.676 MYT1
myelin transcription factor 1
chr8_+_21916858 0.663 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr15_+_68908878 0.651 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr1_+_33231227 0.641 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_26872342 0.620 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_+_21525980 0.608 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr17_+_37894212 0.602 GRB7
growth factor receptor-bound protein 7
chr11_+_118827007 0.582 NM_006760
UPK2
uroplakin 2
chr10_-_116444112 0.579 ABLIM1
actin binding LIM protein 1
chr4_-_72649734 0.570 NM_000583
GC
group-specific component (vitamin D binding protein)
chr6_-_31088195 0.560 NM_001264
CDSN
corneodesmosin
chr1_+_26872306 0.545 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr18_-_53068755 0.542 TCF4
transcription factor 4
chr5_-_176831183 0.536 F12
coagulation factor XII (Hageman factor)
chr4_-_40631846 0.535 NM_001098634
RBM47
RNA binding motif protein 47
chr12_-_110271205 0.535 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr11_-_63330854 0.525 NM_017878
HRASLS2
HRAS-like suppressor 2
chrX_+_128913881 0.522 NM_018990
SASH3
SAM and SH3 domain containing 3
chr7_-_143966380 0.520 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr7_+_143880547 0.520 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr17_-_39092714 0.504 KRT23
keratin 23 (histone deacetylase inducible)
chr4_-_38666429 0.501 FLJ13197
uncharacterized FLJ13197
chr11_+_34642587 0.500 NM_001206615
NM_012153
EHF

ets homologous factor

chr2_+_113875469 0.497 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr17_-_38074842 0.485 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr1_+_161676761 0.482 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr8_-_17580024 0.479 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr8_-_86290333 0.478 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr12_+_49688908 0.476 NM_006262
PRPH
peripherin
chr8_-_38008332 0.472 NM_000349
STAR
steroidogenic acute regulatory protein
chr12_-_53730003 0.467 NM_001173467
SP7
Sp7 transcription factor
chrX_+_128913897 0.463 SASH3
SAM and SH3 domain containing 3
chr1_-_209824641 0.447 NM_001017402
LAMB3
laminin, beta 3
chr9_-_112213663 0.447 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr17_+_37894161 0.447 NM_005310
GRB7
growth factor receptor-bound protein 7
chrX_-_13338517 0.443 NM_001135995
ATXN3L
ataxin 3-like
chr17_-_34266359 0.439 NM_020426
LYZL6
lysozyme-like 6
chr1_-_29450406 0.438 NM_001003682
TMEM200B
transmembrane protein 200B
chr17_-_56358161 0.433 MPO
myeloperoxidase
chr16_-_75528925 0.425 NM_021615
CHST6
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
chr14_-_23445885 0.417 AJUBA
ajuba LIM protein
chr1_+_31882411 0.417 NM_001199038
SERINC2
serine incorporator 2
chr1_+_152486977 0.413 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr12_-_110271182 0.412 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr11_+_60869929 0.412 NM_014207
CD5
CD5 molecule
chr17_-_39646115 0.407 NM_003771
KRT36
keratin 36
chr19_-_42894419 0.403 NM_032488
CNFN
cornifelin
chr12_-_86230158 0.402 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr4_-_53617565 0.401 ERVMER34-1
endogenous retrovirus group MER34, member 1
chr14_+_23775970 0.400 NM_001199864
NM_004050
NM_001199839
BCL2L2-PABPN1
BCL2L2

BCL2L2-PABPN1 readthrough
BCL2-like 2

chr1_+_26485510 0.398 NM_024869
FAM110D
family with sequence similarity 110, member D
chr11_+_124933007 0.393 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr10_-_116444374 0.392 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr3_-_43147470 0.385 NM_032806
C3orf39
chromosome 3 open reading frame 39
chr14_-_24777153 0.383 CIDEB
cell death-inducing DFFA-like effector b
chr2_+_113885145 0.383 IL1RN
interleukin 1 receptor antagonist
chr2_+_75059781 0.381 NM_000189
HK2
hexokinase 2
chrX_-_55057408 0.379 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr11_+_34642651 0.376 EHF
ets homologous factor
chr1_+_13910251 0.370 NM_006474
NM_198389
PDPN

podoplanin

chr19_-_36304200 0.368 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr21_-_46340821 0.365 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chrX_+_50027539 0.359 NM_033031
NM_033670
CCNB3

cyclin B3

chr1_+_81771844 0.357 LPHN2
latrophilin 2
chr16_+_57728711 0.353 NM_032269
CCDC135
coiled-coil domain containing 135
chr6_+_167525294 0.343 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr11_+_2323356 0.342 TSPAN32
tetraspanin 32
chr12_-_110252600 0.341 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr4_+_69313166 0.338 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr15_-_90222572 0.338 NM_001145311
NM_002666
PLIN1

perilipin 1

chr12_+_13043955 0.337 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_+_202183282 0.334 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr12_-_57410275 0.332 NM_001178054
NM_013251
TAC3

tachykinin 3

chr5_+_140345746 0.331 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr15_-_52043649 0.329 NM_001143917
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr13_+_113812967 0.329 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr5_-_150948504 0.328 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr12_-_53729429 0.326 NM_152860
SP7
Sp7 transcription factor
chr18_+_21572736 0.319 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr7_+_63774378 0.319 ZNF736
zinc finger protein 736
chr14_-_107078578 0.315


chr12_-_86229981 0.315 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr10_-_5045967 0.314 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr13_-_46742678 0.311 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_182419255 0.311 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr3_-_190167597 0.311 NM_207316
TMEM207
transmembrane protein 207
chr16_+_78056411 0.309 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr2_-_74756973 0.305 NM_181575
AUP1
ancient ubiquitous protein 1
chr6_-_53013581 0.295 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr10_-_76859247 0.294 NM_016364
DUSP13
dual specificity phosphatase 13
chr2_+_113735595 0.291 NM_019618
IL36G
interleukin 36, gamma
chr11_+_33037397 0.288 NM_001077242
DEPDC7
DEP domain containing 7
chr2_-_216003068 0.287 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr19_-_49243836 0.287 NM_017805
RASIP1
Ras interacting protein 1
chr1_-_156722023 0.287 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr1_-_26680620 0.287 NM_001039775
AIM1L
absent in melanoma 1-like
chr21_+_30517897 0.287 C21orf7
chromosome 21 open reading frame 7
chr20_-_1309809 0.286 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_+_15904760 0.286 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr11_+_71846755 0.285 NM_000804
FOLR3
folate receptor 3 (gamma)
chr17_+_37896219 0.284 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr6_+_26402464 0.284 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr1_+_44444848 0.284 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr11_+_60197061 0.282 NM_023945
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr4_+_87515465 0.281 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr12_+_113416267 0.277 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_154293568 0.277 NM_080429
AQP10
aquaporin 10
chr5_-_137071462 0.275 KLHL3
kelch-like 3 (Drosophila)
chr6_-_55740387 0.274 BMP5
bone morphogenetic protein 5
chr17_+_1646129 0.274 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr3_+_50304989 0.273 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr20_+_816710 0.273 NM_207121
FAM110A
family with sequence similarity 110, member A
chr1_-_59012379 0.272 NM_145243
OMA1
OMA1 zinc metallopeptidase homolog (S. cerevisiae)
chr6_-_134373618 0.271 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr20_+_19867075 0.270 NM_001242581
RIN2
Ras and Rab interactor 2
chr22_-_32853372 0.269 NM_174932
BPIFC
BPI fold containing family C
chr11_+_2323236 0.268 NM_139022
TSPAN32
tetraspanin 32
chr5_+_140186658 0.267 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr14_-_24777160 0.267 CIDEB
cell death-inducing DFFA-like effector b
chr16_-_28608367 0.267 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr17_-_56358266 0.262 NM_000250
MPO
myeloperoxidase
chr10_+_95517565 0.260 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr6_-_13408368 0.259 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr7_+_112092112 0.258 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr4_+_41614911 0.253 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr9_-_5304579 0.251 NM_005059
NM_134441
RLN2

relaxin 2

chr12_-_23737507 0.250 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr3_+_195447751 0.250 NM_152673
MUC20
mucin 20, cell surface associated
chr9_-_25678855 0.250 NM_001004125
TUSC1
tumor suppressor candidate 1
chr9_-_132515290 0.250 NM_004878
PTGES
prostaglandin E synthase
chr3_-_20227618 0.249 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
NM_001199251
NM_001199252
NM_001199253
NM_001199254
NM_001199255
NM_001199256
NM_001199257
SGOL1












shugoshin-like 1 (S. pombe)












chr6_-_55740358 0.246 NM_021073
BMP5
bone morphogenetic protein 5
chr3_-_172241060 0.246 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr19_+_11649578 0.245 NM_001299
CNN1
calponin 1, basic, smooth muscle
chrX_+_70364680 0.245 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 4.63e-05 GO:0005576 extracellular region
1.80 9.17e-04 GO:0005615 extracellular space
1.66 1.90e-03 GO:0044421 extracellular region part

Nothing significant found in function category.