Motif ID: HIC1.p2

Z-value: 1.263


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512
0.945.4e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_101420032 2.243 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr15_+_41136622 2.171 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_101420004 2.104 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr14_-_105635114 1.974 NM_002226
NM_145159
JAG2

jagged 2

chr14_-_105634708 1.826 JAG2
jagged 2
chr8_-_41166931 1.733 NM_003012
SFRP1
secreted frizzled-related protein 1
chr17_+_54671059 1.657 NM_005450
NOG
noggin
chr18_-_28681885 1.503 NM_004949
NM_024422
DSC2

desmocollin 2

chr2_-_46384 1.321 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr1_-_62784971 1.314 KANK4
KN motif and ankyrin repeat domains 4
chr1_+_117452359 1.296 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr8_+_61591358 1.204 CHD7
chromodomain helicase DNA binding protein 7
chr2_-_70781146 1.183 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr1_-_62785067 1.151 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr8_+_61591239 1.127 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr15_+_41136178 1.116 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_48462561 1.095 NM_001194986
LOC388630
UPF0632 protein A
chr7_+_26191732 1.084 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr1_+_109792640 1.067 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr14_+_65171149 1.027 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr18_+_33877630 1.016 NM_025135
FHOD3
formin homology 2 domain containing 3
chrX_+_152953751 0.998 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr7_-_44365019 0.942 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr2_-_70780621 0.909 TGFA
transforming growth factor, alpha
chr14_+_67999915 0.891 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr19_+_45312294 0.878 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr2_-_96811138 0.874 NM_004418
DUSP2
dual specificity phosphatase 2
chr1_+_234349995 0.864 SLC35F3
solute carrier family 35, member F3
chr22_+_45148437 0.850 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr4_-_84255895 0.847 NM_001199830
HPSE
heparanase
chr4_-_84255999 0.847 HPSE
heparanase
chr2_+_106361404 0.829 NM_001004722
NM_003581
NCK2

NCK adaptor protein 2

chr3_-_124931562 0.804 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr4_-_22517339 0.787 NM_145290
GPR125
G protein-coupled receptor 125
chr17_+_30813928 0.771 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr11_+_394238 0.771 PKP3
plakophilin 3
chr2_-_235405692 0.764 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr16_+_81478774 0.761 NM_198390
CMIP
c-Maf inducing protein
chr9_-_135996287 0.758 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr15_+_90744506 0.752 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr18_-_74844710 0.734 MBP
myelin basic protein
chr3_-_189838673 0.726 LEPREL1
leprecan-like 1
chr8_+_145734445 0.725 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chr4_-_84256304 0.724 NM_001166498
NM_006665
HPSE

heparanase

chr11_+_121322848 0.724 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_-_190040192 0.722 NM_021101
CLDN1
claudin 1
chr21_+_46825291 0.721


chr17_-_31203889 0.715 NM_015194
MYO1D
myosin ID
chr1_+_18434236 0.712 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr1_-_85358851 0.702 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr16_+_22825806 0.699 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr18_+_10454620 0.695 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr6_+_7541837 0.692 DSP
desmoplakin
chr18_+_10454542 0.687 APCDD1
adenomatosis polyposis coli down-regulated 1
chr15_-_83621350 0.680 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr1_+_233463513 0.678 NM_032435
KIAA1804
mixed lineage kinase 4
chr17_+_8924822 0.677 NM_004822
NTN1
netrin 1
chr1_-_11714396 0.674 FBXO2
F-box protein 2
chr1_+_234040547 0.673 NM_173508
SLC35F3
solute carrier family 35, member F3
chr1_-_85462622 0.672 NM_153259
MCOLN2
mucolipin 2
chr6_+_7541863 0.662 NM_001008844
NM_004415
DSP

desmoplakin

chr12_+_133067156 0.661 NM_001142641
FBRSL1
fibrosin-like 1
chr3_+_50192847 0.660 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr8_+_98881277 0.657 NM_002380
NM_030583
MATN2

matrilin 2

chr22_+_26825220 0.652 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr17_-_3599298 0.648 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr22_+_45098091 0.644 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr15_-_83953465 0.644 NM_001717
BNC1
basonuclin 1
chr9_+_93564099 0.641 SYK
spleen tyrosine kinase
chr4_+_77610610 0.639 SHROOM3
shroom family member 3
chr10_+_82214066 0.637 TSPAN14
tetraspanin 14
chr4_+_95679075 0.634 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr20_+_9049660 0.631 NM_001172646
PLCB4
phospholipase C, beta 4
chr15_+_68871285 0.631 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr10_-_14646407 0.626 FAM107B
family with sequence similarity 107, member B
chr9_+_93564204 0.625 NM_001174168
SYK
spleen tyrosine kinase
chr21_+_18885104 0.624 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr17_-_74581881 0.615 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr8_-_495330 0.612 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr14_+_61788398 0.607 NM_006255
PRKCH
protein kinase C, eta
chr21_+_42540054 0.606 BACE2
beta-site APP-cleaving enzyme 2
chr4_+_1795004 0.605 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr17_-_74581934 0.604 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr5_+_52776408 0.599 FST
follistatin
chr3_+_50192420 0.599 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr2_-_31361284 0.591 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr10_+_82213892 0.590 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr11_-_17035948 0.587 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr5_+_52776263 0.587 NM_006350
NM_013409
FST

follistatin

chr1_-_19282773 0.587 NM_001136265
IFFO2
intermediate filament family orphan 2
chr13_-_76055872 0.587 NM_014832
TBC1D4
TBC1 domain family, member 4
chr14_-_38064440 0.577 NM_004496
FOXA1
forkhead box A1
chr1_-_27286875 0.575 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr19_+_35739838 0.573 LSR
lipolysis stimulated lipoprotein receptor
chr10_-_123357503 0.572 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr1_+_33207343 0.572 NM_020888
KIAA1522
KIAA1522
chr3_-_10547221 0.571 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr11_+_45944155 0.569 GYLTL1B
glycosyltransferase-like 1B
chr18_-_78005230 0.563 NM_032510
PARD6G
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr2_+_47596447 0.560 EPCAM
epithelial cell adhesion molecule
chr6_+_150464156 0.559 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr1_-_85514174 0.559 NM_001253693
NM_018298
MCOLN3

mucolipin 3

chr18_-_28622624 0.555 NM_001941
NM_024423
DSC3

desmocollin 3

chr1_+_31885962 0.549 NM_178865
SERINC2
serine incorporator 2
chr22_+_43506753 0.545 NM_001197
BIK
BCL2-interacting killer (apoptosis-inducing)
chr18_-_28681429 0.543 DSC2
desmocollin 2
chr1_-_205649537 0.539 SLC45A3
solute carrier family 45, member 3
chr4_+_78978723 0.538 NM_001166133
NM_025074
FRAS1

Fraser syndrome 1

chr21_+_18885296 0.538 CXADR
coxsackie virus and adenovirus receptor
chr5_+_52776479 0.538 FST
follistatin
chr19_+_35739519 0.538 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr10_+_82214071 0.537 TSPAN14
tetraspanin 14
chr7_-_108096693 0.534 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr8_-_125740650 0.533 NM_014751
MTSS1
metastasis suppressor 1
chr9_-_124990706 0.532 NM_001242333
LHX6
LIM homeobox 6
chr6_+_147829784 0.532 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr22_+_33197744 0.532 TIMP3
TIMP metallopeptidase inhibitor 3
chr1_-_9970265 0.531 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr4_-_84256012 0.530 NM_001098540
HPSE
heparanase
chr1_+_31886659 0.528 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr9_-_136024522 0.527 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chr1_+_15250578 0.525 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr22_+_45064323 0.525 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr19_+_35739778 0.519 LSR
lipolysis stimulated lipoprotein receptor
chr10_+_82214074 0.517 TSPAN14
tetraspanin 14
chr20_+_1875382 0.517 NM_080792
SIRPA
signal-regulatory protein alpha
chr8_-_494834 0.513 C8orf42
chromosome 8 open reading frame 42
chr1_+_43996478 0.513 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr6_+_18155535 0.512 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr22_-_20255614 0.512 NM_023004
RTN4R
reticulon 4 receptor
chr2_+_231577624 0.511 CAB39
calcium binding protein 39
chr16_-_85784628 0.510 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr4_+_53728481 0.509 NM_023940
RASL11B
RAS-like, family 11, member B
chr21_-_42219038 0.505 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr21_-_42218587 0.501 DSCAM
Down syndrome cell adhesion molecule
chr1_-_42501573 0.499 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr17_-_31204071 0.498 MYO1D
myosin ID
chr17_+_78075299 0.496 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr7_+_26331493 0.495 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr6_+_1312674 0.494 NM_033260
FOXQ1
forkhead box Q1
chr9_-_124990949 0.493 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr2_-_165697927 0.493 NM_014900
COBLL1
COBL-like 1
chr12_-_123635284 0.491 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr18_+_55711388 0.490 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr1_-_32801606 0.490 NM_023009
MARCKSL1
MARCKS-like 1
chr7_+_26331611 0.485 SNX10
sorting nexin 10
chr22_+_33197678 0.484 TIMP3
TIMP metallopeptidase inhibitor 3
chr1_+_15480213 0.483 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr9_-_139137646 0.479 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr18_+_21269528 0.475 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr8_+_28559010 0.475 EXTL3
exostoses (multiple)-like 3
chr11_+_10472223 0.473 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr20_-_49639616 0.473 NM_002237
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr1_+_14925177 0.472 NM_015209
NM_201628
KAZN

kazrin, periplakin interacting protein

chr7_+_128577990 0.471 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr18_+_10454625 0.469 APCDD1
adenomatosis polyposis coli down-regulated 1
chr17_+_15848230 0.468 NM_000676
ADORA2B
adenosine A2b receptor
chr6_-_170599568 0.468 NM_005618
DLL1
delta-like 1 (Drosophila)
chr7_-_139762339 0.468 PARP12
poly (ADP-ribose) polymerase family, member 12
chr13_+_25946084 0.464 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr8_+_74207093 0.462 RDH10
retinol dehydrogenase 10 (all-trans)
chr10_-_6019454 0.460 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr1_+_26856259 0.458 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_-_125740378 0.455 MTSS1
metastasis suppressor 1
chr6_+_1611544 0.453 FOXC1
forkhead box C1
chr10_+_75670915 0.452 PLAU
plasminogen activator, urokinase
chr12_+_53342654 0.451 NM_199187
KRT18
keratin 18
chr11_+_65554566 0.446 OVOL1
ovo-like 1(Drosophila)
chr2_-_85108202 0.445 C2orf89
chromosome 2 open reading frame 89
chr15_-_73661141 0.439 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr20_-_46414636 0.438 NM_018837
SULF2
sulfatase 2
chr1_-_85514128 0.438 MCOLN3
mucolipin 3
chr8_+_104512975 0.436 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_3456734 0.434 NM_015482
SLC22A23
solute carrier family 22, member 23
chr1_+_233749917 0.433 KCNK1
potassium channel, subfamily K, member 1
chr21_+_42540092 0.432 BACE2
beta-site APP-cleaving enzyme 2
chr2_+_18059923 0.432 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr1_+_220701547 0.431 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr14_+_70078313 0.431 KIAA0247
KIAA0247
chr18_+_23806385 0.430 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr21_+_43933983 0.429 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr17_+_78075390 0.426 GAA
glucosidase, alpha; acid
chr22_+_38035683 0.425 NM_018957
SH3BP1
SH3-domain binding protein 1
chr10_+_75670861 0.422 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr6_+_37137882 0.422 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr21_+_46825001 0.421 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr15_+_80987609 0.420 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr3_+_113666544 0.419 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr7_-_994259 0.419 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr1_-_25256364 0.418 RUNX3
runt-related transcription factor 3
chr17_-_3599359 0.414 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr12_+_53342842 0.413 NM_000224
KRT18
keratin 18
chr3_-_56835829 0.413 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_-_4642638 0.412 CXCL16
chemokine (C-X-C motif) ligand 16
chr1_-_6479880 0.411 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr6_+_135502477 0.409 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_+_44229851 0.408 NM_032256
TMEM117
transmembrane protein 117
chr18_+_59992519 0.408 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr1_+_206680863 0.407 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr11_+_32851469 0.407 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 2.97e-19 GO:0009987 cellular process
1.24 2.24e-13 GO:0007275 multicellular organismal development
1.23 2.78e-13 GO:0032502 developmental process
1.40 4.09e-13 GO:0007399 nervous system development
1.19 4.42e-11 GO:0044260 cellular macromolecule metabolic process
1.25 5.38e-11 GO:0048731 system development
1.36 5.52e-11 GO:0009653 anatomical structure morphogenesis
1.23 9.39e-11 GO:0048856 anatomical structure development
1.13 2.39e-10 GO:0050794 regulation of cellular process
1.15 3.21e-10 GO:0044237 cellular metabolic process
1.12 8.61e-10 GO:0065007 biological regulation
1.17 1.13e-09 GO:0043170 macromolecule metabolic process
1.12 2.57e-09 GO:0050789 regulation of biological process
1.28 3.43e-09 GO:0030154 cell differentiation
1.30 3.57e-09 GO:0006464 protein modification process
1.29 4.02e-09 GO:0043412 macromolecule modification
1.44 4.32e-09 GO:0022008 neurogenesis
1.32 6.03e-09 GO:0023051 regulation of signaling
1.12 8.39e-09 GO:0008152 metabolic process
1.27 8.61e-09 GO:0048869 cellular developmental process
1.13 1.04e-08 GO:0044238 primary metabolic process
1.43 3.48e-08 GO:0048699 generation of neurons
1.23 6.28e-08 GO:0048518 positive regulation of biological process
1.56 7.86e-08 GO:0007417 central nervous system development
1.47 1.50e-07 GO:0030182 neuron differentiation
1.23 2.44e-07 GO:0048522 positive regulation of cellular process
1.38 3.90e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 4.39e-07 GO:0006468 protein phosphorylation
1.31 4.94e-07 GO:0009966 regulation of signal transduction
1.46 2.39e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.67 2.57e-06 GO:0048729 tissue morphogenesis
1.37 5.92e-06 GO:0048468 cell development
1.43 8.53e-06 GO:0010628 positive regulation of gene expression
1.43 9.44e-06 GO:0051254 positive regulation of RNA metabolic process
1.35 9.52e-06 GO:0006793 phosphorus metabolic process
1.35 9.52e-06 GO:0006796 phosphate metabolic process
1.34 9.96e-06 GO:0010646 regulation of cell communication
1.17 1.00e-05 GO:0051179 localization
1.24 1.22e-05 GO:0048513 organ development
1.16 1.26e-05 GO:0023052 signaling
1.49 1.81e-05 GO:0000904 cell morphogenesis involved in differentiation
1.21 2.29e-05 GO:0048519 negative regulation of biological process
1.20 2.53e-05 GO:0044267 cellular protein metabolic process
1.49 3.69e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.16 4.07e-05 GO:0031323 regulation of cellular metabolic process
1.42 5.09e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.44 6.51e-05 GO:0048666 neuron development
1.22 7.50e-05 GO:0048523 negative regulation of cellular process
1.55 8.13e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.15 9.65e-05 GO:0019222 regulation of metabolic process
1.39 1.02e-04 GO:0009790 embryo development
1.17 1.53e-04 GO:0019538 protein metabolic process
1.42 1.94e-04 GO:0000902 cell morphogenesis
1.16 2.06e-04 GO:0007165 signal transduction
1.61 2.07e-04 GO:0035295 tube development
1.35 2.21e-04 GO:0016310 phosphorylation
1.35 3.57e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.39 4.57e-04 GO:0032989 cellular component morphogenesis
1.15 5.11e-04 GO:0080090 regulation of primary metabolic process
1.46 7.60e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.33 8.51e-04 GO:0009888 tissue development
1.78 8.57e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.35 1.02e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.27 1.18e-03 GO:0031325 positive regulation of cellular metabolic process
1.34 1.28e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 1.29e-03 GO:0055085 transmembrane transport
1.18 1.43e-03 GO:0044249 cellular biosynthetic process
1.19 1.90e-03 GO:0065008 regulation of biological quality
1.21 1.96e-03 GO:0007166 cell surface receptor linked signaling pathway
1.46 2.01e-03 GO:0007409 axonogenesis
1.38 2.25e-03 GO:0009887 organ morphogenesis
1.17 2.42e-03 GO:0009058 biosynthetic process
1.62 2.49e-03 GO:0002009 morphogenesis of an epithelium
1.44 2.51e-03 GO:0048812 neuron projection morphogenesis
1.31 2.87e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.40 3.10e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.20 3.66e-03 GO:0048583 regulation of response to stimulus
1.31 3.89e-03 GO:0009891 positive regulation of biosynthetic process
1.51 4.12e-03 GO:0001501 skeletal system development
1.48 4.36e-03 GO:0007420 brain development
1.25 4.37e-03 GO:0009893 positive regulation of metabolic process
1.14 4.95e-03 GO:0060255 regulation of macromolecule metabolic process
1.13 5.53e-03 GO:0051716 cellular response to stimulus
1.48 5.66e-03 GO:0007389 pattern specification process
1.26 5.86e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.16 6.01e-03 GO:0071842 cellular component organization at cellular level
1.50 6.30e-03 GO:0060284 regulation of cell development
1.24 7.05e-03 GO:0051239 regulation of multicellular organismal process
1.34 9.45e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
2.35 9.46e-03 GO:0001704 formation of primary germ layer
1.40 9.55e-03 GO:0072358 cardiovascular system development
1.40 9.55e-03 GO:0072359 circulatory system development
1.39 9.94e-03 GO:0031175 neuron projection development
1.42 9.98e-03 GO:0032583 regulation of gene-specific transcription
1.51 1.09e-02 GO:0001944 vasculature development
1.35 1.13e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.51 1.33e-02 GO:0051270 regulation of cellular component movement
1.43 1.47e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.15 1.67e-02 GO:0051234 establishment of localization
1.28 1.73e-02 GO:0010605 negative regulation of macromolecule metabolic process
2.53 1.74e-02 GO:0001707 mesoderm formation
1.14 1.88e-02 GO:0016043 cellular component organization
1.37 2.13e-02 GO:0032990 cell part morphogenesis
1.34 2.13e-02 GO:0010629 negative regulation of gene expression
1.61 2.14e-02 GO:0032582 negative regulation of gene-specific transcription
1.32 2.25e-02 GO:0009890 negative regulation of biosynthetic process
1.36 2.54e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.43 2.55e-02 GO:0048598 embryonic morphogenesis
1.30 2.65e-02 GO:2000026 regulation of multicellular organismal development
1.60 2.77e-02 GO:0048732 gland development
1.14 2.79e-02 GO:0006810 transport
1.15 3.16e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.26 3.16e-02 GO:0009892 negative regulation of metabolic process
1.43 3.71e-02 GO:0043009 chordate embryonic development
1.89 3.73e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.31 3.73e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.40 3.79e-02 GO:0016477 cell migration
1.28 3.93e-02 GO:0051128 regulation of cellular component organization
1.42 4.15e-02 GO:0009792 embryo development ending in birth or egg hatching
1.39 4.16e-02 GO:0071702 organic substance transport
1.49 4.21e-02 GO:0051960 regulation of nervous system development
1.73 4.27e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.36 4.97e-02 GO:0048858 cell projection morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 5.26e-10 GO:0044424 intracellular part
1.07 4.32e-09 GO:0005622 intracellular
1.10 4.90e-09 GO:0043227 membrane-bounded organelle
1.10 5.85e-09 GO:0043231 intracellular membrane-bounded organelle
1.04 1.42e-08 GO:0044464 cell part
1.04 1.55e-08 GO:0005623 cell
1.08 8.79e-07 GO:0043226 organelle
1.22 1.16e-06 GO:0044459 plasma membrane part
1.08 1.36e-06 GO:0043229 intracellular organelle
1.09 2.03e-06 GO:0005737 cytoplasm
1.10 3.79e-06 GO:0016020 membrane
1.76 5.44e-05 GO:0070161 anchoring junction
1.20 9.93e-05 GO:0031090 organelle membrane
1.29 1.48e-04 GO:0005794 Golgi apparatus
1.76 2.11e-04 GO:0005912 adherens junction
1.22 5.03e-04 GO:0012505 endomembrane system
1.09 6.84e-04 GO:0044425 membrane part
1.10 1.25e-03 GO:0005634 nucleus
1.34 2.27e-03 GO:0030054 cell junction
1.18 3.96e-03 GO:0031981 nuclear lumen
1.32 8.93e-03 GO:0044431 Golgi apparatus part
1.16 9.04e-03 GO:0044428 nuclear part
1.09 1.61e-02 GO:0044446 intracellular organelle part
1.47 1.95e-02 GO:0005667 transcription factor complex
1.20 1.97e-02 GO:0005654 nucleoplasm
1.22 2.88e-02 GO:0005783 endoplasmic reticulum
1.08 3.24e-02 GO:0044422 organelle part
1.08 3.34e-02 GO:0044444 cytoplasmic part
1.27 4.12e-02 GO:0005789 endoplasmic reticulum membrane
1.32 4.72e-02 GO:0000139 Golgi membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.72e-08 GO:0005515 protein binding
1.28 6.27e-08 GO:0016740 transferase activity
1.48 1.03e-07 GO:0004672 protein kinase activity
1.35 7.58e-07 GO:0030528 transcription regulator activity
1.06 1.45e-06 GO:0005488 binding
1.40 1.93e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.36 2.71e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.24 4.54e-06 GO:0032553 ribonucleotide binding
1.24 4.54e-06 GO:0032555 purine ribonucleotide binding
1.26 4.64e-06 GO:0032559 adenyl ribonucleotide binding
1.26 5.07e-06 GO:0030554 adenyl nucleotide binding
1.23 5.86e-06 GO:0017076 purine nucleotide binding
1.76 7.12e-06 GO:0010843 promoter binding
1.36 2.32e-05 GO:0016301 kinase activity
1.22 3.12e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.25 3.59e-05 GO:0005524 ATP binding
1.31 4.26e-05 GO:0001071 nucleic acid binding transcription factor activity
1.31 4.26e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 5.40e-05 GO:0043565 sequence-specific DNA binding
1.69 6.99e-05 GO:0000975 regulatory region DNA binding
1.69 6.99e-05 GO:0001067 regulatory region nucleic acid binding
1.69 6.99e-05 GO:0044212 transcription regulatory region DNA binding
1.47 7.13e-05 GO:0004674 protein serine/threonine kinase activity
1.19 2.02e-04 GO:0000166 nucleotide binding
1.11 4.55e-04 GO:0003824 catalytic activity
1.51 6.28e-04 GO:0016563 transcription activator activity
1.41 2.13e-03 GO:0019904 protein domain specific binding
1.89 2.54e-03 GO:0016566 specific transcriptional repressor activity
1.27 2.56e-03 GO:0022857 transmembrane transporter activity
1.28 4.48e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.46 9.26e-03 GO:0016564 transcription repressor activity
1.24 1.32e-02 GO:0022892 substrate-specific transporter activity
1.46 1.39e-02 GO:0008134 transcription factor binding
1.32 2.47e-02 GO:0008324 cation transmembrane transporter activity
1.85 2.76e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
2.47 3.90e-02 GO:0008378 galactosyltransferase activity
2.78 4.30e-02 GO:0035250 UDP-galactosyltransferase activity
2.87 4.95e-02 GO:0004712 protein serine/threonine/tyrosine kinase activity