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Motif ID: HIF1A.p2

Z-value: 2.008

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_95653272	4.777		ESRP1	epithelial splicing regulatory protein 1
chr22_+_40390935	3.638	NM_138435	FAM83F	family with sequence similarity 83, member F
chr17_-_3599298	3.213		P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5
chr11_+_69924407	2.721	NM_018043	ANO1	anoctamin 1, calcium activated chloride channel
chr1_+_117452359	2.511	NM_020440	PTGFRN	prostaglandin F2 receptor negative regulator
chr22_+_45148437	2.503	NM_001017526 NM_001198726 NM_181335	ARHGAP8	Rho GTPase activating protein 8
chr11_+_32851469	2.425	NM_024081	PRRG4	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr22_+_45098091	2.418	NM_181334	PRR5-ARHGAP8 PRR5	PRR5-ARHGAP8 readthrough proline rich 5 (renal)
chr6_+_36098261	2.413	NM_002754	MAPK13	mitogen-activated protein kinase 13
chr3_-_57113292	2.409	NM_001128615	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr13_-_20806533	2.357	NM_001110219 NM_001110220 NM_001110221	GJB6	gap junction protein, beta 6, 30kDa
chr17_-_3599359	2.356		P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_74497406	2.287	NM_024599	RHBDF2	rhomboid 5 homolog 2 (Drosophila)
chr8_+_31497267	2.168	NM_013962	NRG1	neuregulin 1
chr1_+_65613211	2.055	NM_203464 NM_001005353	AK4	adenylate kinase 4
chr8_-_75233461	2.004	NM_020647	JPH1	junctophilin 1
chr4_+_106816593	1.995	NM_001033047 NM_001184690 NM_001184691 NM_001184692 NM_001184693	NPNT	nephronectin
chr2_+_47596447	1.972		EPCAM	epithelial cell adhesion molecule
chr1_+_65613971	1.888		AK4	adenylate kinase 4
chr14_-_105634708	1.853		JAG2	jagged 2
chr17_-_3599487	1.684	NM_001204519 NM_001204520 NM_002561 NM_175080	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 readthrough purinergic receptor P2X, ligand-gated ion channel, 5
chr6_+_150464156	1.655	NM_030949	PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr19_+_35739838	1.654		LSR	lipolysis stimulated lipoprotein receptor
chr6_+_43738757	1.628		VEGFA	vascular endothelial growth factor A
chr1_+_233749749	1.600	NM_002245	KCNK1	potassium channel, subfamily K, member 1
chr16_+_68771192	1.598	NM_004360	CDH1	cadherin 1, type 1, E-cadherin (epithelial)
chr7_-_22396511	1.585	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr7_-_102920665	1.538		DPY19L2P2	dpy-19-like 2 pseudogene 2 (C. elegans)
chr1_-_159915382	1.502	NM_001135050 NM_020789	IGSF9	immunoglobulin superfamily, member 9
chr1_+_1981902	1.492	NM_002744	PRKCZ	protein kinase C, zeta
chr7_-_102920840	1.490		DPY19L2P2	dpy-19-like 2 pseudogene 2 (C. elegans)
chr16_+_22825806	1.481	NM_006043	HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_68771214	1.479		CDH1	cadherin 1, type 1, E-cadherin (epithelial)
chr7_+_26331493	1.467	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr8_+_28351694	1.465	NM_017412 NM_145866	FZD3	frizzled family receptor 3
chr2_+_223289285	1.459	NM_152386	SGPP2	sphingosine-1-phosphate phosphatase 2
chr17_-_76124767	1.434		TMC6	transmembrane channel-like 6
chr2_+_223289212	1.433		SGPP2	sphingosine-1-phosphate phosphatase 2
chr17_-_76124791	1.408	NM_001127198	TMC6	transmembrane channel-like 6
chr16_-_87903028	1.402	NM_003486	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr1_-_175161832	1.392	NM_001162895 NM_014656 NM_001162893 NM_001162894	KIAA0040	KIAA0040
chr1_+_65613771	1.333	NM_013410	AK4	adenylate kinase 4
chr18_+_33877630	1.303	NM_025135	FHOD3	formin homology 2 domain containing 3
chr4_+_106816627	1.298		NPNT	nephronectin
chr22_+_45098046	1.289	NM_181333	PRR5	proline rich 5 (renal)
chr1_+_233749917	1.256		KCNK1	potassium channel, subfamily K, member 1
chr17_+_55162530	1.252	NM_003488	AKAP1	A kinase (PRKA) anchor protein 1
chr19_+_35739519	1.234	NM_015925 NM_205834 NM_205835	LSR	lipolysis stimulated lipoprotein receptor
chr19_+_35739778	1.230		LSR	lipolysis stimulated lipoprotein receptor
chr14_+_65171243	1.212		PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr13_+_41363754	1.209		SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr7_+_26331611	1.177		SNX10	sorting nexin 10
chr17_-_31204071	1.168		MYO1D	myosin ID
chrX_+_152954965	1.166	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr19_+_7702020	1.161		STXBP2	syntaxin binding protein 2
chr16_+_68679229	1.126		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr16_+_68679198	1.122		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr19_-_291168	1.121	NM_177543	PPAP2C	phosphatidic acid phosphatase type 2C
chr9_-_140196702	1.099	NM_001004354	NRARP	NOTCH-regulated ankyrin repeat protein
chr3_+_113666544	1.095	NM_173570	ZDHHC23	zinc finger, DHHC-type containing 23
chr1_-_209979388	1.082	NM_001206696 NM_006147	IRF6	interferon regulatory factor 6
chrX_-_102565805	1.082	NM_001168399 NM_001168400 NM_001168401 NM_032621	BEX2	brain expressed X-linked 2
chr8_+_24771276	1.079		NEFM	neurofilament, medium polypeptide
chr19_+_7702010	1.067		STXBP2	syntaxin binding protein 2
chr2_+_17721806	1.066	NM_003385	VSNL1	visinin-like 1
chr7_+_86274076	1.057		GRM3	glutamate receptor, metabotropic 3
chr19_-_19738973	1.046	NM_004720	LPAR2	lysophosphatidic acid receptor 2
chr17_+_78075390	1.045		GAA	glucosidase, alpha; acid
chr22_-_43583132	1.042	NM_015140	TTLL12	tubulin tyrosine ligase-like family, member 12
chr7_+_48075107	1.027	NM_001100159	C7orf57	chromosome 7 open reading frame 57
chr7_+_156931631	1.024	NM_014671	UBE3C	ubiquitin protein ligase E3C
chrX_+_16804531	1.012	NM_001168683 NM_018360	TXLNG	taxilin gamma
chr22_-_43583058	1.010		TTLL12	tubulin tyrosine ligase-like family, member 12
chr8_+_24771268	1.004	NM_005382	NEFM	neurofilament, medium polypeptide
chr3_-_69435223	0.997		FRMD4B	FERM domain containing 4B
chr5_+_68788387	0.983	NM_001205254	OCLN	occludin
chr13_+_41363642	0.964		SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr19_+_7701976	0.961	NM_001127396 NM_006949	STXBP2	syntaxin binding protein 2
chr8_-_145515014	0.953		BOP1	block of proliferation 1
chr8_-_125740650	0.952	NM_014751	MTSS1	metastasis suppressor 1
chr16_+_68771304	0.922		CDH1	cadherin 1, type 1, E-cadherin (epithelial)
chr15_-_83953465	0.901	NM_001717	BNC1	basonuclin 1
chr3_-_69435429	0.898	NM_015123	FRMD4B	FERM domain containing 4B
chrX_+_105969875	0.895	NM_194463	RNF128	ring finger protein 128
chr6_+_33589045	0.895	NM_002224	ITPR3	inositol 1,4,5-trisphosphate receptor, type 3
chr7_-_98741605	0.877		SMURF1	SMAD specific E3 ubiquitin protein ligase 1
chr3_+_142315205	0.855	NM_001145319	PLS1	plastin 1
chr2_-_96811138	0.849	NM_004418	DUSP2	dual specificity phosphatase 2
chr10_-_6019454	0.841	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr14_-_105635114	0.840	NM_002226 NM_145159	JAG2	jagged 2
chr13_+_41363546	0.839	NM_014252	SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr19_+_45843997	0.824	NM_177417	KLC3	kinesin light chain 3
chr2_+_17721983	0.821		VSNL1	visinin-like 1
chr9_+_93564063	0.810		SYK	spleen tyrosine kinase
chr17_-_2614926	0.799	NM_015229	KIAA0664	KIAA0664
chr16_-_75529289	0.788
chr14_+_65171149	0.777	NM_015549	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_-_125366048	0.776	NM_005103 NM_022549	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)
chr9_+_22447064	0.768
chr19_+_55591759	0.760	NM_017729	EPS8L1	EPS8-like 1
chr19_-_15090349	0.760		SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr9_+_93564073	0.757		SYK	spleen tyrosine kinase
chr7_+_86273951	0.757		GRM3	glutamate receptor, metabotropic 3
chr1_+_224804175	0.756	NM_152495	CNIH3	cornichon homolog 3 (Drosophila)
chr7_+_156931663	0.738		UBE3C	ubiquitin protein ligase E3C
chr9_-_139137646	0.737	NM_181701	QSOX2	quiescin Q6 sulfhydryl oxidase 2
chr7_+_145813452	0.724	NM_014141	CNTNAP2	contactin associated protein-like 2
chr3_-_52090090	0.722	NM_001947	DUSP7	dual specificity phosphatase 7
chr2_-_75062214	0.721
chr7_-_98741681	0.715	NM_001199847 NM_020429 NM_181349	SMURF1	SMAD specific E3 ubiquitin protein ligase 1
chrX_+_38420690	0.709	NM_004615	TSPAN7	tetraspanin 7
chr20_-_49639616	0.704	NM_002237	KCNG1	potassium voltage-gated channel, subfamily G, member 1
chr1_+_209848994	0.698		G0S2	G0/G1switch 2
chr9_-_100954883	0.682	NM_052820	CORO2A	coronin, actin binding protein, 2A
chr19_+_1071208	0.680		HMHA1	histocompatibility (minor) HA-1
chr7_-_138665853	0.678	NM_001164665 NM_020910	KIAA1549	KIAA1549
chr19_+_38810540	0.653		KCNK6	potassium channel, subfamily K, member 6
chr19_+_45281125	0.650	NM_001130852 NM_012116	CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c
chr3_-_50329702	0.635	NM_006764	IFRD2	interferon-related developmental regulator 2
chr17_-_31203889	0.633	NM_015194	MYO1D	myosin ID
chr11_+_72929392	0.627	NM_176071	P2RY2	purinergic receptor P2Y, G-protein coupled, 2
chr21_-_42219038	0.622	NM_001389	DSCAM	Down syndrome cell adhesion molecule
chr19_-_38746978	0.603		PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr3_+_186648515	0.601		ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr4_-_143767603	0.600	NM_001101669 NM_003866	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr21_-_42218587	0.599		DSCAM	Down syndrome cell adhesion molecule
chr8_-_145515071	0.593		BOP1	block of proliferation 1
chr1_+_4715104	0.590	NM_001042478 NM_018836	AJAP1	adherens junctions associated protein 1
chr7_+_16793320	0.589	NM_014399	TSPAN13	tetraspanin 13
chr14_-_91526912	0.587	NM_004755 NM_182398	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr2_-_20424627	0.577	NM_002997	SDC1	syndecan 1
chr18_-_28681429	0.577		DSC2	desmocollin 2
chr11_+_120081669	0.573	NM_178507	OAF	OAF homolog (Drosophila)
chr8_-_145515099	0.571	NM_015201	BOP1	block of proliferation 1
chr1_-_6526150	0.563	NM_001039664 NM_003790 NM_148965 NM_148966 NM_148967 NM_148970	TNFRSF25	tumor necrosis factor receptor superfamily, member 25
chr1_+_3371020	0.562	NM_014448	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16
chr7_-_95951268	0.561	NM_001160210 NM_014251	SLC25A13	solute carrier family 25, member 13 (citrin)
chr3_+_184032319	0.560		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr20_-_982806	0.559	NM_001029871 NM_001040007	RSPO4	R-spondin 4
chr8_-_124054491	0.559		DERL1	Der1-like domain family, member 1
chr4_-_166034003	0.555	NM_001100389	TMEM192	transmembrane protein 192
chr8_+_98881277	0.554	NM_002380 NM_030583	MATN2	matrilin 2
chr8_-_124054540	0.552		DERL1	Der1-like domain family, member 1
chr8_+_75896707	0.548	NM_031461	CRISPLD1	cysteine-rich secretory protein LCCL domain containing 1
chr1_-_29450406	0.545	NM_001003682	TMEM200B	transmembrane protein 200B
chr3_+_184032414	0.544		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr22_+_29999608	0.543		NF2	neurofibromin 2 (merlin)
chr12_-_106532447	0.540		NUAK1	NUAK family, SNF1-like kinase, 1
chr19_-_6110561	0.537	NM_000635 NM_134433	RFX2	regulatory factor X, 2 (influences HLA class II expression)
chr3_+_112931374	0.535	NM_033254	BOC	Boc homolog (mouse)
chr2_+_206547352	0.535		NRP2	neuropilin 2
chr19_+_34287662	0.533	NM_001129994 NM_001129995 NM_024076	KCTD15	potassium channel tetramerisation domain containing 15
chr15_-_63673918	0.526		CA12	carbonic anhydrase XII
chr4_-_4291817	0.525		LYAR	Ly1 antibody reactive homolog (mouse)
chr1_-_6557448	0.525		PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_-_124054591	0.524	NM_001134671 NM_024295	DERL1	Der1-like domain family, member 1
chr3_+_5229357	0.524	NM_014674	EDEM1	ER degradation enhancer, mannosidase alpha-like 1
chr22_-_20104695	0.521		TRMT2A	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr7_+_30324504	0.519		ZNRF2	zinc and ring finger 2
chr2_+_26915390	0.517	NM_002246	KCNK3	potassium channel, subfamily K, member 3
chr4_-_4291731	0.508	NM_001145725	LYAR	Ly1 antibody reactive homolog (mouse)
chr8_-_81083660	0.506	NM_001025253 NM_005079	TPD52	tumor protein D52
chr9_+_93564011	0.505	NM_001135052 NM_003177	SYK	spleen tyrosine kinase
chr12_-_123635284	0.501		PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2
chr9_+_22446783	0.501	NM_022160	DMRTA1	DMRT-like family A1
chr11_+_75479766	0.501	NM_032564	DGAT2	diacylglycerol O-acyltransferase 2
chr4_-_7069755	0.499	NM_025196	GRPEL1	GrpE-like 1, mitochondrial (E. coli)
chr12_+_44229851	0.497	NM_032256	TMEM117	transmembrane protein 117
chr16_+_66914380	0.497	NM_020786	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr11_+_75479802	0.497		DGAT2	diacylglycerol O-acyltransferase 2
chr22_-_20104745	0.494	NM_022727 NM_182984	TRMT2A	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr2_+_206547131	0.486	NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279	NRP2	neuropilin 2
chr4_-_38666429	0.484		FLJ13197	uncharacterized FLJ13197
chr2_+_173420873	0.483		PDK1	pyruvate dehydrogenase kinase, isozyme 1
chr14_+_67999915	0.482	NM_020715	PLEKHH1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr11_+_65554504	0.480	NM_004561	OVOL1	ovo-like 1(Drosophila)
chr1_+_193091283	0.478		CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr9_-_135996287	0.475	NM_006266	RALGDS	ral guanine nucleotide dissociation stimulator
chr9_-_23821477	0.473	NM_001171197	ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr13_+_25254548	0.473	NM_001185085 NM_001676	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr5_-_59995938	0.472	NM_001145208 NM_018369	DEPDC1B	DEP domain containing 1B
chr3_+_5229430	0.471		EDEM1	ER degradation enhancer, mannosidase alpha-like 1
chr19_+_2164119	0.470	NM_032482	DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr22_+_25960885	0.468		ADRBK2	adrenergic, beta, receptor kinase 2
chr19_+_7968762	0.466		MAP2K7	mitogen-activated protein kinase kinase 7
chr1_-_43637788	0.462		EBNA1BP2	EBNA1 binding protein 2
chr19_-_6110491	0.461		RFX2	regulatory factor X, 2 (influences HLA class II expression)
chr1_+_101702304	0.460	NM_001400	S1PR1	sphingosine-1-phosphate receptor 1
chr21_+_34442446	0.458	NM_138983	OLIG1	oligodendrocyte transcription factor 1
chr15_-_34659245	0.452	NM_153613	LPCAT4	lysophosphatidylcholine acyltransferase 4
chr15_-_63674074	0.450	NM_001218 NM_206925	CA12	carbonic anhydrase XII
chr3_-_128840856	0.449	NM_001204884 NM_001204883	RAB43	RAB43, member RAS oncogene family
chr17_-_73874056	0.447		TRIM47	tripartite motif containing 47
chr18_-_12377168	0.446		AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr2_+_64681270	0.444	NM_014181	LGALSL	lectin, galactoside-binding-like
chr14_-_77279179	0.443		ANGEL1	angel homolog 1 (Drosophila)
chr10_-_88730928	0.442		LOC100133190	uncharacterized LOC100133190
chr14_-_53162418	0.441	NM_014584	ERO1L	ERO1-like (S. cerevisiae)
chrX_+_24483343	0.441	NM_001142386 NM_005391	PDK3	pyruvate dehydrogenase kinase, isozyme 3
chr8_-_144654921	0.440	NM_001100878	C8orf73	chromosome 8 open reading frame 73

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.25	2.28e-09	GO:0044237	cellular metabolic process
1.13	5.35e-09	GO:0009987	cellular process
1.29	2.45e-07	GO:0044260	cellular macromolecule metabolic process
1.18	1.39e-05	GO:0008152	metabolic process
1.19	6.87e-05	GO:0044238	primary metabolic process
1.21	6.42e-04	GO:0043170	macromolecule metabolic process
1.26	2.80e-03	GO:0006807	nitrogen compound metabolic process
1.25	1.04e-02	GO:0034641	cellular nitrogen compound metabolic process
1.27	1.07e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29	1.44e-02	GO:0044267	cellular protein metabolic process
5.11	1.93e-02	GO:0071407	cellular response to organic cyclic compound

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.15	1.93e-15	GO:0044424	intracellular part
1.15	2.96e-15	GO:0005622	intracellular
1.21	7.60e-15	GO:0043227	membrane-bounded organelle
1.21	8.20e-15	GO:0043231	intracellular membrane-bounded organelle
1.17	5.81e-12	GO:0043226	organelle
1.17	1.11e-11	GO:0043229	intracellular organelle
1.17	2.61e-08	GO:0005737	cytoplasm
1.21	5.73e-07	GO:0044444	cytoplasmic part
1.19	8.59e-05	GO:0005634	nucleus
1.73	6.54e-04	GO:0005730	nucleolus
1.18	6.74e-04	GO:0044446	intracellular organelle part
1.17	9.63e-04	GO:0044422	organelle part
1.56	1.26e-03	GO:0044432	endoplasmic reticulum part
1.31	1.42e-03	GO:0070013	intracellular organelle lumen
1.29	2.05e-03	GO:0031974	membrane-enclosed lumen
1.04	3.00e-03	GO:0044464	cell part
1.04	3.09e-03	GO:0005623	cell
1.29	3.25e-03	GO:0043233	organelle lumen
1.30	3.38e-03	GO:0031090	organelle membrane
1.35	4.44e-03	GO:0012505	endomembrane system
1.29	5.19e-03	GO:0044428	nuclear part
2.28	6.46e-03	GO:0031965	nuclear membrane
1.54	1.00e-02	GO:0005789	endoplasmic reticulum membrane
1.52	1.47e-02	GO:0042175	nuclear membrane-endoplasmic reticulum network
1.40	1.80e-02	GO:0005783	endoplasmic reticulum
4.29	1.97e-02	GO:0044452	nucleolar part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.16	8.29e-05	GO:0005515	protein binding
1.31	9.64e-04	GO:0000166	nucleotide binding
1.36	1.26e-03	GO:0016740	transferase activity
1.08	1.76e-03	GO:0005488	binding
1.17	4.11e-03	GO:0003824	catalytic activity
2.21	4.71e-03	GO:0016741	transferase activity, transferring one-carbon groups
1.36	5.15e-03	GO:0030554	adenyl nucleotide binding
1.36	5.44e-03	GO:0032559	adenyl ribonucleotide binding
1.36	6.99e-03	GO:0005524	ATP binding
1.31	8.09e-03	GO:0032553	ribonucleotide binding
1.31	8.09e-03	GO:0032555	purine ribonucleotide binding
1.31	8.25e-03	GO:0017076	purine nucleotide binding
1.31	1.13e-02	GO:0035639	purine ribonucleoside triphosphate binding
1.49	1.36e-02	GO:0003723	RNA binding
2.15	1.61e-02	GO:0008168	methyltransferase activity