Motif ID: NFIX.p2

Z-value: 1.120


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_131347820.492.2e-01Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_50355278 0.426 NM_001651
AQP5
aquaporin 5
chr1_-_160990862 0.397 F11R
F11 receptor
chr1_-_160990971 0.383 NM_016946
F11R
F11 receptor
chr19_-_3028901 0.313 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr6_+_30851860 0.279 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr9_-_25678230 0.276 TUSC1
tumor suppressor candidate 1
chr11_+_113775517 0.268 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr7_-_100844192 0.267 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr10_+_73079044 0.246 SLC29A3
solute carrier family 29 (nucleoside transporters), member 3
chr9_-_25678855 0.237 NM_001004125
TUSC1
tumor suppressor candidate 1
chr18_-_74691951 0.234 MBP
myelin basic protein
chr1_+_158150678 0.228 CD1D
CD1d molecule
chr20_-_44539542 0.227 PLTP
phospholipid transfer protein
chr5_+_122424840 0.225 NM_001136239
PRDM6
PR domain containing 6
chr7_-_80548666 0.225 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr9_+_35605339 0.224 TESK1
testis-specific kinase 1
chr9_+_35605275 0.223 NM_006285
TESK1
testis-specific kinase 1
chr10_+_73079009 0.220 NM_001174098
NM_018344
SLC29A3

solute carrier family 29 (nucleoside transporters), member 3

chr7_+_91763851 0.217 LOC613126
uncharacterized LOC613126
chr3_+_138067678 0.210 NM_001252092
MRAS
muscle RAS oncogene homolog
chr7_-_80548322 0.209 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr17_-_43394326 0.207 NM_003954
MAP3K14
mitogen-activated protein kinase kinase kinase 14
chr1_-_11042093 0.206 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr3_+_138067444 0.200 NM_001085049
NM_001252093
MRAS

muscle RAS oncogene homolog

chr1_+_210502639 0.195 NM_001170580
HHAT
hedgehog acyltransferase
chr9_-_98268866 0.195 PTCH1
patched 1
chr2_-_56151273 0.192 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr5_+_148961035 0.183 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr3_+_138067969 0.183 NM_001252090
MRAS
muscle RAS oncogene homolog
chr15_-_26874236 0.178 NM_001191321
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr9_-_130667571 0.177 LOC100131355
ST6GALNAC6
uncharacterized LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_-_80656461 0.177 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr17_+_39261640 0.174 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr1_+_79086087 0.173 NM_006820
IFI44L
interferon-induced protein 44-like
chr1_-_6526150 0.171 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr6_-_109330190 0.165 NM_001199934
SESN1
sestrin 1
chr17_+_58677489 0.162 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr12_+_20848288 0.161 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr5_+_150400132 0.161 GPX3
glutathione peroxidase 3 (plasma)
chr1_-_207205996 0.160 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr4_+_186317892 0.160 ANKRD37
ankyrin repeat domain 37
chr5_+_150399980 0.158 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chrX_-_101771641 0.155 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr1_+_111415721 0.153 NM_000560
CD53
CD53 molecule
chr14_-_100772774 0.152 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr6_-_109330752 0.152 NM_001199933
SESN1
sestrin 1
chr7_-_12443468 0.151 VWDE
von Willebrand factor D and EGF domains
chr8_+_70405027 0.149 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr1_+_210502188 0.148 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr11_-_30607762 0.148 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr22_+_31644314 0.148 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr10_+_88728187 0.146 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr17_+_6555037 0.146 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr4_+_186317837 0.143 NM_181726
ANKRD37
ankyrin repeat domain 37
chr12_+_7942025 0.143 NANOG
Nanog homeobox
chr1_-_161039745 0.143 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr4_+_186317964 0.142 ANKRD37
ankyrin repeat domain 37
chr22_+_31644368 0.140 LIMK2
LIM domain kinase 2
chr21_+_43933983 0.140 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr3_+_169755733 0.140 NM_014373
GPR160
G protein-coupled receptor 160
chr1_-_161039413 0.138 ARHGAP30
Rho GTPase activating protein 30
chr7_+_108210291 0.137 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr11_-_64527369 0.137 PYGM
phosphorylase, glycogen, muscle
chr8_+_70405080 0.136 SULF1
sulfatase 1
chr8_-_6914251 0.135 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr1_+_901876 0.134 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr16_+_32264642 0.133 NM_001243722
TP53TG3
LOC729264
TP53 target 3
TP53-target gene 3 protein-like
chr2_-_163174816 0.132 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr17_-_4642638 0.132 CXCL16
chemokine (C-X-C motif) ligand 16
chr7_+_108210308 0.132 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr4_-_20985547 0.131 KCNIP4
Kv channel interacting protein 4
chr9_+_104161118 0.131 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr4_+_165878098 0.131 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr16_+_31711914 0.130 KIAA0664L3
KIAA0664-like 3
chr16_-_4852571 0.130 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr1_-_161039649 0.130 ARHGAP30
Rho GTPase activating protein 30
chr17_+_58677603 0.129 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr17_-_37844266 0.129 NM_033419
PGAP3
post-GPI attachment to proteins 3
chr19_-_1237840 0.128 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr18_+_72201799 0.127 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr12_+_83080621 0.126 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr17_+_37844325 0.126 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr11_-_64528186 0.125 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr9_+_130911731 0.123 NM_005564
LCN2
lipocalin 2
chr19_+_41594367 0.122 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr11_-_120008801 0.121 TRIM29
tripartite motif containing 29
chr1_-_161039703 0.121 ARHGAP30
Rho GTPase activating protein 30
chr7_+_108210188 0.120 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr11_-_125366048 0.120 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr20_+_43344005 0.119 WISP2
WNT1 inducible signaling pathway protein 2
chr11_-_61735108 0.119 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr12_+_83080901 0.117 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr16_+_2880172 0.117 NM_145252
ZG16B
zymogen granule protein 16 homolog B (rat)
chr19_-_58090254 0.117 ZNF416
zinc finger protein 416
chr4_+_165878129 0.117 C4orf39
chromosome 4 open reading frame 39
chr19_+_17516502 0.116 LOC100507535
uncharacterized LOC100507535
chr17_+_19281013 0.116 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr16_+_33205582 0.115 NM_001205259
NM_001205260
NM_001099687
NM_001205265
TP53TG3
LOC653550

TP53TG3B

TP53 target 3
TP53-target gene 3 protein-like

TP53 target 3B

chr16_+_33262117 0.115 NM_001205259
NM_001205260
NM_001099687
NM_001205265
TP53TG3
LOC653550

TP53TG3B

TP53 target 3
TP53-target gene 3 protein-like

TP53 target 3B

chr16_-_29910340 0.114 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr21_+_34442446 0.114 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr16_-_32687417 0.114 NM_001205259
NM_001205260
NM_001099687
NM_001205265
TP53TG3
LOC653550

TP53TG3B

TP53 target 3
TP53-target gene 3 protein-like

TP53 target 3B

chr2_+_223536362 0.111 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr7_-_139168408 0.110 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr21_-_28217692 0.110 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr20_+_62887046 0.110 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr11_+_64058772 0.109 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr16_+_31711926 0.109 KIAA0664L3
KIAA0664-like 3
chr22_+_35695267 0.109 NM_001135729
TOM1
target of myb1 (chicken)
chr16_-_32688052 0.107 NM_016212
TP53TG3
TP53 target 3
chr5_-_37839781 0.107 NM_000514
GDNF
glial cell derived neurotrophic factor
chr3_+_126261178 0.107 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr12_-_45270071 0.106 NELL2
NEL-like 2 (chicken)
chr18_+_72201669 0.103 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr22_+_35695792 0.103 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr15_-_72668301 0.101 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chrX_+_106449861 0.100 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr19_-_4065467 0.098 ZBTB7A
zinc finger and BTB domain containing 7A
chr16_+_66968390 0.098 CES2
carboxylesterase 2
chr19_-_6720585 0.097 NM_000064
C3
complement component 3
chr15_-_72668184 0.097 HEXA
hexosaminidase A (alpha polypeptide)
chr6_+_99282597 0.096 POU3F2
POU class 3 homeobox 2
chr8_-_70745624 0.096 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr1_-_156217717 0.095 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_-_153588789 0.094 NM_020672
S100A14
S100 calcium binding protein A14
chr16_-_11680146 0.094 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr5_-_149829264 0.094 NM_001025070
NM_001025071
NM_005617
RPS14


ribosomal protein S14


chr8_-_7212868 0.093 FAM66B
family with sequence similarity 66, member B
chr22_+_35695872 0.092 TOM1
target of myb1 (chicken)
chr19_+_49838646 0.092 CD37
CD37 molecule
chr6_+_99282579 0.091 NM_005604
POU3F2
POU class 3 homeobox 2
chr5_-_9630462 0.091 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr7_+_93551015 0.091 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_141303463 0.090 KIAA0141
KIAA0141
chr22_+_30476452 0.090 NM_152510
HORMAD2
HORMA domain containing 2
chr9_-_33395265 0.090 AQP7
aquaporin 7
chr15_+_65204053 0.089 NM_182703
ANKDD1A
ankyrin repeat and death domain containing 1A
chr11_+_1860718 0.088 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr2_+_201983419 0.088 CFLAR
CASP8 and FADD-like apoptosis regulator
chr16_+_66968360 0.088 CES2
carboxylesterase 2
chr16_+_66968319 0.088 NM_003869
NM_198061
CES2

carboxylesterase 2

chr16_-_1660653 0.088 IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr11_+_560868 0.087 NM_001143993
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr5_-_149829231 0.085 RPS14
ribosomal protein S14
chr22_+_19701968 0.085 NM_002688
SEPT5
septin 5
chr19_+_859658 0.085 NM_001928
CFD
complement factor D (adipsin)
chr10_+_124220990 0.085 NM_002775
HTRA1
HtrA serine peptidase 1
chr7_+_65670256 0.085 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr4_+_3294711 0.085 RGS12
regulator of G-protein signaling 12
chr21_-_48024985 0.084 NM_006272
S100B
S100 calcium binding protein B
chr19_+_572575 0.084 BSG
basigin (Ok blood group)
chr5_+_141303366 0.084 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr9_-_94124149 0.083 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr22_+_38864015 0.083 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr16_+_66968365 0.083 CES2
carboxylesterase 2
chr17_-_4643162 0.083 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr4_-_8442427 0.082 NM_001101667
NM_003501
ACOX3

acyl-CoA oxidase 3, pristanoyl

chr1_+_77333121 0.082 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr17_+_19282058 0.082 MAPK7
mitogen-activated protein kinase 7
chr3_+_184279539 0.080 NM_004443
EPHB3
EPH receptor B3
chr14_+_105266878 0.080 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr1_+_77333158 0.079 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr6_+_139456240 0.078 NM_016217
HECA
headcase homolog (Drosophila)
chr10_+_65224937 0.078 LOC84989
uncharacterized LOC84989
chr1_+_228327966 0.078 GUK1
guanylate kinase 1
chr15_+_63336274 0.078 TPM1
tropomyosin 1 (alpha)
chr5_-_10353690 0.078


chr10_-_100174891 0.077 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr21_-_43373938 0.077 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr15_-_90437616 0.077 NM_005829
AP3S2
adaptor-related protein complex 3, sigma 2 subunit
chr1_+_228327982 0.076 GUK1
guanylate kinase 1
chr17_+_19281726 0.076 NM_002749
NM_139034
MAPK7

mitogen-activated protein kinase 7

chr17_-_5487767 0.076 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr10_-_91011562 0.076 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr11_+_72975569 0.075 NM_176796
NM_176797
P2RY6

pyrimidinergic receptor P2Y, G-protein coupled, 6

chr10_-_43133921 0.075 NM_006955
ZNF33B
zinc finger protein 33B
chr10_-_91011516 0.075 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr16_+_1031807 0.075 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr1_+_228328015 0.075 GUK1
guanylate kinase 1
chr19_-_59066303 0.075 CHMP2A
charged multivesicular body protein 2A
chr19_+_572403 0.075 NM_001728
NM_198589
BSG

basigin (Ok blood group)

chr1_+_228328003 0.075 GUK1
guanylate kinase 1
chr10_-_21462987 0.074 NEBL
nebulette
chr14_+_65016613 0.074 NM_172365
PPP1R36
protein phosphatase 1, regulatory subunit 36
chr1_+_43996478 0.074 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr8_-_8239188 0.074 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr3_+_169755782 0.073 GPR160
G protein-coupled receptor 160
chr19_+_572568 0.073 BSG
basigin (Ok blood group)
chr10_-_91011586 0.073 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr5_+_10353802 0.073 NM_005885
MARCH6
membrane-associated ring finger (C3HC4) 6
chr9_-_94124194 0.073 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr12_+_133264152 0.073 NM_018663
PXMP2
peroxisomal membrane protein 2, 22kDa
chr3_-_46506342 0.073 NM_002343
LTF
lactotransferrin
chr3_-_190580464 0.072 NM_001146686
GMNC
geminin coiled-coil domain containing
chr1_-_160068359 0.072 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr13_+_27131879 0.072 WASF3
WAS protein family, member 3
chr4_+_141445325 0.072 ELMOD2
ELMO/CED-12 domain containing 2
chr19_-_59066353 0.071 NM_198426
CHMP2A
charged multivesicular body protein 2A
chr9_+_35605449 0.071 TESK1
testis-specific kinase 1
chr3_-_195717100 0.070 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 1.08e-03 GO:0016020 membrane
1.35 1.78e-03 GO:0031090 organelle membrane
1.17 3.78e-03 GO:0044444 cytoplasmic part
1.38 7.10e-03 GO:0012505 endomembrane system
1.66 8.06e-03 GO:0044431 Golgi apparatus part
1.70 1.76e-02 GO:0000139 Golgi membrane
1.44 4.70e-02 GO:0005794 Golgi apparatus

Nothing significant found in function category.