Motif ID: NKX2-1,4.p2

Z-value: 0.763


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_369893330.502.0e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_7493389 1.025 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr6_-_11779279 1.021 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr5_+_140186658 0.934 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr2_-_161056573 0.926 NM_000888
ITGB6
integrin, beta 6
chr3_+_189349215 0.636 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr12_-_52886971 0.617 NM_005554
KRT6A
keratin 6A
chr11_+_117947726 0.558 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr12_+_41086189 0.545 NM_001843
NM_175038
CNTN1

contactin 1

chr8_+_124194751 0.533 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr6_-_155777036 0.529 NM_015718
NOX3
NADPH oxidase 3
chr1_-_217250230 0.516 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr19_-_16045669 0.515 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr2_-_161056762 0.512 ITGB6
integrin, beta 6
chr2_+_207804277 0.473 NM_173077
CPO
carboxypeptidase O
chrX_-_33229428 0.429 NM_004006
DMD
dystrophin
chr9_-_124984018 0.394 NM_001242335
LHX6
LIM homeobox 6
chr8_+_124194873 0.372 FAM83A
family with sequence similarity 83, member A
chr15_+_40650411 0.362 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr12_+_50451486 0.333 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr6_+_132859426 0.311 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr19_-_49258646 0.299 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr14_+_39703119 0.292 NM_054024
MIA2
melanoma inhibitory activity 2
chr11_+_34642587 0.286 NM_001206615
NM_012153
EHF

ets homologous factor

chr12_-_54778456 0.286 NM_015481
ZNF385A
zinc finger protein 385A
chr16_+_12058963 0.278 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_-_136847609 0.267 MAP7
microtubule-associated protein 7
chr1_-_226926875 0.266 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr10_-_104211244 0.264 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr11_+_117947785 0.263 TMPRSS4
transmembrane protease, serine 4
chrX_-_117251302 0.262 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr4_-_77328457 0.261 NM_001042784
CCDC158
coiled-coil domain containing 158
chr8_+_74206772 0.255 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr10_-_123353330 0.255 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chrX_+_129139163 0.243 NM_021946
BCORL1
BCL6 corepressor-like 1
chr6_-_136847743 0.242 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr5_+_140247767 0.240 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr11_+_34642651 0.224 EHF
ets homologous factor
chr11_+_6897855 0.223 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr5_-_176836488 0.221 F12
coagulation factor XII (Hageman factor)
chr5_+_66124603 0.221 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_+_142342265 0.214 NM_002670
PLS1
plastin 1
chr1_-_203320287 0.209 NM_002023
FMOD
fibromodulin
chr11_+_6866882 0.208 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr1_-_209824641 0.201 NM_001017402
LAMB3
laminin, beta 3
chr5_+_140235594 0.201 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr11_-_16424391 0.199 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_-_116392099 0.194 ABLIM1
actin binding LIM protein 1
chr14_-_21572789 0.186 NM_001102454
ZNF219
zinc finger protein 219
chr17_-_42976792 0.186 EFTUD2
elongation factor Tu GTP binding domain containing 2
chrX_-_154563735 0.185 NM_001289
CLIC2
chloride intracellular channel 2
chrX_+_105937067 0.183 NM_024539
RNF128
ring finger protein 128
chr17_-_42976774 0.182 EFTUD2
elongation factor Tu GTP binding domain containing 2
chr4_-_24981769 0.175 NM_173463
CCDC149
coiled-coil domain containing 149
chr17_+_7623038 0.170 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr1_+_32716839 0.168 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr10_-_11574273 0.166 NM_001080491
USP6NL
USP6 N-terminal like
chr5_+_140213968 0.164 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr5_+_147443534 0.157 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr6_-_116381765 0.157 NM_002031
FRK
fyn-related kinase
chr12_-_121248679 0.154 SPPL3
signal peptide peptidase-like 3
chr13_-_75901897 0.154 TBC1D4
TBC1 domain family, member 4
chr2_-_133539627 0.152 NCKAP5
NCK-associated protein 5
chr1_+_43735664 0.150 NM_144626
TMEM125
transmembrane protein 125
chr12_+_8975149 0.149 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr8_+_74207093 0.145 RDH10
retinol dehydrogenase 10 (all-trans)
chr4_-_123542165 0.141 NM_001207006
NM_021803
IL21

interleukin 21

chr6_-_3272349 0.139 SLC22A23
solute carrier family 22, member 23
chr17_-_42976825 0.136 EFTUD2
elongation factor Tu GTP binding domain containing 2
chr4_-_122302112 0.135 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr19_-_11688508 0.133 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr10_+_123754141 0.133 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_126327397 0.129 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr2_-_38525527 0.126 ATL2
atlastin GTPase 2
chrX_+_144908927 0.125 NM_004709
CXorf1
chromosome X open reading frame 1
chrX_-_72434656 0.125 NAP1L2
nucleosome assembly protein 1-like 2
chr2_+_46524448 0.122 NM_001430
EPAS1
endothelial PAS domain protein 1
chr8_+_7705401 0.121 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr2_+_103378489 0.120 NM_144632
TMEM182
transmembrane protein 182
chr15_+_80364902 0.119 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr14_-_95599794 0.119 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr11_-_102651321 0.117 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr12_+_29376596 0.114 NM_018099
FAR2
fatty acyl CoA reductase 2
chr1_+_212475147 0.114 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr5_+_147582338 0.114 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr17_+_1646290 0.110 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_-_100273831 0.108 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr7_-_16505292 0.108 NM_015464
SOSTDC1
sclerostin domain containing 1
chrX_-_72434667 0.107 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr10_-_69455926 0.105 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr10_+_70980058 0.103 NM_025130
HKDC1
hexokinase domain containing 1
chr15_+_94899163 0.102 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr2_+_28615668 0.102 FOSL2
FOS-like antigen 2
chr17_-_35656691 0.102 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr1_-_25256364 0.100 RUNX3
runt-related transcription factor 3
chr15_-_72598655 0.099 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr17_+_35849997 0.098 DUSP14
dual specificity phosphatase 14
chr17_-_42976843 0.093 NM_001142605
NM_004247
EFTUD2

elongation factor Tu GTP binding domain containing 2

chr8_-_66701175 0.093 NM_002603
PDE7A
phosphodiesterase 7A
chr4_-_69111333 0.092 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chrX_-_72434623 0.091 NAP1L2
nucleosome assembly protein 1-like 2
chr8_+_75736771 0.090 NM_015886
PI15
peptidase inhibitor 15
chrX_-_117119282 0.089 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr1_-_108231122 0.087 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_10452939 0.087 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr19_-_11688441 0.085 ACP5
acid phosphatase 5, tartrate resistant
chr4_-_80994309 0.085 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr16_-_71318761 0.084 FTSJD1
FtsJ methyltransferase domain containing 1
chr12_-_10962673 0.084 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr2_+_28615771 0.084 NM_005253
FOSL2
FOS-like antigen 2
chr4_+_86749045 0.082 ARHGAP24
Rho GTPase activating protein 24
chr14_+_24782312 0.082 NM_181657
LTB4R
leukotriene B4 receptor
chr18_-_53068755 0.082 TCF4
transcription factor 4
chr11_+_64018991 0.081 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr10_+_98740987 0.079 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr4_-_174320616 0.079 NM_007281
SCRG1
stimulator of chondrogenesis 1
chrX_-_132162297 0.078 NM_031907
USP26
ubiquitin specific peptidase 26
chr2_-_192015751 0.077 STAT4
signal transducer and activator of transcription 4
chr22_+_33196801 0.076 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr10_-_127464389 0.076 NM_147191
MMP21
matrix metallopeptidase 21
chr2_+_28615695 0.075 FOSL2
FOS-like antigen 2
chr2_+_28616346 0.075 FOSL2
FOS-like antigen 2
chr6_+_152011630 0.075 NM_001122742
ESR1
estrogen receptor 1
chr17_-_27402626 0.075 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_-_203320185 0.075 FMOD
fibromodulin
chr16_+_78056411 0.074 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr5_+_161494647 0.074 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr1_+_84864214 0.074 NM_021233
DNASE2B
deoxyribonuclease II beta
chr2_+_1418179 0.073 NM_175721
NM_175722
TPO

thyroid peroxidase

chr9_+_137004913 0.073 NM_052821
WDR5
WD repeat domain 5
chr13_+_78109808 0.072 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr2_+_1417232 0.071 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr17_-_46667596 0.071 HOXB3
homeobox B3
chrX_-_110655384 0.070 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr12_+_21168629 0.070 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr9_-_112191105 0.070 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr11_-_19223516 0.069 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr21_-_46348633 0.066 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_-_36619776 0.066 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr6_-_31088195 0.066 NM_001264
CDSN
corneodesmosin
chr1_+_158323485 0.066 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chrX_+_41548225 0.066 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr2_+_179184970 0.064 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr19_-_55767103 0.063 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr18_+_55862577 0.063 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_138893666 0.063 NM_020464
NHSL1
NHS-like 1
chr15_+_77287428 0.062 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr5_-_35118223 0.062 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr3_-_165555167 0.060 BCHE
butyrylcholinesterase
chr6_+_26368405 0.060 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr7_-_37024664 0.058 NM_001039459
ELMO1
engulfment and cell motility 1
chr3_+_97158453 0.058 NM_173655
EPHA6
EPH receptor A6
chr2_-_192015733 0.058 STAT4
signal transducer and activator of transcription 4
chr1_-_23696267 0.058 NM_001077195
ZNF436
zinc finger protein 436
chr21_-_33074101 0.057 SCAF4
SR-related CTD-associated factor 4
chr11_-_85437457 0.056 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr5_-_131879172 0.056 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr8_-_7321028 0.056 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr14_-_45431121 0.056 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr4_+_166131170 0.056 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr17_-_29641087 0.056 EVI2B
ecotropic viral integration site 2B
chr17_-_56606710 0.056 NM_004574
SEPT4
septin 4
chr2_-_192015934 0.055 NM_003151
STAT4
signal transducer and activator of transcription 4
chr4_-_123377471 0.055 NM_000586
IL2
interleukin 2
chr6_-_51952368 0.055 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr11_-_114466471 0.055 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr1_+_174417211 0.055 NM_005684
GPR52
G protein-coupled receptor 52
chrX_-_131573638 0.053 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr1_-_247054277 0.053 AHCTF1
AT hook containing transcription factor 1
chr3_+_46411632 0.053 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr2_-_242556883 0.053 NM_001164356
THAP4
THAP domain containing 4
chr4_+_110834039 0.053 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr5_-_98262217 0.052 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_59147727 0.052


chr7_-_104909442 0.050 NM_182691
SRPK2
SRSF protein kinase 2
chr5_+_86676620 0.050


chr5_-_93077196 0.049 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr22_-_38714088 0.049 NM_001894
CSNK1E
casein kinase 1, epsilon
chr4_-_89978117 0.049 NM_014883
FAM13A
family with sequence similarity 13, member A
chr1_+_100316530 0.049 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_-_138914384 0.049 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr1_-_62191094 0.048 NM_032027
TM2D1
TM2 domain containing 1
chr16_+_76343734 0.048 NM_138994
CNTNAP4
contactin associated protein-like 4
chr14_+_56078735 0.047 KTN1
kinectin 1 (kinesin receptor)
chr17_+_67498391 0.046 MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_123594974 0.046 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr12_+_113416267 0.046 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr19_+_6135650 0.045 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr11_+_62439134 0.045 C11orf83
chromosome 11 open reading frame 83
chr4_+_102734982 0.045 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr12_+_25205488 0.045 LRMP
lymphoid-restricted membrane protein
chr2_+_103035148 0.045 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_156460390 0.044 MEF2D
myocyte enhancer factor 2D
chr7_+_94297448 0.044 PEG10
paternally expressed 10
chr16_-_68057769 0.043 NM_018380
DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr12_-_16758312 0.043 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_22853360 0.043 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr4_-_69434215 0.042 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr5_+_175298604 0.042 CPLX2
complexin 2
chr2_-_217724781 0.042 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr11_+_56949220 0.042 NM_001005210
LRRC55
leucine rich repeat containing 55

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 6.95e-03 GO:0005576 extracellular region
2.91 4.03e-02 GO:0005792 microsome

Nothing significant found in function category.