Motif ID: NRF1.p2

Z-value: 4.691


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1292699160.561.4e-01Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_49449638 5.049 NM_022171
 TCTA
T-cell leukemia translocation altered gene
chr17_+_260092 4.922 NM_001013672
 C17orf97
chromosome 17 open reading frame 97
chr3_+_49449753 4.599 TCTA
T-cell leukemia translocation altered gene
chr5_+_119800004 4.558 NM_016644
 PRR16
proline rich 16
chr5_+_119799898 4.547 PRR16
proline rich 16
chr7_+_149571029 4.433 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr22_+_24666749 3.141 NM_001145468
NM_015330
 SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1-like

chrX_+_51927918 3.030 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
 MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chrX_-_51812249 2.985 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
 MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr12_-_54070108 2.513 NM_005176
 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr13_-_44361032 2.452 NM_001242863
NM_017993
 ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr19_-_44124013 2.433 NM_182498
 ZNF428
zinc finger protein 428
chr5_+_134181729 2.351 C5orf24
chromosome 5 open reading frame 24
chr19_-_44123732 2.255 ZNF428
zinc finger protein 428
chr13_-_49107250 2.208 NM_001268
 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr12_-_124457099 2.169 NM_025140
 CCDC92
coiled-coil domain containing 92
chr11_+_63706433 2.150 NM_024771
 NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr15_-_48937068 2.148 FBN1
fibrillin 1
chr13_-_49107185 2.135 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr9_+_134378335 2.132 POMT1
protein-O-mannosyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 101 entries
enrichment   p-value GO term description
2.86 5.02e-03 GO:0006200 ATP catabolic process
2.82 1.11e-02 GO:0006405 RNA export from nucleus
2.66 1.29e-03 GO:0022904 respiratory electron transport chain
2.41 8.02e-07 GO:0000375 RNA splicing, via transesterification reactions
2.38 2.59e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.38 2.59e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
2.29 1.02e-02 GO:0045333 cellular respiration
2.24 3.69e-04 GO:0006913 nucleocytoplasmic transport
2.21 5.33e-04 GO:0051169 nuclear transport
2.18 3.11e-02 GO:0022900 electron transport chain
2.17 2.18e-07 GO:0008380 RNA splicing
2.05 1.34e-04 GO:0016567 protein ubiquitination
2.04 5.98e-05 GO:0032446 protein modification by small protein conjugation
2.01 5.09e-07 GO:0006397 mRNA processing
2.01 3.43e-03 GO:0009203 ribonucleoside triphosphate catabolic process
2.01 3.43e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.00 8.52e-05 GO:0006366 transcription from RNA polymerase II promoter
2.00 3.99e-03 GO:0009146 purine nucleoside triphosphate catabolic process
1.99 8.26e-06 GO:0006281 DNA repair
1.97 6.20e-03 GO:0009143 nucleoside triphosphate catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
3.84 4.84e-02 GO:0019005 SCF ubiquitin ligase complex
3.07 1.24e-02 GO:0017053 transcriptional repressor complex
2.78 3.64e-04 GO:0031461 cullin-RING ubiquitin ligase complex
2.71 4.40e-02 GO:0034708 methyltransferase complex
2.71 4.40e-02 GO:0035097 histone methyltransferase complex
2.69 7.64e-03 GO:0070469 respiratory chain
2.68 3.54e-06 GO:0044455 mitochondrial membrane part
2.63 2.70e-02 GO:0005746 mitochondrial respiratory chain
2.47 1.35e-04 GO:0016607 nuclear speck
2.27 1.69e-05 GO:0005819 spindle
2.25 7.52e-04 GO:0000151 ubiquitin ligase complex
1.93 1.76e-03 GO:0016604 nuclear body
1.90 1.90e-05 GO:0005815 microtubule organizing center
1.89 3.98e-03 GO:0005813 centrosome
1.83 1.55e-06 GO:0044427 chromosomal part
1.82 3.59e-07 GO:0030529 ribonucleoprotein complex
1.81 1.27e-07 GO:0005694 chromosome
1.78 1.07e-09 GO:0044451 nucleoplasm part
1.74 2.84e-17 GO:0005654 nucleoplasm
1.64 1.03e-05 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
4.83 4.37e-02 GO:0030983 mismatched DNA binding
1.95 8.16e-03 GO:0003682 chromatin binding
1.84 8.42e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.84 1.01e-02 GO:0019787 small conjugating protein ligase activity
1.81 4.82e-03 GO:0016881 acid-amino acid ligase activity
1.72 1.47e-03 GO:0003712 transcription cofactor activity
1.71 1.64e-03 GO:0000988 protein binding transcription factor activity
1.71 1.64e-03 GO:0000989 transcription factor binding transcription factor activity
1.63 4.95e-07 GO:0003723 RNA binding
1.42 6.75e-17 GO:0003676 nucleic acid binding
1.37 4.11e-08 GO:0003677 DNA binding
1.36 3.06e-02 GO:0030528 transcription regulator activity
1.27 5.85e-03 GO:0008270 zinc ion binding
1.25 1.06e-19 GO:0005515 protein binding
1.24 7.13e-03 GO:0000166 nucleotide binding
1.12 2.75e-13 GO:0005488 binding