Motif ID: PATZ1.p2

Z-value: 2.205


Transcription factors associated with PATZ1.p2:

Gene SymbolEntrez IDGene Name
PATZ1 23598 POZ (BTB) and AT hook containing zinc finger 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PATZ1chr22_-_317415650.502.1e-01Click!


Activity profile for motif PATZ1.p2.

activity profile for motif PATZ1.p2


Sorted Z-values histogram for motif PATZ1.p2

Sorted Z-values for motif PATZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PATZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_2015628 3.277 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr10_+_111985628 2.933 NM_005962
MXI1
MAX interactor 1
chr13_-_114018201 2.881 GRTP1
growth hormone regulated TBC protein 1
chr1_-_11714738 2.708 NM_012168
FBXO2
F-box protein 2
chr1_-_11714471 2.481 FBXO2
F-box protein 2
chr1_-_11714396 2.376 FBXO2
F-box protein 2
chr19_-_55658310 2.285 TNNT1
troponin T type 1 (skeletal, slow)
chr14_-_21566497 1.989 ZNF219
zinc finger protein 219
chr9_+_133971862 1.844 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr9_+_133971902 1.805 AIF1L
allograft inflammatory factor 1-like
chr10_+_111969988 1.707 NM_001008541
MXI1
MAX interactor 1
chr14_-_21566728 1.681 NM_016423
ZNF219
zinc finger protein 219
chr19_-_291335 1.649 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr19_-_54984341 1.622 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr1_-_32801606 1.499 NM_023009
MARCKSL1
MARCKS-like 1
chr18_+_11981421 1.438 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr13_-_114018365 1.417 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr8_-_144650998 1.394 C8orf73
chromosome 8 open reading frame 73
chr22_+_45064323 1.376 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr19_-_47734215 1.372 NM_014417
BBC3
BCL2 binding component 3
chr17_-_42200957 1.360 HDAC5
histone deacetylase 5
chr17_-_42201009 1.330 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr6_+_37137882 1.300 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr1_+_211432726 1.294 RCOR3
REST corepressor 3
chr9_-_124990949 1.282 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr18_+_11981552 1.275 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr9_-_23821808 1.250 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_-_54785018 1.243 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr2_+_30369868 1.237 YPEL5
yippee-like 5 (Drosophila)
chr16_-_30107492 1.230 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr6_+_150464156 1.229 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr19_-_49149252 1.223 NM_001217
CA11
carbonic anhydrase XI
chr22_+_51113069 1.213 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr17_+_55333843 1.194 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr20_-_31071187 1.160 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr9_+_133320247 1.153 ASS1
argininosuccinate synthase 1
chr8_-_495330 1.138 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr22_-_45636584 1.129 NM_001009880
KIAA0930
KIAA0930
chr8_+_86376130 1.115 NM_000067
CA2
carbonic anhydrase II
chr1_-_9970265 1.107 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr9_+_133320093 1.095 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr14_-_21994342 1.075 SALL2
sal-like 2 (Drosophila)
chr19_-_44143943 1.060 NM_145296
CADM4
cell adhesion molecule 4
chr1_+_211432732 1.059 RCOR3
REST corepressor 3
chr1_+_1981902 1.048 NM_002744
PRKCZ
protein kinase C, zeta
chr8_+_86089618 1.040 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr9_-_23821477 1.039 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr11_+_64001974 1.025 NM_001243733
NM_003377
VEGFB

vascular endothelial growth factor B

chr2_+_30369800 1.019 YPEL5
yippee-like 5 (Drosophila)
chr20_-_31071384 1.001 C20orf112
chromosome 20 open reading frame 112
chr6_-_33285493 0.992 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr10_+_23728197 0.982 NM_001145373
OTUD1
OTU domain containing 1
chr4_-_174090305 0.979


chr8_+_95653340 0.974 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr17_+_29718641 0.972 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr14_-_99947080 0.965 SETD3
SET domain containing 3
chr2_+_219187858 0.958 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chr4_+_1795004 0.932 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr19_-_6459735 0.923 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr2_+_47596286 0.923 NM_002354
EPCAM
epithelial cell adhesion molecule
chr14_-_105634708 0.920 JAG2
jagged 2
chr1_-_6321034 0.916 NM_207370
GPR153
G protein-coupled receptor 153
chr12_+_50017340 0.913 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr19_-_6767417 0.897 NM_005490
SH2D3A
SH2 domain containing 3A
chr17_-_43209681 0.891 NM_133373
PLCD3
phospholipase C, delta 3
chr14_-_105635114 0.887 NM_002226
NM_145159
JAG2

jagged 2

chr2_+_47596447 0.883 EPCAM
epithelial cell adhesion molecule
chr6_-_32157511 0.880 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr2_+_219187975 0.875 PNKD
paroxysmal nonkinesigenic dyskinesia
chr1_-_54871681 0.864 SSBP3
single stranded DNA binding protein 3
chr2_+_85360373 0.856 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr9_+_139685760 0.847 NM_032928
TMEM141
transmembrane protein 141
chr1_+_160370363 0.846 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr8_-_144650884 0.845 C8orf73
chromosome 8 open reading frame 73
chr17_+_48503518 0.837 NM_025149
ACSF2
acyl-CoA synthetase family member 2
chr14_-_105647520 0.835 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr12_-_106532447 0.834 NUAK1
NUAK family, SNF1-like kinase, 1
chr9_+_139685816 0.832


chr19_+_8455243 0.829 RAB11B
RAB11B, member RAS oncogene family
chr19_+_8455265 0.825 RAB11B
RAB11B, member RAS oncogene family
chrX_+_135229536 0.824 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr3_-_52444016 0.821 BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr17_+_48503607 0.816 ACSF2
acyl-CoA synthetase family member 2
chr1_+_955609 0.811 AGRN
agrin
chr12_+_70759974 0.809 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_160068359 0.808 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr7_-_98030165 0.807 BAIAP2L1
BAI1-associated protein 2-like 1
chr19_-_291168 0.807 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr7_+_145813452 0.807 NM_014141
CNTNAP2
contactin associated protein-like 2
chr19_+_35606731 0.805 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr16_+_67233013 0.800 NM_024712
ELMO3
engulfment and cell motility 3
chr16_+_11762235 0.793 NM_003498
SNN
stannin
chr22_-_45636760 0.788 KIAA0930
KIAA0930
chr8_-_103251002 0.787 NM_001172477
NM_001172478
NM_015713
RRM2B


ribonucleotide reductase M2 B (TP53 inducible)


chr11_-_119234628 0.781 USP2
ubiquitin specific peptidase 2
chr21_-_44496423 0.777 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr17_+_48610077 0.770 EPN3
epsin 3
chr17_+_29718777 0.768 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr19_+_35759967 0.768 USF2
upstream transcription factor 2, c-fos interacting
chr3_+_127391768 0.764 NM_032548
NM_172027
ABTB1

ankyrin repeat and BTB (POZ) domain containing 1

chr1_-_160068617 0.760 NM_001206665
IGSF8
immunoglobulin superfamily, member 8
chr6_+_126070895 0.759 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr9_-_23821842 0.755 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_-_7197811 0.744 YBX2
Y box binding protein 2
chr19_-_4457789 0.742 NM_025241
UBXN6
UBX domain protein 6
chr8_+_86089641 0.740


chrY_-_1521733 0.737 NM_001173474
NM_004192
ASMTL

acetylserotonin O-methyltransferase-like

chr12_-_58240746 0.736 NM_005730
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr6_+_4776826 0.735 CDYL
chromodomain protein, Y-like
chr1_-_41131323 0.733 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr19_+_17581276 0.732 NM_198580
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr17_-_74497406 0.731 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr1_+_15250578 0.728 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr16_-_755718 0.728 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr14_-_99947113 0.722 SETD3
SET domain containing 3
chr16_+_1203240 0.721 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr2_+_64681270 0.719 NM_014181
LGALSL
lectin, galactoside-binding-like
chr3_-_52443893 0.717 NM_004656
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr18_-_74207145 0.715 NM_014643
ZNF516
zinc finger protein 516
chr1_+_14925177 0.714 NM_015209
NM_201628
KAZN

kazrin, periplakin interacting protein

chr2_-_46384 0.706 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr11_+_64949391 0.701 CAPN1
calpain 1, (mu/I) large subunit
chr12_+_118814310 0.699 NM_022491
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr12_-_56881901 0.698 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr11_-_66234176 0.693 MRPL11
mitochondrial ribosomal protein L11
chr7_+_150783771 0.692 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr8_+_95653272 0.692 ESRP1
epithelial splicing regulatory protein 1
chr1_+_155099935 0.691 EFNA1
ephrin-A1
chr9_-_140317650 0.690 EXD3
exonuclease 3'-5' domain containing 3
chr19_-_49567123 0.688 NM_006179
NTF4
neurotrophin 4
chr17_-_76124767 0.687 TMC6
transmembrane channel-like 6
chr20_-_22564893 0.685 FOXA2
forkhead box A2
chr1_+_212781969 0.685 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr1_+_226250413 0.682 H3F3A
H3 histone, family 3A
chr17_+_36861857 0.680 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr17_-_80656461 0.678 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr6_-_33285718 0.672 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr1_-_160068261 0.672 IGSF8
immunoglobulin superfamily, member 8
chr9_-_116139148 0.667 HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr8_+_95653399 0.666 ESRP1
epithelial splicing regulatory protein 1
chr20_-_62711160 0.659 NM_001039467
RGS19
regulator of G-protein signaling 19
chr16_-_402617 0.658 NM_003502
NM_181050
AXIN1

axin 1

chr17_+_48610045 0.657 NM_017957
EPN3
epsin 3
chr2_+_220325533 0.655 NM_001173476
SPEG
SPEG complex locus
chr18_-_48723689 0.654 MEX3C
mex-3 homolog C (C. elegans)
chr17_+_79989485 0.652 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr19_+_1104068 0.651 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr7_+_97910978 0.649 NM_001159491
NM_015379
BRI3

brain protein I3

chr9_+_33817168 0.649 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr19_+_35759880 0.648 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr2_+_220306772 0.647 SPEG
SPEG complex locus
chr3_-_52090090 0.645 NM_001947
DUSP7
dual specificity phosphatase 7
chr17_+_37896219 0.642 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr19_+_1104614 0.640 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chrX_-_1571733 0.639 NM_001173474
NM_004192
ASMTL

acetylserotonin O-methyltransferase-like

chr19_+_1104007 0.633 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr1_+_206680863 0.629 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr1_-_231175971 0.628 NM_198552
FAM89A
family with sequence similarity 89, member A
chr16_-_30134582 0.627 NM_001040056
NM_001109891
NM_002746
MAPK3


mitogen-activated protein kinase 3


chr8_-_127570465 0.626 FAM84B
family with sequence similarity 84, member B
chr12_+_50451486 0.625 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr8_+_104512975 0.617 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_955468 0.617 NM_198576
AGRN
agrin
chr1_+_11714861 0.615 NM_001014765
NM_033182
NM_183413
FBXO44


F-box protein 44


chr17_-_7197896 0.615 YBX2
Y box binding protein 2
chr14_+_94640648 0.613 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr9_+_130922471 0.608 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr11_-_47207425 0.606 NM_001184975
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr8_-_99837768 0.600 NM_006281
STK3
serine/threonine kinase 3
chr1_-_113257873 0.598 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chrX_-_48828250 0.598 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr14_-_95786095 0.597 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr19_-_38746978 0.597 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr16_+_81478774 0.596 NM_198390
CMIP
c-Maf inducing protein
chr3_+_184053682 0.596 NM_001171093
FAM131A
family with sequence similarity 131, member A
chr19_+_39897457 0.595 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr1_+_26856259 0.595 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr18_+_33877630 0.592 NM_025135
FHOD3
formin homology 2 domain containing 3
chr12_-_58240493 0.592 CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr9_+_140500054 0.592 NM_152285
ARRDC1
arrestin domain containing 1
chr1_+_26856252 0.592 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr16_-_57570455 0.588 NM_033212
CCDC102A
coiled-coil domain containing 102A
chr19_+_7702010 0.587 STXBP2
syntaxin binding protein 2
chr11_-_64570621 0.586 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr11_-_130184459 0.586 NM_014155
ZBTB44
zinc finger and BTB domain containing 44
chr15_+_80445177 0.584 NM_000137
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr6_+_42981975 0.584 KLHDC3
kelch domain containing 3
chr6_-_91006460 0.583 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr21_+_27107671 0.583 GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr19_-_14201230 0.582 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr6_+_37787592 0.578 ZFAND3
zinc finger, AN1-type domain 3
chr1_+_203274646 0.577 NM_006763
BTG2
BTG family, member 2
chr17_-_7197866 0.576 NM_015982
YBX2
Y box binding protein 2
chr5_-_175964223 0.575 NM_014901
RNF44
ring finger protein 44
chr19_-_14316980 0.574 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr1_-_161102210 0.573 NM_001039712
DEDD
death effector domain containing
chr17_+_38334241 0.573 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr6_+_41606193 0.571 NM_005586
MDFI
MyoD family inhibitor
chr1_+_6845381 0.569 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr11_+_64073040 0.563 NM_004451
ESRRA
estrogen-related receptor alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 7.80e-23 GO:0044237 cellular metabolic process
1.18 1.96e-21 GO:0044260 cellular macromolecule metabolic process
1.08 4.60e-20 GO:0009987 cellular process
1.12 1.98e-18 GO:0050794 regulation of cellular process
1.15 2.20e-16 GO:0043170 macromolecule metabolic process
1.11 2.26e-16 GO:0050789 regulation of biological process
1.12 1.08e-15 GO:0044238 primary metabolic process
1.10 1.91e-15 GO:0065007 biological regulation
1.11 6.67e-15 GO:0008152 metabolic process
1.25 1.17e-13 GO:0006464 protein modification process
1.17 3.97e-13 GO:0031323 regulation of cellular metabolic process
1.23 2.98e-12 GO:0043412 macromolecule modification
1.17 1.19e-11 GO:0006807 nitrogen compound metabolic process
1.17 2.21e-11 GO:0060255 regulation of macromolecule metabolic process
1.16 2.44e-11 GO:0080090 regulation of primary metabolic process
1.15 3.16e-11 GO:0019222 regulation of metabolic process
1.17 3.78e-11 GO:0034641 cellular nitrogen compound metabolic process
1.18 1.61e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 4.73e-10 GO:0044267 cellular protein metabolic process
1.17 2.18e-08 GO:0010468 regulation of gene expression
1.18 6.81e-08 GO:0051252 regulation of RNA metabolic process
1.16 9.19e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 9.33e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.17 1.03e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.16 2.54e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.43 4.54e-07 GO:0007264 small GTPase mediated signal transduction
1.17 5.85e-07 GO:0090304 nucleic acid metabolic process
1.15 7.78e-07 GO:0009889 regulation of biosynthetic process
1.22 9.68e-07 GO:0009966 regulation of signal transduction
1.22 1.23e-06 GO:0035556 intracellular signal transduction
1.17 1.42e-06 GO:0048523 negative regulation of cellular process
1.15 1.72e-06 GO:0031326 regulation of cellular biosynthetic process
1.17 2.25e-06 GO:0006355 regulation of transcription, DNA-dependent
1.21 2.52e-06 GO:0007399 nervous system development
1.20 4.38e-06 GO:0023051 regulation of signaling
1.36 4.53e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.13 5.35e-06 GO:0016043 cellular component organization
1.75 5.62e-06 GO:0031098 stress-activated protein kinase signaling cascade
1.53 5.84e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.16 6.08e-06 GO:0048519 negative regulation of biological process
1.25 7.76e-06 GO:0006793 phosphorus metabolic process
1.25 7.76e-06 GO:0006796 phosphate metabolic process
1.36 1.02e-05 GO:0043549 regulation of kinase activity
1.47 1.03e-05 GO:0071900 regulation of protein serine/threonine kinase activity
1.41 1.10e-05 GO:0016568 chromatin modification
1.12 1.66e-05 GO:0071840 cellular component organization or biogenesis
1.20 1.78e-05 GO:0009653 anatomical structure morphogenesis
1.34 2.15e-05 GO:0051338 regulation of transferase activity
1.35 5.05e-05 GO:0045859 regulation of protein kinase activity
1.13 6.02e-05 GO:0019538 protein metabolic process
1.23 8.45e-05 GO:0032268 regulation of cellular protein metabolic process
1.54 9.99e-05 GO:0016569 covalent chromatin modification
1.17 1.29e-04 GO:0016070 RNA metabolic process
1.54 1.57e-04 GO:0016570 histone modification
1.14 1.60e-04 GO:0048522 positive regulation of cellular process
1.16 1.65e-04 GO:0010467 gene expression
1.21 2.63e-04 GO:0051246 regulation of protein metabolic process
1.28 2.82e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.28 3.01e-04 GO:0051726 regulation of cell cycle
1.28 3.28e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.27 3.81e-04 GO:0019220 regulation of phosphate metabolic process
1.27 3.81e-04 GO:0051174 regulation of phosphorus metabolic process
1.11 4.52e-04 GO:0007165 signal transduction
1.26 4.89e-04 GO:0006468 protein phosphorylation
1.13 5.15e-04 GO:0048518 positive regulation of biological process
1.18 5.58e-04 GO:0009056 catabolic process
1.24 6.90e-04 GO:0016310 phosphorylation
1.26 7.18e-04 GO:0009890 negative regulation of biosynthetic process
1.23 7.39e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.13 8.09e-04 GO:0071842 cellular component organization at cellular level
1.20 8.35e-04 GO:0044248 cellular catabolic process
1.25 9.45e-04 GO:0016192 vesicle-mediated transport
1.17 9.96e-04 GO:0065009 regulation of molecular function
1.22 1.08e-03 GO:0022008 neurogenesis
1.93 1.34e-03 GO:0051403 stress-activated MAPK cascade
1.26 1.47e-03 GO:0042325 regulation of phosphorylation
1.27 1.62e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.21 1.82e-03 GO:0009892 negative regulation of metabolic process
1.27 2.14e-03 GO:0010629 negative regulation of gene expression
1.10 2.31e-03 GO:0023052 signaling
1.16 2.73e-03 GO:0006996 organelle organization
1.12 2.81e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.20 3.16e-03 GO:0007049 cell cycle
1.22 4.19e-03 GO:0006351 transcription, DNA-dependent
1.22 4.36e-03 GO:0048699 generation of neurons
1.25 4.46e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.23 4.79e-03 GO:0031399 regulation of protein modification process
1.40 5.37e-03 GO:0000165 MAPKKK cascade
1.19 5.76e-03 GO:0008104 protein localization
1.28 5.78e-03 GO:0010942 positive regulation of cell death
1.11 6.05e-03 GO:0048731 system development
1.17 7.00e-03 GO:0051641 cellular localization
1.25 7.38e-03 GO:0001932 regulation of protein phosphorylation
1.20 7.38e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.18 9.14e-03 GO:0050790 regulation of catalytic activity
1.10 1.01e-02 GO:0007275 multicellular organismal development
1.72 1.06e-02 GO:0071901 negative regulation of protein serine/threonine kinase activity
1.27 1.13e-02 GO:0043068 positive regulation of programmed cell death
1.26 1.25e-02 GO:0051253 negative regulation of RNA metabolic process
1.20 1.43e-02 GO:0031324 negative regulation of cellular metabolic process
1.21 1.43e-02 GO:0008219 cell death
1.25 1.49e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 1.53e-02 GO:0043065 positive regulation of apoptosis
1.09 1.54e-02 GO:0051716 cellular response to stimulus
1.26 1.62e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.41 1.82e-02 GO:0045786 negative regulation of cell cycle
1.14 1.82e-02 GO:0048583 regulation of response to stimulus
1.10 1.87e-02 GO:0048856 anatomical structure development
1.32 1.88e-02 GO:0044419 interspecies interaction between organisms
1.21 2.10e-02 GO:0046907 intracellular transport
1.24 2.29e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.20 2.58e-02 GO:0016265 death
1.49 3.09e-02 GO:0006184 GTP catabolic process
1.20 3.17e-02 GO:0033554 cellular response to stress
1.24 3.62e-02 GO:0048666 neuron development
1.30 3.64e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.29 3.88e-02 GO:0009968 negative regulation of signal transduction
1.53 4.01e-02 GO:0007265 Ras protein signal transduction
1.22 4.07e-02 GO:0030182 neuron differentiation
1.16 4.09e-02 GO:0033036 macromolecule localization
1.17 4.12e-02 GO:0051649 establishment of localization in cell
1.11 4.23e-02 GO:0044249 cellular biosynthetic process
1.27 4.56e-02 GO:0006325 chromatin organization
1.40 4.75e-02 GO:0043405 regulation of MAP kinase activity
1.71 4.88e-02 GO:0034138 toll-like receptor 3 signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 4.73e-51 GO:0005622 intracellular
1.11 4.83e-51 GO:0044424 intracellular part
1.14 9.55e-37 GO:0005737 cytoplasm
1.13 4.50e-34 GO:0043227 membrane-bounded organelle
1.13 5.44e-34 GO:0043231 intracellular membrane-bounded organelle
1.11 4.20e-32 GO:0043226 organelle
1.11 5.80e-32 GO:0043229 intracellular organelle
1.16 9.47e-25 GO:0005634 nucleus
1.13 8.43e-19 GO:0044444 cytoplasmic part
1.24 6.37e-16 GO:0005829 cytosol
1.21 9.36e-13 GO:0044428 nuclear part
1.11 1.42e-11 GO:0044446 intracellular organelle part
1.20 3.13e-11 GO:0043233 organelle lumen
1.20 4.82e-11 GO:0070013 intracellular organelle lumen
1.19 5.93e-11 GO:0031974 membrane-enclosed lumen
1.22 6.57e-11 GO:0031981 nuclear lumen
1.11 7.17e-11 GO:0044422 organelle part
1.03 1.44e-08 GO:0044464 cell part
1.03 1.62e-08 GO:0005623 cell
1.22 1.44e-07 GO:0005654 nucleoplasm
1.39 1.03e-05 GO:0048471 perinuclear region of cytoplasm
1.22 3.48e-05 GO:0005794 Golgi apparatus
1.68 6.92e-05 GO:0005925 focal adhesion
1.52 8.89e-05 GO:0070161 anchoring junction
1.63 3.70e-04 GO:0005924 cell-substrate adherens junction
1.51 5.48e-04 GO:0005912 adherens junction
1.68 7.70e-04 GO:0030027 lamellipodium
1.46 8.06e-04 GO:0031252 cell leading edge
1.11 9.47e-04 GO:0043234 protein complex
1.59 1.02e-03 GO:0030055 cell-substrate junction
1.23 2.37e-03 GO:0015630 microtubule cytoskeleton
1.23 6.10e-03 GO:0044431 Golgi apparatus part
1.08 2.30e-02 GO:0032991 macromolecular complex
1.09 4.08e-02 GO:0043228 non-membrane-bounded organelle
1.09 4.08e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.19 4.13e-02 GO:0044451 nucleoplasm part
1.33 4.40e-02 GO:0016323 basolateral plasma membrane
1.21 4.95e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 2.26e-42 GO:0005515 protein binding
1.09 5.51e-38 GO:0005488 binding
1.19 1.01e-10 GO:0000166 nucleotide binding
1.43 3.19e-09 GO:0019904 protein domain specific binding
1.31 5.03e-08 GO:0019899 enzyme binding
1.19 6.65e-08 GO:0032553 ribonucleotide binding
1.19 6.65e-08 GO:0032555 purine ribonucleotide binding
1.19 7.18e-08 GO:0017076 purine nucleotide binding
1.19 8.50e-08 GO:0035639 purine ribonucleoside triphosphate binding
1.14 1.20e-07 GO:0003676 nucleic acid binding
1.26 3.04e-07 GO:0001071 nucleic acid binding transcription factor activity
1.26 3.04e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.24 3.82e-06 GO:0030528 transcription regulator activity
1.28 8.15e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 1.01e-05 GO:0016301 kinase activity
1.28 1.85e-05 GO:0043565 sequence-specific DNA binding
1.14 3.46e-05 GO:0003677 DNA binding
1.23 1.18e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.16 1.29e-04 GO:0016740 transferase activity
1.17 2.19e-04 GO:0030554 adenyl nucleotide binding
1.17 2.64e-04 GO:0032559 adenyl ribonucleotide binding
1.16 5.88e-04 GO:0005524 ATP binding
1.08 1.16e-03 GO:0003824 catalytic activity
1.24 3.16e-03 GO:0004672 protein kinase activity
1.34 4.48e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.25 5.10e-03 GO:0008092 cytoskeletal protein binding
1.30 6.91e-03 GO:0000988 protein binding transcription factor activity
1.30 6.91e-03 GO:0000989 transcription factor binding transcription factor activity
1.20 7.93e-03 GO:0003723 RNA binding
2.56 7.96e-03 GO:0070412 R-SMAD binding
1.30 9.07e-03 GO:0003712 transcription cofactor activity
1.32 1.04e-02 GO:0016564 transcription repressor activity
1.54 1.20e-02 GO:0017124 SH3 domain binding
1.26 1.73e-02 GO:0030695 GTPase regulator activity
1.25 1.93e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.36 1.98e-02 GO:0019787 small conjugating protein ligase activity
1.34 2.15e-02 GO:0016881 acid-amino acid ligase activity
1.69 2.45e-02 GO:0019902 phosphatase binding
1.35 3.36e-02 GO:0019900 kinase binding
1.31 4.24e-02 GO:0008134 transcription factor binding