Motif ID: PAX4.p2

Z-value: 0.455


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX4chr7_-_1272555740.285.0e-01Click!


Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_56075418 0.509 METTL7B
methyltransferase like 7B
chr9_-_20622476 0.427 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_45067750 0.325 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr12_+_56075329 0.286 NM_152637
METTL7B
methyltransferase like 7B
chr6_-_31697953 0.285 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr9_-_20622433 0.276 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_-_31698033 0.276 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chrX_+_103031753 0.248 NM_000533
NM_199478
PLP1

proteolipid protein 1

chrX_+_85517970 0.245 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr5_+_147258273 0.244 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr2_-_238322770 0.240 COL6A3
collagen, type VI, alpha 3
chr3_+_148447966 0.238 NM_032049
AGTR1
angiotensin II receptor, type 1
chr1_-_72748147 0.235 NM_173808
NEGR1
neuronal growth regulator 1
chr8_+_17434700 0.217 PDGFRL
platelet-derived growth factor receptor-like
chr12_-_81331487 0.213 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr1_-_72748491 0.212


chrX_+_103031433 0.208 NM_001128834
PLP1
proteolipid protein 1
chr3_-_112358510 0.207 CCDC80
coiled-coil domain containing 80
chr2_-_238322840 0.206 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322815 0.202 COL6A3
collagen, type VI, alpha 3
chr19_+_14544216 0.199 PKN1
protein kinase N1
chr1_+_145524989 0.198 NM_003637
ITGA10
integrin, alpha 10
chr16_+_15528324 0.198 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr15_+_63340314 0.192 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr5_-_158526698 0.180 NM_024007
EBF1
early B-cell factor 1
chrX_-_99986496 0.179 NM_001174068
NM_080737
SYTL4

synaptotagmin-like 4

chr3_-_112358758 0.177 CCDC80
coiled-coil domain containing 80
chr12_+_56546203 0.176 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr9_-_5185601 0.170 NM_007179
INSL6
insulin-like 6
chr19_+_6135650 0.168 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr1_-_182357757 0.166 GLUL
glutamate-ammonia ligase
chr11_+_65268313 0.163 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr3_-_112359251 0.162 CCDC80
coiled-coil domain containing 80
chr2_+_217498205 0.161 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr7_+_93551015 0.158 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr2_-_85839178 0.155 NM_001013649
C2orf68
chromosome 2 open reading frame 68
chr2_+_217498082 0.151 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr3_+_51895644 0.150 NM_203424
IQCF2
IQ motif containing F2
chr3_+_9975513 0.146 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr2_-_119605758 0.144 NM_001426
EN1
engrailed homeobox 1
chr12_+_56114150 0.144 NM_001199771
NM_002905
RDH5

retinol dehydrogenase 5 (11-cis/9-cis)

chr1_-_182357871 0.143 GLUL
glutamate-ammonia ligase
chr16_-_3074225 0.141 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr7_+_80267972 0.140 CD36
CD36 molecule (thrombospondin receptor)
chr9_-_99540327 0.138 NM_014930
ZNF510
zinc finger protein 510
chrX_+_16964730 0.137 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr11_+_114166534 0.137 NM_006169
NNMT
nicotinamide N-methyltransferase
chr19_+_14544100 0.135 NM_002741
PKN1
protein kinase N1
chr3_+_138066489 0.134 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr14_+_101300806 0.133 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_104394751 0.132 NM_153046
TDRD9
tudor domain containing 9
chr18_-_65182507 0.131 DSEL
dermatan sulfate epimerase-like
chr7_+_29603388 0.130 NM_175887
PRR15
proline rich 15
chr12_+_121570630 0.129 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr5_-_95158465 0.128 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr20_+_33134691 0.125 NM_181509
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr11_-_58611979 0.125 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr9_+_92219926 0.124 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr7_+_80267922 0.123 CD36
CD36 molecule (thrombospondin receptor)
chr9_+_79115548 0.122 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr8_-_13134028 0.121 DLC1
deleted in liver cancer 1
chr22_-_31688329 0.118 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr11_+_65271145 0.118


chr5_+_139505519 0.118 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr10_+_111967302 0.116 NM_130439
MXI1
MAX interactor 1
chr11_-_94964209 0.114 NM_144665
SESN3
sestrin 3
chr9_-_16870719 0.113 NM_017637
BNC2
basonuclin 2
chr19_+_50015535 0.109 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_-_85839147 0.104 C2orf68
chromosome 2 open reading frame 68
chrX_+_79591002 0.103 NM_001170574
FAM46D
family with sequence similarity 46, member D
chr1_-_182360181 0.102 GLUL
glutamate-ammonia ligase
chr12_-_95945226 0.102 NM_032147
USP44
ubiquitin specific peptidase 44
chr6_+_25963398 0.101 TRIM38
tripartite motif containing 38
chr18_+_72922725 0.099 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr15_+_63335086 0.098 TPM1
tropomyosin 1 (alpha)
chr5_+_139027868 0.098 CXXC5
CXXC finger protein 5
chr19_-_50316360 0.098 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr4_-_84030995 0.097 NM_001130716
PLAC8
placenta-specific 8
chr1_+_153631193 0.096 SNAPIN
SNAP-associated protein
chr4_-_186877869 0.095 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr1_+_46016454 0.094 NM_001202413
NM_001202414
NM_006066
NM_153326
AKR1A1



aldo-keto reductase family 1, member A1 (aldehyde reductase)



chr4_-_120221702 0.094 NM_001001701
C4orf3
chromosome 4 open reading frame 3
chr10_-_70092648 0.094 NM_001033083
NM_022129
PBLD

phenazine biosynthesis-like protein domain containing

chr1_+_46016524 0.094 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr11_+_1874199 0.093 NM_002339
LSP1
lymphocyte-specific protein 1
chr16_+_29831714 0.092 NM_005115
NM_017458
MVP

major vault protein

chr1_+_244816379 0.092 PPPDE1
PPPDE peptidase domain containing 1
chr5_+_150157507 0.091 NM_032947
C5orf62
chromosome 5 open reading frame 62
chr9_-_91793681 0.090 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr19_+_2977480 0.086 NM_001143986
NM_024760
TLE6

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

chr1_+_151032150 0.085 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_53527723 0.085 NM_001199080
NM_001199082
NM_153703
PODN


podocan


chr11_+_63997941 0.084 DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr11_+_67250504 0.084 NM_003977
AIP
aryl hydrocarbon receptor interacting protein
chr1_+_244816349 0.084 NM_016076
PPPDE1
PPPDE peptidase domain containing 1
chr2_+_122407564 0.082 LOC254128
uncharacterized LOC254128
chr1_+_153631144 0.082 NM_012437
SNAPIN
SNAP-associated protein
chr1_+_151032880 0.081 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_+_149570004 0.080 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr12_+_123717458 0.080 C12orf65
chromosome 12 open reading frame 65
chr5_-_126366439 0.079 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr6_-_90062610 0.079 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr1_-_89591685 0.079 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr6_+_25962978 0.079 NM_006355
TRIM38
tripartite motif containing 38
chr11_-_74109417 0.078 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr5_+_139027955 0.078 CXXC5
CXXC finger protein 5
chr1_+_151032683 0.077 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr11_-_70507911 0.077 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr5_-_154230157 0.076 C5orf4
chromosome 5 open reading frame 4
chr1_-_1623942 0.076 SLC35E2B
SLC35E2
solute carrier family 35, member E2B
solute carrier family 35, member E2
chr17_-_33390676 0.076 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_-_1677430 0.075 NM_001199787
NM_182838
SLC35E2B
SLC35E2

solute carrier family 35, member E2B
solute carrier family 35, member E2

chr2_+_231860838 0.075 NM_139073
SPATA3
spermatogenesis associated 3
chrX_-_47004416 0.074 NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr19_-_45996470 0.074 NM_206901
RTN2
reticulon 2
chr10_-_49812996 0.073 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr8_+_41348105 0.073 GOLGA7
golgin A7
chr10_+_5136613 0.073 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_+_67250595 0.073 AIP
aryl hydrocarbon receptor interacting protein
chrX_+_102611379 0.073 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr5_-_125930604 0.072 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr11_+_7506599 0.072 NM_198474
OLFML1
olfactomedin-like 1
chr19_-_35085489 0.072 NM_001025591
SCGBL
secretoglobin-like
chr12_+_10365415 0.071 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr1_-_150978879 0.071 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr7_-_50772997 0.071 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr3_+_197476423 0.071 NM_001011537
FYTTD1
forty-two-three domain containing 1
chr10_+_5136589 0.070 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr8_+_41348094 0.070 GOLGA7
golgin A7
chr6_-_90062450 0.069 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr8_+_41348126 0.069 NM_001002296
GOLGA7
golgin A7
chr1_-_202896315 0.068 KLHL12
kelch-like 12 (Drosophila)
chrX_-_101410761 0.068 NM_001159560
NM_001012978
BEX5

brain expressed, X-linked 5

chr1_-_182360889 0.068 GLUL
glutamate-ammonia ligase
chr1_+_43282775 0.067 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr2_+_12856813 0.067 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr1_-_153348057 0.067 NM_005621
S100A12
S100 calcium binding protein A12
chrX_+_43515406 0.067 NM_000240
MAOA
monoamine oxidase A
chr5_-_58882274 0.067 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_112359277 0.067 CCDC80
coiled-coil domain containing 80
chr9_-_4742042 0.067 NM_001199853
AK3
adenylate kinase 3
chr6_-_130031278 0.066 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr1_-_150669499 0.066 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr17_-_1412995 0.065 INPP5K
inositol polyphosphate-5-phosphatase K
chr20_-_34117447 0.065 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chrX_-_102531673 0.064 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr5_+_81601165 0.064 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr10_+_5136556 0.064 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chrX_+_106163605 0.063 NM_020384
CLDN2
claudin 2
chr4_-_140060601 0.063 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr22_-_32651317 0.063 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr8_-_82395401 0.063 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr6_+_31515352 0.062 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr7_-_23509972 0.062 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr4_+_77953942 0.062 SEPT11
septin 11
chr7_-_99756329 0.062 C7orf43
chromosome 7 open reading frame 43
chrX_+_55744049 0.062 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr10_+_52751114 0.062 PRKG1
protein kinase, cGMP-dependent, type I
chr13_+_49822046 0.062 NM_001193478
NM_030911
CDADC1

cytidine and dCMP deaminase domain containing 1

chr3_-_17741511 0.062 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr9_-_85882093 0.062 NM_001244962
FRMD3
FERM domain containing 3
chr2_-_85839163 0.061 C2orf68
chromosome 2 open reading frame 68
chr12_+_123942650 0.061 NM_022717
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr13_+_76334796 0.061 NM_015842
LMO7
LIM domain 7
chr19_+_11708234 0.060 NM_145295
ZNF627
zinc finger protein 627
chr6_+_35200627 0.059 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr6_-_137494719 0.059 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr5_-_121413906 0.059 LOX
lysyl oxidase
chr17_-_8063946 0.059 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr8_-_145653882 0.058 VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr10_-_25012168 0.058 ARHGAP21
Rho GTPase activating protein 21
chr14_-_50559360 0.058 NM_001014830
C14orf183
chromosome 14 open reading frame 183
chr5_+_157184338 0.058


chr15_-_48937795 0.057 NM_000138
FBN1
fibrillin 1
chr10_+_91152321 0.057 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr4_-_170679027 0.057 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr1_+_155146324 0.057 NM_025058
TRIM46
tripartite motif containing 46
chr11_+_63273555 0.057 LGALS12
lectin, galactoside-binding, soluble, 12
chr7_+_134233848 0.057 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr8_-_145653900 0.056 VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr5_-_93447237 0.056 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr8_-_145653912 0.056 NM_016208
NM_183057
VPS28

vacuolar protein sorting 28 homolog (S. cerevisiae)

chr2_+_88472657 0.055 NM_018271
THNSL2
threonine synthase-like 2 (S. cerevisiae)
chr1_-_154928595 0.055 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr6_+_32605182 0.055 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_+_36644236 0.055 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr7_+_123565285 0.055 NM_001174044
NM_003117
NM_153189
SPAM1


sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)


chr1_+_244816434 0.055 PPPDE1
PPPDE peptidase domain containing 1
chr3_-_21792815 0.054 NM_024697
ZNF385D
zinc finger protein 385D
chr5_-_154230212 0.054 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr12_-_10588543 0.054 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr1_-_149889362 0.053 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr11_-_67211291 0.053 NM_001018070
CORO1B
coronin, actin binding protein, 1B
chr3_-_141868208 0.053 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr11_+_34460421 0.052 NM_001752
CAT
catalase
chr1_-_1624180 0.052 NM_001110781
SLC35E2B
solute carrier family 35, member E2B
chr11_+_46299161 0.052 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr7_-_99756275 0.052 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr5_-_121413967 0.052 LOX
lysyl oxidase
chr1_-_150602020 0.052 ENSA
endosulfine alpha

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 3.55e-03 GO:0005829 cytosol
1.17 3.81e-03 GO:0005737 cytoplasm

Nothing significant found in function category.