Motif ID: PDX1.p2

Z-value: 0.273


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_284941360.462.6e-01Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_166060552 0.114 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr6_+_33043702 0.075 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr4_+_86396251 0.071 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr8_-_17579729 0.071 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr8_-_17580024 0.068 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr18_-_47376156 0.067 MYO5B
myosin VB
chr5_+_147648374 0.067 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr6_-_43423785 0.065 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr6_-_51952368 0.058 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr3_-_21792815 0.058 NM_024697
ZNF385D
zinc finger protein 385D
chrX_+_99899388 0.051 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_47610244 0.050 FAM113B
family with sequence similarity 113, member B
chr8_-_17555158 0.050 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr10_+_118187381 0.048 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr8_+_32579350 0.048 NM_001159996
NRG1
neuregulin 1
chr12_+_47610051 0.046 NM_138371
FAM113B
family with sequence similarity 113, member B
chr18_+_55888799 0.044 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_5410606 0.041 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr14_+_21510384 0.038 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr17_-_9694613 0.038 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr3_+_148447966 0.036 NM_032049
AGTR1
angiotensin II receptor, type 1
chr2_+_185463235 0.033 ZNF804A
zinc finger protein 804A
chr8_-_80993009 0.033 NM_001025252
TPD52
tumor protein D52
chr1_+_63063186 0.032 NM_014495
ANGPTL3
angiopoietin-like 3
chr3_-_151034514 0.032 NM_023915
GPR87
G protein-coupled receptor 87
chr17_+_35732927 0.031 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr13_-_70682458 0.030 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr6_+_72922513 0.029 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr7_+_26400503 0.028 NM_001199837
SNX10
sorting nexin 10
chr9_+_125376947 0.024 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr4_+_113970784 0.022 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr4_-_46996423 0.022 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr1_+_43735664 0.021 NM_144626
TMEM125
transmembrane protein 125
chr14_-_81864726 0.021 NM_033104
STON2
stonin 2
chr1_+_158979681 0.021 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr6_+_112375277 0.021 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chrY_+_16733900 0.020 NM_001164238
NLGN4Y
neuroligin 4, Y-linked
chr18_+_55888838 0.020 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_41742666 0.020 NM_002192
INHBA
inhibin, beta A
chrX_+_99899162 0.019 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr7_-_128543379 0.019 KCP
kielin/chordin-like protein
chr18_+_55888750 0.018 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_143567163 0.018 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr4_-_10023094 0.018 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr15_+_40509628 0.017 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr10_-_62332666 0.017 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_+_174577069 0.016 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr4_-_139163222 0.016 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr15_-_40398286 0.016 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr17_-_7082654 0.015 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr2_+_113735595 0.015 NM_019618
IL36G
interleukin 36, gamma
chr4_+_77356252 0.015 NM_020859
SHROOM3
shroom family member 3
chr9_+_82187469 0.015 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr5_-_16509106 0.014 NM_019000
FAM134B
family with sequence similarity 134, member B
chr3_-_114343791 0.014 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_70557726 0.014 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr17_+_47923271 0.014 NM_001242791
FLJ45513
uncharacterized LOC729220
chr2_+_38893051 0.014 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr6_-_133035180 0.013 NM_004666
VNN1
vanin 1
chr15_+_48498497 0.013 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chrX_-_131547536 0.013 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr6_+_72926144 0.013 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_13911966 0.013 NM_001006624
NM_001006625
PDPN

podoplanin

chr7_+_80267972 0.013 CD36
CD36 molecule (thrombospondin receptor)
chr4_+_88896801 0.013 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr7_+_148287656 0.012 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr3_-_114478117 0.012 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_+_129984629 0.012 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr8_-_20040612 0.011 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr11_-_104905849 0.011 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr21_-_46348633 0.011 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_101003692 0.011 NM_022049
GPR88
G protein-coupled receptor 88
chr11_+_22696318 0.011 NM_005256
GAS2
growth arrest-specific 2
chr3_+_52813936 0.011 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr3_+_35683848 0.010 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_-_45017600 0.010 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr8_+_76452202 0.010 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr12_-_10962673 0.009 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr17_-_15554809 0.009 TRIM16
tripartite motif containing 16
chr15_-_40398573 0.009 NM_033503
BMF
Bcl2 modifying factor
chr15_+_80364902 0.009 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr1_+_10057254 0.008 NM_052960
RBP7
retinol binding protein 7, cellular
chr1_+_84768333 0.008 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr5_+_34684611 0.008 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr10_+_88730497 0.008 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr3_+_35722428 0.008 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr9_+_82187599 0.008 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_+_38893238 0.008 GALM
galactose mutarotase (aldose 1-epimerase)
chr14_+_70918873 0.008 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr3_-_108672547 0.008 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr6_-_41254392 0.008 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr1_+_36636690 0.008 MAP7D1
MAP7 domain containing 1
chr11_-_66488712 0.007 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr1_-_161601251 0.007 NM_001244753
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr21_-_31538970 0.007 NM_012131
CLDN17
claudin 17
chr6_-_143266283 0.007 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr15_+_25281105 0.007 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_+_140201221 0.007 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr1_-_20250051 0.007 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr4_+_74606222 0.007 NM_000584
IL8
interleukin 8
chr6_-_138539626 0.007 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr5_+_140227356 0.007 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr3_+_115342150 0.007 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr19_-_14785626 0.007 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr11_+_111789600 0.006 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr7_-_104567089 0.006 LOC723809
uncharacterized LOC723809
chr11_+_123986103 0.006 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr16_+_57728711 0.006 NM_032269
CCDC135
coiled-coil domain containing 135
chr16_-_70557430 0.006 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr15_-_44969085 0.006 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr19_-_36019194 0.006 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr12_+_105153258 0.006 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_+_147524866 0.006 STXBP5
syntaxin binding protein 5 (tomosyn)
chr5_+_54398473 0.006 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr17_+_18625335 0.006 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr5_+_147582338 0.005 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr12_-_4488707 0.005 NM_020638
FGF23
fibroblast growth factor 23
chr17_-_39165343 0.005 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr4_+_78432905 0.005 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr5_+_140235594 0.005 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr4_-_24981769 0.005 NM_173463
CCDC149
coiled-coil domain containing 149
chr16_-_28620648 0.005 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr4_-_48136245 0.005 NM_003328
TXK
TXK tyrosine kinase
chr4_+_74281884 0.005 ALB
albumin
chr3_+_183770834 0.005 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr7_+_80275967 0.005 CD36
CD36 molecule (thrombospondin receptor)
chr5_+_42565562 0.005 NM_001242406
GHR
growth hormone receptor
chr3_+_97868169 0.004 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr16_+_29674282 0.004 NM_001030288
SPN
sialophorin
chr3_+_46619075 0.004 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_121454285 0.004 NM_022895
C12orf43
chromosome 12 open reading frame 43
chr4_+_123300120 0.004 NM_139243
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr3_+_45017729 0.004 NM_015004
EXOSC7
exosome component 7
chr10_+_70980058 0.004 NM_025130
HKDC1
hexokinase domain containing 1
chr4_+_169013687 0.004 NM_007193
ANXA10
annexin A10
chr12_+_4829751 0.003 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr5_+_68667280 0.003 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr2_+_158114109 0.003 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr6_-_131291480 0.003 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr3_+_45017749 0.003 EXOSC7
exosome component 7
chr3_+_52811601 0.003 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr7_+_156435670 0.003 NM_001184997
RNF32
ring finger protein 32
chr3_-_123339423 0.003 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr18_+_61223392 0.003 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr2_+_137748461 0.003 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr17_+_7960201 0.003


chr17_+_39555993 0.003 GAST
gastrin
chr4_+_123161119 0.002 KIAA1109
KIAA1109
chr8_+_92261515 0.002 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr4_+_108814419 0.002 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr12_-_50616425 0.002 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_-_157670280 0.002 NM_052939
FCRL3
Fc receptor-like 3
chr16_+_28505920 0.002 NM_018690
APOBR
apolipoprotein B receptor
chr20_+_42574535 0.002 NM_001098798
TOX2
TOX high mobility group box family member 2
chr6_+_35310399 0.002 PPARD
peroxisome proliferator-activated receptor delta
chr14_-_77889231 0.002 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr16_+_70557688 0.002 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chrX_-_62780748 0.002 LOC92249
uncharacterized LOC92249
chr20_+_31037447 0.002


chr12_-_14849427 0.002 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr9_-_21239975 0.002 NM_002172
IFNA14
interferon, alpha 14
chrX_+_37639306 0.002 CYBB
cytochrome b-245, beta polypeptide
chr6_-_123957941 0.002 NM_001251987
NM_006073
TRDN

triadin

chr4_+_95376396 0.002 PDLIM5
PDZ and LIM domain 5
chr4_+_88720701 0.002 NM_004967
IBSP
integrin-binding sialoprotein
chr17_-_29641068 0.001 EVI2B
ecotropic viral integration site 2B
chrX_-_118726852 0.001 NM_001173488
NKRF
NFKB repressing factor
chr17_-_39197663 0.001 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr3_+_108541544 0.001 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr16_+_70557724 0.001 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr18_+_31319154 0.001 ASXL3
additional sex combs like 3 (Drosophila)
chr5_+_79615789 0.001 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr6_-_32731266 0.001 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_29455678 0.001 NM_052967
MAS1L
MAS1 oncogene-like
chr17_+_68071386 0.001 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr11_-_116663106 0.001 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr1_+_92632608 0.001 NM_015237
KIAA1107
KIAA1107
chr12_-_121454210 0.001 C12orf43
chromosome 12 open reading frame 43
chr6_+_167536240 0.001 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr14_-_23504353 0.001 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr4_+_189060597 0.001 NM_178556
TRIML1
tripartite motif family-like 1
chr7_-_113559048 0.001 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr8_-_7343903 0.001 NM_152251
NM_001040704
DEFB106A
DEFB106B
defensin, beta 106A
defensin, beta 106B
chr7_+_93535819 0.001 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_-_16763887 0.001 NM_198546
SPATA21
spermatogenesis associated 21
chr10_+_116697914 0.000 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr19_-_7766978 0.000 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr16_-_3085541 0.000 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr8_-_27850368 0.000 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr7_-_27166638 0.000 NM_153631
HOXA3
homeobox A3
chr12_+_131438451 0.000 NM_198827
GPR133
G protein-coupled receptor 133
chr6_-_131321868 0.000 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr15_+_67841341 0.000 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr21_-_32253843 0.000 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr12_+_119616594 0.000 NM_014365
HSPB8
heat shock 22kDa protein 8

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 3.49e-03 GO:0071944 cell periphery
1.95 7.44e-03 GO:0005576 extracellular region
1.58 9.16e-03 GO:0005886 plasma membrane
1.82 2.87e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.