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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: REST.p3

Z-value: 0.722

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_153141398	0.955	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr15_-_72612247	0.451	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr17_+_30813928	0.449	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr15_-_72612497	0.448	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr3_+_193853937	0.424		HES1	hairy and enhancer of split 1, (Drosophila)
chr3_+_193853930	0.419	NM_005524	HES1	hairy and enhancer of split 1, (Drosophila)
chr8_-_91094924	0.393	NM_004929	CALB1	calbindin 1, 28kDa
chr7_+_145813452	0.369	NM_014141	CNTNAP2	contactin associated protein-like 2
chr10_-_50970321	0.340	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr20_+_62328068	0.327		TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_145559831	0.284	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr20_+_62328002	0.284	NM_003823	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr11_-_123524881	0.277		SCN3B	sodium channel, voltage-gated, type III, beta
chr2_+_46524448	0.262	NM_001430	EPAS1	endothelial PAS domain protein 1
chr17_-_3301703	0.238	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr17_-_3337134	0.233	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chrX_-_153141284	0.230		L1CAM	L1 cell adhesion molecule
chr20_-_62284701	0.220	NM_015894	STMN3	stathmin-like 3
chr9_+_135457974	0.199	NM_020064	BARHL1	BarH-like homeobox 1
chr14_+_93389491	0.187		CHGA	chromogranin A (parathyroid secretory protein 1)
chr15_-_72612127	0.167		CELF6	CUGBP, Elav-like family member 6
chrX_-_49056638	0.162	NM_003179	SYP	synaptophysin
chr15_+_75287829	0.149	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr1_+_154540250	0.149	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_+_210111575	0.133		SYT14	synaptotagmin XIV
chr17_+_72667255	0.127	NM_175738	RAB37	RAB37, member RAS oncogene family
chr3_+_120627026	0.123	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr12_+_113796374	0.122		PLBD2	phospholipase B domain containing 2
chr11_-_125773086	0.118	NM_031307	PUS3	pseudouridylate synthase 3
chr8_+_57358361	0.117
chr20_+_44657858	0.116		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_5891973	0.116	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr19_+_34175433	0.113	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr1_-_209825797	0.108	NM_000228	LAMB3	laminin, beta 3
chr12_+_175872	0.108	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr14_+_93389444	0.101	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr11_-_1769086	0.101		IFITM10	interferon induced transmembrane protein 10
chr19_-_3971089	0.100		DAPK3	death-associated protein kinase 3
chr1_+_210111537	0.098	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr16_+_3019341	0.097	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chrX_-_47479229	0.097	NM_006950 NM_133499	SYN1	synapsin I
chr12_+_113796370	0.092	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chr2_+_115199898	0.091	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr19_-_3971032	0.090		DAPK3	death-associated protein kinase 3
chr8_+_6566153	0.087		AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr5_+_175298492	0.085	NM_001008220	CPLX2	complexin 2
chr20_-_13765509	0.083	NM_016649	ESF1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr7_+_8473584	0.078	NM_152745	NXPH1	neurexophilin 1
chr7_+_8473237	0.077		NXPH1	neurexophilin 1
chr17_-_3599487	0.076	NM_001204519 NM_001204520 NM_002561 NM_175080	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 readthrough purinergic receptor P2X, ligand-gated ion channel, 5
chr18_-_5197240	0.075	NM_001145194	C18orf42	chromosome 18 open reading frame 42
chr5_+_175298604	0.073		CPLX2	complexin 2
chr1_-_102462789	0.073	NM_058170	OLFM3	olfactomedin 3
chr20_-_60795270	0.072	NM_007232	HRH3	histamine receptor H3
chr5_+_175298538	0.072		CPLX2	complexin 2
chr16_+_67686813	0.071		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr8_+_6565870	0.067	NM_018361	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr20_+_33814538	0.067	NM_006690	MMP24	matrix metallopeptidase 24 (membrane-inserted)
chr2_-_51259239	0.065		NRXN1	neurexin 1
chr14_-_74892804	0.065	NM_001105579	SYNDIG1L	synapse differentiation inducing 1-like
chr6_+_138725314	0.062	NM_014320	HEBP2	heme binding protein 2
chr16_+_70147528	0.062	NM_017990	PDPR	pyruvate dehydrogenase phosphatase regulatory subunit
chr7_+_8474016	0.062		NXPH1	neurexophilin 1
chr6_+_35773070	0.061	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr16_+_24267474	0.060		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr5_-_151304322	0.055	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr7_-_19812403	0.055	NM_152774	TMEM196	transmembrane protein 196
chr6_+_158957467	0.054	NM_020823	TMEM181	transmembrane protein 181
chr3_-_113897849	0.051	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr9_+_140033588	0.049	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr1_-_102462371	0.048		OLFM3	olfactomedin 3
chr5_+_71014989	0.047	NM_004291	CARTPT	CART prepropeptide
chr1_-_151689246	0.046	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr10_+_73555527	0.044	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr11_+_62380212	0.042	NM_000327	ROM1	retinal outer segment membrane protein 1
chr6_+_138725458	0.041		HEBP2	heme binding protein 2
chr10_-_44880452	0.040	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr17_-_27332888	0.040	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr19_-_40724272	0.040	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr6_+_43603554	0.040	NM_014628	MAD2L1BP	MAD2L1 binding protein
chr15_-_83378488	0.039	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr16_+_24267672	0.038		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr10_-_102790877	0.037	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr14_-_58332591	0.036	NM_001206920	SLC35F4	solute carrier family 35, member F4
chr4_+_158141735	0.034	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr2_-_27531113	0.033	NM_003353	UCN	urocortin
chr1_+_212606194	0.033	NM_013349	NENF	neudesin neurotrophic factor
chr3_+_52812438	0.032	NM_001166434	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chr10_-_102790850	0.032		PDZD7	PDZ domain containing 7
chr10_+_26505593	0.032		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr19_+_41036367	0.031	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr15_+_69222838	0.029	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr6_+_158957652	0.029		TMEM181	transmembrane protein 181
chr1_-_20834609	0.028	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr16_+_5008317	0.026	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr21_-_35828038	0.026	NM_001127670	KCNE1	potassium voltage-gated channel, Isk-related family, member 1
chr15_-_32162778	0.025		OTUD7A	OTU domain containing 7A
chr19_-_11639929	0.025	NM_001142464 NM_001142465 NM_016581	ECSIT	ECSIT homolog (Drosophila)
chr1_-_153123426	0.024	NM_001014291	SPRR2G	small proline-rich protein 2G
chr6_+_43603588	0.024		MAD2L1BP	MAD2L1 binding protein
chr1_-_20834516	0.023		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr4_-_175750377	0.022	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr19_-_11639679	0.020	NM_001243204	ECSIT	ECSIT homolog (Drosophila)
chr15_+_94774763	0.020		MCTP2	multiple C2 domains, transmembrane 2
chrX_+_153237990	0.019	NM_003492	TMEM187	transmembrane protein 187
chr12_+_113229548	0.019	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr17_-_27240982	0.018		PHF12	PHD finger protein 12
chr22_+_20008633	0.017		C22orf25	chromosome 22 open reading frame 25
chr6_+_25652373	0.013	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr14_-_94759594	0.012	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_+_28822428	0.011		WAC	WW domain containing adaptor with coiled-coil
chr12_+_119419299	0.010	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr2_-_51259536	0.010	NM_001135659 NM_004801	NRXN1	neurexin 1
chr19_-_45737466	0.009	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr11_-_128807712	0.009	NM_001195194	TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1
chr10_+_28822387	0.009	NM_016628 NM_100486	WAC	WW domain containing adaptor with coiled-coil
chr4_+_8582216	0.008	NM_080819	GPR78	G protein-coupled receptor 78
chr19_-_55691468	0.008	NM_003180	SYT5	synaptotagmin V
chr5_+_141303366	0.008	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr17_-_65362635	0.006		PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr8_+_68864341	0.006		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_171750760	0.005	NM_001007239 NM_014955 NM_015935	METTL13	methyltransferase like 13
chr19_+_15197790	0.004	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr11_+_32112607	0.004		RCN1	reticulocalbin 1, EF-hand calcium binding domain
chr1_+_171750829	0.003		METTL13	methyltransferase like 13
chr2_+_131513782	0.003	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr7_+_134832765	0.003	NM_018295	TMEM140	transmembrane protein 140
chr6_-_71666740	0.003	NM_080742	B3GAT2	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr1_+_171750807	0.002		METTL13	methyltransferase like 13
chr12_-_99288502	0.002	NM_001204065 NM_001204079 NM_001204080 NM_001204081	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr22_+_31795538	0.001	NM_004147	DRG1	developmentally regulated GTP binding protein 1
chr5_+_69696805	0.001		SMA4	glucuronidase, beta pseudogene
chr11_+_637268	0.001	NM_000797	DRD4	dopamine receptor D4
chr9_-_74061819	0.001		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr17_-_65362667	0.000	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
3.94	8.10e-08	GO:0050877	neurological system process
6.62	3.20e-07	GO:0019226	transmission of nerve impulse
6.62	3.20e-07	GO:0035637	multicellular organismal signaling
6.99	4.90e-07	GO:0007268	synaptic transmission
3.38	6.09e-07	GO:0003008	system process
11.24	2.94e-04	GO:0051969	regulation of transmission of nerve impulse
10.18	6.29e-04	GO:0031644	regulation of neurological system process
4.07	8.68e-04	GO:0007267	cell-cell signaling
23.54	1.12e-03	GO:0051952	regulation of amine transport
5.19	1.71e-03	GO:0046903	secretion
6.06	3.15e-03	GO:0007610	behavior
26.79	7.35e-03	GO:0050433	regulation of catecholamine secretion
3.26	7.69e-03	GO:0007154	cell communication
58.04	8.00e-03	GO:0010155	regulation of proton transport
4.69	1.17e-02	GO:0055082	cellular chemical homeostasis
47.49	1.56e-02	GO:0032225	regulation of synaptic transmission, dopaminergic
9.77	1.83e-02	GO:0007611	learning or memory
13.00	2.17e-02	GO:0030534	adult behavior
9.34	2.37e-02	GO:0050804	regulation of synaptic transmission
40.19	2.68e-02	GO:0051954	positive regulation of amine transport
8.94	3.03e-02	GO:0050890	cognition
5.08	3.73e-02	GO:0044057	regulation of system process
4.42	4.69e-02	GO:0006873	cellular ion homeostasis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.29	4.99e-06	GO:0045202	synapse
7.26	1.06e-05	GO:0044456	synapse part
23.22	2.39e-05	GO:0030672	synaptic vesicle membrane
4.34	3.52e-05	GO:0016023	cytoplasmic membrane-bounded vesicle
4.26	4.58e-05	GO:0031988	membrane-bounded vesicle
14.35	6.48e-05	GO:0030665	clathrin coated vesicle membrane
14.02	7.60e-05	GO:0008021	synaptic vesicle
4.08	8.24e-05	GO:0031410	cytoplasmic vesicle
3.95	1.29e-04	GO:0031982	vesicle
6.76	2.58e-04	GO:0030659	cytoplasmic vesicle membrane
6.53	3.50e-04	GO:0012506	vesicle membrane
8.66	4.60e-04	GO:0030136	clathrin-coated vesicle
10.61	5.00e-04	GO:0030662	coated vesicle membrane
5.61	1.34e-03	GO:0044433	cytoplasmic vesicle part
7.08	2.02e-03	GO:0030135	coated vesicle
3.69	1.09e-02	GO:0030054	cell junction
7.07	2.41e-02	GO:0045211	postsynaptic membrane
4.10	4.06e-02	GO:0043005	neuron projection

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
22.23	3.26e-05	GO:0005231	excitatory extracellular ligand-gated ion channel activity
14.52	4.22e-04	GO:0005230	extracellular ligand-gated ion channel activity
5.04	1.38e-03	GO:0005216	ion channel activity
4.96	1.59e-03	GO:0022838	substrate-specific channel activity
4.81	2.12e-03	GO:0015267	channel activity
4.80	2.17e-03	GO:0022803	passive transmembrane transporter activity
40.19	6.08e-03	GO:0016594	glycine binding
5.22	6.92e-03	GO:0022836	gated channel activity
2.77	8.41e-03	GO:0005215	transporter activity
8.50	9.09e-03	GO:0043176	amine binding
8.37	9.94e-03	GO:0015276	ligand-gated ion channel activity
8.37	9.94e-03	GO:0022834	ligand-gated channel activity
116.07	1.18e-02	GO:0001591	dopamine receptor activity, coupled via Gi/Go
5.29	1.66e-02	GO:0005261	cation channel activity
87.06	2.36e-02	GO:0016933	extracellular-glycine-gated ion channel activity
87.06	2.36e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
3.34	2.95e-02	GO:0005509	calcium ion binding
69.65	3.91e-02	GO:0004952	dopamine receptor activity
69.65	3.91e-02	GO:0022824	transmitter-gated ion channel activity
69.65	3.91e-02	GO:0022835	transmitter-gated channel activity