Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 1.219


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFXANKchr19_+_19303732,
chr19_+_19303007
0.791.9e-02Click!
RFXAPchr13_+_37393306-0.571.4e-01Click!
RFX5chr1_-_1513197170.512.0e-01Click!
RFX2chr19_-_6110561-0.432.9e-01Click!
RFX1chr19_-_14117096-0.413.1e-01Click!
RFX3chr9_-_3525973-0.344.1e-01Click!
RFX4chr12_+_1069949140.157.2e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_179780314 1.589 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr17_-_5404304 1.532 NM_001162371
LOC728392
uncharacterized LOC728392
chr14_-_60337350 1.396 NM_021136
RTN1
reticulon 1
chr14_+_105941061 1.349 NM_001312
CRIP2
cysteine-rich protein 2
chr5_+_92918924 1.156 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_+_133938819 0.956 NM_001205329
NM_032801
JAM3

junctional adhesion molecule 3

chr3_-_197676755 0.923 NM_001134435
IQCG
IQ motif containing G
chr14_+_100259445 0.918 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr1_+_42928873 0.901 CCDC30
coiled-coil domain containing 30
chr11_+_133938965 0.820 JAM3
junctional adhesion molecule 3
chr8_+_120428551 0.819 NM_002514
NOV
nephroblastoma overexpressed gene
chr6_+_30524662 0.808 PRR3
proline rich 3
chr2_-_175869910 0.800 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr16_+_29823557 0.795 PRRT2
proline-rich transmembrane protein 2
chr1_-_109656478 0.779 NM_001122961
C1orf194
chromosome 1 open reading frame 194
chr22_-_31063786 0.777 NM_152511
DUSP18
dual specificity phosphatase 18
chr22_-_43485333 0.767 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr1_-_48937791 0.745 NM_019073
SPATA6
spermatogenesis associated 6
chr3_-_196439067 0.737 NM_032898
CEP19
centrosomal protein 19kDa
chr12_-_63328663 0.719 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_+_8806825 0.714 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr3_-_58563070 0.712 FAM107A
family with sequence similarity 107, member A
chr1_+_161068150 0.702 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr1_+_245133283 0.694 EFCAB2
EF-hand calcium binding domain 2
chr3_+_154797435 0.662 NM_000902
MME
membrane metallo-endopeptidase
chr20_+_43160435 0.634 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr6_+_112408673 0.632 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr7_+_102073953 0.618 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr17_-_64187814 0.616 NM_145036
NM_001199165
CEP112

centrosomal protein 112kDa

chr19_-_58951588 0.608 NM_003433
ZNF132
zinc finger protein 132
chr17_-_16472463 0.604 NM_020653
ZNF287
zinc finger protein 287
chr7_+_102074002 0.596 ORAI2
ORAI calcium release-activated calcium modulator 2
chr14_+_76044939 0.595 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr6_+_30525050 0.585 PRR3
proline rich 3
chrX_+_48456552 0.564 WDR13
WD repeat domain 13
chr10_+_12391471 0.563 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr17_+_78518742 0.561 RPTOR
regulatory associated protein of MTOR, complex 1
chr19_-_59084735 0.559 MZF1
myeloid zinc finger 1
chr8_+_13424351 0.559 NM_001007090
C8orf48
chromosome 8 open reading frame 48
chr3_+_49027770 0.557 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chrX_+_48456122 0.556 WDR13
WD repeat domain 13
chr14_-_73453651 0.553 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr21_+_46707949 0.536 LOC642852
uncharacterized LOC642852
chr3_+_183165402 0.535 LOC100505687
uncharacterized LOC100505687
chr15_+_55700722 0.533 NM_001198784
FLJ27352
uncharacterized LOC145788
chr14_+_74486049 0.525 NM_025057
C14orf45
chromosome 14 open reading frame 45
chrX_+_48456220 0.523 NM_001166426
WDR13
WD repeat domain 13
chr1_-_48937676 0.520 SPATA6
spermatogenesis associated 6
chr3_-_16306283 0.507 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chrX_-_71351750 0.506 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr7_-_44228880 0.501 NM_000162
GCK
glucokinase (hexokinase 4)
chr3_+_49027281 0.498 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr13_-_44361032 0.492 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr5_+_172068188 0.491 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr19_-_59084630 0.491 MZF1
myeloid zinc finger 1
chr16_+_29823408 0.485 NM_145239
PRRT2
proline-rich transmembrane protein 2
chr6_+_30524485 0.476 NM_001077497
NM_025263
PRR3

proline rich 3

chr1_+_38022514 0.474 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr2_+_242811880 0.474 NM_173821
CXXC11
CXXC finger protein 11
chrX_+_135251795 0.472 NM_001167819
FHL1
four and a half LIM domains 1
chr5_-_157098444 0.469 SOX30
SRY (sex determining region Y)-box 30
chr2_+_74648856 0.459 NM_032118
WDR54
WD repeat domain 54
chr12_+_48577365 0.456 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr7_+_150065968 0.456 REPIN1
replication initiator 1
chr17_-_26662439 0.438 NM_174887
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr14_+_24025188 0.437 NM_001126339
NM_024328
THTPA

thiamine triphosphatase

chr22_+_27053392 0.435 MIAT
myocardial infarction associated transcript (non-protein coding)
chr6_-_152702329 0.434 SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_100797685 0.432 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr10_+_124030820 0.429 NM_144587
BTBD16
BTB (POZ) domain containing 16
chrX_-_151143096 0.426 NM_004961
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chrX_+_48455875 0.418 NM_017883
WDR13
WD repeat domain 13
chr12_+_56511969 0.418 NM_032786
ZC3H10
zinc finger CCCH-type containing 10
chrX_+_135251454 0.414 NM_001159704
FHL1
four and a half LIM domains 1
chr5_+_95066628 0.411 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr3_+_48507209 0.410 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr19_-_59084928 0.409 NM_003422
NM_198055
MZF1

myeloid zinc finger 1

chr14_-_74180341 0.409 NM_006029
PNMA1
paraneoplastic antigen MA1
chr12_+_53689234 0.409 NM_002624
NM_145897
PFDN5

prefoldin subunit 5

chr2_-_130902568 0.408 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr15_-_55700456 0.408 NM_004748
NM_001204450
NM_001204451
NM_020739
CCPG1



cell cycle progression 1



chr19_-_4535202 0.406 NM_001013706
PLIN5
perilipin 5
chr7_+_150065330 0.401 REPIN1
replication initiator 1
chr8_+_59465783 0.400 SDCBP
syndecan binding protein (syntenin)
chr19_+_18530423 0.397


chr3_-_48754589 0.394 NM_001005909
NM_001005910
NM_001005911
NM_001146178
NM_001146179
NM_001190316
NM_001190317
NM_016291
IP6K2







inositol hexakisphosphate kinase 2







chr14_+_24838301 0.393 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr16_+_47495166 0.393 NM_000293
NM_001031835
PHKB

phosphorylase kinase, beta

chr6_-_27440459 0.392 NM_007149
ZNF184
zinc finger protein 184
chr12_-_110011286 0.390 NM_052845
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type
chrX_+_30671602 0.389 GK
glycerol kinase
chr7_-_156433115 0.388 C7orf13
chromosome 7 open reading frame 13
chr7_+_150065859 0.383 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr12_-_48499840 0.381 SENP1
SUMO1/sentrin specific peptidase 1
chr15_-_43802666 0.380 NM_005657
TP53BP1
tumor protein p53 binding protein 1
chr1_-_150601554 0.378 NM_207045
NM_207046
NM_207047
ENSA


endosulfine alpha


chr2_+_132285469 0.373 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr16_+_67840976 0.372 NM_018430
TSNAXIP1
translin-associated factor X interacting protein 1
chr12_-_110486275 0.370 C12orf76
chromosome 12 open reading frame 76
chr16_+_8814567 0.369 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr19_-_14048877 0.369 PODNL1
podocan-like 1
chr15_-_71184611 0.369 NM_020147
THAP10
THAP domain containing 10
chr5_+_148520985 0.366 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr20_+_44044706 0.365 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr6_+_52284948 0.360 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chrX_+_48455801 0.359 WDR13
WD repeat domain 13
chr22_+_39052671 0.359 CBY1
chibby homolog 1 (Drosophila)
chrX_+_30671537 0.357 GK
glycerol kinase
chr12_+_53689350 0.354 PFDN5
prefoldin subunit 5
chr6_-_43477980 0.351 LRRC73
leucine rich repeat containing 73
chr22_+_39052628 0.347 NM_001002880
NM_015373
CBY1

chibby homolog 1 (Drosophila)

chr17_-_15244898 0.346 NM_031898
TEKT3
tektin 3
chr6_-_41703938 0.346 NM_001167827
TFEB
transcription factor EB
chr6_-_116575170 0.346 NM_021648
TSPYL4
TSPY-like 4
chr2_-_110962577 0.342 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chrX_+_48455915 0.342 WDR13
WD repeat domain 13
chr4_-_186733372 0.342 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_+_111808017 0.339 DIXDC1
DIX domain containing 1
chr5_-_133702764 0.337 NM_001113575
NM_016508
CDKL3

cyclin-dependent kinase-like 3

chr4_+_153701113 0.335 ARFIP1
ADP-ribosylation factor interacting protein 1
chr11_-_66360485 0.334 NM_018219
CCDC87
coiled-coil domain containing 87
chr16_-_69760367 0.334 NQO1
NAD(P)H dehydrogenase, quinone 1
chr1_+_155147051 0.334 TRIM46
tripartite motif containing 46
chr19_-_50528683 0.334 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr1_-_1551041 0.330 MIB2
mindbomb homolog 2 (Drosophila)
chr16_+_47495225 0.330 PHKB
phosphorylase kinase, beta
chr7_-_14030864 0.330 NM_001163149
ETV1
ets variant 1
chr1_+_3541550 0.330 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr21_+_38445562 0.327 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr6_-_152702450 0.323 SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_-_80170656 0.323 NM_198082
CCDC57
coiled-coil domain containing 57
chr19_-_50528627 0.323 VRK3
vaccinia related kinase 3
chr11_+_46958228 0.323 NM_001003676
NM_001003677
NM_001003678
NM_024113
C11orf49



chromosome 11 open reading frame 49



chr9_-_131418931 0.322 WDR34
WD repeat domain 34
chr12_-_54653369 0.320 NM_001127321
CBX5
chromobox homolog 5
chr3_+_9851643 0.318 NM_001025930
TTLL3
tubulin tyrosine ligase-like family, member 3
chr12_-_63328857 0.318 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_-_163113938 0.317 RGS5
regulator of G-protein signaling 5
chr3_+_184056304 0.315 FAM131A
family with sequence similarity 131, member A
chr17_+_19281726 0.315 NM_002749
NM_139034
MAPK7

mitogen-activated protein kinase 7

chr16_+_3550916 0.315 NM_015041
CLUAP1
clusterin associated protein 1
chr16_+_67312688 0.314 PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr9_-_131419004 0.310 NM_052844
WDR34
WD repeat domain 34
chr16_+_57278979 0.308 NM_012106
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr8_+_16884745 0.307 NM_181723
EFHA2
EF-hand domain family, member A2
chr2_+_39103102 0.306 NM_001145450
MORN2
MORN repeat containing 2
chr4_-_8430185 0.303 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr20_-_50179338 0.303 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr16_-_69760354 0.302 NQO1
NAD(P)H dehydrogenase, quinone 1
chr6_+_35226685 0.300 ZNF76
zinc finger protein 76
chr18_+_51795848 0.300 NM_007195
POLI
polymerase (DNA directed) iota
chr11_+_66278076 0.300 NM_024649
BBS1
Bardet-Biedl syndrome 1
chr7_-_14031049 0.299 NM_001163148
ETV1
ets variant 1
chr21_+_40817793 0.296 NM_001001713
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr19_+_10527448 0.293 NM_001243121
PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_+_51818669 0.290 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr19_+_35630391 0.287 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr5_-_150537261 0.287 ANXA6
annexin A6
chr17_+_260092 0.286 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chr4_+_123653856 0.283 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr12_+_51818592 0.282 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr12_-_131323616 0.281 NM_001980
NM_194356
STX2

syntaxin 2

chr2_+_237994500 0.279 COPS8
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
chr9_+_35829208 0.279 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr6_+_35227478 0.273 NM_003427
ZNF76
zinc finger protein 76
chr14_-_20774089 0.273 TTC5
tetratricopeptide repeat domain 5
chr17_-_53045972 0.272 NM_001162861
NM_001162862
NM_004375
COX11


COX11 cytochrome c oxidase assembly homolog (yeast)


chr9_+_100069909 0.269 NM_020893
C9orf174
chromosome 9 open reading frame 174
chr11_+_66360664 0.268 NM_005125
CCS
copper chaperone for superoxide dismutase
chr16_-_69760444 0.266 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr16_+_72698996 0.264


chr2_+_48667907 0.263 NM_001135629
NM_001193475
NM_152994
PPP1R21


protein phosphatase 1, regulatory subunit 21


chr22_+_24309025 0.262 NM_001084393
DDTL
D-dopachrome tautomerase-like
chr19_-_10679328 0.261 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr13_-_96294282 0.260 DZIP1
DAZ interacting protein 1
chr11_+_63706433 0.260 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr6_+_35227234 0.260 ZNF76
zinc finger protein 76
chr19_+_49977817 0.259 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr15_-_43785368 0.259 TP53BP1
tumor protein p53 binding protein 1
chr1_+_245133067 0.259 NM_032328
EFCAB2
EF-hand calcium binding domain 2
chr19_-_58609606 0.258 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr11_+_111807857 0.258 NM_001037954
DIXDC1
DIX domain containing 1
chr19_-_18392436 0.256 JUND
jun D proto-oncogene
chr1_-_36915969 0.256 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr17_-_1012257 0.256 NM_001092
ABR
active BCR-related gene
chr8_+_59465818 0.256 SDCBP
syndecan binding protein (syntenin)
chr14_-_20774129 0.256 NM_138376
TTC5
tetratricopeptide repeat domain 5
chr12_-_4754275 0.255 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_78444922 0.255 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_-_34620460 0.254 DCTN3
dynactin 3 (p22)
chr9_-_34620483 0.253 DCTN3
dynactin 3 (p22)
chr7_-_100964923 0.251 NM_001130820
NM_001130821
NM_001130822
NM_022777
RABL5



RAB, member RAS oncogene family-like 5



chr19_+_50879681 0.248 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr19_+_46850245 0.248 NM_001204284
NM_006247
PPP5C

protein phosphatase 5, catalytic subunit

chr6_-_84937313 0.248 NM_014895
KIAA1009
KIAA1009
chr22_-_44893903 0.248 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr3_-_196045037 0.247 NM_152773
TCTEX1D2
Tctex1 domain containing 2
chr9_+_127615695 0.245 NM_001045476
WDR38
WD repeat domain 38
chr19_-_18392413 0.244 NM_005354
JUND
jun D proto-oncogene
chr9_-_34620489 0.243 NM_007234
NM_024348
DCTN3

dynactin 3 (p22)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.37 1.06e-05 GO:0042384 cilium assembly
4.67 3.45e-04 GO:0030031 cell projection assembly
6.02 6.17e-04 GO:0060271 cilium morphogenesis
4.73 3.95e-03 GO:0010927 cellular component assembly involved in morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.36 1.94e-08 GO:0005930 axoneme
4.29 2.33e-08 GO:0005929 cilium
1.22 1.69e-05 GO:0005737 cytoplasm
7.00 2.41e-05 GO:0005932 microtubule basal body
5.49 5.68e-05 GO:0044441 cilium part
1.15 5.89e-05 GO:0044424 intracellular part
6.73 1.32e-04 GO:0035085 cilium axoneme
1.14 1.64e-04 GO:0005622 intracellular
1.97 1.32e-03 GO:0015630 microtubule cytoskeleton
1.13 3.86e-02 GO:0043226 organelle
1.13 4.34e-02 GO:0043229 intracellular organelle
2.25 4.81e-02 GO:0005874 microtubule

Nothing significant found in function category.