Motif ID: RREB1.p2

Z-value: 1.754


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_7108864-0.686.5e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_114018201 1.227 GRTP1
growth hormone regulated TBC protein 1
chr6_-_46459010 1.019 NM_001251974
RCAN2
regulator of calcineurin 2
chr21_-_44495894 0.939 NM_000071
CBS
cystathionine-beta-synthase
chr21_+_27011766 0.931 JAM2
junctional adhesion molecule 2
chr13_-_114018365 0.908 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr21_+_27012067 0.796 JAM2
junctional adhesion molecule 2
chr10_+_111969988 0.784 NM_001008541
MXI1
MAX interactor 1
chr19_+_3366575 0.704 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr1_-_184006491 0.693 GLT25D2
glycosyltransferase 25 domain containing 2
chr9_+_130922471 0.641 NM_024112
C9orf16
chromosome 9 open reading frame 16
chrX_+_66763868 0.639 NM_000044
AR
androgen receptor
chrX_+_102585113 0.616 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr21_+_44073650 0.611 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr21_-_44496423 0.606 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr21_+_27011588 0.596 NM_021219
JAM2
junctional adhesion molecule 2
chr11_-_2019007 0.550 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr21_-_47604300 0.530 C21orf56
chromosome 21 open reading frame 56
chr21_-_47604360 0.529 NM_001142854
NM_032261
C21orf56

chromosome 21 open reading frame 56

chr21_-_47604340 0.526 C21orf56
chromosome 21 open reading frame 56
chr11_-_2018703 0.510 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chrX_-_119249774 0.503 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr1_-_156217717 0.490 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr12_-_22487566 0.490 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr21_+_27012045 0.488 JAM2
junctional adhesion molecule 2
chr6_-_167275657 0.462 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chrX_+_102632108 0.459 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr2_-_128432642 0.459 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr19_-_18653680 0.455 FKBP8
FK506 binding protein 8, 38kDa
chr17_-_42201009 0.445 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr12_+_26348268 0.438 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr21_-_28339405 0.428 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr2_+_42795844 0.417 MTA3
metastasis associated 1 family, member 3
chr14_-_21566497 0.415 ZNF219
zinc finger protein 219
chr10_+_135160843 0.413 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr11_-_2018568 0.410 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_64001974 0.402 NM_001243733
NM_003377
VEGFB

vascular endothelial growth factor B

chr11_-_75062650 0.402 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chrX_-_1572648 0.398 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr14_-_21994342 0.396 SALL2
sal-like 2 (Drosophila)
chr5_+_32711437 0.396 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr1_+_145472454 0.394 ANKRD34A
ankyrin repeat domain 34A
chrX_+_135229536 0.387 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr6_+_72596699 0.384 RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_1104007 0.376 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr19_-_30205962 0.371 NM_001031726
C19orf12
chromosome 19 open reading frame 12
chrX_+_102631408 0.371 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr12_+_26348488 0.363 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr22_+_24199058 0.363 NM_001024938
NM_030807
SLC2A11

solute carrier family 2 (facilitated glucose transporter), member 11

chr7_+_75932992 0.356 HSPB1
heat shock 27kDa protein 1
chr1_+_1076275 0.351 LOC254099
uncharacterized LOC254099
chr7_+_75932865 0.351 HSPB1
heat shock 27kDa protein 1
chr7_+_44144002 0.350 AEBP1
AE binding protein 1
chr19_+_3366589 0.349 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chrY_-_1522648 0.345 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr19_+_3366536 0.345 NM_001245002
NM_001245004
NM_005597
NFIC


nuclear factor I/C (CCAAT-binding transcription factor)


chr12_-_56101465 0.338 ITGA7
integrin, alpha 7
chr19_+_44084695 0.335 NM_001193622
LOC390940
uncharacterized protein ENSP00000244321
chr9_-_139890984 0.334 NM_004669
CLIC3
chloride intracellular channel 3
chr12_+_56546203 0.332 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr7_+_94285736 0.332 PEG10
paternally expressed 10
chr11_-_35547144 0.331 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr7_+_94285676 0.330 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr22_-_24640850 0.328 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr7_+_94285620 0.327 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr13_+_88324777 0.327 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr11_+_57365026 0.326 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr7_+_44143945 0.326 NM_001129
AEBP1
AE binding protein 1
chr10_-_64578926 0.324 NM_001136178
EGR2
early growth response 2
chr19_+_44084758 0.321 LOC390940
uncharacterized protein ENSP00000244321
chr17_-_33700619 0.320 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr14_+_100438095 0.319 EVL
Enah/Vasp-like
chr15_-_82338348 0.317 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr6_-_167275997 0.316 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_203274646 0.315 NM_006763
BTG2
BTG family, member 2
chr3_+_12838170 0.314 NM_001162499
NM_012298
CAND2

cullin-associated and neddylation-dissociated 2 (putative)

chr14_+_105941061 0.313 NM_001312
CRIP2
cysteine-rich protein 2
chr7_-_28220342 0.312 NM_175061
JAZF1
JAZF zinc finger 1
chr3_-_18466759 0.310 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr11_-_1769086 0.306 IFITM10
interferon induced transmembrane protein 10
chr17_-_42200957 0.306 HDAC5
histone deacetylase 5
chr15_+_76629101 0.304 NM_145805
ISL2
ISL LIM homeobox 2
chr2_+_48757292 0.298 NM_001198595
NM_006873
STON1

stonin 1

chr19_-_18654280 0.295 FKBP8
FK506 binding protein 8, 38kDa
chr2_+_12856813 0.294 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr3_+_9975513 0.289 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr1_+_53527723 0.288 NM_001199080
NM_001199082
NM_153703
PODN


podocan


chr4_-_5890266 0.286 NM_001313
CRMP1
collapsin response mediator protein 1
chr19_+_1104068 0.286 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr6_+_72596405 0.286 RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_1104614 0.284 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr19_-_3028901 0.283 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr9_-_98270321 0.283 NM_001083604
NM_001083605
PTCH1

patched 1

chr14_+_105196225 0.282 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr6_+_89791510 0.279 PNRC1
proline-rich nuclear receptor coactivator 1
chr5_-_39424930 0.278 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr19_+_1103935 0.277 NM_001039847
NM_002085
GPX4

glutathione peroxidase 4 (phospholipid hydroperoxidase)

chr6_+_124125068 0.276 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr16_+_56666533 0.275 NM_176870
MT1M
metallothionein 1M
chr11_-_2019070 0.271 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_+_47105327 0.267 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr5_+_139027907 0.265 CXXC5
CXXC finger protein 5
chr17_-_53809444 0.265 NM_001099640
TMEM100
transmembrane protein 100
chrX_+_135230736 0.262 NM_001159700
FHL1
four and a half LIM domains 1
chr2_+_24299751 0.259 LOC375190
UPF0638 protein B
chr1_+_215256559 0.254 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr4_-_5890142 0.254 CRMP1
collapsin response mediator protein 1
chr11_+_57365577 0.254 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr19_-_2015628 0.250 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr12_+_4382882 0.248 NM_001759
CCND2
cyclin D2
chrX_-_48828250 0.248 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr3_+_12329332 0.246 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr14_-_101034261 0.246 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr5_+_32711729 0.246 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_-_220173693 0.246 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chr7_-_102257199 0.244 NM_001079877
NM_006989
RASA4

RAS p21 protein activator 4

chr20_+_13976014 0.244 NM_080676
MACROD2
MACRO domain containing 2
chr2_+_42795601 0.243 NM_020744
MTA3
metastasis associated 1 family, member 3
chr2_-_119605758 0.240 NM_001426
EN1
engrailed homeobox 1
chr19_-_3047632 0.240 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr4_-_119273874 0.240 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr10_-_134145333 0.239 STK32C
serine/threonine kinase 32C
chr11_-_67205151 0.235 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr7_+_97911023 0.234 BRI3
brain protein I3
chrX_+_103031433 0.234 NM_001128834
PLP1
proteolipid protein 1
chr9_-_21994329 0.233 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr19_-_11564568 0.232 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr12_-_53614121 0.231 NM_001042728
NM_001243732
RARG

retinoic acid receptor, gamma

chr3_-_21792815 0.231 NM_024697
ZNF385D
zinc finger protein 385D
chr1_-_47080793 0.231 NM_145279
MOB3C
MOB kinase activator 3C
chr9_-_21994414 0.228 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr14_+_96505566 0.228 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr20_-_44144263 0.227 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr10_+_83635069 0.227 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr2_-_128433330 0.226 LIMS2
LIM and senescent cell antigen-like domains 2
chr1_-_231004173 0.225 NM_032800
C1orf198
chromosome 1 open reading frame 198
chr12_+_57482886 0.225 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr4_+_184827882 0.224


chr11_-_8739398 0.224 ST5
suppression of tumorigenicity 5
chr14_+_24837225 0.223 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chrX_-_152486073 0.222 NM_004988
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr19_+_35521591 0.222 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr2_+_30369749 0.222 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr1_-_231004050 0.221 C1orf198
chromosome 1 open reading frame 198
chr16_-_4588379 0.221 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr12_+_70759974 0.220 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_1535446 0.220 NM_001242659
LOC643988
uncharacterized LOC643988
chr4_-_84030995 0.220 NM_001130716
PLAC8
placenta-specific 8
chr8_+_144635556 0.219 NM_001166237
GSDMD
gasdermin D
chr19_-_3062191 0.219 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr14_+_105190533 0.219 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr5_+_139027868 0.219 CXXC5
CXXC finger protein 5
chr4_+_184827805 0.218 STOX2
storkhead box 2
chr16_+_68573660 0.217 NM_133458
ZFP90
zinc finger protein 90 homolog (mouse)
chrX_-_100872926 0.216 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr22_+_24200040 0.214 NM_001024939
SLC2A11
solute carrier family 2 (facilitated glucose transporter), member 11
chr17_-_19290471 0.214 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr3_-_114866090 0.214 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_66453561 0.214 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr11_-_17498419 0.213 NM_000352
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr19_+_41082792 0.211 SHKBP1
SH3KBP1 binding protein 1
chr7_-_150974179 0.211 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr2_+_219264719 0.211 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr11_-_59436366 0.211 PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr3_+_122399665 0.211 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr1_+_24104906 0.210 PITHD1
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr1_+_3541550 0.210 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr9_-_21994379 0.210 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr19_-_18654376 0.210 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr17_-_7590731 0.209 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr19_-_54984341 0.208 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr1_-_17307107 0.207 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chrX_+_103031753 0.207 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr14_+_24867926 0.206 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_-_72371188 0.205 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr2_+_30369800 0.205 YPEL5
yippee-like 5 (Drosophila)
chr3_-_52008645 0.204 NM_001146314
NM_032750
ABHD14B

abhydrolase domain containing 14B

chr2_+_24346339 0.204 NM_001145710
LOC375190
UPF0638 protein B
chrX_+_152760452 0.203 BGN
biglycan
chr1_-_38471170 0.202 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chrX_+_152760346 0.201 NM_001711
BGN
biglycan
chr5_-_81046858 0.201 SSBP2
single-stranded DNA binding protein 2
chrX_+_152990322 0.200 NM_000033
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr2_+_30369868 0.198 YPEL5
yippee-like 5 (Drosophila)
chr19_+_44080951 0.198 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr16_+_20911987 0.197 NM_001128301
NM_001128302
LYRM1

LYR motif containing 1

chr19_+_39279849 0.197 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr19_-_55658310 0.197 TNNT1
troponin T type 1 (skeletal, slow)
chr7_-_28220146 0.196 JAZF1
JAZF zinc finger 1
chr10_-_103535656 0.196 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr1_+_3541587 0.196 TPRG1L
tumor protein p63 regulated 1-like
chrX_-_154114431 0.196 NM_019863
F8
coagulation factor VIII, procoagulant component
chr21_+_46825001 0.195 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr1_-_6321034 0.194 NM_207370
GPR153
G protein-coupled receptor 153
chr1_-_144520987 0.194 LOC728855
uncharacterized LOC728855
chr2_-_68547018 0.193 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr17_+_55333843 0.193 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr5_+_139028483 0.192 CXXC5
CXXC finger protein 5
chr12_+_79258794 0.192 SYT1
synaptotagmin I
chr7_-_20826503 0.191 NM_182700
NM_198956
SP8

Sp8 transcription factor

chr2_-_145090038 0.191 NM_001164629
GTDC1
glycosyltransferase-like domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 3.35e-13 GO:0080090 regulation of primary metabolic process
1.18 3.99e-13 GO:0050794 regulation of cellular process
1.29 4.39e-13 GO:0031323 regulation of cellular metabolic process
1.16 2.50e-12 GO:0065007 biological regulation
1.17 3.45e-12 GO:0050789 regulation of biological process
1.29 1.31e-11 GO:0060255 regulation of macromolecule metabolic process
1.26 1.51e-11 GO:0019222 regulation of metabolic process
1.31 1.17e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.32 1.38e-10 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 1.36e-09 GO:0051252 regulation of RNA metabolic process
1.31 3.02e-09 GO:0010468 regulation of gene expression
1.53 5.44e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.25 7.18e-09 GO:0007275 multicellular organismal development
1.26 2.65e-08 GO:0048856 anatomical structure development
1.32 3.26e-08 GO:0006355 regulation of transcription, DNA-dependent
1.31 3.78e-08 GO:0048519 negative regulation of biological process
1.23 4.02e-08 GO:0032502 developmental process
1.28 4.45e-08 GO:0048731 system development
1.32 7.20e-08 GO:0048523 negative regulation of cellular process
1.41 9.98e-08 GO:0035556 intracellular signal transduction
1.39 1.19e-07 GO:0007399 nervous system development
1.29 1.51e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.28 1.54e-07 GO:0031326 regulation of cellular biosynthetic process
1.27 1.73e-07 GO:0009889 regulation of biosynthetic process
1.29 2.95e-07 GO:0048522 positive regulation of cellular process
1.28 5.61e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.26 9.51e-07 GO:0048518 positive regulation of biological process
1.56 3.19e-06 GO:0051254 positive regulation of RNA metabolic process
1.48 3.23e-06 GO:0006351 transcription, DNA-dependent
1.41 3.76e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.55 3.90e-06 GO:0010628 positive regulation of gene expression
1.20 9.12e-06 GO:0023052 signaling
1.60 9.42e-06 GO:0051253 negative regulation of RNA metabolic process
1.56 9.80e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.39 1.10e-05 GO:0031325 positive regulation of cellular metabolic process
1.44 1.15e-05 GO:0032774 RNA biosynthetic process
1.38 1.16e-05 GO:0009893 positive regulation of metabolic process
1.19 1.93e-05 GO:0051716 cellular response to stimulus
1.59 2.84e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.48 3.80e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.43 4.58e-05 GO:0048468 cell development
1.48 4.84e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.43 5.89e-05 GO:0022008 neurogenesis
1.28 6.75e-05 GO:0030154 cell differentiation
1.27 7.03e-05 GO:0048869 cellular developmental process
1.44 9.64e-05 GO:0048699 generation of neurons
1.88 1.08e-04 GO:0071375 cellular response to peptide hormone stimulus
1.53 1.19e-04 GO:0010629 negative regulation of gene expression
1.20 1.20e-04 GO:0007165 signal transduction
1.31 1.29e-04 GO:0023051 regulation of signaling
1.49 1.31e-04 GO:0009890 negative regulation of biosynthetic process
1.65 1.37e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.52 1.42e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.49 1.44e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.59 1.67e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.52 1.84e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 1.94e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.48 2.24e-04 GO:0030182 neuron differentiation
1.28 2.34e-04 GO:0048513 organ development
1.50 4.02e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.31 4.60e-04 GO:0009653 anatomical structure morphogenesis
1.40 6.64e-04 GO:0031324 negative regulation of cellular metabolic process
1.31 7.37e-04 GO:0009966 regulation of signal transduction
1.44 7.90e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.38 9.00e-04 GO:0009892 negative regulation of metabolic process
1.39 9.95e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.66 1.11e-03 GO:0071495 cellular response to endogenous stimulus
1.47 1.16e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.64 2.09e-03 GO:0043434 response to peptide hormone stimulus
1.67 2.43e-03 GO:0032870 cellular response to hormone stimulus
1.79 2.48e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.52 2.95e-03 GO:0019226 transmission of nerve impulse
1.52 2.95e-03 GO:0035637 multicellular organismal signaling
1.51 3.25e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.29 4.02e-03 GO:0065009 regulation of molecular function
1.30 4.67e-03 GO:0051239 regulation of multicellular organismal process
1.44 5.70e-03 GO:0071310 cellular response to organic substance
1.36 6.16e-03 GO:0070887 cellular response to chemical stimulus
1.38 6.23e-03 GO:0009891 positive regulation of biosynthetic process
1.46 6.52e-03 GO:0048666 neuron development
1.38 7.08e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.06 9.55e-03 GO:0009987 cellular process
1.35 1.32e-02 GO:0050793 regulation of developmental process
1.24 1.61e-02 GO:0007166 cell surface receptor linked signaling pathway
1.88 1.71e-02 GO:0046039 GTP metabolic process
1.40 1.76e-02 GO:0045595 regulation of cell differentiation
1.51 1.81e-02 GO:0007268 synaptic transmission
1.23 2.86e-02 GO:0048583 regulation of response to stimulus
1.41 4.47e-02 GO:0009887 organ morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 7.85e-18 GO:0005634 nucleus
1.10 2.30e-15 GO:0005622 intracellular
1.11 2.42e-15 GO:0044424 intracellular part
1.11 4.36e-09 GO:0043226 organelle
1.11 4.59e-09 GO:0043229 intracellular organelle
1.12 1.24e-08 GO:0043227 membrane-bounded organelle
1.11 1.81e-08 GO:0043231 intracellular membrane-bounded organelle
1.12 3.08e-08 GO:0005737 cytoplasm
1.29 5.33e-07 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 7.33e-20 GO:0005515 protein binding
1.61 5.77e-14 GO:0001071 nucleic acid binding transcription factor activity
1.61 5.77e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.09 8.96e-13 GO:0005488 binding
1.71 2.45e-12 GO:0043565 sequence-specific DNA binding
1.47 5.33e-08 GO:0030528 transcription regulator activity
1.48 7.78e-06 GO:0019899 enzyme binding
1.24 5.07e-05 GO:0003677 DNA binding
1.98 4.34e-04 GO:0003714 transcription corepressor activity
1.16 6.92e-03 GO:0003676 nucleic acid binding
1.50 1.62e-02 GO:0003712 transcription cofactor activity
1.50 1.82e-02 GO:0000988 protein binding transcription factor activity
1.50 1.82e-02 GO:0000989 transcription factor binding transcription factor activity
1.60 2.51e-02 GO:0003702 RNA polymerase II transcription factor activity