Motif ID: SOX2.p2

Z-value: 0.575


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_181429711-0.452.7e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_26400503 1.516 NM_001199837
SNX10
sorting nexin 10
chr2_-_161056762 1.319 ITGB6
integrin, beta 6
chr12_-_52886971 1.014 NM_005554
KRT6A
keratin 6A
chr11_-_16424391 0.823 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr18_+_29027731 0.766 NM_001944
DSG3
desmoglein 3
chr18_-_74728677 0.751 MBP
myelin basic protein
chr12_-_67072881 0.736 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr7_-_83824216 0.733 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr8_+_32504250 0.610 NM_013959
NRG1
neuregulin 1
chr3_+_189349215 0.597 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_+_189507448 0.568 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr8_+_124194751 0.552 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr10_-_105845619 0.546 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr8_-_80993009 0.545 NM_001025252
TPD52
tumor protein D52
chr3_-_151034514 0.530 NM_023915
GPR87
G protein-coupled receptor 87
chr5_+_140213968 0.514 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr2_-_165424993 0.512 GRB14
growth factor receptor-bound protein 14
chr10_-_105845556 0.511 COL17A1
collagen, type XVII, alpha 1
chr7_-_41742666 0.509 NM_002192
INHBA
inhibin, beta A
chr10_-_123356158 0.509 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr9_-_23826062 0.485 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_+_140254930 0.478 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr1_+_209602164 0.474 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chr2_-_161056573 0.474 NM_000888
ITGB6
integrin, beta 6
chr6_-_136788012 0.464 NM_001198615
MAP7
microtubule-associated protein 7
chr8_+_104831415 0.437 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_24690740 0.429 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr15_+_41136622 0.428 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr5_+_140186658 0.427 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr15_+_41136178 0.423 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_-_95611023 0.420 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr17_-_39675078 0.415 NM_002275
KRT15
keratin 15
chr1_-_153029987 0.402 NM_005988
SPRR2A
small proline-rich protein 2A
chr12_-_8815479 0.400 MFAP5
microfibrillar associated protein 5
chrX_-_31526414 0.400 NM_004014
DMD
dystrophin
chr8_+_124194873 0.393 FAM83A
family with sequence similarity 83, member A
chr5_+_140207562 0.392 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr7_+_16793320 0.390 NM_014399
TSPAN13
tetraspanin 13
chr10_-_103874661 0.385 NM_003893
LDB1
LIM domain binding 1
chr19_+_35606731 0.383 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr3_+_122044010 0.373 NM_005213
CSTA
cystatin A (stefin A)
chrX_-_106449543 0.369 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr12_-_8815266 0.368 MFAP5
microfibrillar associated protein 5
chr12_-_28124915 0.365 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr5_+_140201221 0.359 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr5_+_147258273 0.354 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr6_+_90276556 0.346 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr15_+_43885251 0.345 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_155099935 0.343 EFNA1
ephrin-A1
chr2_-_31352489 0.340 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr20_+_20348744 0.339 NM_002196
INSM1
insulinoma-associated 1
chr10_-_14646237 0.336 FAM107B
family with sequence similarity 107, member B
chr3_-_189840225 0.332 NM_001134418
LEPREL1
leprecan-like 1
chrX_+_105937067 0.328 NM_024539
RNF128
ring finger protein 128
chr11_-_85430382 0.323 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr4_+_41258941 0.318 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_+_140235594 0.316 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr5_-_175964223 0.300 NM_014901
RNF44
ring finger protein 44
chr19_+_751108 0.295 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr11_-_85430117 0.289 NM_206929
SYTL2
synaptotagmin-like 2
chrX_-_33357725 0.285 NM_000109
DMD
dystrophin
chr1_-_226926875 0.282 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr11_+_34654010 0.276 NM_001206616
EHF
ets homologous factor
chr8_+_102504836 0.272 GRHL2
grainyhead-like 2 (Drosophila)
chr7_+_20370324 0.271 ITGB8
integrin, beta 8
chr4_-_15939949 0.269 FGFBP1
fibroblast growth factor binding protein 1
chr8_-_17579729 0.266 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr1_-_57888785 0.262 DAB1
disabled homolog 1 (Drosophila)
chr7_+_18548899 0.261 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr1_-_116383323 0.261 NM_001111061
NHLH2
nescient helix loop helix 2
chr4_+_41258909 0.261 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_121756744 0.260 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr10_-_14646407 0.255 FAM107B
family with sequence similarity 107, member B
chr4_+_41258895 0.254 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_+_56815703 0.253 NM_001242795
NUP93
nucleoporin 93kDa
chr11_-_16497917 0.249 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr16_+_57673206 0.249 NM_001145774
GPR56
G protein-coupled receptor 56
chr20_+_58630965 0.242 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr12_-_8815370 0.242 NM_003480
MFAP5
microfibrillar associated protein 5
chr5_+_36608430 0.236 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_6866882 0.236 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr4_+_77356252 0.235 NM_020859
SHROOM3
shroom family member 3
chr5_+_36606667 0.235 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_11779279 0.230 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr21_+_18885104 0.229 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr7_+_94297448 0.228 PEG10
paternally expressed 10
chr2_+_18059923 0.227 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr2_+_75061234 0.227 HK2
hexokinase 2
chr3_-_139258373 0.227 RBP1
retinol binding protein 1, cellular
chr17_-_46651809 0.226 NM_002146
HOXB3
homeobox B3
chr10_-_61900659 0.224 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_139258477 0.223 RBP1
retinol binding protein 1, cellular
chr11_+_6897855 0.223 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr1_+_81771844 0.221 LPHN2
latrophilin 2
chr22_-_27014037 0.221 CRYBB1
crystallin, beta B1
chrX_-_117107700 0.213 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr1_+_82266081 0.212 NM_012302
LPHN2
latrophilin 2
chr7_+_20370724 0.211 NM_002214
ITGB8
integrin, beta 8
chr1_-_32801606 0.210 NM_023009
MARCKSL1
MARCKS-like 1
chr5_+_36606456 0.209 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr20_+_9198036 0.208 NM_182797
PLCB4
phospholipase C, beta 4
chr21_+_18885296 0.206 CXADR
coxsackie virus and adenovirus receptor
chr10_+_24755459 0.206 KIAA1217
KIAA1217
chr6_-_136847743 0.205 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr17_+_54230835 0.204 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr10_-_88717319 0.204 NM_024756
MMRN2
multimerin 2
chr4_-_123542165 0.204 NM_001207006
NM_021803
IL21

interleukin 21

chr8_-_21988518 0.203 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr10_-_62332666 0.203 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_140165875 0.202 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr5_+_145317297 0.202 SH3RF2
SH3 domain containing ring finger 2
chrX_-_84634396 0.201 POF1B
premature ovarian failure, 1B
chr4_+_40198526 0.201 NM_004310
RHOH
ras homolog gene family, member H
chr10_-_11574273 0.200 NM_001080491
USP6NL
USP6 N-terminal like
chr2_-_26205437 0.199 NM_002254
KIF3C
kinesin family member 3C
chr7_+_129015483 0.199 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_-_160472960 0.199 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr6_-_134373618 0.198 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr1_+_13911966 0.197 NM_001006624
NM_001006625
PDPN

podoplanin

chrX_-_117119282 0.197 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr1_+_15272414 0.197 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr21_-_32201926 0.196 NM_181606
KRTAP7-1
keratin associated protein 7-1 (gene/pseudogene)
chr9_-_126030854 0.195 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr22_-_27013959 0.195 NM_001887
CRYBB1
crystallin, beta B1
chr2_-_38525527 0.194 ATL2
atlastin GTPase 2
chr15_+_52201590 0.193 TMOD3
tropomodulin 3 (ubiquitous)
chr18_-_52988916 0.192 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr4_-_53617781 0.192 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr7_-_139876718 0.191 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr4_+_146403955 0.191 NM_001003688
SMAD1
SMAD family member 1
chr4_+_166131170 0.190 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr12_-_31477080 0.187 FAM60A
family with sequence similarity 60, member A
chr5_-_176836535 0.187 NM_000505
F12
coagulation factor XII (Hageman factor)
chr1_+_955609 0.186 AGRN
agrin
chr1_+_955468 0.185 NM_198576
AGRN
agrin
chr10_-_116444374 0.184 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr3_-_123339178 0.184 MYLK
myosin light chain kinase
chr18_-_53177999 0.183 NM_001243231
TCF4
transcription factor 4
chr5_-_176836488 0.183 F12
coagulation factor XII (Hageman factor)
chr8_-_125579395 0.182 MTSS1
metastasis suppressor 1
chr12_-_24103842 0.179 SOX5
SRY (sex determining region Y)-box 5
chr9_-_117150217 0.178 AKNA
AT-hook transcription factor
chrX_-_128788913 0.178 NM_017413
APLN
apelin
chr9_-_124989755 0.175 NM_001242334
LHX6
LIM homeobox 6
chr3_+_111261039 0.173 CD96
CD96 molecule
chr1_+_9711781 0.172 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr5_+_140220811 0.172 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr2_+_85360373 0.170 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr3_-_111314181 0.169 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr2_-_113594325 0.169 NM_000576
IL1B
interleukin 1, beta
chr3_+_136676706 0.169 NM_144717
IL20RB
interleukin 20 receptor beta
chr17_+_36861857 0.168 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr17_+_30814708 0.168


chr1_-_153514096 0.168 NM_002962
S100A5
S100 calcium binding protein A5
chrX_-_33229428 0.168 NM_004006
DMD
dystrophin
chr7_-_37025696 0.168 ELMO1
engulfment and cell motility 1
chr16_-_75529289 0.167


chr10_-_14816895 0.165 NM_031453
FAM107B
family with sequence similarity 107, member B
chr2_-_60780404 0.165 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr2_+_27665232 0.164 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chrX_-_84634742 0.162 NM_024921
POF1B
premature ovarian failure, 1B
chr18_+_11751470 0.161 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr4_+_95679075 0.161 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr18_+_55888838 0.160 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_116164321 0.160 LSAMP
limbic system-associated membrane protein
chr6_+_13925423 0.159 NM_001165033
RNF182
ring finger protein 182
chr10_+_11206928 0.159 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr12_-_48963802 0.159 NM_002289
LALBA
lactalbumin, alpha-
chr7_+_73245192 0.158 NM_001305
CLDN4
claudin 4
chr9_+_2622134 0.158 VLDLR
very low density lipoprotein receptor
chr18_+_55888799 0.158 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_2622099 0.157 VLDLR
very low density lipoprotein receptor
chr12_-_6740814 0.156 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr17_-_41623652 0.156 NM_001079675
ETV4
ets variant 4
chr12_-_54779482 0.156 ZNF385A
zinc finger protein 385A
chr2_-_26205327 0.155 KIF3C
kinesin family member 3C
chr8_+_103563847 0.153 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr6_+_130339715 0.152 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr3_+_186648273 0.152 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr2_+_203499667 0.152 FAM117B
family with sequence similarity 117, member B
chrX_+_152954965 0.151 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr13_-_75901897 0.151 TBC1D4
TBC1 domain family, member 4
chr14_+_23305816 0.151 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_-_139163222 0.150 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr3_+_186648515 0.148 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr2_+_206547131 0.147 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr11_-_119234628 0.147 USP2
ubiquitin specific peptidase 2
chr14_+_23305792 0.146 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_217250230 0.145 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr14_-_65409445 0.145 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_153044083 0.144 NM_001017418
SPRR2B
small proline-rich protein 2B
chr5_+_121465214 0.144 NM_207317
ZNF474
zinc finger protein 474
chrY_-_21154560 0.143 NM_013230
CD24
CD24P4
CD24 molecule
CD24 molecule pseudogene 4
chr20_+_6748744 0.143 NM_001200
BMP2
bone morphogenetic protein 2
chrX_+_123234462 0.143 STAG2
stromal antigen 2
chr3_-_149051258 0.142 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr1_-_54871681 0.141 SSBP3
single stranded DNA binding protein 3
chr17_-_56494889 0.140 RNF43
ring finger protein 43
chr17_-_39743085 0.140 NM_000526
KRT14
keratin 14
chr2_-_110874142 0.140 NM_005434
MALL
mal, T-cell differentiation protein-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 1.33e-09 GO:0007275 multicellular organismal development
1.27 3.28e-08 GO:0032502 developmental process
1.33 3.40e-08 GO:0048731 system development
1.30 8.77e-08 GO:0048856 anatomical structure development
1.44 1.30e-06 GO:0007399 nervous system development
1.18 2.96e-05 GO:0032501 multicellular organismal process
1.13 8.25e-05 GO:0065007 biological regulation
1.08 1.62e-04 GO:0009987 cellular process
1.22 2.02e-04 GO:0023052 signaling
1.30 7.39e-04 GO:0030154 cell differentiation
1.28 2.41e-03 GO:0048869 cellular developmental process
1.20 3.77e-03 GO:0071840 cellular component organization or biogenesis
1.12 3.87e-03 GO:0050794 regulation of cellular process
1.49 4.09e-03 GO:2000026 regulation of multicellular organismal development
1.12 4.42e-03 GO:0050789 regulation of biological process
1.20 9.56e-03 GO:0016043 cellular component organization
1.38 2.17e-02 GO:0022607 cellular component assembly
1.27 2.51e-02 GO:0048513 organ development
2.56 2.57e-02 GO:0050671 positive regulation of lymphocyte proliferation
1.19 3.02e-02 GO:0007165 signal transduction
2.52 3.34e-02 GO:0032946 positive regulation of mononuclear cell proliferation
2.49 4.32e-02 GO:0070665 positive regulation of leukocyte proliferation
1.34 4.75e-02 GO:0044085 cellular component biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 9.89e-03 GO:0005634 nucleus
1.03 1.77e-02 GO:0044464 cell part
1.03 1.84e-02 GO:0005623 cell
1.86 2.04e-02 GO:0030424 axon
1.54 2.66e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.13e-03 GO:0005515 protein binding
2.86 1.61e-02 GO:0005070 SH3/SH2 adaptor activity