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• Activity deltas table
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Motif ID: SREBF1,2.p2

Z-value: 1.209

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_183605207	2.656	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr5_-_150537306	2.269		ANXA6	annexin A6
chr19_+_49458151	2.138		BAX	BCL2-associated X protein
chr5_-_150537261	2.067		ANXA6	annexin A6
chr19_+_49458031	2.060	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr19_+_49458129	2.006		BAX	BCL2-associated X protein
chr10_-_93392857	1.984	NM_005398	PPP1R3C	protein phosphatase 1, regulatory subunit 3C
chr5_-_172198160	1.979	NM_004417	DUSP1	dual specificity phosphatase 1
chrX_+_55744049	1.953	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr22_+_35777087	1.870		HMOX1	heme oxygenase (decycling) 1
chr12_+_56109832	1.859		BLOC1S1-RDH5 BLOC1S1	BLOC1S1-RDH5 readthrough biogenesis of lysosomal organelles complex-1, subunit 1
chr19_+_14544100	1.707	NM_002741	PKN1	protein kinase N1
chr15_+_44084039	1.648	NM_001018108 NM_001199875 NM_001199876	SERF2	small EDRK-rich factor 2
chr5_-_150537335	1.552	NM_001155	ANXA6	annexin A6
chr22_+_35695872	1.527		TOM1	target of myb1 (chicken)
chr12_-_63328663	1.494	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_33859835	1.471	NM_178006	STARD13	StAR-related lipid transfer (START) domain containing 13
chr19_+_14544216	1.448		PKN1	protein kinase N1
chr1_-_31845818	1.371	NM_004102	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr19_-_36545298	1.335		THAP8	THAP domain containing 8
chr22_-_36903086	1.331	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr1_-_26232890	1.296	NM_001145454 NM_005563	STMN1	stathmin 1
chr13_+_113951461	1.255	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr19_-_48018163	1.239		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr22_-_36903033	1.233		FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr20_+_44519590	1.182	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chr8_-_13134028	1.152		DLC1	deleted in liver cancer 1
chr17_-_66951381	1.139	NM_007168	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8
chr7_+_102074002	1.132		ORAI2	ORAI calcium release-activated calcium modulator 2
chr22_+_35777051	1.126	NM_002133	HMOX1	heme oxygenase (decycling) 1
chr7_+_29603499	1.126		PRR15	proline rich 15
chr15_-_50978921	1.119		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr12_+_90103470	1.115		LOC338758	uncharacterized LOC338758
chr6_-_33386064	1.097	NM_001014433 NM_001014837 NM_001014838 NM_001014840 NM_015921	CUTA	cutA divalent cation tolerance homolog (E. coli)
chrX_-_101397370	1.090	NM_001006938	TCEAL6	transcription elongation factor A (SII)-like 6
chr1_-_241520467	1.053	NM_002924	RGS7	regulator of G-protein signaling 7
chr2_+_46926049	1.033	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr14_+_96505566	1.030	NM_001252507	C14orf132	chromosome 14 open reading frame 132
chr1_-_212873306	1.029	NM_018664	BATF3	basic leucine zipper transcription factor, ATF-like 3
chr19_-_36545119	1.024		THAP8	THAP domain containing 8
chrX_+_102883891	1.021	NM_001006639 NM_004780	TCEAL1	transcription elongation factor A (SII)-like 1
chr20_+_44520021	0.993		CTSA	cathepsin A
chr12_-_56122840	0.991	NM_001040034 NM_001780	CD63	CD63 molecule
chr5_-_176730659	0.986	NM_001031677 NM_130781	RAB24	RAB24, member RAS oncogene family
chr5_-_121413967	0.984		LOX	lysyl oxidase
chr15_+_44084493	0.967		SERF2	small EDRK-rich factor 2
chr5_-_121413906	0.967		LOX	lysyl oxidase
chr22_+_35695792	0.965	NM_001135730 NM_001135732 NM_005488	TOM1	target of myb1 (chicken)
chr10_-_93392744	0.956		PPP1R3C	protein phosphatase 1, regulatory subunit 3C
chr4_-_175443601	0.951		HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
chr6_-_84937313	0.951	NM_014895	KIAA1009	KIAA1009
chr12_+_90102639	0.923		LOC338758	uncharacterized LOC338758
chr6_+_160390128	0.914	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr12_-_63328857	0.906		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_+_56109851	0.886		BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1
chr20_-_2821245	0.880	NM_022760	FAM113A	family with sequence similarity 113, member A
chr12_-_56122800	0.878		CD63	CD63 molecule
chr1_-_241520384	0.876		RGS7	regulator of G-protein signaling 7
chr4_+_668250	0.865		MYL5	myosin, light chain 5, regulatory
chr7_-_27196163	0.863	NM_006896	HOXA7	homeobox A7
chr1_+_11866240	0.862		CLCN6	chloride channel 6
chrX_-_100872926	0.861	NM_001009584 NM_001184768 NM_019007	ARMCX6	armadillo repeat containing, X-linked 6
chr13_+_113951589	0.860		LAMP1	lysosomal-associated membrane protein 1
chr7_-_47621741	0.857	NM_022748	TNS3	tensin 3
chr15_+_44084517	0.856	NM_001199878	SERF2-C15ORF63 SERF2	SERF2-C15orf63 readthrough small EDRK-rich factor 2
chr5_-_154230157	0.854		C5orf4	chromosome 5 open reading frame 4
chr2_+_148778573	0.845	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr9_-_37904098	0.842		MCART1	mitochondrial carrier triple repeat 1
chr1_-_212873104	0.840		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr7_-_47621635	0.838		TNS3	tensin 3
chr19_-_48018317	0.832	NM_003827	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr15_-_50978726	0.825		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr5_-_121414011	0.819	NM_002317	LOX	lysyl oxidase
chr5_-_154230212	0.819	NM_032385	C5orf4	chromosome 5 open reading frame 4
chr4_-_100242487	0.805	NM_000668	ADH1A ADH1B	alcohol dehydrogenase 1A (class I), alpha polypeptide alcohol dehydrogenase 1B (class I), beta polypeptide
chr11_+_18343794	0.801	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr20_+_44519965	0.798		CTSA	cathepsin A
chr12_-_56122792	0.794		CD63	CD63 molecule
chr12_-_65153182	0.790		GNS	glucosamine (N-acetyl)-6-sulfatase
chr11_-_1785126	0.785		CTSD	cathepsin D
chr9_-_138391696	0.778	NM_001048265 NM_144654	C9orf116	chromosome 9 open reading frame 116
chr8_-_95961543	0.773	NM_001135733 NM_033285	TP53INP1	tumor protein p53 inducible nuclear protein 1
chr12_-_65153148	0.769		GNS	glucosamine (N-acetyl)-6-sulfatase
chr7_+_149570004	0.759	NM_001100592 NM_145230	ATP6V0E2	ATPase, H+ transporting V0 subunit e2
chr5_+_172483285	0.757	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr20_-_2821120	0.751		FAM113A	family with sequence similarity 113, member A
chr11_-_1785104	0.745		CTSD	cathepsin D
chr12_+_56109817	0.743	NM_001487	BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1
chrX_-_15872921	0.738		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr4_+_668312	0.728		MYL5	myosin, light chain 5, regulatory
chr17_-_46688279	0.728		HOXB7	homeobox B7
chr12_-_65153055	0.726		GNS	glucosamine (N-acetyl)-6-sulfatase
chr12_-_56122748	0.725		CD63	CD63 molecule
chr1_-_39325317	0.724	NM_022157	RRAGC	Ras-related GTP binding C
chr11_+_18344113	0.720		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr17_+_80332152	0.715	NM_018949	UTS2R	urotensin 2 receptor
chr20_-_44519629	0.710	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr5_-_139944045	0.701	NM_006051 NM_133172 NM_133173 NM_133174	APBB3	amyloid beta (A4) precursor protein-binding, family B, member 3
chrX_-_15872882	0.700		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr20_+_44519924	0.698		CTSA	cathepsin A
chr16_+_53133063	0.695		CHD9	chromodomain helicase DNA binding protein 9
chrX_-_15872905	0.694
chr2_+_238395863	0.688	NM_001042467 NM_024101	MLPH	melanophilin
chr7_+_150065859	0.684	NM_001099695 NM_001099696 NM_013400	REPIN1	replication initiator 1
chr19_+_50016500	0.682		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chrX_-_15872938	0.680		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr16_-_88923233	0.678		GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase
chr12_+_54332575	0.678	NM_017410	HOXC13	homeobox C13
chr12_+_113796370	0.675	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chr18_+_9136742	0.673	NM_001083625 NM_015208	ANKRD12	ankyrin repeat domain 12
chrX_-_15872871	0.672		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr20_+_44520203	0.670		CTSA	cathepsin A
chr1_-_212873197	0.667		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr19_-_48018277	0.658		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr5_+_59784004	0.655		PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr1_-_26232643	0.645	NM_203401	STMN1	stathmin 1
chr19_+_50016490	0.641		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chrX_+_103031797	0.638		PLP1	proteolipid protein 1
chr16_-_4897265	0.636	NM_032569	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)
chr11_+_67776016	0.635	NM_001161473	ALDH3B1	aldehyde dehydrogenase 3 family, member B1
chrX_-_102531673	0.634	NM_001012979	TCEAL5	transcription elongation factor A (SII)-like 5
chr5_-_178054072	0.630		CLK4	CDC-like kinase 4
chr8_+_17780492	0.627		PCM1	pericentriolar material 1
chr14_+_76044939	0.627	NM_017791	FLVCR2	feline leukemia virus subgroup C cellular receptor family, member 2
chr3_-_112280759	0.618		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr8_+_26240522	0.617	NM_004331	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr3_-_187463227	0.615		BCL6	B-cell CLL/lymphoma 6
chr3_-_187463474	0.614	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr6_-_33385814	0.612
chr17_+_47074749	0.607	NM_001160423 NM_006546	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1
chr1_+_11866206	0.606	NM_001286 NM_021735 NM_021736 NM_021737	CLCN6	chloride channel 6
chrX_-_106960268	0.603	NM_004089	TSC22D3	TSC22 domain family, member 3
chr20_+_34042908	0.590	NM_007186	CEP250	centrosomal protein 250kDa
chr13_-_50699775	0.589		DLEU2	deleted in lymphocytic leukemia 2 (non-protein coding)
chr14_-_74551159	0.586	NM_005589	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr11_-_6640645	0.577		TPP1	tripeptidyl peptidase I
chrX_+_103031753	0.577	NM_000533 NM_199478	PLP1	proteolipid protein 1
chrX_+_102883647	0.573	NM_001006640	TCEAL1	transcription elongation factor A (SII)-like 1
chrX_-_34675366	0.570	NM_031442	TMEM47	transmembrane protein 47
chr17_+_78194090	0.566	NM_001166347 NM_001166348 NM_001166349 NM_173626	SLC26A11	solute carrier family 26, member 11
chr14_-_92572950	0.565	NM_001127696 NM_001127697 NM_001164774 NM_001164776 NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660	ATXN3	ataxin 3
chr5_-_81574198	0.563	NM_001025	RPS23	ribosomal protein S23
chr11_-_1785087	0.560		CTSD	cathepsin D
chr22_+_31003069	0.557	NM_000355 NM_001184726	TCN2	transcobalamin II
chrX_-_15873094	0.557	NM_003916	AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr5_-_178054001	0.555	NM_020666	CLK4	CDC-like kinase 4
chr22_-_20850075	0.553	NM_032775	KLHL22	kelch-like 22 (Drosophila)
chr8_+_17780351	0.552	NM_006197	PCM1	pericentriolar material 1
chr6_+_30524485	0.549	NM_001077497 NM_025263	PRR3	proline rich 3
chr14_-_89883306	0.548	NM_005197	FOXN3	forkhead box N3
chrX_+_102862833	0.545	NM_001006933 NM_032926	TCEAL3	transcription elongation factor A (SII)-like 3
chr7_+_28448970	0.543		LOC401317	uncharacterized LOC401317
chr12_+_113796374	0.543		PLBD2	phospholipase B domain containing 2
chr6_-_33385662	0.542		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr17_-_62915580	0.538		LRRC37A3	leucine rich repeat containing 37, member A3
chr5_+_133706869	0.536	NM_003337	UBE2B	ubiquitin-conjugating enzyme E2B
chr7_+_102073953	0.529	NM_001126340 NM_032831	ORAI2	ORAI calcium release-activated calcium modulator 2
chr6_+_42018264	0.527		TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr14_-_24682658	0.525		CHMP4A	charged multivesicular body protein 4A
chr12_+_104458235	0.519	NM_013320	HCFC2	host cell factor C2
chr5_+_149340437	0.517		SLC26A2	solute carrier family 26 (sulfate transporter), member 2
chr19_+_50016606	0.515		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr7_+_150065968	0.515		REPIN1	replication initiator 1
chr5_+_149340287	0.514	NM_000112	SLC26A2	solute carrier family 26 (sulfate transporter), member 2
chr17_+_61851512	0.513
chr10_+_69644708	0.511		SIRT1	sirtuin 1
chr5_+_122110778	0.509		SNX2	sorting nexin 2
chr12_+_133614138	0.504		ZNF84	zinc finger protein 84
chr16_+_1401936	0.504		GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr22_-_41593466	0.499
chr1_-_155211049	0.496	NM_001171812 NM_000157	GBA	glucosidase, beta, acid
chr9_-_19127494	0.496	NM_001122	PLIN2	perilipin 2
chr1_-_26233367	0.493	NM_203399	STMN1	stathmin 1
chr5_-_159797618	0.492	NM_031908	C1QTNF2	C1q and tumor necrosis factor related protein 2
chr2_+_46926323	0.491	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr5_-_132299248	0.490		AFF4	AF4/FMR2 family, member 4
chr11_-_18343670	0.490	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chr2_-_133427624	0.490		LYPD1	LY6/PLAUR domain containing 1
chr7_+_23286390	0.488		GPNMB	glycoprotein (transmembrane) nmb
chr15_-_83316621	0.487	NM_030594	CPEB1	cytoplasmic polyadenylation element binding protein 1
chr11_+_64001974	0.487	NM_001243733 NM_003377	VEGFB	vascular endothelial growth factor B
chr17_+_48172508	0.487	NM_001199900 NM_002611 NM_001199899	PDK2	pyruvate dehydrogenase kinase, isozyme 2
chr16_+_85061303	0.486	NM_014732	KIAA0513	KIAA0513
chr14_-_88459459	0.485		GALC	galactosylceramidase
chr4_-_164253946	0.482	NM_000909	NPY1R	neuropeptide Y receptor Y1
chr17_-_30186217	0.481	NM_018405	C17orf79	chromosome 17 open reading frame 79
chr20_+_37590969	0.475	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr9_-_16870664	0.475		BNC2	basonuclin 2
chrX_-_39956655	0.474	NM_001123385 NM_017745	BCOR	BCL6 corepressor
chr5_+_173315313	0.473	NM_030627	CPEB4	cytoplasmic polyadenylation element binding protein 4
chr12_+_50355278	0.473	NM_001651	AQP5	aquaporin 5
chr11_-_36310934	0.472		COMMD9	COMM domain containing 9
chr2_-_211035913	0.472	NM_152519	C2orf67	chromosome 2 open reading frame 67
chr19_-_5340700	0.471	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr12_+_133614052	0.469		ZNF84	zinc finger protein 84
chr14_-_24682639	0.468		CHMP4A	charged multivesicular body protein 4A
chr5_+_133707105	0.468		UBE2B	ubiquitin-conjugating enzyme E2B
chr5_-_139943829	0.465		APBB3	amyloid beta (A4) precursor protein-binding, family B, member 3
chr8_+_17780510	0.465		PCM1	pericentriolar material 1
chr3_+_133118789	0.464	NM_003571	BFSP2	beaded filament structural protein 2, phakinin

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.25	1.50e-06	GO:0044237	cellular metabolic process
1.20	1.21e-04	GO:0008152	metabolic process
7.29	5.34e-04	GO:0032006	regulation of TOR signaling cascade
4.13	8.40e-04	GO:0006818	hydrogen transport
1.20	1.14e-03	GO:0044238	primary metabolic process
1.63	2.34e-03	GO:0032774	RNA biosynthetic process
4.02	2.75e-03	GO:0015992	proton transport
1.30	3.55e-03	GO:0006807	nitrogen compound metabolic process
1.25	3.67e-03	GO:0044260	cellular macromolecule metabolic process
1.31	4.43e-03	GO:0034641	cellular nitrogen compound metabolic process
5.34	6.02e-03	GO:0015682	ferric iron transport
5.34	6.02e-03	GO:0033572	transferrin transport
4.25	6.19e-03	GO:0007033	vacuole organization
1.65	8.40e-03	GO:0033554	cellular response to stress
1.10	9.19e-03	GO:0009987	cellular process
8.50	1.00e-02	GO:0032008	positive regulation of TOR signaling cascade
1.32	1.31e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.43	1.45e-02	GO:0034645	cellular macromolecule biosynthetic process
1.41	2.74e-02	GO:0009059	macromolecule biosynthetic process
1.33	2.79e-02	GO:0044249	cellular biosynthetic process
1.59	3.18e-02	GO:0006351	transcription, DNA-dependent
4.86	4.61e-02	GO:0015988	energy coupled proton transport, against electrochemical gradient
4.86	4.61e-02	GO:0015991	ATP hydrolysis coupled proton transport
1.31	4.73e-02	GO:0009058	biosynthetic process
1.38	4.80e-02	GO:0010467	gene expression

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.17	2.36e-14	GO:0005622	intracellular
1.17	1.12e-13	GO:0044424	intracellular part
1.22	1.42e-11	GO:0043227	membrane-bounded organelle
1.22	1.71e-11	GO:0043231	intracellular membrane-bounded organelle
1.19	2.34e-11	GO:0043226	organelle
1.19	3.65e-11	GO:0043229	intracellular organelle
1.30	8.63e-11	GO:0044444	cytoplasmic part
2.79	1.86e-10	GO:0005773	vacuole
1.22	5.29e-10	GO:0005737	cytoplasm
1.31	5.81e-10	GO:0044446	intracellular organelle part
1.30	1.15e-09	GO:0044422	organelle part
3.18	5.36e-07	GO:0044437	vacuolar part
3.23	6.06e-07	GO:0005774	vacuolar membrane
2.10	8.45e-06	GO:0005768	endosome
2.40	3.00e-05	GO:0000323	lytic vacuole
2.40	3.00e-05	GO:0005764	lysosome
1.21	5.74e-04	GO:0005634	nucleus
6.56	1.13e-03	GO:0033176	proton-transporting V-type ATPase complex
1.35	1.39e-03	GO:0031974	membrane-enclosed lumen
4.41	1.52e-03	GO:0016469	proton-transporting two-sector ATPase complex
2.65	1.78e-03	GO:0005769	early endosome
1.35	2.04e-03	GO:0070013	intracellular organelle lumen
1.36	3.03e-03	GO:0005829	cytosol
1.34	3.36e-03	GO:0043233	organelle lumen
1.36	3.52e-03	GO:0031090	organelle membrane
2.81	3.55e-03	GO:0005765	lysosomal membrane
1.34	6.13e-03	GO:0044428	nuclear part
1.44	1.17e-02	GO:0005654	nucleoplasm
1.35	2.08e-02	GO:0031981	nuclear lumen
1.59	2.18e-02	GO:0031975	envelope
3.38	3.40e-02	GO:0016605	PML body
1.23	3.56e-02	GO:0032991	macromolecular complex
1.72	3.64e-02	GO:0005740	mitochondrial envelope
1.57	3.71e-02	GO:0031967	organelle envelope

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.20	3.15e-06	GO:0005515	protein binding
1.11	2.77e-05	GO:0005488	binding
2.85	1.65e-02	GO:0015078	hydrogen ion transmembrane transporter activity