Motif ID: SRF.p3

Z-value: 1.074


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_43138919-0.147.4e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_35169876 3.843 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 3.229 MYL9
myosin, light chain 9, regulatory
chr10_-_64576123 2.311 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64576074 2.250 EGR2
early growth response 2
chr3_-_151987332 1.968 LOC401093
uncharacterized LOC401093
chr5_+_137801166 1.766 EGR1
early growth response 1
chr9_+_36136710 1.386 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr11_+_117070039 1.379 NM_001001522
NM_003186
TAGLN

transgelin

chr19_+_2476122 1.306 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr5_+_137801178 1.256 NM_001964
EGR1
early growth response 1
chr9_-_79520878 1.240 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr10_+_31610063 1.095 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr14_-_53417808 1.012 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr5_+_92918924 0.978 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_+_92219926 0.885 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr10_-_90712510 0.634 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_119294242 0.629 NM_006288
THY1
Thy-1 cell surface antigen
chr20_+_33146500 0.610 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_27183225 0.564 NM_019102
HOXA5
homeobox A5
chr3_-_46904879 0.550 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr17_+_3379295 0.534 NM_000049
ASPA
aspartoacylase
chr20_-_33735060 0.517 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr1_-_89530890 0.464 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr5_-_124080773 0.456 NM_020747
ZNF608
zinc finger protein 608
chr1_+_223889253 0.445 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_-_6772252 0.410 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr7_+_143078358 0.407 NM_001010972
NM_003461
ZYX

zyxin

chr11_-_2162167 0.405 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_26348488 0.398 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_-_99594915 0.394 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr11_-_119293848 0.389 THY1
Thy-1 cell surface antigen
chr17_-_72357957 0.378 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr7_+_143078399 0.375 ZYX
zyxin
chr2_-_128432642 0.368 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr19_-_36247917 0.368 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chrX_-_37706816 0.359 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr3_+_187930720 0.358 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_143078444 0.348 ZYX
zyxin
chr7_+_143078447 0.348 ZYX
zyxin
chr2_+_219283809 0.345 NM_007127
VIL1
villin 1
chr7_+_143078395 0.341 ZYX
zyxin
chr5_-_58295758 0.337 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_28099682 0.332 NM_177424
STX12
syntaxin 12
chr5_-_111093251 0.320 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr7_+_93551015 0.308 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_140749830 0.304 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr14_+_104394751 0.289 NM_153046
TDRD9
tudor domain containing 9
chr7_+_143078457 0.287 ZYX
zyxin
chr2_-_106015423 0.286 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr2_+_87754991 0.285 LINC00152
long intergenic non-protein coding RNA 152
chr12_+_75874512 0.283 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr6_+_151561094 0.281 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_86043932 0.273 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_172087823 0.272 NM_001136554
TLK1
tousled-like kinase 1
chr2_-_242212244 0.264 NM_001243900
NM_203346
HDLBP

high density lipoprotein binding protein

chr15_-_35087748 0.264 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr9_+_139249251 0.259 NM_001200003
GPSM1
G-protein signaling modulator 1
chr6_-_109775423 0.257 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_+_16178170 0.254 NM_001145160
TPM4
tropomyosin 4
chr19_+_45417576 0.242 APOC1
apolipoprotein C-I
chr5_+_42565562 0.240 NM_001242406
GHR
growth hormone receptor
chr4_-_185747051 0.240 ACSL1
acyl-CoA synthetase long-chain family member 1
chr5_+_42565963 0.237 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr1_-_31845818 0.235 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr15_+_74218962 0.235 LOXL1
lysyl oxidase-like 1
chr15_-_55581969 0.213 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr19_+_56153417 0.210 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr18_-_65182507 0.200 DSEL
dermatan sulfate epimerase-like
chr2_-_242212198 0.197 HDLBP
high density lipoprotein binding protein
chr10_-_16859389 0.195 RSU1
Ras suppressor protein 1
chr6_+_144612872 0.193 NM_007124
UTRN
utrophin
chr1_-_208084432 0.187 NM_001025109
NM_001773
CD34

CD34 molecule

chr11_+_59807747 0.181 NM_173801
PLAC1L
placenta-specific 1-like
chr12_-_11463353 0.173 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr12_-_91505541 0.173 NM_002345
LUM
lumican
chr15_+_96869156 0.171 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_+_35849487 0.171 NM_005304
FFAR3
free fatty acid receptor 3
chr9_+_18474078 0.170 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr7_+_143078608 0.169 ZYX
zyxin
chr2_+_74120092 0.168 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr3_-_9834357 0.164 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr7_+_94285676 0.163 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr16_+_30077120 0.161 ALDOA
aldolase A, fructose-bisphosphate
chr1_+_50574601 0.159 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr20_+_2276612 0.154 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr17_+_39868577 0.152 NM_000805
GAST
gastrin
chr1_-_150552077 0.151 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr5_+_67588395 0.151 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr2_+_161993465 0.151 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr2_-_21266915 0.149 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_49027281 0.149 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr20_-_1974393 0.148 NM_001190900
PDYN
prodynorphin
chr16_+_30077146 0.147 ALDOA
aldolase A, fructose-bisphosphate
chr2_+_74120132 0.143 ACTG2
actin, gamma 2, smooth muscle, enteric
chr1_-_89591685 0.141 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr2_+_87755059 0.140 LINC00152
long intergenic non-protein coding RNA 152
chr6_+_158402928 0.139 SYNJ2
synaptojanin 2
chr11_-_57282315 0.137 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr7_+_94285736 0.137 PEG10
paternally expressed 10
chr2_+_219264477 0.136 NM_021198
NM_182642
CTDSP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

chr18_-_3219846 0.135 MYOM1
myomesin 1, 185kDa
chr1_-_91487769 0.134 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr3_+_187871473 0.133 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_+_126240369 0.131 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr10_+_88428167 0.128 NM_001171610
LDB3
LIM domain binding 3
chr17_-_74099855 0.127 NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_015219
EXOC7




exocyst complex component 7




chr14_-_94443065 0.127 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr16_+_31483066 0.123 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr19_-_58858900 0.120 A1BG
alpha-1-B glycoprotein
chr20_-_42815732 0.119 JPH2
junctophilin 2
chr10_-_16859336 0.118 RSU1
Ras suppressor protein 1
chr17_+_42634598 0.118 NM_001466
FZD2
frizzled family receptor 2
chr4_+_87968191 0.117 AFF1
AF4/FMR2 family, member 1
chr20_-_33872505 0.116 NM_181468
EIF6
eukaryotic translation initiation factor 6
chr1_+_6105980 0.113 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_+_207024614 0.112 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr9_-_98269686 0.111 NM_001083606
PTCH1
patched 1
chr19_+_57901330 0.111 ZNF548
ZNF17
zinc finger protein 548
zinc finger protein 17
chr3_-_9834065 0.111 TADA3
transcriptional adaptor 3
chr4_-_10118444 0.109 WDR1
WD repeat domain 1
chrX_-_153602928 0.108 FLNA
filamin A, alpha
chr10_-_16859408 0.108 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr1_-_91487593 0.106 ZNF644
zinc finger protein 644
chr19_+_13135368 0.105 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_134464161 0.104 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr9_+_97521930 0.104 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr9_+_116356199 0.104 NM_144489
RGS3
regulator of G-protein signaling 3
chr20_-_1974701 0.102 NM_001190898
NM_001190899
NM_024411
PDYN


prodynorphin


chr16_+_30076993 0.100 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr20_-_21494663 0.095 NM_002509
NKX2-2
NK2 homeobox 2
chr21_-_47704166 0.095 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr10_+_88428263 0.091 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr5_-_39425297 0.090 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr4_-_10118460 0.088 WDR1
WD repeat domain 1
chr15_+_96873845 0.087 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr16_-_67977956 0.085 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr12_-_11548485 0.084 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr3_-_121379757 0.083 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr9_-_98269480 0.080 NM_001083607
PTCH1
patched 1
chr5_+_176875325 0.080 NM_001174102
PRR7
proline rich 7 (synaptic)
chr17_+_16318911 0.080 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_58390145 0.079 NM_000614
CNTF
ciliary neurotrophic factor
chr19_+_42082530 0.079 NM_001098506
NM_033543
CEACAM21

carcinoembryonic antigen-related cell adhesion molecule 21

chr2_-_135476541 0.079 NM_030923
TMEM163
transmembrane protein 163
chr1_+_219347195 0.079 LYPLAL1
lysophospholipase-like 1
chr21_-_28217272 0.078 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_-_140060601 0.078 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr4_-_88450601 0.078 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr1_+_219347123 0.077 NM_138794
LYPLAL1
lysophospholipase-like 1
chr19_+_57901188 0.076 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr3_-_157221362 0.076 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr8_+_37620100 0.076 NM_007198
PROSC
proline synthetase co-transcribed homolog (bacterial)
chr2_+_219264719 0.074 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr6_+_158402916 0.073 SYNJ2
synaptojanin 2
chr2_+_85132762 0.072 NM_021103
TMSB10
thymosin beta 10
chr3_+_9834778 0.072 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr14_-_106111114 0.070 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr12_+_113860146 0.070 NM_138432
SDSL
serine dehydratase-like
chr16_-_11375094 0.069 NM_002761
PRM1
protamine 1
chr19_+_1026608 0.069 CNN2
calponin 2
chr9_+_116356407 0.069 RGS3
regulator of G-protein signaling 3
chr12_-_8765438 0.069 NM_020661
AICDA
activation-induced cytidine deaminase
chr7_+_12726413 0.068 NM_001037164
NM_212460
ARL4A

ADP-ribosylation factor-like 4A

chr17_+_16318848 0.067 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr1_-_935469 0.067 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr6_-_86388419 0.067 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr17_-_79479780 0.067 ACTG1
actin, gamma 1
chr19_-_46283763 0.065 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr17_-_41132019 0.064 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr1_+_244816434 0.063 PPPDE1
PPPDE peptidase domain containing 1
chr22_-_43343046 0.062 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr17_-_1389013 0.061 NM_001080950
MYO1C
myosin IC
chr19_+_45417920 0.060 NM_001645
APOC1
apolipoprotein C-I
chr2_+_131513007 0.060 NM_152698
NM_001105193
FAM123C

family with sequence similarity 123C

chr17_-_78450247 0.060 NM_002522
NPTX1
neuronal pentraxin I
chr17_+_80193649 0.060 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_+_33474835 0.059 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chrX_-_153602998 0.059 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr2_-_21266893 0.059 APOB
apolipoprotein B (including Ag(x) antigen)
chr11_-_19223516 0.057 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr14_-_74226634 0.056 C14orf43
chromosome 14 open reading frame 43
chr7_+_114055048 0.054 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr3_+_119187782 0.053 NM_152305
POGLUT1
protein O-glucosyltransferase 1
chr3_-_178984789 0.051 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr12_+_6881669 0.050 NM_002286
LAG3
lymphocyte-activation gene 3
chr17_+_33914320 0.047 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr19_-_42894419 0.046 NM_032488
CNFN
cornifelin
chr18_-_47806361 0.046 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr1_-_89488412 0.046 NM_018284
GBP3
guanylate binding protein 3
chr11_-_85780899 0.045 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr17_-_4890664 0.045 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr15_-_102029872 0.044 PCSK6
proprotein convertase subtilisin/kexin type 6
chr2_-_27531113 0.043 NM_003353
UCN
urocortin
chr11_+_34073188 0.043 NM_005898
NM_203364
CAPRIN1

cell cycle associated protein 1

chr1_-_150552005 0.043 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr1_-_935352 0.043 HES4
hairy and enhancer of split 4 (Drosophila)
chr3_-_71294229 0.043 NM_001244814
FOXP1
forkhead box P1
chr11_+_75273245 0.043 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr18_-_37380249 0.042 LOC647946
uncharacterized LOC647946
chr4_-_10118500 0.042 NM_005112
NM_017491
WDR1

WD repeat domain 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.93 4.78e-07 GO:0003012 muscle system process
7.10 1.11e-06 GO:0006936 muscle contraction
1.38 6.40e-04 GO:0065007 biological regulation
12.91 1.06e-03 GO:0070252 actin-mediated cell contraction
1.51 1.49e-03 GO:0032501 multicellular organismal process
1.39 1.57e-03 GO:0050789 regulation of biological process
9.62 8.29e-03 GO:0030048 actin filament-based movement
3.90 9.10e-03 GO:0030029 actin filament-based process
1.59 1.28e-02 GO:0023052 signaling
11.37 1.41e-02 GO:0030049 muscle filament sliding
11.37 1.41e-02 GO:0033275 actin-myosin filament sliding
4.57 1.52e-02 GO:0007517 muscle organ development
1.84 2.54e-02 GO:0030154 cell differentiation
2.09 4.00e-02 GO:0010033 response to organic substance

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.12 4.66e-09 GO:0043292 contractile fiber
9.31 1.49e-08 GO:0044449 contractile fiber part
9.06 2.18e-08 GO:0030016 myofibril
10.01 2.37e-08 GO:0030017 sarcomere
5.15 1.95e-07 GO:0015629 actin cytoskeleton
11.68 7.36e-05 GO:0031674 I band
14.02 7.33e-04 GO:0032432 actin filament bundle
1.31 1.27e-03 GO:0005737 cytoplasm
12.74 1.32e-03 GO:0042641 actomyosin
2.05 1.33e-03 GO:0005856 cytoskeleton
1.20 4.16e-03 GO:0044424 intracellular part
12.52 8.82e-03 GO:0001725 stress fiber
1.18 1.09e-02 GO:0005622 intracellular
5.67 1.78e-02 GO:0005925 focal adhesion
15.58 2.18e-02 GO:0005859 muscle myosin complex
5.39 2.52e-02 GO:0005924 cell-substrate adherens junction
1.22 2.68e-02 GO:0043229 intracellular organelle
1.22 3.01e-02 GO:0043226 organelle
5.19 3.29e-02 GO:0030055 cell-substrate junction
14.02 3.38e-02 GO:0016460 myosin II complex
9.22 4.01e-02 GO:0030018 Z disc

Gene overrepresentation in function category:

enrichment   p-value GO term description
9.78 7.04e-03 GO:0008307 structural constituent of muscle
1.32 9.84e-03 GO:0005515 protein binding
3.35 1.09e-02 GO:0003779 actin binding
1.17 1.97e-02 GO:0005488 binding
2.59 3.61e-02 GO:0008092 cytoskeletal protein binding