Motif ID: T.p2

Z-value: 0.501


Transcription factors associated with T.p2:

Gene SymbolEntrez IDGene Name
T 6862 T, brachyury homolog (mouse)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Tchr6_-_1665821290.226.0e-01Click!


Activity profile for motif T.p2.

activity profile for motif T.p2


Sorted Z-values histogram for motif T.p2

Sorted Z-values for motif T.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of T.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52845862 0.692 NM_005555
KRT6B
keratin 6B
chr12_-_52867521 0.603 NM_173086
KRT6C
keratin 6C
chr11_+_117947785 0.456 TMPRSS4
transmembrane protease, serine 4
chr5_+_31799030 0.451 NM_178140
PDZD2
PDZ domain containing 2
chr11_+_117947726 0.440 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr10_-_123356158 0.332 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_-_205290756 0.306 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chrX_+_16804531 0.261 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr19_-_44174497 0.237 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr2_-_216003068 0.214 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr4_+_153864134 0.213 NM_033393
FHDC1
FH2 domain containing 1
chrX_+_128913881 0.211 NM_018990
SASH3
SAM and SH3 domain containing 3
chr17_-_43502992 0.201 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr11_-_124310980 0.196 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr3_-_52444016 0.192 BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr5_+_68788118 0.184 NM_002538
OCLN
occludin
chrX_+_128913897 0.180 SASH3
SAM and SH3 domain containing 3
chr17_+_34431219 0.179 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr15_+_40861509 0.175 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr3_-_52443893 0.174 NM_004656
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr16_+_57653649 0.173 GPR56
G protein-coupled receptor 56
chr7_-_16505292 0.170 NM_015464
SOSTDC1
sclerostin domain containing 1
chr7_+_121513158 0.167 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr3_-_111314181 0.162 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr19_+_7049349 0.160 NM_144614
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr8_+_103563847 0.149 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr1_-_117210301 0.140 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr3_-_48471401 0.134 NM_001130082
PLXNB1
plexin B1
chr11_-_120008848 0.134 NM_012101
TRIM29
tripartite motif containing 29
chr1_+_55007927 0.131 ACOT11
acyl-CoA thioesterase 11
chr2_-_69098502 0.131 NM_014482
BMP10
bone morphogenetic protein 10
chr4_-_73434467 0.130 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr12_-_8815479 0.126 MFAP5
microfibrillar associated protein 5
chr1_+_26737306 0.117 LIN28A
lin-28 homolog A (C. elegans)
chr2_-_113542970 0.114 NM_000575
IL1A
interleukin 1, alpha
chr8_-_42234562 0.112 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr11_-_120008738 0.111 TRIM29
tripartite motif containing 29
chr21_+_25801042 0.107 FLJ42200
FLJ42200 protein
chr11_-_7847518 0.107 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr11_+_69061599 0.104 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr1_-_204329043 0.097 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr11_-_44972227 0.097 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr12_-_53074172 0.096 NM_006121
KRT1
keratin 1
chr6_+_167536240 0.096 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr15_+_40861491 0.094 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr5_+_61714710 0.093 NM_001134779
IPO11
importin 11
chrX_+_70443055 0.088 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr11_-_120008801 0.088 TRIM29
tripartite motif containing 29
chr1_-_153029987 0.087 NM_005988
SPRR2A
small proline-rich protein 2A
chr6_+_109762204 0.087 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr15_-_83621350 0.087 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr22_-_41215251 0.085 NM_006358
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr1_+_26737232 0.084 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr19_+_55591759 0.083 NM_017729
EPS8L1
EPS8-like 1
chr9_-_117150217 0.081 AKNA
AT-hook transcription factor
chr16_-_67965754 0.080 NM_001907
CTRL
chymotrypsin-like
chr19_-_13947101 0.079 LOC284454
uncharacterized LOC284454
chr9_-_36276930 0.077 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr1_+_32043745 0.075 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr6_+_36922208 0.073 NM_153370
PI16
peptidase inhibitor 16
chr7_+_143013218 0.073 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr8_-_119123804 0.072 NM_000127
EXT1
exostosin 1
chr3_-_119582422 0.072 GSK3B
glycogen synthase kinase 3 beta
chr8_-_87242508 0.072 NM_138817
SLC7A13
solute carrier family 7 (anionic amino acid transporter), member 13
chr14_-_21572789 0.070 NM_001102454
ZNF219
zinc finger protein 219
chr6_+_29079586 0.067 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr5_+_35856990 0.067 NM_002185
IL7R
interleukin 7 receptor
chr17_-_74533623 0.067 NM_134268
CYGB
cytoglobin
chr20_-_43743723 0.065 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr2_+_171571800 0.064 NM_001003845
SP5
Sp5 transcription factor
chr11_+_9779832 0.063 LOC283104
uncharacterized LOC283104
chr5_+_36608430 0.063 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_93747453 0.063 NM_001001850
STX19
syntaxin 19
chr1_+_26503973 0.063 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr3_+_10857867 0.061 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr12_+_113623364 0.060 NM_032848
C12orf52
chromosome 12 open reading frame 52
chr7_+_86274076 0.059 GRM3
glutamate receptor, metabotropic 3
chr2_+_176972005 0.057 NM_021192
HOXD11
homeobox D11
chr11_-_7818488 0.057 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr19_-_44174271 0.056 PLAUR
plasminogen activator, urokinase receptor
chr20_+_2517252 0.056 NM_080751
TMC2
transmembrane channel-like 2
chr19_-_11688441 0.056 ACP5
acid phosphatase 5, tartrate resistant
chr3_+_167453431 0.055 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr12_-_86229981 0.055 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr1_-_12677347 0.054 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr4_-_186456580 0.053 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr19_-_11688508 0.053 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_29012951 0.051 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr12_-_86230158 0.051 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr17_-_61523544 0.051 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr7_+_107220622 0.051 BCAP29
B-cell receptor-associated protein 29
chr8_-_130799133 0.051 NM_031415
GSDMC
gasdermin C
chr3_+_52812438 0.050 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr16_+_77233348 0.050 NM_001129979
SYCE1L
synaptonemal complex central element protein 1-like
chr19_+_50084586 0.050 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr16_+_4838397 0.048 NM_001253790
NM_001253791
LOC440335

uncharacterized LOC440335

chr20_+_35973083 0.047 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chrM_+_8857 0.047


chr5_-_9630462 0.047 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr8_-_8239188 0.047 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr4_+_128554079 0.047 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr16_-_4323000 0.046 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr8_-_17580024 0.045 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr16_+_25228282 0.044 NM_001169
AQP8
aquaporin 8
chr17_-_40307015 0.044 NM_001252039
NM_004583
NM_201434
RAB5C


RAB5C, member RAS oncogene family


chr2_-_39664291 0.044 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr2_-_219031646 0.043 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr11_+_129685732 0.043 NM_138788
TMEM45B
transmembrane protein 45B
chr1_+_156123321 0.043 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chrX_+_37639306 0.042 CYBB
cytochrome b-245, beta polypeptide
chr2_-_39664430 0.042 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr2_-_100722328 0.042 AFF3
AF4/FMR2 family, member 3
chr7_+_107221203 0.042 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr21_-_34185943 0.041 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr17_+_7533452 0.041 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr1_+_27101217 0.040 ARID1A
AT rich interactive domain 1A (SWI-like)
chr17_-_39768939 0.040 NM_005557
KRT16
keratin 16
chr3_+_128532267 0.039


chr17_+_3118911 0.038 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr2_-_39664129 0.038 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr15_+_91411884 0.038 NM_002569
FURIN
furin (paired basic amino acid cleaving enzyme)
chr19_-_14260728 0.038 LPHN1
latrophilin 1
chr20_-_22565050 0.037 NM_021784
FOXA2
forkhead box A2
chr1_-_21415672 0.037 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_147013181 0.037 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr10_+_5488521 0.036 NM_005863
NET1
neuroepithelial cell transforming 1
chr19_-_17958773 0.035 JAK3
Janus kinase 3
chrX_-_106146546 0.035 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chrM_+_9217 0.035


chr6_-_109762373 0.035 NM_001111298
NM_173672
PPIL6

peptidylprolyl isomerase (cyclophilin)-like 6

chr17_-_40306935 0.034 RAB5C
RAB5C, member RAS oncogene family
chr1_-_114414245 0.034 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr11_-_59950498 0.034 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr21_-_31869427 0.034 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr11_-_111249902 0.033 POU2AF1
POU class 2 associating factor 1
chr17_+_7461591 0.033 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr12_-_7848324 0.033 NM_020634
GDF3
growth differentiation factor 3
chr1_-_24126031 0.033 NM_001127621
GALE
UDP-galactose-4-epimerase
chr12_-_25706177 0.032 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr5_+_14664764 0.032 NM_138348
FAM105B
family with sequence similarity 105, member B
chr19_-_55767103 0.032 PPP6R1
protein phosphatase 6, regulatory subunit 1
chrX_-_33146543 0.031 NM_004010
NM_004009
DMD

dystrophin

chrX_-_18690187 0.031 NM_000330
RS1
retinoschisin 1
chr18_-_74729049 0.031 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr19_-_54311958 0.031 NM_033297
NLRP12
NLR family, pyrin domain containing 12
chr11_-_113577023 0.031 NM_030770
TMPRSS5
transmembrane protease, serine 5
chrX_+_100663229 0.029 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chrM_+_9182 0.029


chr7_-_87849341 0.029 SRI
sorcin
chr5_-_134914968 0.029 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr14_-_51411118 0.027 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr12_-_8043743 0.027 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr5_-_33984688 0.027 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr1_+_33231227 0.027 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr8_+_22462532 0.027 NM_021174
KIAA1967
KIAA1967
chrM_+_8364 0.026


chr16_+_12058963 0.026 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr14_+_96722546 0.026 NM_000710
BDKRB1
bradykinin receptor B1
chr7_+_76090971 0.026 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr14_-_45603668 0.026 NM_002013
FKBP3
FK506 binding protein 3, 25kDa
chr5_+_113698304 0.025 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr6_-_31620142 0.025 NM_001098534
BAG6
BCL2-associated athanogene 6
chr12_-_56359794 0.025 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr2_+_120770606 0.025 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr11_+_59856136 0.025 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr19_+_3708358 0.025 TJP3
tight junction protein 3 (zona occludens 3)
chr7_-_752083 0.025 PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_+_90319588 0.024 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr5_+_140566655 0.024 NM_019119
PCDHB9
protocadherin beta 9
chr3_+_40428672 0.024 NM_001248
ENTPD3
ectonucleoside triphosphate diphosphohydrolase 3
chr1_-_153067000 0.023 NM_001024209
SPRR2E
small proline-rich protein 2E
chrX_+_152908819 0.023 DUSP9
dual specificity phosphatase 9
chr12_-_123594974 0.023 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr5_+_1225469 0.023 NM_182632
SLC6A18
solute carrier family 6, member 18
chr2_-_103353300 0.023 NM_032718
MFSD9
major facilitator superfamily domain containing 9
chr5_+_96211643 0.023 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr9_-_14722669 0.023 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr10_-_125853102 0.022 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr1_-_45253376 0.022 NM_153274
BEST4
bestrophin 4
chr20_+_42574535 0.022 NM_001098798
TOX2
TOX high mobility group box family member 2
chr11_-_16430425 0.022 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr17_-_61988614 0.022 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr11_+_61008643 0.022 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr4_-_4249928 0.021 NM_032927
TMEM128
transmembrane protein 128
chr11_-_62689011 0.021 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr3_+_23851933 0.021 NM_001202476
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr5_+_14664803 0.021 FAM105B
family with sequence similarity 105, member B
chr11_-_57195052 0.021 NM_017611
SLC43A3
solute carrier family 43, member 3
chrY_+_4924128 0.020 NM_032972
NM_032973
PCDH11X
PCDH11Y

protocadherin 11 X-linked
protocadherin 11 Y-linked

chr13_-_30169795 0.020 NM_003045
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr6_+_33387846 0.020 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr20_+_825284 0.020 NM_031424
FAM110A
family with sequence similarity 110, member A
chr17_+_57970442 0.020 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chrX_-_53629607 0.020 HUWE1
HECT, UBA and WWE domain containing 1
chr1_+_174933904 0.020 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_40562917 0.020 PPT1
palmitoyl-protein thioesterase 1
chr5_-_49737216 0.020 NM_198449
EMB
embigin
chr17_+_7465316 0.019 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr2_+_39664544 0.019 LOC728730
uncharacterized LOC728730
chr20_+_43343523 0.019 WISP2
WNT1 inducible signaling pathway protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 3.18e-03 GO:0032501 multicellular organismal process
1.50 9.95e-03 GO:0023052 signaling
1.33 3.08e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.90 2.62e-03 GO:0009986 cell surface
1.64 1.14e-02 GO:0005576 extracellular region

Nothing significant found in function category.