Motif ID: TFEB.p2

Z-value: 1.711


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41702734,
chr6_-_41703938
0.902.5e-03Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_35777087 3.310 HMOX1
heme oxygenase (decycling) 1
chr1_+_183605207 3.225 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr17_-_66951381 2.966 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr19_+_49458151 2.935 BAX
BCL2-associated X protein
chr19_+_49458031 2.870 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr19_+_49458129 2.842 BAX
BCL2-associated X protein
chr11_+_67776016 2.689 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chrX_+_55744049 2.629 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr10_-_93392857 2.423 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr19_-_36545119 2.362 THAP8
THAP domain containing 8
chr12_+_56109832 2.270 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr7_+_102074002 2.236 ORAI2
ORAI calcium release-activated calcium modulator 2
chr5_-_172198160 2.219 NM_004417
DUSP1
dual specificity phosphatase 1
chr1_-_26232890 2.141 NM_001145454
NM_005563
STMN1

stathmin 1

chr5_-_150537306 1.985 ANXA6
annexin A6
chr19_+_14544100 1.973 NM_002741
PKN1
protein kinase N1
chr4_-_100242487 1.956 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr20_+_44520021 1.946 CTSA
cathepsin A
chr7_-_27196163 1.904 NM_006896
HOXA7
homeobox A7
chr19_+_14544216 1.878 PKN1
protein kinase N1
chr20_+_44519924 1.841 CTSA
cathepsin A
chr19_-_36545298 1.730 THAP8
THAP domain containing 8
chr1_-_31845818 1.727 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr7_-_47622127 1.684 TNS3
tensin 3
chr5_-_154230157 1.654 C5orf4
chromosome 5 open reading frame 4
chrX_-_106960268 1.653 NM_004089
TSC22D3
TSC22 domain family, member 3
chr5_-_150537261 1.648 ANXA6
annexin A6
chr2_+_148778573 1.641 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr5_+_172483285 1.638 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr22_+_35777051 1.613 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr1_-_241520467 1.609 NM_002924
RGS7
regulator of G-protein signaling 7
chr2_+_238395863 1.607 NM_001042467
NM_024101
MLPH

melanophilin

chr2_+_46926049 1.601 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr16_+_8806825 1.597 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr18_+_9136742 1.593 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr12_-_63328663 1.580 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr20_+_44519965 1.572 CTSA
cathepsin A
chr1_+_11866240 1.568 CLCN6
chloride channel 6
chr4_-_39640461 1.557 NM_174921
C4orf34
chromosome 4 open reading frame 34
chr5_-_154230212 1.541 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr13_+_113951461 1.539 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr6_-_84937313 1.522 NM_014895
KIAA1009
KIAA1009
chr15_+_44084493 1.519 SERF2
small EDRK-rich factor 2
chr7_-_47621741 1.474 NM_022748
TNS3
tensin 3
chr1_-_212873306 1.472 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr15_-_50978921 1.469 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr12_-_65153148 1.443 GNS
glucosamine (N-acetyl)-6-sulfatase
chr6_+_160390128 1.417 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr11_+_18344113 1.369 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr16_-_4897265 1.360 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr5_-_172755195 1.356 STC2
stanniocalcin 2
chr19_-_48018163 1.349 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr15_+_44084517 1.331 NM_001199878
SERF2-C15ORF63
SERF2
SERF2-C15orf63 readthrough
small EDRK-rich factor 2
chr12_-_56122840 1.312 NM_001040034
NM_001780
CD63

CD63 molecule

chrX_+_102883891 1.297 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr1_-_39325317 1.294 NM_022157
RRAGC
Ras-related GTP binding C
chr12_-_65153055 1.272 GNS
glucosamine (N-acetyl)-6-sulfatase
chr13_-_50699775 1.266 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr20_-_44519629 1.240 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chrX_-_106960028 1.218 TSC22D3
TSC22 domain family, member 3
chr1_-_155210887 1.212 GBA
glucosidase, beta, acid
chr1_-_155211049 1.210 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr16_-_88923233 1.205 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr12_-_56122800 1.204 CD63
CD63 molecule
chr20_+_44520203 1.200 CTSA
cathepsin A
chr12_+_90103470 1.199 LOC338758
uncharacterized LOC338758
chr22_+_35695872 1.185 TOM1
target of myb1 (chicken)
chr3_-_187463474 1.179 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr13_+_113951589 1.174 LAMP1
lysosomal-associated membrane protein 1
chrX_-_15872921 1.168 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_101397370 1.147 NM_001006938
TCEAL6
transcription elongation factor A (SII)-like 6
chrX_-_15873094 1.146 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_158519888 1.139 MFSD1
major facilitator superfamily domain containing 1
chr12_-_56122792 1.136 CD63
CD63 molecule
chr11_-_1785104 1.131 CTSD
cathepsin D
chr5_-_150537335 1.125 NM_001155
ANXA6
annexin A6
chr19_-_48018317 1.122 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr1_-_241520384 1.120 RGS7
regulator of G-protein signaling 7
chr16_-_67514989 1.117 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr7_+_102073953 1.112 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr12_-_65153182 1.110 GNS
glucosamine (N-acetyl)-6-sulfatase
chrX_-_15872882 1.106 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_-_88459459 1.105 GALC
galactosylceramidase
chrX_-_15872938 1.104 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_176730659 1.103 NM_001031677
NM_130781
RAB24

RAB24, member RAS oncogene family

chrX_-_15872871 1.098 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_-_212873104 1.097 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr11_-_27723061 1.090 NM_170733
BDNF
brain-derived neurotrophic factor
chr5_+_149340287 1.082 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr12_-_56122748 1.075 CD63
CD63 molecule
chr3_-_112280759 1.072 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr22_-_20850075 1.063 NM_032775
KLHL22
kelch-like 22 (Drosophila)
chr3_+_158519911 1.062 MFSD1
major facilitator superfamily domain containing 1
chrX_+_102862833 1.062 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chrX_-_15872905 1.033


chr15_-_50978726 1.031 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr5_+_133706869 1.020 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B
chr6_-_33385814 1.018


chr5_-_139944045 1.008 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr7_+_23286390 1.005 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_26232643 1.001 NM_203401
STMN1
stathmin 1
chr5_-_131132690 1.000 FNIP1
folliculin interacting protein 1
chr13_+_113951537 0.996 LAMP1
lysosomal-associated membrane protein 1
chr10_-_64576123 0.993 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr4_+_668250 0.983 MYL5
myosin, light chain 5, regulatory
chr1_+_11866206 0.983 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr7_+_97910978 0.982 NM_001159491
NM_015379
BRI3

brain protein I3

chr11_-_1785087 0.981 CTSD
cathepsin D
chr19_-_5340700 0.977 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr4_+_128651518 0.977 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr7_+_23286384 0.974 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_149340437 0.972 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr5_-_159797618 0.971 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr1_-_212873197 0.966 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr14_-_92572950 0.955 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chrX_-_34675366 0.945 NM_031442
TMEM47
transmembrane protein 47
chr19_-_48018277 0.941 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr7_+_97911023 0.939 BRI3
brain protein I3
chr16_+_85061303 0.932 NM_014732
KIAA0513
KIAA0513
chr7_+_28448970 0.922 LOC401317
uncharacterized LOC401317
chr6_+_158589378 0.921 NM_207118
GTF2H5
general transcription factor IIH, polypeptide 5
chr12_+_56109851 0.918 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr7_-_47621635 0.906 TNS3
tensin 3
chr8_+_17780492 0.906 PCM1
pericentriolar material 1
chr12_-_63328857 0.905 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr22_-_36903033 0.892 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr3_-_187463227 0.886 BCL6
B-cell CLL/lymphoma 6
chr14_+_24630421 0.878 NM_006084
IRF9
interferon regulatory factor 9
chr4_+_668312 0.877 MYL5
myosin, light chain 5, regulatory
chr6_+_151646634 0.874 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chrX_-_100872926 0.872 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr10_-_64576074 0.871 EGR2
early growth response 2
chr9_-_19127462 0.859 PLIN2
perilipin 2
chr5_-_131132709 0.858 FNIP1
folliculin interacting protein 1
chr6_-_33386064 0.857 NM_001014433
NM_001014837
NM_001014838
NM_001014840
NM_015921
CUTA




cutA divalent cation tolerance homolog (E. coli)




chr17_-_46688279 0.851 HOXB7
homeobox B7
chr12_+_56109817 0.845 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr7_-_27183225 0.844 NM_019102
HOXA5
homeobox A5
chr6_-_33385662 0.840 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr17_-_21156577 0.840 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr2_+_220042901 0.837 NM_024293
FAM134A
family with sequence similarity 134, member A
chrX_+_10124984 0.831 NM_001830
CLCN4
chloride channel 4
chr15_+_44084039 0.829 NM_001018108
NM_001199875
NM_001199876
SERF2


small EDRK-rich factor 2


chr14_-_20929635 0.829 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr10_-_14050453 0.817 FRMD4A
FERM domain containing 4A
chrX_+_30671456 0.817 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr14_-_88459469 0.816 NM_000153
NM_001201401
GALC

galactosylceramidase

chr16_-_67184822 0.799 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr20_+_37590969 0.795 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr7_+_23286386 0.794 GPNMB
glycoprotein (transmembrane) nmb
chr17_+_78237389 0.788


chr8_-_95961543 0.787 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr9_-_16870664 0.786 BNC2
basonuclin 2
chr8_+_17780351 0.781 NM_006197
PCM1
pericentriolar material 1
chr16_+_1401936 0.775 GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr9_-_138391696 0.772 NM_001048265
NM_144654
C9orf116

chromosome 9 open reading frame 116

chr1_+_236305831 0.763 NM_003272
GPR137B
G protein-coupled receptor 137B
chrX_+_100878350 0.760 NM_177948
ARMCX3
armadillo repeat containing, X-linked 3
chr6_+_151561094 0.757 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr21_+_38445562 0.754 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr12_-_65153189 0.751 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr9_-_19127494 0.751 NM_001122
PLIN2
perilipin 2
chr11_+_64781584 0.750 NM_001199745
NM_001667
ARL2-SNX15
ARL2

ARL2-SNX15 readthrough
ADP-ribosylation factor-like 2

chr2_+_27805892 0.744 NM_032434
ZNF512
zinc finger protein 512
chr1_-_52831817 0.743 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chr22_+_35695792 0.742 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr11_+_120894756 0.739 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr2_+_109204777 0.739 LIMS1
LIM and senescent cell antigen-like domains 1
chr17_-_79791026 0.738 FAM195B
family with sequence similarity 195, member B
chr17_-_37886781 0.736 NM_032339
MIEN1
migration and invasion enhancer 1
chr12_+_113796370 0.734 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr7_-_14031049 0.734 NM_001163148
ETV1
ets variant 1
chr3_+_44903376 0.733 NM_144638
TMEM42
transmembrane protein 42
chr14_-_89883306 0.726 NM_005197
FOXN3
forkhead box N3
chr10_+_69644341 0.717 NM_012238
SIRT1
sirtuin 1
chr17_-_37886729 0.716 MIEN1
migration and invasion enhancer 1
chr8_+_59465783 0.715 SDCBP
syndecan binding protein (syntenin)
chr1_-_186344801 0.713 TPR
translocated promoter region (to activated MET oncogene)
chr7_+_150065859 0.707 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr11_-_18343670 0.702 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr1_-_154928595 0.699 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chrX_+_102631408 0.697 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_-_1785126 0.696 CTSD
cathepsin D
chr20_-_2821245 0.696 NM_022760
FAM113A
family with sequence similarity 113, member A
chr6_+_160221291 0.695 NM_173516
PNLDC1
poly(A)-specific ribonuclease (PARN)-like domain containing 1
chr8_+_17780510 0.694 PCM1
pericentriolar material 1
chr16_+_1401899 0.693 NM_032520
GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr20_+_56884749 0.691 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr17_-_7137675 0.690 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr14_-_20929484 0.684 TMEM55B
transmembrane protein 55B
chr7_+_99070513 0.679 NM_001013258
NM_213603
ZNF789

zinc finger protein 789

chr5_-_133706717 0.673 CDKL3
cyclin-dependent kinase-like 3
chr12_-_59314069 0.667 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr19_+_1104614 0.666 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr5_+_43603287 0.664 NNT
nicotinamide nucleotide transhydrogenase
chr7_+_150065968 0.659 REPIN1
replication initiator 1
chrX_+_102840412 0.657 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr7_-_27142301 0.656 NM_006735
HOXA2
homeobox A2
chr17_+_48172508 0.654 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chr17_-_79791152 0.653 NM_001093767
NM_207368
FAM195B

family with sequence similarity 195, member B


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 1.38e-04 GO:0044237 cellular metabolic process
5.48 2.27e-03 GO:0007033 vacuole organization
8.77 2.78e-03 GO:0032006 regulation of TOR signaling cascade
1.21 4.34e-03 GO:0008152 metabolic process
4.75 4.73e-03 GO:0006818 hydrogen transport
1.37 6.70e-03 GO:0034641 cellular nitrogen compound metabolic process
1.36 6.72e-03 GO:0006807 nitrogen compound metabolic process
1.81 9.19e-03 GO:0033554 cellular response to stress
1.68 1.50e-02 GO:0008104 protein localization
1.39 1.80e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.54 1.91e-02 GO:0015992 proton transport
1.59 2.19e-02 GO:0033036 macromolecule localization
1.21 2.69e-02 GO:0044238 primary metabolic process
1.35 4.55e-02 GO:0006810 transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.70 6.69e-14 GO:0005773 vacuole
1.17 4.11e-09 GO:0044424 intracellular part
1.24 4.62e-09 GO:0043227 membrane-bounded organelle
3.36 5.07e-09 GO:0000323 lytic vacuole
3.36 5.07e-09 GO:0005764 lysosome
1.17 5.33e-09 GO:0005622 intracellular
4.22 5.93e-09 GO:0044437 vacuolar part
1.24 6.25e-09 GO:0043231 intracellular membrane-bounded organelle
4.27 9.49e-09 GO:0005774 vacuolar membrane
1.21 1.11e-08 GO:0043226 organelle
1.21 2.14e-08 GO:0043229 intracellular organelle
2.60 1.36e-07 GO:0005768 endosome
1.32 1.96e-07 GO:0044444 cytoplasmic part
3.99 4.72e-07 GO:0005769 early endosome
1.33 5.38e-07 GO:0044446 intracellular organelle part
1.32 7.36e-07 GO:0044422 organelle part
1.23 7.91e-07 GO:0005737 cytoplasm
4.04 1.41e-05 GO:0005765 lysosomal membrane
3.94 2.26e-05 GO:0005770 late endosome
2.75 1.12e-04 GO:0010008 endosome membrane
2.73 1.33e-04 GO:0044440 endosomal part
5.10 6.09e-03 GO:0016469 proton-transporting two-sector ATPase complex
7.68 6.24e-03 GO:0033176 proton-transporting V-type ATPase complex
4.47 8.94e-03 GO:0031901 early endosome membrane
4.11 9.35e-03 GO:0031902 late endosome membrane
1.42 1.01e-02 GO:0031090 organelle membrane
1.35 4.99e-02 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 2.67e-04 GO:0005515 protein binding
1.09 3.88e-02 GO:0005488 binding