Motif ID: TP53.p2

Z-value: 1.769


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_75788100.792.0e-02Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_28622624 2.101 NM_001941
NM_024423
DSC3

desmocollin 3

chr6_+_36098261 1.948 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr6_+_36644236 1.909 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr10_+_47746919 1.755 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr15_+_40532034 1.602 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr13_+_37006628 1.323 CCNA1
cyclin A1
chr11_+_706607 1.280 EPS8L2
EPS8-like 2
chr1_-_38412720 1.176 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr19_+_17905935 1.165 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr1_-_38412704 1.158 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr8_-_10587942 1.131 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr10_-_47173917 1.029 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr10_+_5566923 1.028 NM_005185
CALML3
calmodulin-like 3
chr14_+_68086633 1.008 ARG2
arginase, type II
chr2_+_74757127 0.972 HTRA2
HtrA serine peptidase 2
chr2_-_26205437 0.964 NM_002254
KIF3C
kinesin family member 3C
chr2_+_74757116 0.958 HTRA2
HtrA serine peptidase 2
chr1_-_38412725 0.950 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr2_+_74757158 0.949 HTRA2
HtrA serine peptidase 2
chr3_-_12800739 0.939 NM_018306
TMEM40
transmembrane protein 40
chr2_+_74756986 0.937 HTRA2
HtrA serine peptidase 2
chr10_-_105212149 0.856 NM_015916
CALHM2
calcium homeostasis modulator 2
chr10_-_105212022 0.817 CALHM2
calcium homeostasis modulator 2
chr11_-_108464344 0.816 NM_015065
EXPH5
exophilin 5
chr4_-_103422436 0.808


chr13_+_37006408 0.780 NM_001111045
NM_003914
CCNA1

cyclin A1

chr2_-_26205327 0.764 KIF3C
kinesin family member 3C
chr1_+_13910251 0.751 NM_006474
NM_198389
PDPN

podoplanin

chr2_-_110874142 0.750 NM_005434
MALL
mal, T-cell differentiation protein-like
chr17_+_18087091 0.741 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr16_+_57653909 0.727 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr17_+_18086813 0.725 NM_017758
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr16_+_57406398 0.705 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_-_138428477 0.687 NM_022121
PERP
PERP, TP53 apoptosis effector
chr14_+_68086655 0.684 ARG2
arginase, type II
chr8_-_22926406 0.656 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr14_-_23623493 0.643 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chrX_-_15683153 0.635 NM_020665
TMEM27
transmembrane protein 27
chr9_-_138853146 0.629 NM_016172
UBAC1
UBA domain containing 1
chr1_-_10532513 0.621 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr1_+_84764048 0.620 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr16_+_57653649 0.616 GPR56
G protein-coupled receptor 56
chr14_-_103989112 0.599 CKB
creatine kinase, brain
chr5_-_176831385 0.599 F12
coagulation factor XII (Hageman factor)
chr2_+_233734993 0.593 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr22_-_18257194 0.579 BID
BH3 interacting domain death agonist
chr22_+_29168628 0.575 NM_173510
CCDC117
coiled-coil domain containing 117
chr4_+_103422553 0.572 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_-_54872075 0.551 NM_001009955
SSBP3
single stranded DNA binding protein 3
chr2_+_74757243 0.547 HTRA2
HtrA serine peptidase 2
chr16_+_30194730 0.544 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr22_-_18257221 0.542 BID
BH3 interacting domain death agonist
chr18_+_33877630 0.538 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_17905907 0.526 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr14_+_68086570 0.521 NM_001172
ARG2
arginase, type II
chr1_+_234040547 0.514 NM_173508
SLC35F3
solute carrier family 35, member F3
chr14_-_103989195 0.514 NM_001823
CKB
creatine kinase, brain
chr19_-_47735858 0.508 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr8_-_22926490 0.502 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr9_-_138853007 0.501 UBAC1
UBA domain containing 1
chrX_-_109561427 0.497 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr22_+_29168721 0.490 CCDC117
coiled-coil domain containing 117
chr1_-_160068359 0.483 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr1_+_233463513 0.482 NM_032435
KIAA1804
mixed lineage kinase 4
chr5_-_95297424 0.480 ELL2
elongation factor, RNA polymerase II, 2
chr11_+_33279167 0.473 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr22_+_29168679 0.470 CCDC117
coiled-coil domain containing 117
chr10_-_118501981 0.463 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr11_-_59383616 0.439 NM_002556
OSBP
oxysterol binding protein
chr9_-_135996287 0.435 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr4_+_103422479 0.432 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr1_-_1356823 0.430 NM_001145210
NM_001243535
NM_001243536
ANKRD65


ankyrin repeat domain 65


chr12_+_56546203 0.422 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr2_+_163200623 0.418 GCA
grancalcin, EF-hand calcium binding protein
chr1_-_10532603 0.414 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr9_-_116037823 0.412 NM_139286
CDC26
cell division cycle 26 homolog (S. cerevisiae)
chr2_+_47168362 0.406 TTC7A
tetratricopeptide repeat domain 7A
chr9_-_115774471 0.403 NM_001101338
ZNF883
zinc finger protein 883
chr1_+_212781969 0.398 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr1_-_41131323 0.395 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr19_+_15783827 0.392 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr19_+_49458129 0.392 BAX
BCL2-associated X protein
chr8_-_12293895 0.390 FAM86B2
FAM86B1
family with sequence similarity 86, member B2
family with sequence similarity 86, member B1
chr11_+_33279859 0.371 HIPK3
homeodomain interacting protein kinase 3
chr20_-_1373571 0.368 FKBP1A
FK506 binding protein 1A, 12kDa
chr22_+_40766649 0.368 SGSM3
small G protein signaling modulator 3
chr19_-_42928152 0.367 LIPE
lipase, hormone-sensitive
chr16_-_70713927 0.365 MTSS1L
metastasis suppressor 1-like
chr17_-_8021806 0.355 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr19_+_49458151 0.353 BAX
BCL2-associated X protein
chr14_-_92302612 0.353 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr6_-_30712294 0.351 NM_003897
IER3
immediate early response 3
chr19_-_42746678 0.346 GSK3A
glycogen synthase kinase 3 alpha
chr16_-_15149827 0.346 NM_173474
NTAN1
N-terminal asparagine amidase
chr19_-_8809054 0.340 NM_178525
ACTL9
actin-like 9
chr19_+_49458031 0.339 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr5_-_176831183 0.337 F12
coagulation factor XII (Hageman factor)
chr11_+_36397534 0.336 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr6_-_101329006 0.335 ASCC3
activating signal cointegrator 1 complex subunit 3
chr20_+_4129409 0.335 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr6_-_32163299 0.333 NM_022107
GPSM3
G-protein signaling modulator 3
chrX_-_109561314 0.331 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr1_-_160068261 0.329 IGSF8
immunoglobulin superfamily, member 8
chr19_-_17137449 0.329 NM_015692
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr6_+_4776826 0.328 CDYL
chromodomain protein, Y-like
chr1_-_54871978 0.323 NM_018070
NM_145716
SSBP3

single stranded DNA binding protein 3

chr6_+_116692098 0.322 NM_013352
DSE
dermatan sulfate epimerase
chr19_-_42746743 0.322 GSK3A
glycogen synthase kinase 3 alpha
chr12_+_44229851 0.319 NM_032256
TMEM117
transmembrane protein 117
chr1_-_85358851 0.319 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr12_+_104850986 0.317 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_-_52479042 0.316 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr10_-_118765087 0.315 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr8_-_23082572 0.311 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr19_-_19887186 0.310 LOC284440
uncharacterized LOC284440
chr5_+_176513819 0.308 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr1_-_209825673 0.308 NM_001127641
LAMB3
laminin, beta 3
chr8_-_12293806 0.304 NM_001137610
FAM86B2
FAM86B1
family with sequence similarity 86, member B2
family with sequence similarity 86, member B1
chr4_+_85504056 0.297 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr12_+_104850784 0.296 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr22_-_18257160 0.296 BID
BH3 interacting domain death agonist
chr1_+_54519259 0.296 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr12_+_104850762 0.292 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr10_+_124134206 0.291 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_+_34663414 0.289 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr17_-_72869068 0.289 NM_004110
NM_024417
FDXR

ferredoxin reductase

chrX_-_109561298 0.289 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_+_86889768 0.286 NM_006536
CLCA2
chloride channel accessory 2
chr12_+_104850750 0.285 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr2_+_163200582 0.285 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr18_+_57567191 0.284 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr20_-_1373702 0.279 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr21_+_30671736 0.278 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr9_-_104160876 0.277 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr19_-_42746723 0.276 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr10_+_124134093 0.273 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr9_-_112260529 0.272 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr5_-_95297597 0.272 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr16_-_1470709 0.271 C16orf91
chromosome 16 open reading frame 91
chr8_-_12051533 0.271 NM_001083537
FAM86B2
FAM86B1
family with sequence similarity 86, member B2
family with sequence similarity 86, member B1
chr9_-_95896498 0.271 NM_004148
NINJ1
ninjurin 1
chr12_+_56498347 0.270 PA2G4
proliferation-associated 2G4, 38kDa
chr12_+_69202796 0.269 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr17_+_18128868 0.269 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr19_-_42721802 0.266 NM_133328
DEDD2
death effector domain containing 2
chr5_-_112824526 0.266 NM_001085377
MCC
mutated in colorectal cancers
chr5_-_72861376 0.265 NM_023039
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr19_-_4817502 0.263 TICAM1
toll-like receptor adaptor molecule 1
chr9_+_130922471 0.261 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr4_-_48908744 0.261 NM_001014446
NM_152398
OCIAD2

OCIA domain containing 2

chr19_+_35491329 0.259 GRAMD1A
GRAM domain containing 1A
chr8_-_144650998 0.257 C8orf73
chromosome 8 open reading frame 73
chr7_+_43622638 0.255 NM_004760
STK17A
serine/threonine kinase 17a
chr1_+_16085245 0.253 NM_017556
FBLIM1
filamin binding LIM protein 1
chr3_+_23851933 0.252 NM_001202476
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr19_+_56652689 0.252 ZNF444
zinc finger protein 444
chrX_+_152912655 0.251 DUSP9
dual specificity phosphatase 9
chr9_+_22447064 0.250


chr12_+_116997185 0.249 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr20_-_1373744 0.249 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr6_+_42018250 0.245 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_-_159644439 0.244 NM_005038
PPID
peptidylprolyl isomerase D
chr18_+_10454542 0.244 APCDD1
adenomatosis polyposis coli down-regulated 1
chr1_-_85514128 0.244 MCOLN3
mucolipin 3
chr19_+_35607218 0.243 FXYD3
FXYD domain containing ion transport regulator 3
chr19_+_44080951 0.243 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr1_-_209825797 0.243 NM_000228
LAMB3
laminin, beta 3
chr12_+_56498324 0.243 PA2G4
proliferation-associated 2G4, 38kDa
chr19_-_16008870 0.242 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr11_-_3078596 0.242 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr19_+_827821 0.241 NM_001700
AZU1
azurocidin 1
chr1_-_1182101 0.240 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr4_+_6675654 0.237 LOC93622
Morf4 family associated protein 1-like 1 pseudogene
chr2_+_74756531 0.232 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr19_+_45843997 0.232 NM_177417
KLC3
kinesin light chain 3
chrX_-_48828250 0.231 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr6_+_24403144 0.231 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr14_-_94854910 0.230 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_+_125635440 0.230 LOC100125556
family with sequence similarity 86, member A pseudogene
chr3_-_14166292 0.230 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr22_+_18111598 0.228 BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr4_+_6675798 0.227 LOC93622
Morf4 family associated protein 1-like 1 pseudogene
chr22_+_40766563 0.227 NM_015705
SGSM3
small G protein signaling modulator 3
chr19_-_41903226 0.225 NM_020158
EXOSC5
exosome component 5
chr10_-_76859247 0.223 NM_016364
DUSP13
dual specificity phosphatase 13
chr18_+_10454625 0.222 APCDD1
adenomatosis polyposis coli down-regulated 1
chr16_-_31146992 0.221 PRSS8
protease, serine, 8
chr1_+_11796211 0.221 AGTRAP
angiotensin II receptor-associated protein
chr18_+_10454620 0.220 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr16_+_447175 0.219 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr14_+_91580467 0.219 C14orf159
chromosome 14 open reading frame 159
chr6_+_5030202 0.218 LOC100129461
uncharacterized LOC100129461
chr1_-_117210301 0.218 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr12_+_56498334 0.217 PA2G4
proliferation-associated 2G4, 38kDa
chr18_-_44497307 0.216 NM_004671
NM_173206
PIAS2

protein inhibitor of activated STAT, 2

chr12_+_104850641 0.214 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr22_+_40766630 0.213 SGSM3
small G protein signaling modulator 3
chr1_+_3607232 0.213 NM_001126240
NM_001126241
NM_001126242
NM_001204189
NM_001204190
NM_001204191
TP73





tumor protein p73





chr5_-_137071462 0.213 KLHL3
kelch-like 3 (Drosophila)
chr1_-_38412667 0.213 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.69e-06 GO:0044444 cytoplasmic part
1.64 6.20e-06 GO:0005829 cytosol
1.22 2.43e-05 GO:0005737 cytoplasm
1.78 3.31e-05 GO:0005739 mitochondrion
1.13 1.44e-03 GO:0044424 intracellular part
2.20 1.77e-03 GO:0005740 mitochondrial envelope
2.18 3.88e-03 GO:0031966 mitochondrial membrane
1.92 4.35e-03 GO:0044429 mitochondrial part
1.12 5.20e-03 GO:0005622 intracellular
1.16 9.28e-03 GO:0043227 membrane-bounded organelle
1.16 1.15e-02 GO:0043231 intracellular membrane-bounded organelle
1.79 3.02e-02 GO:0031967 organelle envelope
1.76 4.58e-02 GO:0031975 envelope

Nothing significant found in function category.