Motif ID: UUGUUCG

Z-value: 0.424


Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
hsa-miR-375 MIMAT0000728



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_136834887 0.338 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr5_+_95066628 0.292 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr1_+_78956727 0.276 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr8_-_122653493 0.260 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_79086087 0.247 NM_006820
IFI44L
interferon-induced protein 44-like
chr8_+_77593506 0.220 NM_024721
ZFHX4
zinc finger homeobox 4
chrX_+_16964730 0.203 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr1_-_232651227 0.187 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_+_89990396 0.183 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr14_-_30396811 0.178 NM_002742
PRKD1
protein kinase D1
chr2_-_214016332 0.168 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr3_+_148415657 0.167 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr3_+_148447966 0.167 NM_032049
AGTR1
angiotensin II receptor, type 1
chr17_+_38599651 0.163 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_+_90024271 0.159 NM_015350
LRRC8B
leucine rich repeat containing 8 family, member B
chr9_+_4985243 0.155 NM_004972
JAK2
Janus kinase 2
chr7_-_131241321 0.153 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr1_-_57045235 0.131 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_208417635 0.125 NM_025179
PLXNA2
plexin A2
chr10_-_64028457 0.120 NM_145307
RTKN2
rhotekin 2
chr5_-_146833150 0.117 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr5_-_121412805 0.117 NM_001178102
LOX
lysyl oxidase
chr5_-_121414011 0.114 NM_002317
LOX
lysyl oxidase
chr2_-_68547018 0.112 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr5_-_146889618 0.111 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr4_+_56212381 0.109 NM_024592
SRD5A3
steroid 5 alpha-reductase 3
chr8_-_82024277 0.105 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr16_+_2587951 0.105 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr2_-_214015053 0.103 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr9_-_110252045 0.100 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr3_-_169487602 0.099 NM_032487
ARPM1
actin related protein M1
chr5_-_180688095 0.098 NM_032765
TRIM52
tripartite motif containing 52
chr5_-_58334936 0.097 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr8_+_70405027 0.097 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr16_+_4421774 0.093 NM_138440
VASN
vasorin
chr5_+_32710742 0.093 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr5_+_32711437 0.093 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr4_-_157892545 0.091 NM_016205
PDGFC
platelet derived growth factor C
chr11_-_74109417 0.091 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chrX_+_73641084 0.090 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr5_-_127873734 0.089 NM_001999
FBN2
fibrillin 2
chr7_-_47621741 0.089 NM_022748
TNS3
tensin 3
chr5_+_134240752 0.089 NM_032151
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr16_-_12897693 0.089 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr3_+_63850181 0.087 NM_000333
ATXN7
ataxin 7
chr1_+_145524989 0.087 NM_003637
ITGA10
integrin, alpha 10
chr2_-_99347588 0.087 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_-_55521330 0.087 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr3_+_197687070 0.086 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chr4_+_15004297 0.086 NM_001177381
NM_001177382
NM_001177383
NM_001177384
NM_182485
NM_182646
CPEB2





cytoplasmic polyadenylation element binding protein 2





chr3_+_133502876 0.085 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr22_+_31090792 0.083 NM_030758
OSBP2
oxysterol binding protein 2
chr10_+_124768401 0.082 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr13_-_29292961 0.081 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr1_+_78354199 0.080 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr13_-_107187312 0.079 NM_004093
EFNB2
ephrin-B2
chr1_+_213031596 0.079 NM_014053
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr3_-_8811263 0.078 NM_000916
OXTR
oxytocin receptor
chr3_+_156008775 0.076 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr6_-_137113624 0.076 NM_005923
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr3_-_114343791 0.076 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_50800018 0.075 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chr7_-_139477437 0.074 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr7_-_50861114 0.074 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr6_-_132272311 0.073 NM_001901
CTGF
connective tissue growth factor
chr13_+_35516390 0.073 NM_015678
NBEA
neurobeachin
chr8_-_22549901 0.073 NM_001199880
EGR3
early growth response 3
chr3_-_114102488 0.072 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_22550057 0.072 NM_001199881
EGR3
early growth response 3
chrX_-_83757398 0.071 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_162467594 0.070 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chrX_+_70521627 0.070 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr8_-_22550708 0.069 NM_004430
EGR3
early growth response 3
chr12_+_1100352 0.068 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr6_+_101846860 0.068 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr3_-_114790221 0.068 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chrX_+_72782961 0.068 NM_001039840
CHIC1
cysteine-rich hydrophobic domain 1
chr10_+_104503724 0.067 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr7_-_16685360 0.067 NM_020319
ANKMY2
ankyrin repeat and MYND domain containing 2
chr8_+_70378858 0.066 NM_001128204
NM_015170
SULF1

sulfatase 1

chr1_+_110009099 0.066 NM_001040709
SYPL2
synaptophysin-like 2
chr19_+_57078889 0.066 NM_001001668
ZNF470
zinc finger protein 470
chr2_+_133174146 0.065 NM_001508
GPR39
G protein-coupled receptor 39
chr4_+_72204769 0.065 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr11_+_131240370 0.064 NM_001048209
NTM
neurotrimin
chr7_-_50772997 0.064 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr14_+_74486049 0.063 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr2_-_120980971 0.063 NM_024121
TMEM185B
transmembrane protein 185B
chr2_-_99279935 0.063 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_-_58295758 0.062 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_114343052 0.061 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_55095263 0.061 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_+_162466963 0.061 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr3_+_137483133 0.060 NM_004189
SOX14
SRY (sex determining region Y)-box 14
chr3_+_155860750 0.060 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_-_8680382 0.059 NM_014818
TRIM66
tripartite motif containing 66
chr3_-_114478117 0.059 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr11_-_70507911 0.059 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr11_+_108093558 0.059 NM_000051
ATM
ataxia telangiectasia mutated
chr5_-_59783885 0.058 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_62785067 0.058 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr9_-_93405066 0.058 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr11_-_70935807 0.057 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_236445294 0.057 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr7_+_17338182 0.056 NM_001621
AHR
aryl hydrocarbon receptor
chr22_-_41842853 0.056 NM_016272
TOB2
transducer of ERBB2, 2
chr6_-_105584220 0.056 NM_147147
BVES
blood vessel epicardial substance
chr15_-_41047448 0.056 NM_018145
FAM82A2
family with sequence similarity 82, member A2
chr6_+_111580481 0.055 NM_153369
KIAA1919
KIAA1919
chr6_-_105584542 0.054 NM_007073
BVES
blood vessel epicardial substance
chr1_+_77747602 0.054 NM_174858
AK5
adenylate kinase 5
chr2_+_203241044 0.053 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chrX_-_135056132 0.052 NM_173470
MMGT1
membrane magnesium transporter 1
chr5_-_59189620 0.052 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_125633716 0.052 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr19_-_7293876 0.052 NM_000208
NM_001079817
INSR

insulin receptor

chr10_+_104535887 0.052 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr9_-_135230358 0.052 NM_015046
SETX
senataxin
chr15_+_91643429 0.052 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chrX_-_153640358 0.051 NM_001009932
NM_001009933
NM_001009934
DNASE1L1


deoxyribonuclease I-like 1


chr15_+_62359175 0.051 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr1_+_77748286 0.051 NM_012093
AK5
adenylate kinase 5
chr12_-_63546589 0.051 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr3_-_52719514 0.050 NM_018313
PBRM1
polybromo 1
chr11_+_12695851 0.050 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chrX_-_153637503 0.049 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr1_+_62902325 0.049 NM_003368
USP1
ubiquitin specific peptidase 1
chr10_+_104613966 0.049 NM_001136200
NM_144591
C10orf32-AS3MT
C10orf32

C10orf32-AS3MT readthrough
chromosome 10 open reading frame 32

chr2_+_46926323 0.049 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr13_-_36788665 0.048 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr14_+_55034329 0.048 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr17_-_6554842 0.048 NM_016060
MED31
mediator complex subunit 31
chr8_-_116681103 0.048 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr1_+_62901974 0.048 NM_001017415
NM_001017416
USP1

ubiquitin specific peptidase 1

chr7_+_66093854 0.048 NM_001167961
NM_153033
KCTD7

potassium channel tetramerisation domain containing 7

chr3_-_114866090 0.048 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_134001749 0.048 NM_032826
SLC35B4
solute carrier family 35, member B4
chr8_-_11058847 0.047 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr2_-_166060552 0.047 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr2_+_149632772 0.047 NM_004522
KIF5C
kinesin family member 5C
chr17_-_49198084 0.046 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr2_+_46926049 0.046 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr7_-_86688944 0.046 NM_001142749
KIAA1324L
KIAA1324-like
chr11_+_131780537 0.046 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr8_-_94753211 0.045 NM_203390
RBM12B
RNA binding motif protein 12B
chr17_+_4046417 0.045 NM_144611
CYB5D2
cytochrome b5 domain containing 2
chr8_+_96037186 0.045 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr3_+_155838336 0.044 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr5_-_90679115 0.044 NM_020801
ARRDC3
arrestin domain containing 3
chr6_+_34482646 0.044 NM_001199583
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr6_+_126102278 0.044 NM_001199619
NM_001199620
NCOA7

nuclear receptor coactivator 7

chr12_+_14927269 0.044 NM_177925
H2AFJ
H2A histone family, member J
chr1_-_241799101 0.044 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr13_-_45775174 0.044 NM_198404
KCTD4
potassium channel tetramerisation domain containing 4
chr16_+_12995454 0.043 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr5_-_145562235 0.043 NM_020117
LARS
leucyl-tRNA synthetase
chr5_-_59064437 0.043 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_164253946 0.043 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr17_-_1613661 0.043 NM_001164407
TLCD2
TLC domain containing 2
chr6_-_35696359 0.042 NM_001145775
FKBP5
FK506 binding protein 5
chr10_-_30024594 0.042 NM_003174
SVIL
supervillin
chr12_-_39299335 0.042 NM_153634
CPNE8
copine VIII
chr1_-_160313353 0.042 NM_001098398
NM_004371
COPA

coatomer protein complex, subunit alpha

chr3_+_179370779 0.042 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr12_+_26126687 0.042 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_231114617 0.042 NM_001122835
NM_024525
TTC13

tetratricopeptide repeat domain 13

chr7_+_155089483 0.041 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr1_-_173793776 0.041 NM_001127181
NM_033319
CENPL

centromere protein L

chr17_+_64298844 0.041 NM_002737
PRKCA
protein kinase C, alpha
chr19_-_50316360 0.041 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr6_-_105584982 0.040 NM_001199563
BVES
blood vessel epicardial substance
chr7_+_11013453 0.040 NM_014660
PHF14
PHD finger protein 14
chr1_+_2160133 0.040 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr6_+_34433849 0.040 NM_020804
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr3_-_52713728 0.039 NM_018165
NM_181042
PBRM1

polybromo 1

chr3_-_151047309 0.039 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr9_-_21335239 0.039 NM_018847
KLHL9
kelch-like 9 (Drosophila)
chr17_-_60142598 0.039 NM_005121
MED13
mediator complex subunit 13
chr7_-_102715014 0.039 NM_145032
FBXL13
F-box and leucine-rich repeat protein 13
chr11_-_105892908 0.039 NM_032424
KIAA1826
KIAA1826
chr2_+_25016174 0.039 NM_001199803
NM_024322
CENPO

centromere protein O

chr6_+_86159301 0.039 NM_001204813
NM_002526
NT5E

5'-nucleotidase, ecto (CD73)

chr2_+_223725675 0.038 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr15_-_101792125 0.038 NM_014918
CHSY1
chondroitin sulfate synthase 1
chr9_+_35161950 0.038 NM_006377
UNC13B
unc-13 homolog B (C. elegans)
chr1_-_173793268 0.037 NM_001171182
CENPL
centromere protein L
chr15_+_81071708 0.037 NM_018689
KIAA1199
KIAA1199
chr17_+_46908371 0.037 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr7_-_102715171 0.037 NM_001111038
FBXL13
F-box and leucine-rich repeat protein 13
chr3_+_63953419 0.036 NM_001128149
ATXN7
ataxin 7
chr11_-_68609358 0.036 NM_001031847
NM_001876
CPT1A

carnitine palmitoyltransferase 1A (liver)

chr15_+_39542884 0.036 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr17_-_58469577 0.035 NM_032582
USP32
ubiquitin specific peptidase 32
chr14_-_95623665 0.035 NM_177438
DICER1
dicer 1, ribonuclease type III
chr1_-_152332481 0.035 NM_001014342
FLG2
filaggrin family member 2
chr8_+_106331146 0.035 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr2_+_242641310 0.035 NM_032329
ING5
inhibitor of growth family, member 5
chr15_+_57210823 0.035 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr8_-_57123858 0.034 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr2_-_198650937 0.034 NM_197970
BOLL
bol, boule-like (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 7.90e-04 GO:0007275 multicellular organismal development
1.44 1.80e-03 GO:0032502 developmental process
1.53 4.37e-03 GO:0009889 regulation of biosynthetic process
1.44 5.26e-03 GO:0080090 regulation of primary metabolic process
1.52 7.66e-03 GO:0031326 regulation of cellular biosynthetic process
1.42 1.11e-02 GO:0031323 regulation of cellular metabolic process
2.09 1.13e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 1.32e-02 GO:0043412 macromolecule modification
2.16 1.43e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.48 1.54e-02 GO:0048731 system development
1.81 1.67e-02 GO:0031325 positive regulation of cellular metabolic process
11.13 1.72e-02 GO:0060322 head development
1.62 1.98e-02 GO:0006464 protein modification process
1.70 2.31e-02 GO:0009653 anatomical structure morphogenesis
1.77 2.35e-02 GO:0009893 positive regulation of metabolic process
2.31 2.75e-02 GO:0031175 neuron projection development
1.42 2.79e-02 GO:0060255 regulation of macromolecule metabolic process
13.91 2.81e-02 GO:0060323 head morphogenesis
1.95 2.82e-02 GO:0009891 positive regulation of biosynthetic process
1.80 2.91e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.51 3.52e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.50 3.66e-02 GO:0010556 regulation of macromolecule biosynthetic process
3.58 3.71e-02 GO:0001655 urogenital system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 2.49e-02 GO:0005622 intracellular
3.16 4.32e-02 GO:0045121 membrane raft
1.56 4.32e-02 GO:0012505 endomembrane system

Gene overrepresentation in function category:

enrichment   p-value GO term description
13.91 6.05e-03 GO:0043548 phosphatidylinositol 3-kinase binding