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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ARNT
Z-value: 0.70
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Transcription factors associated with ARNT
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT | hg19_v2_chr1_-_150849208_150849244 | -0.83 | 1.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARNT
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_55163075 | 0.44 |
ENST00000571629.1 ENST00000570423.1 ENST00000575186.1 ENST00000573085.1 ENST00000572814.1 |
AKAP1 |
A kinase (PRKA) anchor protein 1 |
| chr17_+_55162453 | 0.44 |
ENST00000575322.1 ENST00000337714.3 ENST00000314126.3 |
AKAP1 |
A kinase (PRKA) anchor protein 1 |
| chr17_-_2614927 | 0.43 |
ENST00000435359.1 |
CLUH |
clustered mitochondria (cluA/CLU1) homolog |
| chr11_+_72929402 | 0.34 |
ENST00000393596.2 |
P2RY2 |
purinergic receptor P2Y, G-protein coupled, 2 |
| chr11_+_72929319 | 0.33 |
ENST00000393597.2 ENST00000311131.2 |
P2RY2 |
purinergic receptor P2Y, G-protein coupled, 2 |
| chr2_+_173420697 | 0.31 |
ENST00000282077.3 ENST00000392571.2 ENST00000410055.1 |
PDK1 |
pyruvate dehydrogenase kinase, isozyme 1 |
| chr1_+_92495528 | 0.31 |
ENST00000370383.4 |
EPHX4 |
epoxide hydrolase 4 |
| chr3_-_71834318 | 0.31 |
ENST00000353065.3 |
PROK2 |
prokineticin 2 |
| chr22_+_40390930 | 0.30 |
ENST00000333407.6 |
FAM83F |
family with sequence similarity 83, member F |
| chr6_+_43739697 | 0.30 |
ENST00000230480.6 |
VEGFA |
vascular endothelial growth factor A |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 0.7 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 0.5 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.5 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.1 | 0.4 | GO:0086021 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) |
| 0.1 | 0.4 | GO:0015862 | uridine transport(GO:0015862) |
| 0.1 | 0.4 | GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway(GO:0097411) |
| 0.1 | 0.4 | GO:1903750 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.0 | 0.4 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.4 | GO:0015691 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.5 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.1 | 0.3 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.1 | 0.3 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.3 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.3 | GO:0034709 | methylosome(GO:0034709) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.7 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 0.5 | GO:0072510 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.0 | 0.5 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.4 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.4 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.0 | 0.4 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 0.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.5 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 0.4 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |