Motif ID: ESRRA.p2

Z-value: 1.366


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha



Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_540849 3.122 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr19_+_1358531 1.892 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr19_+_1358664 1.711 DAZAP1
DAZ associated protein 1
chr1_+_29086206 1.579 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_+_1358604 1.475 DAZAP1
DAZ associated protein 1
chr15_+_38520594 1.409 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr1_+_29086156 1.401 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr5_+_271447 1.397 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr12_+_131577229 1.389 NM_001142641
FBRSL1
fibrosin-like 1
chr5_+_271428 1.351 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_1358750 1.346 DAZAP1
DAZ associated protein 1
chr19_+_59796858 1.345 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr5_+_271441 1.344 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_+_39124534 1.254 NM_002062
GLP1R
glucagon-like peptide 1 receptor
chr1_+_151147646 1.230 NM_005547
IVL
involucrin
chr5_+_271355 1.227 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_+_34314545 1.209 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_+_44726635 1.183 NM_001123376
TMEM72
transmembrane protein 72
chr5_+_38481392 1.111 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr19_-_4468715 1.109 NM_001080400
PLIN4
perilipin 4
chr1_+_55237193 1.097 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr1_-_19089971 1.087 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr6_+_44076281 1.077 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr22_+_29151651 1.073 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr11_-_64284762 1.049 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr1_+_29011240 1.045 NM_000911
OPRD1
opioid receptor, delta 1
chr22_-_24088523 1.029 NM_182492
LRP5L
low density lipoprotein receptor-related protein 5-like
chr22_+_22703107 1.020 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr17_-_70367479 1.017 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr10_+_80777248 0.987 PPIF
peptidylprolyl isomerase F
chr8_+_145221973 0.963 CYC1
cytochrome c-1
chr10_+_80777265 0.945 PPIF
peptidylprolyl isomerase F
chr16_-_65510230 0.943 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr1_+_15955719 0.939 FBLIM1
filamin binding LIM protein 1
chr7_+_45580704 0.917 ADCY1
adenylate cyclase 1 (brain)
chr17_+_7549138 0.916 NM_001406
EFNB3
ephrin-B3
chr1_+_29113589 0.912 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr16_-_73842884 0.906 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr16_+_55456619 0.903 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr14_-_104507862 0.902 AHNAK2
AHNAK nucleoprotein 2
chr7_+_45580606 0.897 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr11_-_780103 0.891 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr19_+_45807909 0.842


chrX_+_69371229 0.832 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr22_+_38903825 0.831 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr9_-_116190038 0.827 AKNA
AT-hook transcription factor
chr11_-_780065 0.818 CEND1
cell cycle exit and neuronal differentiation 1
chr3_+_130730171 0.813 NM_000539
RHO
rhodopsin
chr15_+_41597097 0.801 NM_002373
MAP1A
microtubule-associated protein 1A
chr7_+_97679501 0.798 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr7_-_158304062 0.792 ESYT2
extended synaptotagmin-like protein 2
chr15_+_62991106 0.780 NM_182703
ANKDD1A
ankyrin repeat and death domain containing 1A
chr5_-_271235 0.760 NM_145265
CCDC127
coiled-coil domain containing 127
chr2_-_128792515 0.750 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr1_-_150065176 0.727 NM_001001523
RORC
RAR-related orphan receptor C
chr7_+_116238309 0.723 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr19_+_1199548 0.716 NM_177401
MIDN
midnolin
chr11_+_65815940 0.706 NM_153266
TMEM151A
transmembrane protein 151A
chr2_+_119905812 0.698 NM_183240
TMEM37
transmembrane protein 37
chr6_+_37081387 0.698 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr11_+_65140207 0.693 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chr12_+_6846955 0.686 TPI1
triosephosphate isomerase 1
chr12_+_6846844 0.686 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr8_-_139995417 0.683 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr19_+_3136860 0.676 NM_020170
NCLN
nicalin
chr1_+_151655623 0.671 NM_176823
S100A7A
S100 calcium binding protein A7A
chr1_+_226337425 0.648 NM_001024227
NM_001024228
ARF1

ADP-ribosylation factor 1

chr14_-_105245959 0.648 IGHA1
immunoglobulin heavy constant alpha 1
chr19_-_60360768 0.645 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr11_-_18704294 0.643 NM_173588
IGSF22
immunoglobulin superfamily, member 22
chr22_+_48740432 0.634 PIM3
pim-3 oncogene
chr3_-_42719322 0.630 NM_020707
HHATL
hedgehog acyltransferase-like
chr9_+_37640996 0.629 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chrX_+_48505097 0.616 NM_001080489
GLOD5
glyoxalase domain containing 5
chr8_+_145221924 0.616 NM_001916
CYC1
cytochrome c-1
chr9_-_130006309 0.616 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr22_+_18485145 0.612 RANBP1
RAN binding protein 1
chr20_+_39402834 0.612 NM_022896
LPIN3
lipin 3
chr14_+_99220349 0.609 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr8_+_145221966 0.599 CYC1
cytochrome c-1
chr8_-_145099963 0.595 NM_201379
PLEC
plectin
chr16_-_65984836 0.595 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr12_+_103677388 0.593 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_121233615 0.593 NM_001098519
LRRC43
leucine rich repeat containing 43
chr11_+_65815911 0.587 TMEM151A
transmembrane protein 151A
chr14_+_104523660 0.583 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr15_+_73281288 0.582 C15orf39
chromosome 15 open reading frame 39
chr1_+_38032045 0.580 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr17_-_34014390 0.577 SRCIN1
SRC kinase signaling inhibitor 1
chr20_-_61600834 0.564 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chrX_-_13744933 0.564 GPM6B
glycoprotein M6B
chr7_+_138859213 0.560 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr9_-_129719031 0.553 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr17_-_70430839 0.549 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr19_-_54250808 0.548 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr19_+_2200112 0.545 NM_000479
AMH
anti-Mullerian hormone
chr17_-_31332568 0.545 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_7734034 0.545 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr22_+_18485095 0.541 RANBP1
RAN binding protein 1
chr3_+_180805266 0.538 NM_002492
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr22_+_18485076 0.536 RANBP1
RAN binding protein 1
chr1_-_1679940 0.535 NM_001198995
NADK
NAD kinase
chr10_+_80777234 0.535 PPIF
peptidylprolyl isomerase F
chr15_+_73281286 0.533 C15orf39
chromosome 15 open reading frame 39
chr16_+_658081 0.530 NM_138769
RHOT2
ras homolog gene family, member T2
chr2_-_128149112 0.530 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr9_+_130005429 0.528 NM_001005336
NM_004408
DNM1

dynamin 1

chr9_+_130005489 0.527 DNM1
dynamin 1
chr10_+_75427853 0.527 NM_003373
NM_014000
VCL

vinculin

chr10_+_80777199 0.526 NM_005729
PPIF
peptidylprolyl isomerase F
chr9_+_130005487 0.525 DNM1
dynamin 1
chr17_-_8756524 0.524 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr6_-_2785682 0.520 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr22_+_18484810 0.512 NM_002882
RANBP1
RAN binding protein 1
chr15_+_73281249 0.510 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr3_-_180805104 0.510 NM_020409
NM_177988
MRPL47

mitochondrial ribosomal protein L47

chr1_+_32530294 0.507 NM_004964
HDAC1
histone deacetylase 1
chr1_+_243384868 0.503 NM_018012
KIF26B
kinesin family member 26B
chr7_+_97748959 0.502 BRI3
brain protein I3
chr4_+_7096123 0.502 TADA2B
transcriptional adaptor 2B
chr1_+_32530298 0.500 HDAC1
histone deacetylase 1
chr1_+_32530289 0.495 HDAC1
histone deacetylase 1
chr1_+_9338531 0.484


chr19_+_44308224 0.484 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr19_+_17923110 0.480 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr12_+_119360274 0.476 NM_004373
COX6A1
cytochrome c oxidase subunit VIa polypeptide 1
chr14_-_102045849 0.474 NM_152326
ANKRD9
ankyrin repeat domain 9
chr4_+_7245218 0.473 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr3_+_9720509 0.472 NM_153635
CPNE9
copine family member IX
chr10_-_97190885 0.471 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr16_+_66464492 0.469 NM_014329
EDC4
enhancer of mRNA decapping 4
chr15_-_38417564 0.468 C15orf52
chromosome 15 open reading frame 52
chr19_+_4134350 0.461 NM_133475
ANKRD24
ankyrin repeat domain 24
chr19_+_59866217 0.450 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr3_-_51971915 0.447 NM_033010
PCBP4
poly(rC) binding protein 4
chrX_-_53002900 0.447 NM_014138
FAM156A
family with sequence similarity 156, member A
chr13_+_112349358 0.446 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr22_+_28032950 0.445 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr22_+_18485068 0.435 RANBP1
RAN binding protein 1
chr14_+_69021149 0.433 NM_001161498
UPF0639
UPF0639 protein
chr7_-_100630912 0.427 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr13_+_97856148 0.426


chr16_+_4370879 0.422 VASN
vasorin
chr7_+_150413814 0.418 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_13263334 0.418 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr19_+_54238913 0.417 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr19_-_1464187 0.413 NM_213604
ADAMTSL5
ADAMTS-like 5
chr16_+_658158 0.413 RHOT2
ras homolog gene family, member T2
chr14_-_102045749 0.409 ANKRD9
ankyrin repeat domain 9
chr11_+_67554653 0.409 NM_002496
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_33110668 0.405 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr4_-_40212670 0.405 NM_019027
RBM47
RNA binding motif protein 47
chr19_+_59297953 0.403 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr16_+_30844707 0.402 FBXL19
F-box and leucine-rich repeat protein 19
chr2_-_172675873 0.401 DLX2
distal-less homeobox 2
chr2_-_27339278 0.401 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr17_+_45008473 0.401 NXPH3
neurexophilin 3
chr17_+_45778381 0.398 NM_022167
XYLT2
xylosyltransferase II
chr19_+_38867273 0.398 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr19_-_12028126 0.394 NM_001080404
ZNF878
zinc finger protein 878
chr11_+_43920385 0.394 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr16_-_2663375 0.391


chr19_+_2279679 0.390 SPPL2B
signal peptide peptidase-like 2B
chr22_+_35586950 0.388 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_20269239 0.388 NM_000929
PLA2G5
phospholipase A2, group V
chr15_-_76210611 0.386 NM_006383
CIB2
calcium and integrin binding family member 2
chr5_+_176807931 0.386 NM_001174102
PRR7
proline rich 7 (synaptic)
chr20_-_45848684 0.385 NM_001161841
NM_198596
SULF2

sulfatase 2

chr16_+_2528022 0.384 PDPK1
3-phosphoinositide dependent protein kinase-1
chr4_-_1827475 0.382 NM_012318
LETM1
leucine zipper-EF-hand containing transmembrane protein 1
chr11_+_1817294 0.381 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr20_-_1922393 0.380 NM_001190900
PDYN
prodynorphin
chr20_-_3696344 0.378 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr19_+_2279685 0.378 SPPL2B
signal peptide peptidase-like 2B
chrX_-_44087778 0.378 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr1_+_17719405 0.377 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_75769514 0.374 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr1_+_234625338 0.372 NM_080738
EDARADD
EDAR-associated death domain
chr16_+_4614820 0.372 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr19_-_1463997 0.371 ADAMTSL5
ADAMTS-like 5
chr16_+_2528001 0.370 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_+_36773605 0.370 RAB44
RAB44, member RAS oncogene family
chr1_-_13484119 0.366 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr17_+_77289775 0.365 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr9_-_137992967 0.364 NM_016172
UBAC1
UBA domain containing 1
chr22_+_18485057 0.363 RANBP1
RAN binding protein 1
chr8_-_131098015 0.360 FAM49B
family with sequence similarity 49, member B
chr16_+_2527952 0.359 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chrX_+_152682772 0.359 NM_001163257
NM_005393
PLXNB3

plexin B3

chr17_+_35075124 0.357 NM_003673
TCAP
titin-cap (telethonin)
chr16_+_4614959 0.352 MGRN1
mahogunin, ring finger 1
chr19_+_62434188 0.352 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr8_-_145090892 0.351 NM_201381
PLEC
plectin
chr17_-_45619038 0.347 COL1A1
collagen, type I, alpha 1
chr3_-_10003512 0.344 NM_018447
TMEM111
transmembrane protein 111
chr22_-_43040063 0.343 NM_001099294
KIAA1644
KIAA1644
chr1_-_202726068 0.343 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr11_+_111462821 0.342 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr11_+_66381077 0.342 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr13_+_113587674 0.341 GAS6
growth arrest-specific 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 2.07e-06 GO:0006810 transport
2.55 3.98e-06 GO:0006091 generation of precursor metabolites and energy
3.95 5.65e-06 GO:0045333 cellular respiration
1.46 7.55e-06 GO:0051234 establishment of localization
4.40 1.38e-05 GO:0022904 respiratory electron transport chain
2.80 2.63e-05 GO:0015980 energy derivation by oxidation of organic compounds
1.89 3.44e-05 GO:0055114 oxidation-reduction process
3.61 7.27e-05 GO:0022900 electron transport chain
1.37 2.13e-04 GO:0051179 localization
2.15 8.00e-03 GO:0008610 lipid biosynthetic process
4.72 1.10e-02 GO:0006119 oxidative phosphorylation
4.82 2.19e-02 GO:0042773 ATP synthesis coupled electron transport
4.82 2.19e-02 GO:0042775 mitochondrial ATP synthesis coupled electron transport
5.21 2.61e-02 GO:0006941 striated muscle contraction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.54 2.46e-14 GO:0005743 mitochondrial inner membrane
3.31 2.98e-13 GO:0019866 organelle inner membrane
2.48 3.85e-12 GO:0044429 mitochondrial part
2.83 4.62e-12 GO:0005740 mitochondrial envelope
2.86 6.56e-12 GO:0031966 mitochondrial membrane
2.16 2.75e-08 GO:0031975 envelope
2.17 2.96e-08 GO:0031967 organelle envelope
1.74 7.87e-07 GO:0005739 mitochondrion
3.95 9.54e-07 GO:0044455 mitochondrial membrane part
4.96 9.34e-06 GO:0070469 respiratory chain
1.24 6.74e-05 GO:0044444 cytoplasmic part
4.74 1.19e-04 GO:0005746 mitochondrial respiratory chain
1.17 3.26e-04 GO:0005737 cytoplasm
1.17 1.05e-03 GO:0016020 membrane
3.16 2.61e-03 GO:0030016 myofibril
3.34 3.57e-03 GO:0030017 sarcomere
2.98 6.21e-03 GO:0043292 contractile fiber
3.07 6.68e-03 GO:0044449 contractile fiber part
1.38 8.57e-03 GO:0031090 organelle membrane
1.19 1.86e-02 GO:0044422 organelle part
1.17 3.10e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.20 7.04e-04 GO:0030246 carbohydrate binding
1.80 2.29e-03 GO:0016491 oxidoreductase activity
2.61 3.68e-03 GO:0005529 sugar binding