Motif ID: MTF1.p2

Z-value: 1.886


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1



Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_1704661 4.896 NM_001080488
 ONECUT3
one cut homeobox 3
chr16_-_87535106 3.214 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr20_-_60228665 2.964 NM_007232
 HRH3
histamine receptor H3
chr14_+_105012106 2.944 NM_001312
 CRIP2
cysteine-rich protein 2
chr17_+_72880967 2.651 SEPT9
septin 9
chr2_-_128792515 2.559 NM_004807
 HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr2_+_232281491 2.533 PTMA
prothymosin, alpha
chr2_+_120820140 2.518 NM_002193
 INHBB
inhibin, beta B
chr6_+_41622267 2.341 FOXP4
forkhead box P4
chr2_+_241156776 2.286 NM_018226
 RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr9_+_125813849 2.284 LHX2
LIM homeobox 2
chr12_+_130878870 2.097 NM_016155
 MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr16_+_1143738 2.006 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr20_-_60484420 1.978 NM_080473
 GATA5
GATA binding protein 5
chr12_+_55896844 1.939 NM_007224
 NXPH4
neurexophilin 4
chr7_+_1239078 1.917 NM_001080461
 UNCX
UNC homeobox
chr16_+_49139694 1.894 NM_033119
 NKD1
naked cuticle homolog 1 (Drosophila)
chr1_-_6402467 1.866 NM_019089
 HES2
hairy and enhancer of split 2 (Drosophila)
chr11_+_119887630 1.862 LOC100293636
GRIK4
hypothetical protein LOC100293636
glutamate receptor, ionotropic, kainate 4
chr1_+_2149993 1.803 NM_003036
 SKI
v-ski sarcoma viral oncogene homolog (avian)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 164 entries
enrichment   p-value GO term description
2.40 2.01e-03 GO:0050768 negative regulation of neurogenesis
2.28 1.05e-03 GO:0010721 negative regulation of cell development
2.14 5.46e-03 GO:0050769 positive regulation of neurogenesis
2.11 3.14e-04 GO:0010720 positive regulation of cell development
2.09 1.15e-02 GO:0008016 regulation of heart contraction
1.90 9.60e-05 GO:0030155 regulation of cell adhesion
1.90 4.76e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.88 6.35e-03 GO:0022604 regulation of cell morphogenesis
1.83 2.05e-06 GO:0050767 regulation of neurogenesis
1.83 4.89e-03 GO:0045165 cell fate commitment
1.83 1.21e-02 GO:0016055 Wnt receptor signaling pathway
1.82 4.22e-04 GO:0014070 response to organic cyclic compound
1.80 6.15e-08 GO:0060284 regulation of cell development
1.80 3.53e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.77 3.36e-06 GO:0051960 regulation of nervous system development
1.77 4.08e-03 GO:0030900 forebrain development
1.76 1.64e-05 GO:0045596 negative regulation of cell differentiation
1.75 2.19e-03 GO:0032582 negative regulation of gene-specific transcription
1.74 6.29e-07 GO:0007411 axon guidance
1.73 2.23e-03 GO:0045664 regulation of neuron differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
2.32 1.91e-02 GO:0017053 transcriptional repressor complex
1.83 2.87e-02 GO:0005925 focal adhesion
1.68 1.90e-02 GO:0005912 adherens junction
1.66 6.83e-03 GO:0044297 cell body
1.65 1.06e-02 GO:0043025 neuronal cell body
1.63 2.73e-02 GO:0070161 anchoring junction
1.53 6.05e-05 GO:0045202 synapse
1.50 8.35e-03 GO:0044456 synapse part
1.46 2.24e-02 GO:0005578 proteinaceous extracellular matrix
1.44 1.07e-02 GO:0031012 extracellular matrix
1.40 2.82e-02 GO:0043005 neuron projection
1.32 3.60e-02 GO:0030054 cell junction
1.21 2.77e-02 GO:0005654 nucleoplasm
1.20 3.41e-03 GO:0031981 nuclear lumen
1.17 8.47e-03 GO:0044459 plasma membrane part
1.17 1.59e-02 GO:0044428 nuclear part
1.15 4.52e-02 GO:0070013 intracellular organelle lumen
1.11 9.17e-04 GO:0044422 organelle part
1.10 1.74e-03 GO:0044446 intracellular organelle part
1.09 8.33e-06 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.91 2.78e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.73 1.63e-02 GO:0022843 voltage-gated cation channel activity
1.71 1.45e-03 GO:0005244 voltage-gated ion channel activity
1.71 1.45e-03 GO:0022832 voltage-gated channel activity
1.67 1.79e-03 GO:0000975 regulatory region DNA binding
1.67 1.79e-03 GO:0001067 regulatory region nucleic acid binding
1.67 1.79e-03 GO:0044212 transcription regulatory region DNA binding
1.67 3.10e-03 GO:0010843 promoter binding
1.59 2.69e-04 GO:0016564 transcription repressor activity
1.54 7.72e-03 GO:0005261 cation channel activity
1.52 2.20e-08 GO:0043565 sequence-specific DNA binding
1.52 4.09e-03 GO:0022836 gated channel activity
1.47 2.89e-02 GO:0016563 transcription activator activity
1.45 1.60e-09 GO:0001071 nucleic acid binding transcription factor activity
1.45 1.60e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 1.16e-04 GO:0004672 protein kinase activity
1.41 3.88e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.41 2.91e-02 GO:0022838 substrate-specific channel activity
1.41 3.03e-02 GO:0015267 channel activity
1.40 2.22e-02 GO:0004674 protein serine/threonine kinase activity