Motif ID: RXRG_dimer.p3

Z-value: 1.603


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma



Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_161725172 2.964 TANK
TRAF family member-associated NFKB activator
chr20_+_37024383 2.754 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr20_+_30409649 2.746 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr1_+_61320213 2.585 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr13_+_99539269 2.319 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr6_+_144040751 2.318 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr3_+_37259684 2.265 NM_001172713
NM_002078
GOLGA4

golgin A4

chr12_+_65949631 2.202 CAND1
cullin-associated and neddylation-dissociated 1
chr11_+_86426518 2.040 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr2_+_206732859 1.894 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr12_+_65949414 1.891 CAND1
cullin-associated and neddylation-dissociated 1
chr20_+_36095621 1.831


chr2_+_219141761 1.818 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr20_+_36095263 1.795 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr12_+_65949327 1.777 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr6_+_142510108 1.755 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_+_142510094 1.755 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_-_219141199 1.724 NM_020935
USP37
ubiquitin specific peptidase 37
chr6_+_142510075 1.645 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_159021653 1.634 PKP4
plakophilin 4
chr9_+_114182216 1.630 HSDL2
hydroxysteroid dehydrogenase like 2
chr2_+_119841611 1.490 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr2_+_108432008 1.484 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr9_+_114182009 1.482 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr20_+_36095552 1.450 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr2_+_108604111 1.438 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_206732575 1.400 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr20_-_36095236 1.391 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr2_+_219141546 1.386 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_108432097 1.349 GCC2
GRIP and coiled-coil domain containing 2
chr10_+_103995297 1.330 NM_004193
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr2_+_73294852 1.318 NM_006062
SMYD5
SMYD family member 5
chr4_+_109761170 1.314 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr6_+_142510034 1.302 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_206732562 1.263 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr2_+_220007943 1.179 NM_005876
SPEG
SPEG complex locus
chr20_+_19981157 1.163 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr2_-_177965626 1.147 LOC100130691
hypothetical LOC100130691
chr16_+_30617962 1.089 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr2_+_201691664 1.067 CFLAR
CASP8 and FADD-like apoptosis regulator
chr10_+_103995248 1.051 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr2_-_206732348 1.032 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr12_+_94776836 1.023 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr2_-_175754366 1.018 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr12_+_67489063 1.009 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr2_+_177965617 0.973 NM_003659
AGPS
alkylglycerone phosphate synthase
chr2_+_218992053 0.965 NM_007127
VIL1
villin 1
chr11_+_117948301 0.964 NM_001142281
NM_001655
ARCN1

archain 1

chr12_+_94776901 0.961 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr3_+_142587973 0.929


chr11_+_117948350 0.917 ARCN1
archain 1
chr2_-_198072805 0.893 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_+_101263989 0.890


chr20_-_19981005 0.869 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr10_-_21854616 0.858 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr1_-_101263867 0.850 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr2_-_198072767 0.835 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_-_114947681 0.832 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_219354692 0.824 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr10_+_102722275 0.797 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr2_+_201691513 0.766 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr14_+_49157150 0.763 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr7_-_139409989 0.756 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr17_+_35532994 0.738 MSL1
male-specific lethal 1 homolog (Drosophila)
chr2_+_119841298 0.722 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr5_+_92944680 0.699 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_-_139632870 0.682 C9orf37
chromosome 9 open reading frame 37
chr5_-_14717703 0.680 LOC728178
hypothetical protein LOC728178
chr2_+_198072965 0.680 NM_002157
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr2_-_159021201 0.675 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr6_-_39801088 0.674 NM_145027
KIF6
kinesin family member 6
chr2_+_198073257 0.664 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr1_+_144439069 0.656 NM_002614
PDZK1
PDZ domain containing 1
chr2_+_138438277 0.650 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr17_-_8138849 0.631 NM_201520
SLC25A35
solute carrier family 25, member 35
chr16_+_31105579 0.611


chr5_+_14717803 0.610 FAM105B
family with sequence similarity 105, member B
chr6_-_146327238 0.608 SHPRH
SNF2 histone linker PHD RING helicase
chr8_+_96106362 0.602 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr3_-_152173475 0.597 NM_001195794
NM_174878
CLRN1

clarin 1

chr2_-_64099935 0.590 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr2_+_198073358 0.589 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr14_-_20642214 0.588


chr12_+_105692466 0.585 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr10_+_119796324 0.583 CASC2
cancer susceptibility candidate 2
chr5_+_14717764 0.581 NM_138348
FAM105B
family with sequence similarity 105, member B
chr17_+_7474128 0.570 SHBG
sex hormone-binding globulin
chr4_+_140806536 0.564 MGST2
microsomal glutathione S-transferase 2
chr18_+_45594326 0.562


chr3_-_114947330 0.547 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_26422495 0.534 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr2_-_219742950 0.532 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr5_+_80292313 0.527 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr2_-_198072868 0.522 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_+_54708302 0.522 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_-_8139330 0.519 SLC25A35
solute carrier family 25, member 35
chr20_+_43943254 0.509 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr17_+_7474177 0.492 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr1_-_120285753 0.485 NOTCH2
notch 2
chr11_+_117735558 0.482 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr19_+_54708312 0.482 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr18_+_52469559 0.479 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr1_-_76170563 0.460 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr15_-_80342045 0.456 EFTUD1
elongation factor Tu GTP binding domain containing 1
chr12_-_52407470 0.455 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr18_-_50004458 0.454 MBD2
methyl-CpG binding domain protein 2
chr14_-_30927931 0.449 NM_015473
HEATR5A
HEAT repeat containing 5A
chr2_+_177965734 0.433 AGPS
alkylglycerone phosphate synthase
chr15_+_80342156 0.421 NM_001008226
FAM154B
family with sequence similarity 154, member B
chr20_+_42593849 0.421 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr6_+_7052798 0.419 NM_001168344
RREB1
ras responsive element binding protein 1
chr14_+_23937766 0.417 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr8_+_22479115 0.417 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr2_+_86521781 0.414 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr7_-_65084641 0.401 GUSB
glucuronidase, beta
chr22_-_49413326 0.398 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr14_+_94693744 0.386 FLJ45244
hypothetical locus FLJ45244
chr2_-_198073242 0.384 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_-_27966715 0.383 NM_022128
RBKS
ribokinase
chr15_-_80342131 0.380 NM_001040610
NM_024580
EFTUD1

elongation factor Tu GTP binding domain containing 1

chr6_+_31731647 0.379 NM_019101
APOM
apolipoprotein M
chr4_+_91035025 0.379 NM_007351
MMRN1
multimerin 1
chr14_-_94693359 0.376 DICER1
dicer 1, ribonuclease type III
chr7_-_65084597 0.375 GUSB
glucuronidase, beta
chr7_-_65084622 0.368 GUSB
glucuronidase, beta
chr9_+_103335983 0.368 RNF20
ring finger protein 20
chr6_-_146327155 0.361 SHPRH
SNF2 histone linker PHD RING helicase
chr7_-_106991941 0.358 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr1_+_78126787 0.352 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr1_+_36169260 0.350 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr15_+_94674849 0.347 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_-_146326918 0.340 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr2_-_27457088 0.340 NM_144631
ZNF513
zinc finger protein 513
chr6_+_31731667 0.336 APOM
apolipoprotein M
chr19_+_41980248 0.331 LOC284408
hypothetical LOC284408
chr7_-_72574528 0.328 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr17_+_1592893 0.326 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr11_+_116205830 0.320 NM_000040
APOC3
apolipoprotein C-III
chr5_+_132237253 0.316 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr7_-_65084668 0.316 NM_000181
GUSB
glucuronidase, beta
chr18_-_45594206 0.315 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr20_+_43919662 0.315 NM_080752
ZSWIM3
zinc finger, SWIM-type containing 3
chr4_+_140806371 0.311 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr22_-_40194602 0.302 NM_032758
PHF5A
PHD finger protein 5A
chr20_-_32363268 0.298 NM_001161766
AHCY
adenosylhomocysteinase
chr22_+_28493351 0.297 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr1_-_111771877 0.294 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr1_+_45046740 0.287 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr1_-_154147787 0.281 NM_006912
RIT1
Ras-like without CAAX 1
chr12_+_67291016 0.280 RAP1B
RAP1B, member of RAS oncogene family
chr22_+_40195058 0.279 NM_001098
ACO2
aconitase 2, mitochondrial
chr15_-_54997964 0.277 LOC145783
hypothetical LOC145783
chr19_+_56452775 0.275 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr12_+_48422220 0.272 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr15_-_98091143 0.270 NM_152449
LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr15_+_54998144 0.270 TCF12
transcription factor 12
chr1_+_210525885 0.268 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr12_+_67290951 0.264 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr20_+_55569542 0.263 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr15_+_54998115 0.255 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr1_-_159306037 0.251 ARHGAP30
Rho GTPase activating protein 30
chr9_+_103335964 0.246 RNF20
ring finger protein 20
chr1_+_210525792 0.245 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr7_+_100450080 0.244 NM_001040105
MUC17
mucin 17, cell surface associated
chr10_-_62431203 0.244 RHOBTB1
Rho-related BTB domain containing 1
chr18_-_50004770 0.243 MBD2
methyl-CpG binding domain protein 2
chr5_-_42847716 0.241 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr13_+_31211678 0.240 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr11_+_85690900 0.239 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr20_-_43919360 0.233 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr13_-_69580459 0.232 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr16_+_31446703 0.231 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr10_+_120957084 0.223 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr12_-_117295095 0.220 NM_016281
TAOK3
TAO kinase 3
chr12_-_117294933 0.213 TAOK3
TAO kinase 3
chr1_+_195123766 0.213 NM_006684
CFHR4
complement factor H-related 4
chr2_-_24160683 0.212 TP53I3
tumor protein p53 inducible protein 3
chr6_+_127006298 0.211 LOC728666
PRELI domain containing 1 pseudogene
chr17_+_1592879 0.208 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr17_+_38403935 0.207 NM_000988
RPL27
ribosomal protein L27
chr1_+_148603769 0.204 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr6_-_146326863 0.204 SHPRH
SNF2 histone linker PHD RING helicase
chr13_+_20612709 0.199 SAP18
Sin3A-associated protein, 18kDa
chr22_-_43271843 0.197 LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr6_+_30632641 0.196 PRR3
proline rich 3
chr12_+_67290881 0.195 NM_001010942
NM_015646
RAP1B

RAP1B, member of RAS oncogene family

chr9_+_73954237 0.195 GDA
guanine deaminase
chr6_+_143813472 0.194 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr11_+_117735530 0.193 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr6_-_2696152 0.191 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr11_+_117735529 0.191 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr18_+_27852785 0.191 RNF125
ring finger protein 125
chr22_-_43272100 0.190 LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr19_+_54708247 0.189 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_+_54400979 0.186 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_+_113018989 0.182 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_67290975 0.179 RAP1B
RAP1B, member of RAS oncogene family
chr12_+_67290977 0.178 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr9_+_73954206 0.177 GDA
guanine deaminase
chr15_-_98091118 0.172 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.23 2.43e-03 GO:0005740 mitochondrial envelope
3.71 5.14e-03 GO:0005743 mitochondrial inner membrane
2.12 6.37e-03 GO:0005739 mitochondrion
2.63 1.01e-02 GO:0044429 mitochondrial part
3.41 1.29e-02 GO:0019866 organelle inner membrane
3.00 1.78e-02 GO:0031966 mitochondrial membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
26.90 3.27e-02 GO:0003706 ligand-regulated transcription factor activity