Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.677


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_78520634-0.514.5e-02Click!
AHRchr7_+_173047070.495.6e-02Click!
ARNTchr1_-_149115771-0.371.6e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_203208064 4.451 NM_173511
 FAM117B
family with sequence similarity 117, member B
chr20_+_30409649 4.348 NM_001164603
NM_015338
 ASXL1

additional sex combs like 1 (Drosophila)

chr18_+_75760434 4.035


chr6_+_43846735 4.030 VEGFA
vascular endothelial growth factor A
chr2_+_203208456 3.635 FAM117B
family with sequence similarity 117, member B
chr5_+_151131655 3.280 NM_005754
NM_198395
 G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr17_+_69939806 3.272 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr5_+_151131709 3.162 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131853 3.052 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131707 3.042 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131704 2.938 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131676 2.782 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr20_+_30410447 2.599 ASXL1
additional sex combs like 1 (Drosophila)
chr20_+_41519947 2.472 SRSF6
serine/arginine-rich splicing factor 6
chr17_+_69939130 2.436 NM_022036
 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr8_+_126079929 2.384 SQLE
squalene epoxidase
chr2_+_203207912 2.246 FAM117B
family with sequence similarity 117, member B
chr2_+_26110232 1.979 NM_016131
 RAB10
RAB10, member RAS oncogene family
chr10_-_105442868 1.959 SH3PXD2A
SH3 and PX domains 2A
chr20_+_11819364 1.946 NM_181443
 BTBD3
BTB (POZ) domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 131 entries
enrichment   p-value GO term description
3.52 4.24e-02 GO:0030850 prostate gland development
2.78 2.44e-03 GO:0021915 neural tube development
2.68 3.15e-02 GO:0048638 regulation of developmental growth
2.30 1.33e-04 GO:0035270 endocrine system development
2.29 2.27e-03 GO:0045165 cell fate commitment
2.20 3.24e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.17 2.30e-02 GO:0031016 pancreas development
2.12 6.85e-03 GO:0030900 forebrain development
2.06 1.09e-09 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.03 3.87e-03 GO:0043193 positive regulation of gene-specific transcription
1.98 3.31e-02 GO:0048732 gland development
1.97 3.38e-11 GO:0045893 positive regulation of transcription, DNA-dependent
1.96 9.39e-03 GO:0002009 morphogenesis of an epithelium
1.95 1.21e-11 GO:0051254 positive regulation of RNA metabolic process
1.93 2.78e-11 GO:0010628 positive regulation of gene expression
1.92 4.18e-04 GO:0060284 regulation of cell development
1.89 2.77e-02 GO:0003002 regionalization
1.88 1.47e-11 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.88 1.03e-02 GO:0045596 negative regulation of cell differentiation
1.87 2.83e-03 GO:0048729 tissue morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.50 7.50e-03 GO:0000790 nuclear chromatin
2.24 4.04e-03 GO:0016607 nuclear speck
2.02 2.57e-04 GO:0016604 nuclear body
1.69 6.35e-05 GO:0030529 ribonucleoprotein complex
1.68 4.42e-07 GO:0044451 nucleoplasm part
1.66 1.12e-13 GO:0005654 nucleoplasm
1.60 1.91e-16 GO:0031981 nuclear lumen
1.54 3.52e-17 GO:0043233 organelle lumen
1.54 3.62e-17 GO:0070013 intracellular organelle lumen
1.53 3.41e-17 GO:0031974 membrane-enclosed lumen
1.52 8.16e-15 GO:0044428 nuclear part
1.52 2.98e-02 GO:0005730 nucleolus
1.43 2.02e-02 GO:0031988 membrane-bounded vesicle
1.29 5.86e-17 GO:0005634 nucleus
1.29 7.50e-04 GO:0005829 cytosol
1.24 2.24e-11 GO:0044446 intracellular organelle part
1.24 7.80e-11 GO:0044422 organelle part
1.24 1.90e-05 GO:0032991 macromolecular complex
1.21 3.43e-19 GO:0043231 intracellular membrane-bounded organelle
1.21 5.57e-19 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
3.02 1.35e-02 GO:0003743 translation initiation factor activity
2.05 2.07e-02 GO:0003714 transcription corepressor activity
2.01 2.58e-06 GO:0016563 transcription activator activity
1.79 3.27e-04 GO:0005525 GTP binding
1.74 1.12e-03 GO:0019001 guanyl nucleotide binding
1.74 1.12e-03 GO:0032561 guanyl ribonucleotide binding
1.69 1.39e-08 GO:0003723 RNA binding
1.68 3.50e-02 GO:0016564 transcription repressor activity
1.66 4.02e-06 GO:0043565 sequence-specific DNA binding
1.61 2.14e-08 GO:0030528 transcription regulator activity
1.56 9.20e-07 GO:0001071 nucleic acid binding transcription factor activity
1.56 9.20e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 2.27e-14 GO:0003676 nucleic acid binding
1.39 6.90e-09 GO:0000166 nucleotide binding
1.33 2.11e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.32 4.22e-04 GO:0032553 ribonucleotide binding
1.32 4.22e-04 GO:0032555 purine ribonucleotide binding
1.31 2.01e-05 GO:0003677 DNA binding
1.31 6.85e-04 GO:0017076 purine nucleotide binding
1.24 3.87e-18 GO:0005515 protein binding