Motif ID: PBX1.p2

Z-value: 1.019


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_1630847070.562.5e-02Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_20510312 3.082 NM_004040
RHOB
ras homolog gene family, member B
chr5_+_162797149 1.693 NM_004060
NM_199246
CCNG1

cyclin G1

chr2_+_191453792 1.300 GLS
glutaminase
chr2_+_191453791 1.271 NM_014905
GLS
glutaminase
chr2_+_191454036 1.267 GLS
glutaminase
chr2_+_191453813 1.218 GLS
glutaminase
chr14_+_54104383 1.199 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr2_+_191454157 1.196 GLS
glutaminase
chr7_+_106596641 1.048 NM_012257
HBP1
HMG-box transcription factor 1
chr14_+_23008742 1.033 NGDN
neuroguidin, EIF4E binding protein
chr14_+_64041257 1.025 ZBTB1
zinc finger and BTB domain containing 1
chr2_+_44249487 0.963 NM_001033556
NM_001033557
NM_002706
NM_177968
NM_177969
PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr2_+_44249565 0.868 PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr2_+_241944333 0.868 NM_014808
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr16_+_15503623 0.853 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr13_+_96726415 0.846 MBNL2
muscleblind-like 2 (Drosophila)
chr14_+_23008723 0.841 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr13_+_96726197 0.813 MBNL2
muscleblind-like 2 (Drosophila)
chr5_+_151131655 0.769 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr5_+_151131676 0.726 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr4_+_169250281 0.701 NM_007193
ANXA10
annexin A10
chr5_+_151131709 0.699 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr3_+_122109716 0.695 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr20_-_45410033 0.681 ZMYND8
zinc finger, MYND-type containing 8
chr12_+_77782719 0.663 SYT1
synaptotagmin I
chr5_+_151131704 0.656 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr1_+_13948518 0.656 PRDM2
PR domain containing 2, with ZNF domain
chr1_+_13948504 0.654 PRDM2
PR domain containing 2, with ZNF domain
chr5_+_151131707 0.642 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr12_+_63090008 0.635 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr20_+_56369012 0.633


chr20_+_56455866 0.623 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_13948448 0.617 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr5_-_178977441 0.594 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_+_149763187 0.591 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr21_+_37661063 0.582 DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr11_+_95163457 0.581 CEP57
centrosomal protein 57kDa
chr11_+_113671744 0.570 NM_006169
NNMT
nicotinamide N-methyltransferase
chr19_+_12064077 0.555 ZNF788
zinc finger family member 788
chr4_+_86968069 0.547 ARHGAP24
Rho GTPase activating protein 24
chr1_-_58920315 0.533


chr5_+_151131853 0.510 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr18_+_58005519 0.508 KIAA1468
KIAA1468
chr13_-_45577144 0.503 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr18_-_58005159 0.499 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr17_+_43539909 0.499 NM_152244
NM_013323
SNX11

sorting nexin 11

chr11_+_95163256 0.493 NM_014679
CEP57
centrosomal protein 57kDa
chr17_+_43480724 0.487 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr16_+_24459173 0.487 RBBP6
retinoblastoma binding protein 6
chr15_+_39363442 0.486 LOC729082
hypothetical LOC729082
chr14_+_23654161 0.483 DCAF11
DDB1 and CUL4 associated factor 11
chr17_+_43480674 0.481 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr17_+_43480723 0.476 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr13_-_109236897 0.476 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_58005494 0.463 NM_020854
KIAA1468
KIAA1468
chr18_-_58005195 0.462 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr11_-_7804094 0.461 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr20_+_11846536 0.443 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr18_-_58005209 0.441 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr2_+_238540361 0.438 UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr2_+_238540411 0.435 UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr9_+_112470871 0.435 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr1_-_147665783 0.430 HIST2H2BF
histone cluster 2, H2bf
chr3_-_21767819 0.427 NM_024697
ZNF385D
zinc finger protein 385D
chr3_+_173951163 0.421 ECT2
epithelial cell transforming sequence 2 oncogene
chr16_+_3433606 0.419 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr3_+_52545660 0.415 NM_001124767
C3orf78
chromosome 3 open reading frame 78
chr16_+_67778441 0.412 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr18_-_58005268 0.409 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr10_+_115514567 0.407 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr2_+_28469850 0.406 FOSL2
FOS-like antigen 2
chr18_+_42780784 0.406 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr3_+_138063764 0.400 NCK1
NCK adaptor protein 1
chr2_+_62786290 0.400 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr17_+_43540124 0.393 SNX11
sorting nexin 11
chr7_-_77163475 0.391


chr2_-_154043403 0.389 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr20_+_186376 0.388 NM_207469
DEFB132
defensin, beta 132
chr5_+_90711887 0.383 LOC100129716
hypothetical LOC100129716
chr16_-_3433490 0.382 NM_152457
ZNF597
zinc finger protein 597
chr12_+_21546012 0.381 GOLT1B
golgi transport 1B
chr13_+_78953258 0.378 NM_001161407
NM_019080
NDFIP2

Nedd4 family interacting protein 2

chr8_-_79880095 0.378 NM_000880
IL7
interleukin 7
chr12_+_21545965 0.374 NM_016072
GOLT1B
golgi transport 1B
chr14_-_75196911 0.372 C14orf1
chromosome 14 open reading frame 1
chr2_+_238540428 0.369 NM_080678
UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr12_+_21059896 0.367 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr12_+_28301399 0.366 NM_018318
CCDC91
coiled-coil domain containing 91
chr4_+_74499651 0.365 ALB
albumin
chr2_-_192767844 0.363 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr1_+_148603613 0.360 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr12_-_21545751 0.354 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr5_+_147562531 0.348 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr8_+_99145925 0.346 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr6_+_111302679 0.345 NM_001634
NM_001033059
AMD1

adenosylmethionine decarboxylase 1

chr14_+_74030195 0.344 NM_194279
ISCA2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr17_-_8034071 0.342 C17orf59
chromosome 17 open reading frame 59
chr3_-_88190737 0.342 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr6_-_32892705 0.340 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_79995927 0.339 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr19_+_54067450 0.339 NM_014330
PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr19_+_54067489 0.339 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr4_-_70115037 0.338 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr2_+_208284484 0.336 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr1_-_150398327 0.330 NM_001122965
RPTN
repetin
chr14_+_57834962 0.329 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr14_+_36200867 0.328 PAX9
paired box 9
chr2_-_21079145 0.327 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_113495763 0.323 NM_183061
SLC9A10
solute carrier family 9, member 10
chr7_+_77163665 0.320 NM_198467
RSBN1L
round spermatid basic protein 1-like
chr17_-_8034217 0.317 NM_017622
C17orf59
chromosome 17 open reading frame 59
chr14_+_57835028 0.317 ARID4A
AT rich interactive domain 4A (RBP1-like)
chr6_+_54281161 0.317 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr19_+_54067491 0.316 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr16_-_70306198 0.313 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr4_-_186537145 0.312 NM_018409
LRP2BP
LRP2 binding protein
chr9_+_73716189 0.312 NM_182505
C9orf85
chromosome 9 open reading frame 85
chr3_+_138063697 0.310 NM_006153
NCK1
NCK adaptor protein 1
chr2_-_63518589 0.310 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr13_+_51933228 0.309 CKAP2
cytoskeleton associated protein 2
chr11_-_30562324 0.306 MPPED2
metallophosphoesterase domain containing 2
chr20_-_604443 0.302


chr18_+_30327243 0.300 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr1_+_148603208 0.297 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr13_-_60887655 0.293 NM_022843
PCDH20
protocadherin 20
chr9_-_83494198 0.289 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr8_+_98857190 0.289 LAPTM4B
lysosomal protein transmembrane 4 beta
chr14_+_22860511 0.288 PABPN1
poly(A) binding protein, nuclear 1
chr2_+_162908828 0.288 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr5_-_58607673 0.287 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_25679197 0.287


chr1_+_60053050 0.285 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr5_+_145807059 0.282 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr1_+_224317036 0.281 NM_002107
H3F3A
H3 histone, family 3A
chr14_+_22860547 0.281 PABPN1
poly(A) binding protein, nuclear 1
chr16_+_65868913 0.277 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr14_+_95071136 0.277 GLRX5
glutaredoxin 5
chr13_-_47510033 0.276 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr10_+_63331401 0.275 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_36074812 0.274 NM_152349
KRT222
keratin 222
chr12_-_10853940 0.273 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr1_+_149493861 0.268 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr2_+_208284610 0.266 CCNYL1
cyclin Y-like 1
chr13_-_60887210 0.263 PCDH20
protocadherin 20
chr2_+_208284691 0.263 CCNYL1
cyclin Y-like 1
chr12_+_52960745 0.260 NM_002136
NM_031157
HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr14_+_75197409 0.259 TTLL5
tubulin tyrosine ligase-like family, member 5
chr1_+_25629968 0.259 NM_018202
TMEM57
transmembrane protein 57
chr17_+_16225117 0.256 UBB
ubiquitin B
chr1_+_157526127 0.255 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr6_-_26343139 0.254 NM_005320
HIST1H1D
histone cluster 1, H1d
chr2_-_144768529 0.252 NM_001006636
GTDC1
glycosyltransferase-like domain containing 1
chr3_+_195336625 0.252 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr5_+_44844724 0.250 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr16_-_70339666 0.249 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr14_-_103251497 0.248 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chr18_+_30427279 0.248 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr9_-_73715927 0.246 NM_001025780
NM_016014
FAM108B1

family with sequence similarity 108, member B1

chr3_+_214668 0.242


chr11_-_5916424 0.242 TRIM5
tripartite motif containing 5
chr18_-_55177430 0.241 NM_005570
LMAN1
lectin, mannose-binding, 1
chr2_-_192767494 0.241 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr12_+_12761085 0.241 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr14_-_57834558 0.239 FLJ31306
hypothetical LOC379025
chr10_-_108448990 0.239 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr9_+_79158164 0.237 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr17_+_16225130 0.236


chr11_-_102174032 0.232 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_+_22646229 0.231 NM_177553
GAS2
growth arrest-specific 2
chr6_-_130224108 0.230 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr2_+_105834635 0.229 NM_001004720
NCK2
NCK adaptor protein 2
chr2_-_95846109 0.228 LOC150759
hypothetical LOC150759
chr14_-_99016959 0.228 NM_032233
NM_199123
SETD3

SET domain containing 3

chr14_+_61532293 0.227 NM_031914
SYT16
synaptotagmin XVI
chr17_+_16225133 0.225 UBB
ubiquitin B
chr2_+_28469864 0.224 FOSL2
FOS-like antigen 2
chr14_+_75197303 0.223 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr14_+_99017485 0.222 NM_001099402
CCNK
cyclin K
chr14_+_36200815 0.222 PAX9
paired box 9
chr5_-_147191428 0.221 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr14_-_23653965 0.220 NRL
neural retina leucine zipper
chr17_+_16225075 0.219 NM_018955
UBB
ubiquitin B
chr10_+_17310263 0.219 NM_003380
VIM
vimentin
chr15_+_43036194 0.217 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr3_+_161040343 0.213 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr1_-_42574116 0.212 NM_001198850
FOXJ3
forkhead box J3
chr2_-_179380301 0.211 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr11_-_105398118 0.210 NM_032424
KIAA1826
KIAA1826
chr3_-_184300031 0.209 NM_020166
MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr3_+_173240126 0.208 FNDC3B
fibronectin type III domain containing 3B
chr13_+_78953367 0.208 NDFIP2
Nedd4 family interacting protein 2
chr4_+_141514251 0.208 SCOC
short coiled-coil protein
chr3_+_157877146 0.207 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr2_+_162908869 0.207 GCA
grancalcin, EF-hand calcium binding protein
chr8_-_68037378 0.206 NM_001193502
TCF24
transcription factor 24
chr1_+_224317056 0.206 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr12_+_77782648 0.206 SYT1
synaptotagmin I
chr2_-_108972100 0.203 NM_022336
EDAR
ectodysplasin A receptor
chr14_+_75197345 0.202 TTLL5
tubulin tyrosine ligase-like family, member 5
chr15_-_35180656 0.202 NM_002399
MEIS2
Meis homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 1.88e-02 GO:0071842 cellular component organization at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 3.91e-03 GO:0043233 organelle lumen
1.46 7.91e-03 GO:0031974 membrane-enclosed lumen
1.46 1.20e-02 GO:0070013 intracellular organelle lumen
1.14 4.19e-02 GO:0043229 intracellular organelle
1.58 4.22e-02 GO:0005654 nucleoplasm

Nothing significant found in function category.