Motif ID: RREB1.p2

Z-value: 4.720


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_7052798-0.449.2e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_191232653 10.822 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135343649 10.235 NM_012147
DUX2
double homeobox 2
chr10_+_135333667 8.990 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135330357 8.836 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191235959 8.638 NM_001177376
DUX4L4
double homeobox 4 like 4
chr4_-_809879 8.053 NM_006651
CPLX1
complexin 1
chr4_+_191239247 7.910 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191229360 7.730 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr14_+_104244998 7.668 INF2
inverted formin, FH2 and WH2 domain containing
chr4_+_191226073 7.578 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr1_-_30977931 7.270 LAPTM5
lysosomal protein transmembrane 5
chr19_+_540849 7.194 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_-_96924582 6.380 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr4_+_191242540 5.613 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_56984702 5.324 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr1_+_1066138 5.320


chr20_-_61574259 5.293 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr21_+_42946719 5.215 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr2_-_128149112 5.171 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr1_+_1940605 4.880 NM_000815
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr8_+_145461356 4.320 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr2_+_72998111 4.255 NM_004097
EMX1
empty spiracles homeobox 1
chrX_+_151617900 4.093 NM_005363
NM_175868
MAGEA6

melanoma antigen family A, 6

chr20_-_26137755 3.975 LOC284801
hypothetical protein LOC284801
chr11_-_404975 3.932 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_+_945331 3.931 NM_198576
AGRN
agrin
chr4_+_191245840 3.798 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_+_40213431 3.582 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr8_-_145119627 3.499 NM_201378
PLEC
plectin
chrX_+_151633730 3.494 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr20_-_47618059 3.473 NM_000961
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr11_+_66939720 3.444 NM_001166222
NM_020811
CARNS1

carnosine synthase 1

chr9_+_138997265 3.412 NM_207510
LCNL1
lipocalin-like 1
chr20_+_44070946 3.390 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr19_+_54786723 3.386 NM_020719
PRR12
proline rich 12
chrX_+_148671394 3.377 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr7_+_100111689 3.337 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chrX_-_135161185 3.324 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr3_-_50515857 3.279 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr17_-_75427644 3.263 NM_003655
CBX4
chromobox homolog 4
chr16_+_2068186 3.207 TSC2
tuberous sclerosis 2
chr2_-_218551786 3.182 TNS1
tensin 1
chr10_-_103525646 3.052 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr14_+_105012106 3.051 NM_001312
CRIP2
cysteine-rich protein 2
chr1_+_3378030 3.047 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr20_-_62151216 3.016 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr19_+_45996881 3.009 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chrX_-_100759562 3.005 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr9_+_129962292 2.949 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr7_-_100331417 2.945 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr17_-_44047299 2.908 NM_024016
HOXB8
homeobox B8
chr12_-_131816604 2.907 ANKLE2
ankyrin repeat and LEM domain containing 2
chr3_-_48607596 2.868 NM_000094
COL7A1
collagen, type VII, alpha 1
chrX_+_119379967 2.847 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr22_+_48966394 2.843 TRABD
TraB domain containing
chr1_+_945399 2.840


chr9_+_138341752 2.836 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr12_-_7153068 2.806 NM_016546
C1RL
complement component 1, r subcomponent-like
chr1_+_945472 2.796 AGRN
agrin
chr14_+_102458745 2.741 NM_030943
AMN
amnionless homolog (mouse)
chr10_-_135000464 2.739 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr16_-_53520208 2.651 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr11_-_1731273 2.649


chr22_+_49333327 2.627 NM_138433
KLHDC7B
kelch domain containing 7B
chr2_+_233443237 2.618 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr17_-_60208083 2.580 LOC146880
hypothetical LOC146880
chr11_+_359723 2.570 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr21_+_43985728 2.568 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr2_+_20729904 2.536 NM_182828
GDF7
growth differentiation factor 7
chrX_-_39841599 2.518 NM_001123385
NM_017745
BCOR

BCL6 corepressor

chr2_-_128149800 2.501 LIMS2
LIM and senescent cell antigen-like domains 2
chr12_+_4253143 2.466 NM_001759
CCND2
cyclin D2
chr22_+_48966480 2.447 NM_025204
TRABD
TraB domain containing
chr3_-_12983959 2.429 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr12_+_52665196 2.427 NM_017409
HOXC10
homeobox C10
chr1_-_1525309 2.411 LOC643988
hypothetical LOC643988
chr22_-_30929463 2.404 NM_001098527
RFPL2
ret finger protein-like 2
chr10_-_98935652 2.398 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr18_+_75261231 2.395 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr17_+_71975224 2.385 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr8_-_145530639 2.382 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr8_-_41624030 2.321 NM_152568
NKX6-3
NK6 homeobox 3
chrX_+_46967360 2.317 NM_001170460
CDK16
cyclin-dependent kinase 16
chr10_-_135000358 2.304 CALY
calcyon neuron-specific vesicular protein
chr9_+_139006663 2.300 NM_183241
C9orf142
chromosome 9 open reading frame 142
chr11_-_1007140 2.283 MUC6
mucin 6, oligomeric mucus/gel-forming
chr19_+_12995782 2.278 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_7891884 2.277 SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr8_+_145393450 2.274 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr11_-_8695974 2.257 ST5
suppression of tumorigenicity 5
chr19_-_7896974 2.247 NM_206833
CTXN1
cortexin 1
chrX_+_134383533 2.210 NCRNA00086
non-protein coding RNA 86
chrX_-_153534951 2.204 NM_020994
NM_172377
CTAG2

cancer/testis antigen 2

chr4_-_154929657 2.199 NM_003013
SFRP2
secreted frizzled-related protein 2
chr7_+_45163891 2.197 NM_005856
RAMP3
receptor (G protein-coupled) activity modifying protein 3
chr7_+_100111712 2.190 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr11_-_72031083 2.187 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr8_-_144583718 2.186 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr21_-_45173061 2.155 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_-_185578621 2.143 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr9_+_138760432 2.124 LOC100128593
hypothetical LOC100128593
chr11_-_76058542 2.116 NM_005512
LRRC32
leucine rich repeat containing 32
chr11_+_183079 2.106 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr17_+_72982919 2.104 NM_001113495
SEPT9
septin 9
chr1_+_18830086 2.089 NM_001135254
NM_002584
NM_013945
PAX7


paired box 7


chr21_+_44699796 2.068 NM_030891
LRRC3
leucine rich repeat containing 3
chr14_+_104267270 2.058 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr19_+_45996940 2.055 EGLN2
egl nine homolog 2 (C. elegans)
chr11_+_10283171 2.049 NM_001124
ADM
adrenomedullin
chr10_-_88116181 2.036 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr8_+_144870482 2.035 NM_139021
MAPK15
mitogen-activated protein kinase 15
chrX_-_74062005 2.021 NM_001008537
KIAA2022
KIAA2022
chr4_+_995395 2.009 FGFRL1
fibroblast growth factor receptor-like 1
chr11_+_279113 2.002 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr7_+_5609416 2.000 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_+_2975590 1.996 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr21_+_44560779 1.994 PFKL
phosphofructokinase, liver
chrX_+_102471769 1.980 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr14_+_104261578 1.972 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr7_-_4965270 1.939 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr6_+_33486750 1.937 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr9_+_76302071 1.927 NM_006914
RORB
RAR-related orphan receptor B
chr19_+_659766 1.922 NM_001040134
NM_002579
PALM

paralemmin

chr19_+_811615 1.916 CFD
complement factor D (adipsin)
chr19_-_51168396 1.914 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr12_+_130878870 1.913 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr17_-_45562112 1.897 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr4_+_995609 1.895 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr22_-_49240594 1.864 SBF1
SET binding factor 1
chr17_+_35751796 1.864 NM_001024809
RARA
retinoic acid receptor, alpha
chr9_-_129564517 1.863 NM_001142532
NM_001142531
SH2D3C

SH2 domain containing 3C

chr11_-_133786935 1.859 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr11_-_66961709 1.858 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_-_60557875 1.858 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr16_+_1062756 1.856 NM_001172560
SSTR5
somatostatin receptor 5
chr9_-_139068269 1.848 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr18_+_42168180 1.843 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chr17_+_58908152 1.836 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr17_+_39741306 1.835 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chrX_-_148476903 1.832 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr19_+_54299686 1.831 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr8_-_82916982 1.827 NM_022133
NM_152836
NM_152837
SNX16


sorting nexin 16


chr9_+_132529801 1.821 NM_021619
PRDM12
PR domain containing 12
chr19_+_60487345 1.821 NM_032430
BRSK1
BR serine/threonine kinase 1
chr7_-_44331544 1.808 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr1_-_200879203 1.803 NM_001136504
SYT2
synaptotagmin II
chr19_-_1989937 1.801 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr22_+_28446288 1.792 NM_182527
CABP7
calcium binding protein 7
chrX_-_137621492 1.787 NM_004114
FGF13
fibroblast growth factor 13
chr19_+_1055007 1.787 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr4_-_109308893 1.780 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr1_+_968522 1.779 AGRN
agrin
chr10_-_98935570 1.776 SLIT1
slit homolog 1 (Drosophila)
chr22_+_17337970 1.774 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chrX_+_151975518 1.774 PNMA3
paraneoplastic antigen MA3
chr15_+_72687765 1.770 NM_003992
CLK3
CDC-like kinase 3
chr1_-_47468029 1.764 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr19_+_13111072 1.756 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr8_-_145725289 1.756 C8orf82
chromosome 8 open reading frame 82
chr11_-_1006736 1.753 MUC6
mucin 6, oligomeric mucus/gel-forming
chr17_-_6400470 1.752 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr19_+_60691671 1.752 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr5_-_1397941 1.750 NM_030782
CLPTM1L
CLPTM1-like
chr17_+_62391216 1.727 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr19_-_360138 1.719 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr11_+_566482 1.707 NM_020901
PHRF1
PHD and ring finger domains 1
chr8_-_139995417 1.705 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr15_+_38430517 1.695 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr3_-_42719322 1.692 NM_020707
HHATL
hedgehog acyltransferase-like
chr19_-_15421761 1.691 NM_021241
WIZ
widely interspaced zinc finger motifs
chr21_-_43368963 1.687 NM_000071
CBS
cystathionine-beta-synthase
chr11_+_45863774 1.687 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr9_-_100510657 1.685 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chrX_+_51944658 1.683 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chr11_+_124539768 1.678 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr22_+_35777561 1.672 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr1_-_16812274 1.666 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr19_+_1055614 1.664 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr12_+_52634950 1.663 NM_173860
HOXC12
homeobox C12
chr11_+_63864263 1.661 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr7_-_75794919 1.658 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr12_+_6179736 1.653 NM_001769
CD9
CD9 molecule
chr19_+_13924318 1.650 NM_138353
DCAF15
DDB1 and CUL4 associated factor 15
chr17_+_75507750 1.647


chr4_-_8180278 1.641 ABLIM2
actin binding LIM protein family, member 2
chr1_-_1465602 1.634 NM_001114748
C1orf70
chromosome 1 open reading frame 70
chr2_+_218833982 1.623 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr7_+_73341640 1.619 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr7_-_101906311 1.619 NM_006234
POLR2J2
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr10_-_103589586 1.618 NM_173194
KCNIP2
Kv channel interacting protein 2
chr17_-_44010543 1.612 NM_024015
HOXB4
homeobox B4
chr14_-_64508547 1.609 NM_198686
RAB15
RAB15, member RAS onocogene family
chr12_+_6807831 1.607 NM_014262
LEPREL2
leprecan-like 2
chr16_+_1143738 1.606 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr17_-_44058612 1.605 NM_024017
HOXB9
homeobox B9
chrX_+_151975421 1.603 NM_013364
PNMA3
paraneoplastic antigen MA3
chr6_+_32515596 1.600 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chrX_-_99778340 1.592 NM_003270
TSPAN6
tetraspanin 6
chr9_-_129729518 1.592 NM_173492
PIP5KL1
phosphatidylinositol-4-phosphate 5-kinase-like 1
chrX_+_23262905 1.592 NM_173495
PTCHD1
patched domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.51 6.50e-17 GO:0007399 nervous system development
1.34 3.60e-16 GO:0048731 system development
1.31 4.99e-16 GO:0048856 anatomical structure development
1.29 1.51e-15 GO:0007275 multicellular organismal development
1.27 6.96e-15 GO:0032502 developmental process
1.15 4.31e-14 GO:0065007 biological regulation
1.38 2.26e-13 GO:0030154 cell differentiation
1.37 4.03e-13 GO:0048869 cellular developmental process
1.59 4.63e-13 GO:0022008 neurogenesis
1.60 8.58e-13 GO:0048699 generation of neurons
1.66 3.40e-12 GO:0030182 neuron differentiation
1.54 7.27e-12 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.37 8.49e-12 GO:0048513 organ development
1.14 1.46e-10 GO:0050789 regulation of biological process
1.53 1.77e-10 GO:0048468 cell development
1.14 1.03e-09 GO:0050794 regulation of cellular process
1.39 1.19e-09 GO:0009653 anatomical structure morphogenesis
1.54 9.35e-09 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 1.75e-08 GO:0048518 positive regulation of biological process
1.53 2.07e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.56 3.17e-08 GO:0010628 positive regulation of gene expression
1.56 3.21e-08 GO:0045595 regulation of cell differentiation
1.26 5.24e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 1.01e-07 GO:0007417 central nervous system development
1.66 1.08e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.25 1.19e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.27 1.62e-07 GO:0048519 negative regulation of biological process
1.54 2.80e-07 GO:0051254 positive regulation of RNA metabolic process
1.28 4.02e-07 GO:0048523 negative regulation of cellular process
1.52 4.56e-07 GO:0009790 embryo development
1.26 6.52e-07 GO:0048522 positive regulation of cellular process
1.46 9.03e-07 GO:0009888 tissue development
1.54 1.41e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.44 1.52e-06 GO:0050793 regulation of developmental process
1.76 2.15e-06 GO:0060284 regulation of cell development
1.55 2.35e-06 GO:0048666 neuron development
1.18 2.56e-06 GO:0019222 regulation of metabolic process
1.26 2.59e-06 GO:0051252 regulation of RNA metabolic process
1.36 3.56e-06 GO:0009893 positive regulation of metabolic process
1.19 4.32e-06 GO:0080090 regulation of primary metabolic process
1.59 4.76e-06 GO:0000904 cell morphogenesis involved in differentiation
1.19 5.11e-06 GO:0031323 regulation of cellular metabolic process
1.53 7.21e-06 GO:0009887 organ morphogenesis
1.37 8.05e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.46 8.47e-06 GO:0007267 cell-cell signaling
1.62 1.19e-05 GO:0007409 axonogenesis
1.57 1.45e-05 GO:0031175 neuron projection development
1.51 1.75e-05 GO:0010629 negative regulation of gene expression
1.60 1.84e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 2.19e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.35 2.22e-05 GO:0031325 positive regulation of cellular metabolic process
1.42 2.35e-05 GO:0009891 positive regulation of biosynthetic process
1.59 3.15e-05 GO:0048812 neuron projection morphogenesis
1.53 3.53e-05 GO:0051253 negative regulation of RNA metabolic process
1.65 3.68e-05 GO:0007420 brain development
1.24 3.86e-05 GO:0006355 regulation of transcription, DNA-dependent
1.53 4.70e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.14 5.36e-05 GO:0032501 multicellular organismal process
1.64 6.43e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.21 7.18e-05 GO:0031326 regulation of cellular biosynthetic process
1.37 7.44e-05 GO:0007154 cell communication
1.43 8.22e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.32 1.10e-04 GO:0051239 regulation of multicellular organismal process
1.21 1.28e-04 GO:0009889 regulation of biosynthetic process
1.71 1.63e-04 GO:0051960 regulation of nervous system development
1.84 1.68e-04 GO:0045664 regulation of neuron differentiation
1.75 1.81e-04 GO:0050767 regulation of neurogenesis
1.56 2.09e-04 GO:0007268 synaptic transmission
1.55 2.45e-04 GO:0032583 regulation of gene-specific transcription
1.58 2.51e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.18 2.65e-04 GO:0060255 regulation of macromolecule metabolic process
1.52 2.70e-04 GO:0019226 transmission of nerve impulse
1.52 2.70e-04 GO:0035637 multicellular organismal signaling
1.47 2.95e-04 GO:0000902 cell morphogenesis
1.69 3.48e-04 GO:0061061 muscle structure development
1.51 3.64e-04 GO:0048858 cell projection morphogenesis
1.16 3.71e-04 GO:0023052 signaling
1.21 3.90e-04 GO:0010468 regulation of gene expression
1.71 4.18e-04 GO:0045596 negative regulation of cell differentiation
1.46 4.32e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.59 5.04e-04 GO:0043009 chordate embryonic development
1.62 5.67e-04 GO:0007411 axon guidance
1.44 5.94e-04 GO:0030030 cell projection organization
1.45 6.30e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.49 6.46e-04 GO:0032990 cell part morphogenesis
1.40 6.60e-04 GO:2000026 regulation of multicellular organismal development
2.30 7.15e-04 GO:0021953 central nervous system neuron differentiation
1.90 7.43e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.80 9.80e-04 GO:0032582 negative regulation of gene-specific transcription
1.57 9.81e-04 GO:0009792 embryo development ending in birth or egg hatching
1.41 1.26e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.41 1.35e-03 GO:0009890 negative regulation of biosynthetic process
1.42 1.69e-03 GO:0032989 cellular component morphogenesis
1.56 1.82e-03 GO:0048598 embryonic morphogenesis
1.82 2.28e-03 GO:0030900 forebrain development
1.96 2.31e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
1.61 2.98e-03 GO:0048729 tissue morphogenesis
1.20 3.06e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 3.89e-03 GO:0042221 response to chemical stimulus
1.57 4.71e-03 GO:0051093 negative regulation of developmental process
1.56 5.01e-03 GO:0007389 pattern specification process
1.40 5.29e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.61 6.26e-03 GO:0007423 sensory organ development
1.74 6.34e-03 GO:0007517 muscle organ development
1.31 6.59e-03 GO:0009892 negative regulation of metabolic process
1.22 6.83e-03 GO:0007166 cell surface receptor linked signaling pathway
1.81 7.41e-03 GO:0006813 potassium ion transport
1.33 7.74e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.24 9.02e-03 GO:0023051 regulation of signaling
1.18 1.08e-02 GO:0010556 regulation of macromolecule biosynthetic process
3.15 1.09e-02 GO:0071300 cellular response to retinoic acid
1.31 1.13e-02 GO:0009605 response to external stimulus
1.39 1.21e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.32 1.51e-02 GO:0031324 negative regulation of cellular metabolic process
1.89 1.77e-02 GO:0030802 regulation of cyclic nucleotide biosynthetic process
1.89 1.77e-02 GO:0030808 regulation of nucleotide biosynthetic process
2.75 2.25e-02 GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel activity
3.03 2.29e-02 GO:0071299 cellular response to vitamin A
1.05 2.32e-02 GO:0009987 cellular process
1.63 2.83e-02 GO:0002009 morphogenesis of an epithelium
1.46 2.94e-02 GO:0040008 regulation of growth
1.62 3.02e-02 GO:0003002 regionalization
1.19 3.84e-02 GO:0065008 regulation of biological quality
1.61 4.19e-02 GO:0048568 embryonic organ development
1.31 4.49e-02 GO:0040011 locomotion
1.95 4.98e-02 GO:0045761 regulation of adenylate cyclase activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 3.63e-07 GO:0044459 plasma membrane part
2.00 2.60e-05 GO:0034703 cation channel complex
1.75 1.20e-04 GO:0034702 ion channel complex
1.43 2.00e-04 GO:0030054 cell junction
1.53 2.00e-04 GO:0045202 synapse
1.13 1.40e-03 GO:0005886 plasma membrane
2.04 3.45e-03 GO:0008076 voltage-gated potassium channel complex
2.04 3.45e-03 GO:0034705 potassium channel complex
1.12 3.86e-03 GO:0071944 cell periphery
1.46 3.93e-03 GO:0043005 neuron projection
2.12 5.72e-03 GO:0042383 sarcolemma
1.53 6.24e-03 GO:0044456 synapse part
1.22 4.98e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.73 2.54e-16 GO:0043565 sequence-specific DNA binding
1.54 4.25e-13 GO:0001071 nucleic acid binding transcription factor activity
1.54 4.25e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 3.82e-11 GO:0030528 transcription regulator activity
1.83 1.89e-07 GO:0005261 cation channel activity
1.11 7.81e-07 GO:0005515 protein binding
2.11 8.05e-07 GO:0022843 voltage-gated cation channel activity
1.59 1.69e-05 GO:0022838 substrate-specific channel activity
1.87 2.06e-05 GO:0005244 voltage-gated ion channel activity
1.87 2.06e-05 GO:0022832 voltage-gated channel activity
1.58 4.37e-05 GO:0005216 ion channel activity
1.55 6.42e-05 GO:0015267 channel activity
1.55 7.52e-05 GO:0022803 passive transmembrane transporter activity
1.63 1.00e-04 GO:0022836 gated channel activity
1.99 1.98e-04 GO:0005267 potassium channel activity
1.75 3.12e-04 GO:0000975 regulatory region DNA binding
1.75 3.12e-04 GO:0001067 regulatory region nucleic acid binding
1.75 3.12e-04 GO:0044212 transcription regulatory region DNA binding
1.75 6.00e-04 GO:0010843 promoter binding
1.54 4.33e-03 GO:0016564 transcription repressor activity
1.52 5.97e-03 GO:0016563 transcription activator activity
1.96 8.65e-03 GO:0005249 voltage-gated potassium channel activity
1.31 3.11e-02 GO:0015075 ion transmembrane transporter activity