Motif ID: bHLH_family.p2

Z-value: 1.652


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
OLIG1chr21_+_33365874-0.524.1e-02Click!
NPAS2chr2_+_1008029230.495.5e-02Click!
MLXIPLchr7_-_72676750-0.495.5e-02Click!
OLIG2chr21_+_33320080-0.391.4e-01Click!
HEY1chr8_-_80842452-0.361.7e-01Click!
ARNTLchr11_+_132559670.342.0e-01Click!
HEY2chr6_+_1261124170.312.4e-01Click!
HEYLchr1_-_39871226-0.292.7e-01Click!
MITFchr3_+_700684400.253.6e-01Click!
MXI1chr10_+_111957292-0.214.2e-01Click!
TFE3chrX_-_487878760.204.5e-01Click!
ARNTL2chr12_+_27377034-0.165.5e-01Click!
CLOCKchr4_-_56107725-0.146.1e-01Click!
HES6chr2_-_238813365-0.146.1e-01Click!
MXD4chr4_-_22335040.146.2e-01Click!
MNTchr17_-_2250967-0.126.6e-01Click!
ID1chr20_+_296567440.097.3e-01Click!
MXD3chr5_-_176671437-0.078.1e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_38720881 3.054 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr8_+_120289735 2.610 NM_052886
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr6_+_138230045 2.232 NM_006290
 TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr20_+_46971618 1.794 NM_006420
 ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr8_+_32525269 1.509 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
 NRG1










neuregulin 1










chr2_+_28971007 1.308 NM_015131
 WDR43
WD repeat domain 43
chr6_+_96570565 1.281 NM_006581
 FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr17_+_44429748 1.180 NM_001160423
NM_006546
 IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr2_+_46779553 1.165 NM_014011
 SOCS5
suppressor of cytokine signaling 5
chr8_+_22281118 1.133 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr2_+_202838725 1.124 NM_015934
 NOP58
NOP58 ribonucleoprotein homolog (yeast)
chr2_+_113119985 1.106 NM_005415
 SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr2_+_46779827 1.065 NM_144949
 SOCS5
suppressor of cytokine signaling 5
chr14_-_46190690 1.020 NM_080746
 RPL10L
ribosomal protein L10-like
chr11_-_85457736 1.020 PICALM
phosphatidylinositol binding clathrin assembly protein
chr16_+_67236699 1.004 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr8_+_22280942 1.004 NM_001135153
 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr17_-_33043514 1.000 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
 SYNRG






synergin, gamma






chr5_+_110455768 0.988 NM_139281
 WDR36
WD repeat domain 36
chr2_+_206732859 0.971 EEF1B2
eukaryotic translation elongation factor 1 beta 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.17 2.57e-02 GO:0048856 anatomical structure development
1.15 2.59e-03 GO:0044260 cellular macromolecule metabolic process
1.15 3.12e-02 GO:0032502 developmental process
1.13 6.43e-05 GO:0044237 cellular metabolic process
1.13 1.31e-04 GO:0044238 primary metabolic process
1.13 7.01e-03 GO:0043170 macromolecule metabolic process
1.11 5.86e-04 GO:0008152 metabolic process
1.09 1.19e-08 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.98 4.57e-02 GO:0042470 melanosome
1.98 4.57e-02 GO:0048770 pigment granule
1.52 2.32e-04 GO:0005730 nucleolus
1.26 1.98e-05 GO:0044428 nuclear part
1.26 2.39e-04 GO:0031981 nuclear lumen
1.24 3.93e-02 GO:0005654 nucleoplasm
1.23 9.52e-05 GO:0043233 organelle lumen
1.23 1.20e-04 GO:0031974 membrane-enclosed lumen
1.23 3.08e-04 GO:0070013 intracellular organelle lumen
1.20 8.26e-03 GO:0005829 cytosol
1.17 1.08e-02 GO:0043228 non-membrane-bounded organelle
1.17 1.08e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.15 3.07e-06 GO:0044422 organelle part
1.14 8.82e-06 GO:0044446 intracellular organelle part
1.13 1.28e-09 GO:0005737 cytoplasm
1.13 9.35e-06 GO:0044444 cytoplasmic part
1.11 6.05e-03 GO:0005634 nucleus
1.09 1.12e-10 GO:0044424 intracellular part
1.09 2.41e-10 GO:0005622 intracellular
1.09 8.23e-07 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.72 1.91e-02 GO:0043566 structure-specific DNA binding
1.14 2.12e-09 GO:0005515 protein binding
1.06 1.86e-04 GO:0005488 binding