Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.577


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_78483624-0.533.5e-02Click!
AHRchr7_+_17304707-0.401.3e-01Click!
ARNTchr1_-_1491158350.107.1e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_19523526 2.959 NM_001127717
NM_198129
 LAMA3

laminin, alpha 3

chr2_+_203208064 1.990 NM_173511
 FAM117B
family with sequence similarity 117, member B
chr12_+_4253143 1.477 NM_001759
 CCND2
cyclin D2
chr6_-_10520592 1.452 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr16_+_22733307 1.251 NM_006043
 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr8_+_126079929 1.019 SQLE
squalene epoxidase
chr15_+_38923914 1.017 NM_001032367
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_38923470 0.997 NM_003710
NM_181642
 SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_6585268 0.988 KLHL21
kelch-like 21 (Drosophila)
chr10_-_103869923 0.976 NM_001113407
 LDB1
LIM domain binding 1
chr1_-_43196911 0.965 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr1_-_58815415 0.942 TACSTD2
tumor-associated calcium signal transducer 2
chr15_-_35178888 0.939 NM_172316
 MEIS2
Meis homeobox 2
chr15_+_81906983 0.896 NM_003027
 SH3GL3
SH3-domain GRB2-like 3
chr7_-_91601613 0.852 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chrX_+_37429927 0.844 NM_021083
 XK
X-linked Kx blood group (McLeod syndrome)
chr15_-_73719546 0.833 NM_018285
 IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr8_+_126079900 0.832 NM_003129
 SQLE
squalene epoxidase
chr15_-_66900266 0.822 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr15_+_50098730 0.816 MAPK6
mitogen-activated protein kinase 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 78 entries
enrichment   p-value GO term description
2.51 1.78e-02 GO:0048638 regulation of developmental growth
2.31 3.09e-04 GO:0045165 cell fate commitment
2.20 3.49e-02 GO:0006399 tRNA metabolic process
1.88 4.49e-02 GO:0016569 covalent chromatin modification
1.81 1.09e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.77 2.66e-02 GO:0045596 negative regulation of cell differentiation
1.75 3.63e-02 GO:0034660 ncRNA metabolic process
1.68 3.53e-06 GO:0051276 chromosome organization
1.68 8.88e-03 GO:0016568 chromatin modification
1.67 5.78e-04 GO:0006325 chromatin organization
1.67 1.15e-03 GO:0032583 regulation of gene-specific transcription
1.64 4.36e-06 GO:0010628 positive regulation of gene expression
1.64 2.65e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.62 3.35e-05 GO:0006396 RNA processing
1.62 2.50e-02 GO:0006397 mRNA processing
1.61 2.39e-05 GO:0051254 positive regulation of RNA metabolic process
1.61 1.53e-03 GO:0019226 transmission of nerve impulse
1.61 1.53e-03 GO:0035637 multicellular organismal signaling
1.61 6.12e-03 GO:0007268 synaptic transmission
1.58 1.15e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
4.22 2.95e-03 GO:0031519 PcG protein complex
2.64 1.57e-02 GO:0034708 methyltransferase complex
2.64 1.57e-02 GO:0035097 histone methyltransferase complex
1.82 1.33e-03 GO:0000785 chromatin
1.74 7.34e-03 GO:0005667 transcription factor complex
1.64 6.92e-08 GO:0044451 nucleoplasm part
1.61 8.22e-15 GO:0005654 nucleoplasm
1.53 3.03e-16 GO:0031981 nuclear lumen
1.52 5.97e-03 GO:0030529 ribonucleoprotein complex
1.49 5.53e-17 GO:0044428 nuclear part
1.47 3.71e-16 GO:0070013 intracellular organelle lumen
1.47 1.05e-02 GO:0005694 chromosome
1.45 9.74e-16 GO:0031974 membrane-enclosed lumen
1.45 4.84e-15 GO:0043233 organelle lumen
1.33 5.70e-25 GO:0005634 nucleus
1.28 4.80e-02 GO:0005739 mitochondrion
1.24 1.56e-06 GO:0032991 macromolecular complex
1.20 4.72e-03 GO:0043234 protein complex
1.19 2.73e-20 GO:0043231 intracellular membrane-bounded organelle
1.19 5.33e-20 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
1.89 2.93e-02 GO:0003714 transcription corepressor activity
1.80 1.13e-04 GO:0016563 transcription activator activity
1.68 8.57e-03 GO:0016564 transcription repressor activity
1.67 5.63e-04 GO:0000988 protein binding transcription factor activity
1.67 5.63e-04 GO:0000989 transcription factor binding transcription factor activity
1.66 9.65e-04 GO:0003712 transcription cofactor activity
1.65 5.24e-11 GO:0030528 transcription regulator activity
1.59 2.29e-07 GO:0003723 RNA binding
1.58 2.58e-05 GO:0043565 sequence-specific DNA binding
1.55 2.20e-07 GO:0001071 nucleic acid binding transcription factor activity
1.55 2.20e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 7.43e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.37 9.71e-14 GO:0003676 nucleic acid binding
1.33 2.63e-07 GO:0000166 nucleotide binding
1.33 7.70e-04 GO:0005524 ATP binding
1.32 3.18e-06 GO:0003677 DNA binding
1.32 1.20e-03 GO:0032559 adenyl ribonucleotide binding
1.32 1.22e-03 GO:0030554 adenyl nucleotide binding
1.28 1.28e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.27 2.83e-03 GO:0032553 ribonucleotide binding