Motif ID: LMO2.p2

Z-value: 1.520


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LMO2chr11_-_33848061,
chr11_-_33848013,
chr11_-_33847834
-0.039.3e-01Click!


Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_86983038 4.030 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr14_-_105279740 3.509


chr14_-_105308639 3.125


chr14_-_105308531 3.071


chr14_-_105308720 2.974 IGHM
immunoglobulin heavy constant mu
chr5_+_168996816 2.705 NM_004946
DOCK2
dedicator of cytokinesis 2
chrX_-_118711088 2.349 SEPT6
septin 6
chr5_+_168996852 2.232 DOCK2
dedicator of cytokinesis 2
chr19_+_1033816 2.193 HMHA1
histocompatibility (minor) HA-1
chr16_+_23754822 2.132 PRKCB
protein kinase C, beta
chr16_+_23754860 2.122 PRKCB
protein kinase C, beta
chr5_+_156625629 2.066 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr1_-_111548440 2.019 DENND2D
DENN/MADD domain containing 2D
chr14_-_105279582 2.006


chr16_+_23754772 1.994 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr14_+_30413393 1.941 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr22_+_21027538 1.910


chr17_+_73676219 1.910 NM_004710
SYNGR2
synaptogyrin 2
chr19_+_18145631 1.862 IFI30
interferon, gamma-inducible protein 30
chr19_+_18145619 1.839 IFI30
interferon, gamma-inducible protein 30
chr14_-_105476678 1.822 IGHM
immunoglobulin heavy constant mu
chr22_+_20880112 1.766


chr22_+_21552897 1.762 LOC100290481
immunoglobulin lambda light chain-like
chr6_-_32659958 1.704 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr19_-_11550765 1.678 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr19_+_1033797 1.673 HMHA1
histocompatibility (minor) HA-1
chr14_-_105163301 1.633 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr19_-_11550576 1.559 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr2_+_79593679 1.551 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr4_-_35922288 1.536 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_80370426 1.462 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_80370400 1.449 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chrX_+_152562013 1.416 DUSP9
dual specificity phosphatase 9
chr7_-_960534 1.412 ADAP1
ArfGAP with dual PH domains 1
chr2_-_162883062 1.393 NM_022168
IFIH1
interferon induced with helicase C domain 1
chrX_-_118711350 1.367 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr20_+_60744268 1.346 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr2_-_216586488 1.309 NM_018000
MREG
melanoregulin
chr20_+_48844837 1.301 NM_001010974
NM_017843
NM_198799
BCAS4


breast carcinoma amplified sequence 4


chr4_-_42353640 1.298 NM_001105529
NM_006095
ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

chr20_+_60744231 1.291 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr22_+_23153529 1.288 NM_000675
ADORA2A
adenosine A2a receptor
chrX_+_115481774 1.277 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_91063441 1.270 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr14_-_105206106 1.265


chr14_-_105280425 1.249 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_105181939 1.210 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr6_+_31647854 1.196 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr16_+_12902955 1.194 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chrX_+_130985316 1.183 NM_001042452
MST4
serine/threonine protein kinase MST4
chr9_-_6635564 1.164 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr3_+_53855630 1.159 IL17RB
interleukin 17 receptor B
chr4_+_154606900 1.157 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr19_-_6643953 1.151 C3
complement component 3
chrX_-_132947141 1.138 GPC3
glypican 3
chr2_+_79593567 1.133 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr7_+_73262264 1.131 LAT2
linker for activation of T cells family, member 2
chr19_+_13736352 1.131 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr2_+_162908869 1.122 GCA
grancalcin, EF-hand calcium binding protein
chr3_+_53855603 1.120 NM_018725
IL17RB
interleukin 17 receptor B
chr7_+_73262283 1.118 LAT2
linker for activation of T cells family, member 2
chr8_-_28299850 1.114 NM_018660
ZNF395
zinc finger protein 395
chr22_+_35586950 1.112 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_-_27113018 1.100 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_-_11588525 1.098 LITAF
lipopolysaccharide-induced TNF factor
chr1_+_60053050 1.089 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr17_-_74348447 1.086 NM_025090
USP36
ubiquitin specific peptidase 36
chr6_-_90178544 1.076 RRAGD
Ras-related GTP binding D
chr12_-_61615124 1.076 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_-_90178630 1.073 RRAGD
Ras-related GTP binding D
chr14_-_54438913 1.067 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr4_+_39874921 1.058 NM_004310
RHOH
ras homolog gene family, member H
chr9_-_122731263 1.047 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr14_-_105762742 1.044


chr3_+_53855646 1.041 IL17RB
interleukin 17 receptor B
chr16_-_11588257 1.036 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr19_+_1022208 1.034 HMHA1
histocompatibility (minor) HA-1
chr6_+_160310118 1.023 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chrX_-_118711183 1.022 SEPT6
septin 6
chr19_+_5082230 1.021 KDM4B
lysine (K)-specific demethylase 4B
chr12_-_61614930 1.015 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_-_50375143 1.014 NM_018728
MYO5C
myosin VC
chr8_-_81155564 1.014 NM_001025252
TPD52
tumor protein D52
chr2_-_73350103 1.012 NM_001080410
FBXO41
F-box protein 41
chr2_-_160469438 1.012 LY75-CD302
LY75
LY75-CD302 read-through transcript
lymphocyte antigen 75
chr7_+_73262022 1.009 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr17_-_35975227 1.003 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_+_7491789 1.003 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_132947290 0.992 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr1_-_27834210 0.988 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr12_+_6925997 0.982 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_18145578 0.971 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr21_+_41719847 0.969 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr4_+_89597257 0.959 NM_016323
HERC5
hect domain and RLD 5
chr11_+_7491576 0.950 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_-_105851580 0.950 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_71747867 0.944 NM_052916
RNF157
ring finger protein 157
chr3_-_126412882 0.939 NM_001195483
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr3_-_13436802 0.937 NM_024923
NUP210
nucleoporin 210kDa
chr20_+_36867708 0.937 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr17_+_63252704 0.927 BPTF
bromodomain PHD finger transcription factor
chr5_-_94646033 0.926 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr19_+_13736345 0.914 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr1_+_32512298 0.913 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_159257567 0.902 F11R
F11 receptor
chr19_+_47073029 0.873 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr14_-_105182025 0.870


chr2_+_95055155 0.870 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr10_-_23043042 0.869 PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr9_-_91302707 0.866 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr7_+_102502852 0.862 ARMC10
armadillo repeat containing 10
chr1_-_159257486 0.856 F11R
F11 receptor
chr14_-_105589467 0.853 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr16_+_66022551 0.848 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr15_-_43458247 0.845 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr5_+_126140746 0.845 LMNB1
lamin B1
chr14_-_105644300 0.843 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr9_+_70509925 0.840 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr22_+_40027529 0.837 ZC3H7B
zinc finger CCCH-type containing 7B
chr5_-_138753443 0.836 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr6_-_90178685 0.833 NM_021244
RRAGD
Ras-related GTP binding D
chr8_-_81246215 0.832 NM_001025253
NM_005079
TPD52

tumor protein D52

chr14_-_22358752 0.831 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_-_116517945 0.827 ABLIM1
actin binding LIM protein 1
chr14_-_106270497 0.826 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr1_+_36544549 0.822 NM_001162530
SH3D21
SH3 domain containing 21
chr6_+_31648071 0.820 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr3_+_16901455 0.816 NM_001144382
PLCL2
phospholipase C-like 2
chr6_+_36206239 0.813 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr7_-_22363036 0.806 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_+_102502816 0.805 ARMC10
armadillo repeat containing 10
chr16_-_55875953 0.800 PLLP
plasmolipin
chr22_+_20880159 0.799 IGLV6-57
immunoglobulin lambda variable 6-57
chr4_-_15694407 0.796 PROM1
prominin 1
chr1_-_24067347 0.790 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr5_-_88235624 0.782 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr3_+_180853473 0.782 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr4_+_3738093 0.781 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr16_+_66022520 0.778 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_+_6723801 0.778


chr7_+_1092968 0.775 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr17_-_6958282 0.772 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr12_+_27377034 0.769 NM_020183
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr6_-_90178375 0.768 RRAGD
Ras-related GTP binding D
chr16_-_55876099 0.768 PLLP
plasmolipin
chr17_+_40655060 0.765 NM_005892
FMNL1
formin-like 1
chr2_+_65069986 0.758 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_+_72620570 0.756 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr17_+_75849221 0.755 NM_020914
NM_020954
RNF213

ring finger protein 213

chr19_+_6723705 0.754 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr10_-_103337872 0.752 POLL
polymerase (DNA directed), lambda
chrX_+_129133234 0.751 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr8_-_28299508 0.746 ZNF395
zinc finger protein 395
chr22_+_21340757 0.746


chr16_-_55876075 0.745 NM_015993
PLLP
plasmolipin
chr18_+_27332024 0.735 NM_001943
DSG2
desmoglein 2
chr2_+_230798687 0.733 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chrX_-_118711144 0.729 SEPT6
septin 6
chr1_+_1971762 0.728 NM_002744
PRKCZ
protein kinase C, zeta
chr2_-_160469512 0.727 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 read-through transcript

lymphocyte antigen 75
chr10_+_89613347 0.725 PTEN
phosphatase and tensin homolog
chr8_-_103205662 0.719 NM_001040624
NM_001040625
NM_001040626
NM_001040627
NM_001040628
NM_001040629
NCALD





neurocalcin delta





chr15_-_43457916 0.718 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr14_-_106149623 0.717


chr10_-_115603848 0.711 NM_014881
DCLRE1A
DNA cross-link repair 1A
chr12_-_116021473 0.707 NM_001168325
NM_017899
TESC

tescalcin

chr4_-_15694764 0.704 PROM1
prominin 1
chr6_-_25019173 0.702 NM_014722
FAM65B
family with sequence similarity 65, member B
chr18_-_72973750 0.697 NM_001025100
NM_001025101
MBP

myelin basic protein

chr16_+_84204424 0.695 NM_014615
KIAA0182
KIAA0182
chr10_-_98935652 0.693 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr15_+_72861470 0.688 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr16_+_66022729 0.687 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr14_+_71468902 0.684 RGS6
regulator of G-protein signaling 6
chr1_+_161027115 0.679 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr7_-_37454933 0.675 NM_014800
ELMO1
engulfment and cell motility 1
chr15_-_58671929 0.674 NM_134262
RORA
RAR-related orphan receptor A
chr1_+_39229474 0.671 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr16_-_51138306 0.668 NM_001080430
TOX3
TOX high mobility group box family member 3
chrX_+_78087484 0.666 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr13_-_38510183 0.658 C13orf23
chromosome 13 open reading frame 23
chr20_-_32354736 0.658 NM_000687
AHCY
adenosylhomocysteinase
chr10_-_116382089 0.657 ABLIM1
actin binding LIM protein 1
chr16_-_87570716 0.650 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr6_-_3172775 0.650 NM_178012
TUBB2B
tubulin, beta 2B
chr6_-_32605898 0.646 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr10_+_89613071 0.646 NM_000314
PTEN
phosphatase and tensin homolog
chr12_+_54760153 0.645 NM_001005915
NM_001982
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr1_+_167342149 0.641 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr3_-_198767202 0.636 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr2_-_208197940 0.635 NM_145280
METTL21A
methyltransferase like 21A
chr11_+_67836575 0.631 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chrX_-_106905545 0.630 TSC22D3
TSC22 domain family, member 3
chr3_-_57174442 0.629 NM_017563
IL17RD
interleukin 17 receptor D
chr20_+_61838479 0.628 LIME1
Lck interacting transmembrane adaptor 1
chr17_-_6958695 0.627 ASGR2
asialoglycoprotein receptor 2
chr2_-_241737495 0.627 NM_015148
PASK
PAS domain containing serine/threonine kinase
chr4_-_15694691 0.624 NM_001145847
NM_001145848
PROM1

prominin 1

chr17_+_26060617 0.623


chr16_+_84202515 0.622 NM_001134473
KIAA0182
KIAA0182

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.52 7.62e-03 GO:0030695 GTPase regulator activity
1.51 8.49e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.61 2.82e-02 GO:0005083 small GTPase regulator activity