Motif ID: NHLH1,2.p2

Z-value: 2.113


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1161848460.401.2e-01Click!
NHLH1chr1_+_158603480-0.194.8e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_113546841 4.628 NM_000820
GAS6
growth arrest-specific 6
chr10_+_17311283 4.281 VIM
vimentin
chr10_+_17311307 4.264 VIM
vimentin
chr10_+_17311242 4.254 VIM
vimentin
chr10_+_17311282 4.127 VIM
vimentin
chr10_+_17311347 4.118 VIM
vimentin
chr13_+_113546897 3.953 GAS6
growth arrest-specific 6
chr14_-_51605487 3.918 NID2
nidogen 2 (osteonidogen)
chr13_+_113546943 3.836 GAS6
growth arrest-specific 6
chrX_-_13866451 3.786 GPM6B
glycoprotein M6B
chr4_-_57671307 3.689 IGFBP7
insulin-like growth factor binding protein 7
chr11_-_6298284 3.581 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr14_-_51605461 3.561 NID2
nidogen 2 (osteonidogen)
chr14_-_51605515 3.448 NID2
nidogen 2 (osteonidogen)
chr9_-_35679799 3.328 TPM2
tropomyosin 2 (beta)
chr2_-_229844198 3.311 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr4_-_57671273 3.149 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr9_-_35679902 3.088 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr10_+_124211353 2.990 HTRA1
HtrA serine peptidase 1
chr7_+_129919157 2.825 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr4_-_81213207 2.750


chr2_-_37752731 2.612 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_1727247 2.520 PXDN
peroxidasin homolog (Drosophila)
chr12_-_21702021 2.491 LDHB
lactate dehydrogenase B
chr10_+_17311788 2.478 VIM
vimentin
chr12_-_21702000 2.471 LDHB
lactate dehydrogenase B
chr12_-_21702036 2.422 LDHB
lactate dehydrogenase B
chr11_+_86189138 2.361 NM_007173
PRSS23
protease, serine, 23
chr11_-_65841077 2.349 NM_020404
CD248
CD248 molecule, endosialin
chr13_+_113546912 2.342 GAS6
growth arrest-specific 6
chr4_-_40911212 2.318 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr15_+_72006015 2.293 LOXL1
lysyl oxidase-like 1
chr3_-_73756668 2.290 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr12_-_53099269 2.262 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_53099203 2.157 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_-_151171576 2.089 PFN2
profilin 2
chr1_+_67168470 2.043 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr7_-_130891861 2.040 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_-_45927263 2.000 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr7_+_17304707 1.975 NM_001621
AHR
aryl hydrocarbon receptor
chr12_-_53099277 1.940 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_+_16048047 1.925 NM_003290
TPM4
tropomyosin 4
chr1_+_28791593 1.889 NM_001193532
RAB42
RAB42, member RAS oncogene family
chr14_-_51605695 1.861 NM_007361
NID2
nidogen 2 (osteonidogen)
chr1_+_77520315 1.851 NM_174858
AK5
adenylate kinase 5
chr14_+_89933118 1.819 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chrX_-_13866565 1.815 NM_001001994
GPM6B
glycoprotein M6B
chr1_-_85703321 1.813 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_+_6179736 1.738 NM_001769
CD9
CD9 molecule
chr12_+_51777684 1.631 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr13_-_35603432 1.626 DCLK1
doublecortin-like kinase 1
chr21_+_46367216 1.576 COL6A2
collagen, type VI, alpha 2
chr11_+_133444175 1.572 JAM3
junctional adhesion molecule 3
chr3_-_151171190 1.530 NM_002628
NM_053024
PFN2

profilin 2

chr12_-_45759691 1.525 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr1_-_95165089 1.524 NM_001839
CNN3
calponin 3, acidic
chr19_-_63301418 1.523 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr1_+_85819004 1.519 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_15106597 1.501 NM_153321
PMP22
peripheral myelin protein 22
chr3_-_87122936 1.498 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr17_-_15106579 1.493 PMP22
peripheral myelin protein 22
chrX_-_154341451 1.482 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr10_+_124210980 1.477 NM_002775
HTRA1
HtrA serine peptidase 1
chrX_+_135057202 1.469 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr9_-_139060416 1.462 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr5_-_136862786 1.460 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr4_+_174326464 1.432 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chrX_+_153767803 1.430 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr3_+_8518508 1.424 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr2_-_227371698 1.397 NM_005544
IRS1
insulin receptor substrate 1
chr12_-_74710741 1.381 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_-_191422346 1.379 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr19_+_43446937 1.367 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chrX_-_37964924 1.352 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr8_-_98359248 1.316 TSPYL5
TSPY-like 5
chr1_-_31154023 1.307 NM_014654
SDC3
syndecan 3
chr2_-_1727324 1.301 PXDN
peroxidasin homolog (Drosophila)
chr8_-_41286088 1.298 NM_003012
SFRP1
secreted frizzled-related protein 1
chr20_+_19818209 1.296 NM_018993
RIN2
Ras and Rab interactor 2
chr19_+_43447078 1.295 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr7_+_98084531 1.292 NM_002523
NPTX2
neuronal pentraxin II
chr11_+_44543716 1.275 NM_001024844
NM_002231
CD82

CD82 molecule

chr5_+_102229612 1.237 PAM
peptidylglycine alpha-amidating monooxygenase
chr14_+_89933055 1.233 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr2_-_1727292 1.229 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_59020875 1.227 JUN
jun proto-oncogene
chr3_+_49034494 1.214 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr9_+_123070234 1.210 GSN
gelsolin
chr6_-_109883635 1.201 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_-_56817717 1.200 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_-_98359347 1.186 NM_033512
TSPYL5
TSPY-like 5
chrX_-_13866366 1.177


chr6_-_109883639 1.177 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_+_4300607 1.173 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr1_+_163867057 1.168 NM_004528
MGST3
microsomal glutathione S-transferase 3
chr3_-_45162865 1.165 CDCP1
CUB domain containing protein 1
chr20_-_57015698 1.165 NM_001336
CTSZ
cathepsin Z
chr5_-_175776137 1.164 NM_001834
NM_007097
CLTB

clathrin, light chain B

chrX_+_80344253 1.158 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_51474531 1.158 NM_014372
RNF11
ring finger protein 11
chr6_+_129245978 1.158 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr19_+_16048266 1.150 TPM4
tropomyosin 4
chr19_+_16048306 1.149 TPM4
tropomyosin 4
chr6_-_46566969 1.147 RCAN2
regulator of calcineurin 2
chr3_+_49034050 1.141 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr4_-_120769275 1.141 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr2_+_46779827 1.140 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr6_-_139737432 1.117 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr12_-_67613213 1.114 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr1_-_94475840 1.114 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chrX_+_152699616 1.109 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr6_-_139737477 1.106 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr19_+_16048315 1.105 TPM4
tropomyosin 4
chr3_-_45162901 1.089 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr11_+_822965 1.085 CD151
CD151 molecule (Raph blood group)
chr2_+_202607554 1.077 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr8_+_37773991 1.073 GPR124
G protein-coupled receptor 124
chr1_-_199732323 1.064 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr11_+_823007 1.060 CD151
CD151 molecule (Raph blood group)
chr11_+_822909 1.060 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr9_+_113433364 1.046 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chrX_+_73557809 1.042 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr3_-_45162847 1.039 CDCP1
CUB domain containing protein 1
chr8_+_37773564 1.039 GPR124
G protein-coupled receptor 124
chr8_+_37773915 1.037 GPR124
G protein-coupled receptor 124
chr21_+_25933459 1.030 NM_021219
JAM2
junctional adhesion molecule 2
chr21_+_45318861 1.025 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr15_-_21483457 1.020 NDN
necdin homolog (mouse)
chr14_-_29466562 1.018 NM_002742
PRKD1
protein kinase D1
chr7_+_65307816 1.015 TPST1
tyrosylprotein sulfotransferase 1
chr12_-_102968044 1.013 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr6_-_109883525 0.996 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_-_54409107 0.991 NM_001040034
NM_001780
CD63

CD63 molecule

chr12_-_102967828 0.983 GLT8D2
glycosyltransferase 8 domain containing 2
chr9_+_89530896 0.983 CTSL1
cathepsin L1
chr12_-_75796898 0.978 NM_001321
CSRP2
cysteine and glycine-rich protein 2
chr5_+_102229425 0.975 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr11_-_102174032 0.973 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr6_-_139737042 0.969 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr1_-_94475504 0.969 ARHGAP29
Rho GTPase activating protein 29
chr1_+_51474583 0.966 RNF11
ring finger protein 11
chr7_-_526005 0.964 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr9_+_89530838 0.962 CTSL1
cathepsin L1
chr12_+_47498778 0.962 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr2_-_202024472 0.961 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr7_-_124192265 0.959 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_191818124 0.955 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr13_-_109757442 0.953 NM_001845
COL4A1
collagen, type IV, alpha 1
chr1_-_154913712 0.952 NM_006617
NES
nestin
chr14_-_74148422 0.949 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr6_+_139497933 0.948 NM_016217
HECA
headcase homolog (Drosophila)
chr2_-_175578156 0.946 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr4_+_78298326 0.945 CCNG2
cyclin G2
chr18_+_9324820 0.943 TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr11_-_124871258 0.933 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr15_-_46725087 0.929 NM_000138
FBN1
fibrillin 1
chr5_-_175775966 0.925 CLTB
clathrin, light chain B
chr3_-_126088530 0.925 ITGB5
integrin, beta 5
chr1_-_43691932 0.922 HYI
hydroxypyruvate isomerase (putative)
chr18_+_9324762 0.921 NM_020648
TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr12_-_123023312 0.919 CCDC92
coiled-coil domain containing 92
chr15_+_61127367 0.918 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr13_-_44048391 0.917 TSC22D1
TSC22 domain family, member 1
chr22_+_22652248 0.914 NM_000854
GSTT2
GSTT2B
glutathione S-transferase theta 2
glutathione S-transferase theta 2B (gene/pseudogene)
chr19_+_43447262 0.914 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr8_+_31616809 0.908 NM_013962
NRG1
neuregulin 1
chr1_-_199613427 0.907 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr7_+_44754978 0.906 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr2_-_235070431 0.906 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr2_-_55131202 0.904 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr9_+_89530793 0.897 NM_001912
NM_145918
CTSL1

cathepsin L1

chr7_+_55054416 0.896 EGFR
epidermal growth factor receptor
chr2_+_202949289 0.889 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr9_-_139060377 0.889 NPDC1
neural proliferation, differentiation and control, 1
chrX_-_106905545 0.887 TSC22D3
TSC22 domain family, member 3
chr9_+_124173143 0.882 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_139060285 0.875 NPDC1
neural proliferation, differentiation and control, 1
chr3_-_55490401 0.872 WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_147361465 0.868 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr13_-_35603513 0.866 NM_004734
DCLK1
doublecortin-like kinase 1
chr12_+_77782719 0.866 SYT1
synaptotagmin I
chr1_-_201420927 0.864 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr2_+_5750229 0.860 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr2_+_238060602 0.860 NM_001042467
NM_024101
MLPH

melanophilin

chr11_-_35503720 0.859 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr4_+_158216631 0.859 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr1_-_199613406 0.857 TNNT2
troponin T type 2 (cardiac)
chr4_-_57671112 0.845 IGFBP7
insulin-like growth factor binding protein 7
chr8_+_70567581 0.842 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr7_+_102340579 0.841 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr5_+_17270474 0.841 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr13_+_48967746 0.838 NM_001040443
PHF11
PHD finger protein 11
chr21_-_45118037 0.835 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chrX_-_153767625 0.835 NM_019863
F8
coagulation factor VIII, procoagulant component
chr2_-_55130925 0.834 RTN4
reticulon 4
chr1_+_200584421 0.822 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr11_+_12355600 0.815 NM_018222
PARVA
parvin, alpha
chr1_+_84316217 0.813 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_+_114018459 0.811 NM_001078645
NM_003903
CDC16

cell division cycle 16 homolog (S. cerevisiae)

chr1_-_113051545 0.810 NM_001042678
NM_175744
RHOC

ras homolog gene family, member C


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 3.47e-05 GO:0048869 cellular developmental process
1.42 4.87e-05 GO:0048468 cell development
1.27 7.74e-05 GO:0030154 cell differentiation
1.41 1.34e-04 GO:0022008 neurogenesis
1.18 3.36e-04 GO:0032502 developmental process
1.20 3.45e-04 GO:0048856 anatomical structure development
1.30 5.01e-04 GO:0009653 anatomical structure morphogenesis
1.29 8.47e-04 GO:0007399 nervous system development
1.40 8.58e-04 GO:0048699 generation of neurons
1.18 1.19e-03 GO:0007275 multicellular organismal development
1.49 3.43e-03 GO:0048858 cell projection morphogenesis
1.53 4.18e-03 GO:0007409 axonogenesis
1.52 5.00e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.51 5.84e-03 GO:0048812 neuron projection morphogenesis
1.48 6.01e-03 GO:0032990 cell part morphogenesis
1.18 9.29e-03 GO:0048731 system development
1.46 1.79e-02 GO:0000904 cell morphogenesis involved in differentiation
1.41 1.79e-02 GO:0030030 cell projection organization
1.24 2.23e-02 GO:0023051 regulation of signaling
1.42 2.24e-02 GO:0000902 cell morphogenesis
1.46 2.35e-02 GO:0031175 neuron projection development
1.40 2.93e-02 GO:0032989 cellular component morphogenesis
1.38 3.05e-02 GO:0030182 neuron differentiation
1.12 3.76e-02 GO:0032501 multicellular organismal process
1.29 3.88e-02 GO:0010646 regulation of cell communication
1.41 4.32e-02 GO:0048666 neuron development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.76e-05 GO:0005737 cytoplasm
1.23 1.97e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 7.04e-04 GO:0003779 actin binding
1.39 3.86e-02 GO:0008092 cytoskeletal protein binding