Motif ID: TEAD1.p2

Z-value: 4.174


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TEAD1chr11_+_126524270.924.6e-07Click!
TEAD3chr6_-_355726940.611.3e-02Click!
TEAD4chr12_+_29392500.391.4e-01Click!


Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_132314004 26.304 NM_001901
CTGF
connective tissue growth factor
chr5_-_39460687 25.548 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_135575925 14.807 NM_016201
AMOTL2
angiomotin like 2
chr5_-_39460787 13.858 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr15_+_37660568 13.512 NM_003246
THBS1
thrombospondin 1
chr1_+_85819004 12.503 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr6_-_128883125 12.372 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_-_160972606 12.278 RBMS1
RNA binding motif, single stranded interacting protein 1
chr10_-_90702490 11.816 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_6298284 11.570 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr10_-_17699309 11.284 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr5_-_39461054 11.220 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr15_+_61121806 10.678 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr7_+_134114701 10.306 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_-_189752575 10.132 NM_000393
COL5A2
collagen, type V, alpha 2
chr15_+_61122139 9.944 TPM1
tropomyosin 1 (alpha)
chr11_+_113671744 9.850 NM_006169
NNMT
nicotinamide N-methyltransferase
chr4_+_184257337 9.715 NM_024949
WWC2
WW and C2 domain containing 2
chr5_-_151046680 9.179 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr10_-_125843092 8.955 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr20_+_34603290 8.616 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr11_-_2907169 8.456 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr8_-_42184194 8.432 PLAT
plasminogen activator, tissue
chr3_-_150569574 8.228 TM4SF1
transmembrane 4 L six family member 1
chr7_+_134114957 8.174 CALD1
caldesmon 1
chr20_+_34603311 8.039 MYL9
myosin, light chain 9, regulatory
chr8_-_42184350 7.963 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chrX_-_10548458 7.874 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr8_+_1759502 7.739 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr7_+_115952279 7.715 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr8_-_13018123 7.370 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_1283770 7.257 NM_032348
MXRA8
matrix-remodelling associated 8
chr12_-_13044467 7.207 NM_015987
HEBP1
heme binding protein 1
chr1_+_114323552 7.156 NM_020190
OLFML3
olfactomedin-like 3
chr16_-_62573 7.142 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr12_-_13044314 7.039 HEBP1
heme binding protein 1
chr6_-_134538762 6.871 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr11_-_8789457 6.820 NM_139157
ST5
suppression of tumorigenicity 5
chr1_-_199613427 6.817 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr10_+_123862430 6.605 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_134538526 6.601 SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_158439868 6.561 NM_001105
ACVR1
activin A receptor, type I
chr1_-_199613406 6.469 TNNT2
troponin T type 2 (cardiac)
chr5_-_151046638 6.289 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr18_+_8707368 6.249 NM_015210
KIAA0802
KIAA0802
chr4_-_186970366 6.242 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr5_+_34723420 6.060 NM_001145523
RAI14
retinoic acid induced 14
chr17_-_37828643 6.053 NM_012232
PTRF
polymerase I and transcript release factor
chr8_+_70541412 5.989 NM_001128204
NM_015170
SULF1

sulfatase 1

chr10_+_102782151 5.850 SFXN3
sideroflexin 3
chr10_-_33287184 5.606 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr3_-_115825742 5.572 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_115952325 5.459 CAV1
caveolin 1, caveolae protein, 22kDa
chr15_-_46725087 5.457 NM_000138
FBN1
fibrillin 1
chr2_-_217248967 5.313 IGFBP5
insulin-like growth factor binding protein 5
chr11_-_8788765 5.199 NM_213618
ST5
suppression of tumorigenicity 5
chr3_-_52463070 5.103 NM_003280
TNNC1
troponin C type 1 (slow)
chr10_-_99436889 5.032 NM_021732
AVPI1
arginine vasopressin-induced 1
chr11_-_2127368 5.017 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr13_+_109936080 4.969 COL4A2
collagen, type IV, alpha 2
chr12_-_7136147 4.700 NM_001733
C1R
complement component 1, r subcomponent
chr12_-_8706746 4.677 MFAP5
microfibrillar associated protein 5
chr7_+_115952074 4.509 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chrX_-_6156655 4.427 NM_181332
NLGN4X
neuroligin 4, X-linked
chr12_-_7136189 4.409 C1R
complement component 1, r subcomponent
chr1_+_181422016 4.269 LAMC2
laminin, gamma 2
chr12_-_8706637 4.151 NM_003480
MFAP5
microfibrillar associated protein 5
chr6_+_83130220 4.002 TPBG
trophoblast glycoprotein
chr10_+_102782156 3.929 SFXN3
sideroflexin 3
chr1_-_207892420 3.809 NM_000228
LAMB3
laminin, beta 3
chr3_+_148609841 3.763 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr17_-_15495534 3.755 TRIM16
tripartite motif containing 16
chr2_-_192420168 3.747 NM_004657
SDPR
serum deprivation response
chr12_-_53099269 3.727 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr15_-_58477407 3.721 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr2_-_20075889 3.659 MATN3
matrilin 3
chr1_-_207892296 3.603 NM_001127641
LAMB3
laminin, beta 3
chr4_-_186815116 3.568 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_+_26480134 3.552 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr9_+_111927601 3.533 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr7_+_134114912 3.453 CALD1
caldesmon 1
chr11_-_47427263 3.442 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr12_-_8706533 3.441 MFAP5
microfibrillar associated protein 5
chr11_+_57123927 3.378 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_-_53099277 3.348 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr21_+_46369606 3.332 COL6A2
collagen, type VI, alpha 2
chr9_+_19039424 3.312 RRAGA
Ras-related GTP binding A
chr6_+_83129641 3.278 NM_006670
TPBG
trophoblast glycoprotein
chr1_-_212791597 3.276 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_201411533 3.238 NM_004997
MYBPH
myosin binding protein H
chr15_+_30721161 3.235 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr1_-_16355013 3.223 NM_004431
EPHA2
EPH receptor A2
chr2_-_192419896 3.203 SDPR
serum deprivation response
chr12_-_53099203 3.181 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_+_66580884 3.071 RHOD
ras homolog gene family, member D
chr11_+_66580861 3.046 NM_014578
RHOD
ras homolog gene family, member D
chr12_+_77782648 2.899 SYT1
synaptotagmin I
chr8_+_56177567 2.886 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr12_-_119172339 2.858 NM_025157
PXN
paxillin
chr19_-_49523747 2.846 ZFP112
zinc finger protein 112 homolog (mouse)
chr6_+_123152044 2.833 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr5_-_83052606 2.816 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr12_+_47498778 2.796 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chrX_-_152794592 2.776 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chrX_-_10761729 2.761 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_212791467 2.761 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr19_-_14467939 2.709 NM_005716
NM_202467
NM_202468
NM_202469
NM_202470
NM_202494
GIPC1





GIPC PDZ domain containing family, member 1





chr21_-_26345294 2.639


chr3_-_129023850 2.625 NM_007283
MGLL
monoglyceride lipase
chr12_+_77782579 2.552 NM_005639
SYT1
synaptotagmin I
chr10_+_123738678 2.552 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr19_-_14467890 2.502 GIPC1
GIPC PDZ domain containing family, member 1
chr12_+_26239755 2.461 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr12_+_77782719 2.444 SYT1
synaptotagmin I
chr5_-_175775966 2.426 CLTB
clathrin, light chain B
chr19_+_55918405 2.413 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr16_+_55156461 2.406 NM_032935
MT4
metallothionein 4
chr15_+_94670160 2.388 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr12_-_54387934 2.382 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr19_+_55918450 2.337 CLEC11A
C-type lectin domain family 11, member A
chr6_+_134251957 2.334 TCF21
transcription factor 21
chr21_+_46369617 2.328 COL6A2
collagen, type VI, alpha 2
chr6_+_134251940 2.309 NM_198392
NM_003206
TCF21

transcription factor 21

chr11_+_19328846 2.304 NM_001111018
NAV2
neuron navigator 2
chr11_-_14336606 2.297 NM_001177315
NM_001102669
RRAS2

related RAS viral (r-ras) oncogene homolog 2

chr1_+_181380837 2.295 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr12_+_51728999 2.246 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_77781903 2.221 NM_001135805
SYT1
synaptotagmin I
chr1_-_17179694 2.205 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr12_-_54387732 2.200 ITGA7
integrin, alpha 7
chr6_+_158653679 2.199 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr17_-_3518628 2.190 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr1_-_199704773 2.190 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr9_+_34980715 1.989 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr6_+_144040751 1.951 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr19_+_50041424 1.950 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_+_216585298 1.941 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr5_+_140848905 1.936 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr11_+_2881080 1.910 SLC22A18
solute carrier family 22, member 18
chr8_-_116750427 1.866 TRPS1
trichorhinophalangeal syndrome I
chr17_-_3518568 1.852 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr4_+_169789327 1.794 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr22_+_43451600 1.794 PRR5
proline rich 5 (renal)
chr14_-_22974707 1.763 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr22_+_43451351 1.755 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chrX_+_107569671 1.752 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr5_-_16989371 1.721 NM_012334
MYO10
myosin X
chr12_-_78608873 1.662 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr12_-_45506001 1.649 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr4_-_187114863 1.627 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr12_+_27568311 1.609 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chrX_+_48253007 1.608 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr5_-_55326358 1.607 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr18_+_3237527 1.595 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr16_-_46052596 1.592 ITFG1
integrin alpha FG-GAP repeat containing 1
chr18_+_3237774 1.582 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr9_-_16717887 1.570 BNC2
basonuclin 2
chr5_+_140730014 1.565 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr16_-_21344158 1.560 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr8_+_70567634 1.559 SULF1
sulfatase 1
chr5_-_176857158 1.527 PDLIM7
PDZ and LIM domain 7 (enigma)
chr17_+_71229151 1.511 ITGB4
integrin, beta 4
chr1_-_149047329 1.502 NM_000396
CTSK
cathepsin K
chr5_+_34720368 1.485 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr16_+_22432344 1.450 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr15_+_30797466 1.443 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr10_-_33287137 1.433 ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr17_-_38421363 1.432 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr14_+_75114692 1.430 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr11_+_7463175 1.420 NM_198474
OLFML1
olfactomedin-like 1
chr12_-_105057940 1.418 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_+_15435825 1.411 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr5_+_76150637 1.374 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_-_80386258 1.361 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr18_+_3237825 1.332 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_-_3102690 1.323 NM_001069
TUBB2A
tubulin, beta 2A
chr6_+_131508153 1.282 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr3_+_160269734 1.278 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr12_+_118100977 1.269 NM_014365
HSPB8
heat shock 22kDa protein 8
chr6_+_30958672 1.264 DDR1
discoidin domain receptor tyrosine kinase 1
chr4_-_186814852 1.262 SORBS2
sorbin and SH3 domain containing 2
chr19_-_56147971 1.256 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr1_+_86942810 1.247 NM_016009
SH3GLB1
SH3-domain GRB2-like endophilin B1
chr11_-_6600385 1.229 DCHS1
dachsous 1 (Drosophila)
chr18_+_3252110 1.210 NM_033546
MYL12B
myosin, light chain 12B, regulatory
chr1_-_116112921 1.206 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr2_+_151922350 1.202 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_150858274 1.198 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr4_+_148758014 1.189 TMEM184C
transmembrane protein 184C
chr5_+_179165957 1.184 NM_001142298
SQSTM1
sequestosome 1
chr1_-_148175383 1.181 NM_001145862
MTMR11
myotubularin related protein 11
chr1_+_144236346 1.178 NM_003637
ITGA10
integrin, alpha 10
chr3_+_138020550 1.176 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr18_+_3237815 1.165 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_181258952 1.162 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr9_+_123123364 1.140 GSN
gelsolin
chr7_+_142789476 1.137 ZYX
zyxin
chr11_-_65082705 1.122 LTBP3
latent transforming growth factor beta binding protein 3
chr3_+_171422908 1.108 NM_002740
PRKCI
protein kinase C, iota
chrX_+_48252290 1.099 NM_022825
NM_203473
PORCN

porcupine homolog (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.99 1.44e-04 GO:0048468 cell development
1.73 2.45e-04 GO:0009653 anatomical structure morphogenesis
1.51 1.39e-03 GO:0042221 response to chemical stimulus
2.11 1.67e-03 GO:0032989 cellular component morphogenesis
1.42 2.21e-03 GO:0048856 anatomical structure development
1.97 3.64e-03 GO:0007155 cell adhesion
1.97 3.64e-03 GO:0022610 biological adhesion
2.67 4.23e-03 GO:0061061 muscle structure development
2.05 4.89e-03 GO:0030030 cell projection organization
1.35 7.38e-03 GO:0032502 developmental process
2.97 9.38e-03 GO:0007517 muscle organ development
3.55 1.01e-02 GO:0014706 striated muscle tissue development
2.13 1.49e-02 GO:0048858 cell projection morphogenesis
1.41 1.68e-02 GO:0048731 system development
2.11 1.88e-02 GO:0032990 cell part morphogenesis
2.18 1.99e-02 GO:0048812 neuron projection morphogenesis
2.45 2.26e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.10 2.52e-02 GO:0031175 neuron projection development
2.00 2.53e-02 GO:0000902 cell morphogenesis
2.06 2.59e-02 GO:0006935 chemotaxis
2.06 2.59e-02 GO:0042330 taxis
2.35 2.60e-02 GO:0007411 axon guidance
3.24 3.47e-02 GO:0060537 muscle tissue development
2.16 4.03e-02 GO:0007409 axonogenesis
6.32 4.58e-02 GO:0007044 cell-substrate junction assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.70 4.37e-06 GO:0005576 extracellular region
1.92 1.62e-05 GO:0044421 extracellular region part
2.74 6.98e-05 GO:0015629 actin cytoskeleton
5.33 1.73e-04 GO:0016459 myosin complex
3.84 4.96e-04 GO:0044420 extracellular matrix part
3.31 1.24e-03 GO:0043235 receptor complex
2.31 3.82e-03 GO:0031012 extracellular matrix
1.82 3.95e-03 GO:0005615 extracellular space
1.30 1.36e-02 GO:0071944 cell periphery
4.20 1.43e-02 GO:0005604 basement membrane
14.76 1.69e-02 GO:0001527 microfibril
2.26 3.73e-02 GO:0005578 proteinaceous extracellular matrix
1.29 4.02e-02 GO:0005886 plasma membrane
5.74 4.41e-02 GO:0001725 stress fiber
1.39 4.56e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.96 3.31e-03 GO:0005509 calcium ion binding
2.28 1.75e-02 GO:0003779 actin binding
3.91 1.90e-02 GO:0005201 extracellular matrix structural constituent
6.74 1.96e-02 GO:0050840 extracellular matrix binding
2.92 2.85e-02 GO:0005539 glycosaminoglycan binding
4.86 2.88e-02 GO:0008307 structural constituent of muscle
1.17 3.43e-02 GO:0005515 protein binding
22.13 3.67e-02 GO:0004924 oncostatin-M receptor activity