Motif ID: AAGGUGC

Z-value: 1.211


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a-5p MIMAT0000072
hsa-miR-18b-5p MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_235860616 3.386 ENST00000392011.2
 SH3BP4
SH3-domain binding protein 4
chr3_-_123603137 3.193 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
 MYLK



myosin light chain kinase



chr1_-_20812690 3.151 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr15_+_39873268 2.430 ENST00000397591.2
ENST00000260356.5
 THBS1

thrombospondin 1

chr2_+_36582857 2.265 ENST00000280527.2
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr22_+_38093005 2.005 ENST00000406386.3
 TRIOBP
TRIO and F-actin binding protein
chr6_-_132272504 1.647 ENST00000367976.3
 CTGF
connective tissue growth factor
chr8_-_18871159 1.640 ENST00000327040.8
ENST00000440756.2
 PSD3

pleckstrin and Sec7 domain containing 3

chr9_-_74383799 1.568 ENST00000377044.4
 TMEM2
transmembrane protein 2
chr3_+_105085734 1.527 ENST00000306107.5
 ALCAM
activated leukocyte cell adhesion molecule
chr4_-_157892498 1.159 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chr3_-_114790179 1.105 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr3_+_107241783 1.014 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
 BBX



bobby sox homolog (Drosophila)



chr3_+_187930719 0.969 ENST00000312675.4
 LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_120612240 0.841 ENST00000256646.2
 NOTCH2
notch 2
chr4_-_186877502 0.835 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
 SORBS2


sorbin and SH3 domain containing 2


chr6_-_11232891 0.832 ENST00000379433.5
ENST00000379446.5
 NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr5_-_73937244 0.826 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
 ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr10_-_735553 0.768 ENST00000280886.6
ENST00000423550.1
 DIP2C

DIP2 disco-interacting protein 2 homolog C (Drosophila)

chr11_+_108093839 0.764 ENST00000452508.2
 ATM
ataxia telangiectasia mutated
chr15_-_56209306 0.763 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
 NEDD4


neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase


chr20_+_34700333 0.744 ENST00000441639.1
 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_39760783 0.729 ENST00000398904.2
ENST00000538976.1
 DAAM2

dishevelled associated activator of morphogenesis 2

chr3_-_185542817 0.693 ENST00000382199.2
 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_161993616 0.686 ENST00000294794.3
 OLFML2B
olfactomedin-like 2B
chr6_-_111136513 0.544 ENST00000368911.3
 CDK19
cyclin-dependent kinase 19
chr3_+_37903432 0.509 ENST00000443503.2
 CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_-_34379546 0.506 ENST00000435224.2
 ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr9_+_125703282 0.503 ENST00000373647.4
ENST00000402311.1
 RABGAP1

RAB GTPase activating protein 1

chr3_+_171758344 0.492 ENST00000336824.4
ENST00000423424.1
 FNDC3B

fibronectin type III domain containing 3B

chr1_-_95007193 0.431 ENST00000370207.4
ENST00000334047.7
 F3

coagulation factor III (thromboplastin, tissue factor)

chr17_-_1395954 0.427 ENST00000359786.5
 MYO1C
myosin IC
chr12_-_44200052 0.391 ENST00000548315.1
ENST00000552521.1
ENST00000546662.1
ENST00000548403.1
ENST00000546506.1
 TWF1




twinfilin actin-binding protein 1




chr10_-_119806085 0.371 ENST00000355624.3
 RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr20_+_56884752 0.363 ENST00000244040.3
 RAB22A
RAB22A, member RAS oncogene family
chr17_+_48423453 0.355 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
 XYLT2


xylosyltransferase II


chr17_+_40834580 0.352 ENST00000264638.4
 CNTNAP1
contactin associated protein 1
chr6_-_99873145 0.346 ENST00000369239.5
ENST00000438806.1
 PNISR

PNN-interacting serine/arginine-rich protein

chr21_-_36260980 0.314 ENST00000344691.4
ENST00000358356.5
 RUNX1

runt-related transcription factor 1

chr4_+_154125565 0.312 ENST00000338700.5
 TRIM2
tripartite motif containing 2
chr2_-_26101374 0.306 ENST00000435504.4
 ASXL2
additional sex combs like 2 (Drosophila)
chr2_+_46926048 0.291 ENST00000306503.5
 SOCS5
suppressor of cytokine signaling 5
chr12_+_49212514 0.289 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
 CACNB3


calcium channel, voltage-dependent, beta 3 subunit


chr2_+_28615669 0.273 ENST00000379619.1
ENST00000264716.4
 FOSL2

FOS-like antigen 2

chr7_-_111846435 0.263 ENST00000437633.1
ENST00000428084.1
 DOCK4

dedicator of cytokinesis 4

chr19_-_36523709 0.262 ENST00000592017.1
ENST00000360535.4
 CLIP3

CAP-GLY domain containing linker protein 3

chr5_-_59189545 0.242 ENST00000340635.6
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_72853091 0.241 ENST00000311172.7
ENST00000409314.1
 FCHSD2

FCH and double SH3 domains 2

chr4_+_183164574 0.233 ENST00000511685.1
 TENM3
teneurin transmembrane protein 3
chr16_+_69599861 0.227 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr19_-_46000251 0.223 ENST00000590526.1
ENST00000344680.4
ENST00000245923.4
 RTN2


reticulon 2


chr10_-_81205373 0.222 ENST00000372336.3
 ZCCHC24
zinc finger, CCHC domain containing 24
chr16_-_74640986 0.189 ENST00000422840.2
ENST00000565260.1
ENST00000447066.2
ENST00000205061.5
 GLG1



golgi glycoprotein 1



chr7_-_121036337 0.176 ENST00000426156.1
ENST00000359943.3
ENST00000412653.1
 FAM3C


family with sequence similarity 3, member C


chr20_+_5107420 0.175 ENST00000460006.1
 CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr11_-_79151695 0.163 ENST00000278550.7
 TENM4
teneurin transmembrane protein 4
chr1_+_84543734 0.161 ENST00000370689.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_+_30960375 0.154 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
 ORAI3


ORAI calcium release-activated calcium modulator 3


chr5_-_142783175 0.146 ENST00000231509.3
ENST00000394464.2
 NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

chr12_+_12764773 0.146 ENST00000228865.2
 CREBL2
cAMP responsive element binding protein-like 2
chr10_+_72575643 0.144 ENST00000373202.3
 SGPL1
sphingosine-1-phosphate lyase 1
chr10_+_102295616 0.144 ENST00000299163.6
 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr14_-_81687197 0.132 ENST00000553612.1
 GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr7_+_90225796 0.129 ENST00000380050.3
 CDK14
cyclin-dependent kinase 14
chr20_+_60697480 0.119 ENST00000370915.1
ENST00000253001.4
ENST00000400318.2
ENST00000279068.6
ENST00000279069.7
 LSM14B




LSM14B, SCD6 homolog B (S. cerevisiae)




chr10_+_111767720 0.102 ENST00000356080.4
ENST00000277900.8
 ADD3

adducin 3 (gamma)

chr17_+_46985731 0.101 ENST00000360943.5
 UBE2Z
ubiquitin-conjugating enzyme E2Z
chr17_+_68165657 0.097 ENST00000243457.3
 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr11_+_94822968 0.095 ENST00000278505.4
 ENDOD1
endonuclease domain containing 1
chr17_-_62340581 0.092 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
 TEX2


testis expressed 2


chr20_+_30865429 0.081 ENST00000375712.3
 KIF3B
kinesin family member 3B
chr17_-_40306934 0.072 ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
ENST00000592574.1
 RAB5C



CTD-2132N18.3
RAB5C, member RAS oncogene family



Uncharacterized protein
chr16_-_17564738 0.062 ENST00000261381.6
 XYLT1
xylosyltransferase I
chr5_+_31193847 0.062 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr20_+_43104508 0.059 ENST00000262605.4
ENST00000372904.3
 TTPAL

tocopherol (alpha) transfer protein-like

chr20_+_43595115 0.058 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
 STK4



serine/threonine kinase 4



chr15_+_73344791 0.045 ENST00000261908.6
 NEO1
neogenin 1
chr9_+_91003271 0.038 ENST00000375859.3
ENST00000541629.1
 SPIN1

spindlin 1

chr19_+_3572925 0.037 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
 HMG20B



high mobility group 20B



chr3_-_169899504 0.036 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
 PHC3









polyhomeotic homolog 3 (Drosophila)









chr1_-_204329013 0.010 ENST00000272203.3
ENST00000414478.1
 PLEKHA6

pleckstrin homology domain containing, family A member 6

chr18_-_45456930 0.008 ENST00000262160.6
ENST00000587269.1
 SMAD2

SMAD family member 2

chr2_+_24714729 0.006 ENST00000406961.1
ENST00000405141.1
 NCOA1

nuclear receptor coactivator 1

chr6_-_53409890 0.003 ENST00000229416.6
 GCLC
glutamate-cysteine ligase, catalytic subunit
chr1_+_78245303 0.002 ENST00000370791.3
ENST00000443751.2
 FAM73A

family with sequence similarity 73, member A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.5 3.2 GO:0060414 aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.6 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.2 0.8 GO:0002331 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.1 0.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 2.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 0.8 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.1 0.3 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515)
0.1 1.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.8 GO:0007220 Notch receptor processing(GO:0007220)
0.0 1.8 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 1.2 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.3 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853) positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.0 0.4 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.4 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 3.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 4.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.8 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0070052 collagen V binding(GO:0070052)
0.8 2.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.6 3.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 2.0 GO:0045159 myosin II binding(GO:0045159)
0.3 0.8 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.3 0.8 GO:0050816 beta-2 adrenergic receptor binding(GO:0031698) phosphothreonine binding(GO:0050816)
0.2 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.6 GO:0043498 obsolete cell surface binding(GO:0043498)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.8 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 2.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0 1.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton