Motif ID: ACCCUGU

Z-value: 1.051


Mature miRNA associated with seed ACCCUGU:

NamemiRBase Accession
hsa-miR-10a-5p MIMAT0000253
hsa-miR-10b-5p MIMAT0000254



Activity profile for motif ACCCUGU.

activity profile for motif ACCCUGU


Sorted Z-values histogram for motif ACCCUGU

Sorted Z-values for motif ACCCUGU



Network of associatons between targets according to the STRING database.



First level regulatory network of ACCCUGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_15246501 1.013 ENST00000341776.2
 JARID2
jumonji, AT rich interactive domain 2
chr20_+_55204351 0.919 ENST00000201031.2
 TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr6_-_10415470 0.844 ENST00000379604.2
ENST00000379613.3
 TFAP2A

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

chr10_-_62149433 0.822 ENST00000280772.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_64681219 0.817 ENST00000238875.5
 LGALSL
lectin, galactoside-binding-like
chr11_-_115375107 0.766 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr1_-_9970227 0.636 ENST00000377263.1
 CTNNBIP1
catenin, beta interacting protein 1
chr1_-_39339777 0.626 ENST00000397572.2
 MYCBP
MYC binding protein
chr1_+_93544791 0.603 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
 MTF2


metal response element binding transcription factor 2


chr2_-_20424844 0.564 ENST00000403076.1
ENST00000254351.4
 SDC1

syndecan 1

chr3_-_72496035 0.508 ENST00000477973.2
 RYBP
RING1 and YY1 binding protein
chr7_-_92463210 0.456 ENST00000265734.4
 CDK6
cyclin-dependent kinase 6
chr22_+_39898325 0.454 ENST00000325301.2
ENST00000404569.1
 MIEF1

mitochondrial elongation factor 1

chr16_+_69599861 0.424 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_+_20370746 0.411 ENST00000222573.4
 ITGB8
integrin, beta 8
chr3_+_14989076 0.409 ENST00000413118.1
ENST00000425241.1
 NR2C2

nuclear receptor subfamily 2, group C, member 2

chr2_+_120517174 0.385 ENST00000263708.2
 PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr3_-_142166904 0.377 ENST00000264951.4
 XRN1
5'-3' exoribonuclease 1
chr9_+_100263912 0.365 ENST00000259365.4
 TMOD1
tropomodulin 1
chr7_-_44924939 0.363 ENST00000395699.2
 PURB
purine-rich element binding protein B
chr2_-_2334888 0.358 ENST00000428368.2
ENST00000399161.2
 MYT1L

myelin transcription factor 1-like

chr14_+_33408449 0.358 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
 NPAS3




neuronal PAS domain protein 3




chr17_-_29151794 0.354 ENST00000324238.6
 CRLF3
cytokine receptor-like factor 3
chr1_-_217262969 0.347 ENST00000361525.3
 ESRRG
estrogen-related receptor gamma
chr5_-_160973649 0.336 ENST00000393959.1
ENST00000517547.1
 GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr16_+_50187556 0.331 ENST00000561678.1
ENST00000357464.3
 PAPD5

PAP associated domain containing 5

chr22_+_40573921 0.310 ENST00000454349.2
ENST00000335727.9
 TNRC6B

trinucleotide repeat containing 6B

chr1_+_93913713 0.301 ENST00000604705.1
ENST00000370253.2
 FNBP1L

formin binding protein 1-like

chr1_-_38325256 0.282 ENST00000373036.4
 MTF1
metal-regulatory transcription factor 1
chr2_-_206950781 0.275 ENST00000403263.1
 INO80D
INO80 complex subunit D
chr15_-_61521495 0.252 ENST00000335670.6
 RORA
RAR-related orphan receptor A
chr9_+_112403088 0.250 ENST00000448454.2
 PALM2
paralemmin 2
chr4_+_184020398 0.220 ENST00000403733.3
ENST00000378925.3
 WWC2

WW and C2 domain containing 2

chrX_+_28605516 0.219 ENST00000378993.1
 IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr1_-_85156216 0.206 ENST00000342203.3
ENST00000370612.4
 SSX2IP

synovial sarcoma, X breakpoint 2 interacting protein

chr2_+_166326157 0.205 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
 CSRNP3


cysteine-serine-rich nuclear protein 3


chr9_-_127533519 0.203 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
 NR6A1


nuclear receptor subfamily 6, group A, member 1


chr7_-_72936531 0.202 ENST00000339594.4
 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr4_-_111119804 0.199 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr3_-_196159268 0.198 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
 UBXN7



UBX domain protein 7



chr21_+_45285050 0.189 ENST00000291572.8
 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_+_10527449 0.189 ENST00000592685.1
ENST00000380702.2
 PDE4A

phosphodiesterase 4A, cAMP-specific

chr4_-_66536057 0.188 ENST00000273854.3
 EPHA5
EPH receptor A5
chr3_-_9994021 0.175 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr22_+_45559722 0.174 ENST00000347635.4
ENST00000407019.2
ENST00000424634.1
ENST00000417702.1
ENST00000425733.2
ENST00000430547.1
 NUP50





nucleoporin 50kDa





chr11_+_20620946 0.174 ENST00000525748.1
 SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr10_-_79686284 0.173 ENST00000372391.2
ENST00000372388.2
 DLG5

discs, large homolog 5 (Drosophila)

chr17_-_76713100 0.171 ENST00000585509.1
 CYTH1
cytohesin 1
chr1_+_199996702 0.169 ENST00000367362.3
 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr12_+_69864129 0.167 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
 FRS2









fibroblast growth factor receptor substrate 2









chr10_-_121632266 0.156 ENST00000360003.3
ENST00000369077.3
 MCMBP

minichromosome maintenance complex binding protein

chr4_+_47033345 0.155 ENST00000295454.3
 GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr11_-_18656028 0.154 ENST00000336349.5
 SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr1_-_94374946 0.142 ENST00000370238.3
 GCLM
glutamate-cysteine ligase, modifier subunit
chr3_+_178866199 0.142 ENST00000263967.3
 PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr14_+_70078303 0.140 ENST00000342745.4
 KIAA0247
KIAA0247
chr12_-_14956396 0.140 ENST00000535328.1
ENST00000261167.2
 WBP11

WW domain binding protein 11

chr19_+_3880581 0.139 ENST00000450849.2
ENST00000301260.6
ENST00000398448.3
 ATCAY


ataxia, cerebellar, Cayman type


chr17_+_36861735 0.139 ENST00000378137.5
ENST00000325718.7
 MLLT6

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6

chr6_-_11044509 0.138 ENST00000354666.3
 ELOVL2
ELOVL fatty acid elongase 2
chr3_+_183873098 0.131 ENST00000313143.3
 DVL3
dishevelled segment polarity protein 3
chr18_+_43914159 0.131 ENST00000588679.1
ENST00000269439.7
ENST00000543885.1
 RNF165


ring finger protein 165


chr2_-_37193606 0.130 ENST00000379213.2
ENST00000263918.4
 STRN

striatin, calmodulin binding protein

chr8_+_1449532 0.123 ENST00000421627.2
 DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chrX_+_9431324 0.123 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr20_+_31407692 0.106 ENST00000375571.5
 MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr10_+_89622870 0.106 ENST00000371953.3
 PTEN
phosphatase and tensin homolog
chr1_+_57110972 0.103 ENST00000371244.4
 PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr16_-_85722530 0.103 ENST00000253462.3
 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr14_+_23775971 0.101 ENST00000250405.5
 BCL2L2
BCL2-like 2
chr19_-_14316980 0.098 ENST00000361434.3
ENST00000340736.6
 LPHN1

latrophilin 1

chr1_-_39347255 0.096 ENST00000454994.2
ENST00000357771.3
 GJA9

gap junction protein, alpha 9, 59kDa

chr18_+_9136758 0.090 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
 ANKRD12


ankyrin repeat domain 12


chr11_-_8680383 0.085 ENST00000299550.6
 TRIM66
tripartite motif containing 66
chr1_+_36396677 0.084 ENST00000373191.4
ENST00000397828.2
 AGO3

argonaute RISC catalytic component 3

chr22_+_30279144 0.081 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
 MTMR3




myotubularin related protein 3




chr10_+_8096631 0.079 ENST00000379328.3
 GATA3
GATA binding protein 3
chr17_-_49198216 0.077 ENST00000262013.7
ENST00000357122.4
 SPAG9

sperm associated antigen 9

chr2_+_208394616 0.073 ENST00000432329.2
ENST00000353267.3
ENST00000445803.1
 CREB1


cAMP responsive element binding protein 1


chr19_+_1407517 0.066 ENST00000336761.6
ENST00000233078.4
 DAZAP1

DAZ associated protein 1

chr3_+_238273 0.065 ENST00000256509.2
 CHL1
cell adhesion molecule L1-like
chr1_+_28052456 0.064 ENST00000373954.6
ENST00000419687.2
 FAM76A

family with sequence similarity 76, member A

chr5_+_149109825 0.062 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
 PPARGC1B


peroxisome proliferator-activated receptor gamma, coactivator 1 beta


chr8_+_22857048 0.057 ENST00000251822.6
 RHOBTB2
Rho-related BTB domain containing 2
chr2_+_111878483 0.054 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
 BCL2L11




BCL2-like 11 (apoptosis facilitator)




chr2_-_166060571 0.052 ENST00000360093.3
 SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr18_-_33647487 0.051 ENST00000590898.1
ENST00000357384.4
ENST00000319040.6
ENST00000588737.1
ENST00000399022.4
 RPRD1A




regulation of nuclear pre-mRNA domain containing 1A




chr15_+_42066632 0.051 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
 MAPKBP1



mitogen-activated protein kinase binding protein 1



chr11_+_18344106 0.048 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
 GTF2H1


general transcription factor IIH, polypeptide 1, 62kDa


chr17_-_73775839 0.048 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
 H3F3B




H3 histone, family 3B (H3.3B)




chr2_-_160472952 0.040 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
 BAZ2B



bromodomain adjacent to zinc finger domain, 2B



chr1_+_224301787 0.039 ENST00000366862.5
ENST00000424254.2
 FBXO28

F-box protein 28

chr1_+_89990431 0.038 ENST00000330947.2
ENST00000358200.4
 LRRC8B

leucine rich repeat containing 8 family, member B

chr3_+_48956249 0.036 ENST00000452882.1
ENST00000430423.1
ENST00000356401.4
ENST00000449376.1
ENST00000420814.1
ENST00000449729.1
ENST00000433170.1
 ARIH2






ariadne RBR E3 ubiquitin protein ligase 2






chr2_-_69870835 0.032 ENST00000409085.4
ENST00000406297.3
 AAK1

AP2 associated kinase 1

chr1_+_202976493 0.030 ENST00000367242.3
 TMEM183A
transmembrane protein 183A
chr9_-_95527079 0.029 ENST00000356884.6
ENST00000375512.3
 BICD2

bicaudal D homolog 2 (Drosophila)

chr4_+_3076388 0.027 ENST00000355072.5
 HTT
huntingtin
chr19_+_19496624 0.027 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A


GATA zinc finger domain containing 2A


chr8_-_41655107 0.025 ENST00000347528.4
ENST00000289734.7
ENST00000379758.2
ENST00000396945.1
ENST00000396942.1
ENST00000352337.4
 ANK1





ankyrin 1, erythrocytic





chr10_-_88281494 0.020 ENST00000298767.5
 WAPAL
wings apart-like homolog (Drosophila)
chr5_+_179921430 0.020 ENST00000393356.1
 CNOT6
CCR4-NOT transcription complex, subunit 6
chr7_+_94139105 0.019 ENST00000297273.4
 CASD1
CAS1 domain containing 1
chr3_-_179754706 0.001 ENST00000465751.1
ENST00000467460.1
 PEX5L

peroxisomal biogenesis factor 5-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.2 1.0 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.2 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.6 GO:0048627 myoblast development(GO:0048627)
0.2 0.6 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.1 0.4 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 0.2 GO:0042759 fatty acid elongation, saturated fatty acid(GO:0019367) long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.2 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0030497 fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation(GO:0030497) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.3 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.1 GO:0090103 cochlea morphogenesis(GO:0090103)
0.0 0.1 GO:0060292 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) long term synaptic depression(GO:0060292)
0.0 0.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.2 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.4 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0032916 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916)
0.0 0.2 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.2 GO:0034339 obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)
0.0 0.3 GO:0046686 response to cadmium ion(GO:0046686)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032422 translation repressor activity, nucleic acid binding(GO:0000900) purine-rich negative regulatory element binding(GO:0032422)
0.1 0.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 1.0 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.3 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187) glycine:sodium symporter activity(GO:0015375)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0046934 obsolete inositol or phosphatidylinositol kinase activity(GO:0004428) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.8 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.