ISMARA results: AGCUUAU

Motif ID: AGCUUAU

Z-value: 0.649

Mature miRNA associated with seed AGCUUAU:

Name	miRBase Accession
hsa-miR-21-5p	MIMAT0000076
hsa-miR-590-5p	MIMAT0003258

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_+_135364584	1.996	ENST00000442011.2 ENST00000305126.8	TGFBI	transforming growth factor, beta-induced, 68kDa
chr22_+_33197683	1.253	ENST00000266085.6	TIMP3	TIMP metallopeptidase inhibitor 3
chr11_-_115375107	0.945	ENST00000545380.1 ENST00000452722.3 ENST00000537058.1 ENST00000536727.1 ENST00000542447.2 ENST00000331581.6	CADM1	cell adhesion molecule 1
chr4_+_124320665	0.812	ENST00000394339.2	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_+_228678550	0.796	ENST00000409189.3 ENST00000358813.4	CCL20	chemokine (C-C motif) ligand 20
chr20_-_10654639	0.744	ENST00000254958.5	JAG1	jagged 1
chr11_+_101981169	0.663	ENST00000526343.1 ENST00000282441.5 ENST00000537274.1 ENST00000345877.2	YAP1	Yes-associated protein 1
chr6_-_82462425	0.616	ENST00000369754.3 ENST00000320172.6 ENST00000369756.3	FAM46A	family with sequence similarity 46, member A
chr7_-_139876812	0.578	ENST00000397560.2	JHDM1D	lysine (K)-specific demethylase 7A
chr16_+_69599861	0.475	ENST00000354436.2	NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive
chr1_-_72748417	0.424	ENST00000357731.5	NEGR1	neuronal growth regulator 1
chr8_+_87354945	0.402	ENST00000517970.1	WWP1	WW domain containing E3 ubiquitin protein ligase 1
chr13_+_73632897	0.395	ENST00000377687.4	KLF5	Kruppel-like factor 5 (intestinal)
chr13_-_41706864	0.354	ENST00000379485.1 ENST00000499385.2	KBTBD6	kelch repeat and BTB (POZ) domain containing 6
chr17_+_21187976	0.351	ENST00000342679.4	MAP2K3	mitogen-activated protein kinase kinase 3
chr4_-_89744457	0.293	ENST00000395002.2	FAM13A	family with sequence similarity 13, member A
chrX_-_20284958	0.273	ENST00000379565.3	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr2_-_85581701	0.266	ENST00000295802.4	RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)
chr7_+_102715315	0.245	ENST00000428183.2 ENST00000323716.3 ENST00000441711.2 ENST00000454559.1 ENST00000425331.1 ENST00000541300.1	ARMC10	armadillo repeat containing 10
chr7_-_44924939	0.245	ENST00000395699.2	PURB	purine-rich element binding protein B
chr4_+_113152881	0.239	ENST00000274000.5	AP1AR	adaptor-related protein complex 1 associated regulatory protein
chr2_+_86947296	0.234	ENST00000283632.4	RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr5_+_125758813	0.213	ENST00000285689.3 ENST00000515200.1	GRAMD3	GRAM domain containing 3
chr4_+_38665810	0.212	ENST00000261438.5 ENST00000514033.1	KLF3	Kruppel-like factor 3 (basic)
chr3_+_30648066	0.212	ENST00000359013.4	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)
chr15_-_33360085	0.203	ENST00000334528.9	FMN1	formin 1
chr4_+_4861385	0.201	ENST00000382723.4	MSX1	msh homeobox 1
chr12_+_53848505	0.190	ENST00000552819.1 ENST00000455667.3	PCBP2	poly(rC) binding protein 2
chr11_-_1593150	0.189	ENST00000397374.3	DUSP8	dual specificity phosphatase 8
chr8_+_61591337	0.181	ENST00000423902.2	CHD7	chromodomain helicase DNA binding protein 7
chr15_-_102029873	0.165	ENST00000348070.1 ENST00000358417.3 ENST00000344273.2	PCSK6	proprotein convertase subtilisin/kexin type 6
chr8_-_9008206	0.163	ENST00000310455.3	PPP1R3B	protein phosphatase 1, regulatory subunit 3B
chr2_+_148602058	0.157	ENST00000241416.7 ENST00000535787.1 ENST00000404590.1	ACVR2A	activin A receptor, type IIA
chr8_-_82024290	0.152	ENST00000220597.4	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1
chr3_+_110790590	0.148	ENST00000485303.1	PVRL3	poliovirus receptor-related 3
chr2_-_43453734	0.145	ENST00000282388.3	ZFP36L2	ZFP36 ring finger protein-like 2
chr2_-_218808771	0.139	ENST00000449814.1 ENST00000171887.4	TNS1	tensin 1
chr1_+_39456895	0.136	ENST00000432648.3 ENST00000446189.2 ENST00000372984.4	AKIRIN1	akirin 1
chr5_+_67511524	0.135	ENST00000521381.1 ENST00000521657.1	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr15_-_42840961	0.132	ENST00000563454.1 ENST00000397130.3 ENST00000570160.1 ENST00000323443.2	LRRC57	leucine rich repeat containing 57
chr2_+_198318147	0.131	ENST00000263960.2	COQ10B	coenzyme Q10 homolog B (S. cerevisiae)
chr8_+_56014949	0.129	ENST00000327381.6	XKR4	XK, Kell blood group complex subunit-related family, member 4
chr1_-_214724566	0.127	ENST00000366956.5	PTPN14	protein tyrosine phosphatase, non-receptor type 14
chr12_-_12419703	0.120	ENST00000543091.1 ENST00000261349.4	LRP6	low density lipoprotein receptor-related protein 6
chr7_+_89975979	0.119	ENST00000257659.8 ENST00000222511.6 ENST00000417207.1	GTPBP10	GTP-binding protein 10 (putative)
chr4_-_102268628	0.112	ENST00000323055.6 ENST00000512215.1 ENST00000394854.3	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr11_+_33278811	0.109	ENST00000303296.4 ENST00000379016.3	HIPK3	homeodomain interacting protein kinase 3
chr12_-_121342170	0.107	ENST00000353487.2	SPPL3	signal peptide peptidase like 3
chr5_-_168006591	0.102	ENST00000239231.6	PANK3	pantothenate kinase 3
chr18_+_67956135	0.100	ENST00000397942.3	SOCS6	suppressor of cytokine signaling 6
chr16_-_47007545	0.096	ENST00000317089.5	DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2
chr2_-_37193606	0.095	ENST00000379213.2 ENST00000263918.4	STRN	striatin, calmodulin binding protein
chr1_+_154377669	0.092	ENST00000368485.3 ENST00000344086.4	IL6R	interleukin 6 receptor
chr17_+_59477233	0.092	ENST00000240328.3	TBX2	T-box 2
chr5_-_141704566	0.084	ENST00000344120.4 ENST00000434127.2	SPRY4	sprouty homolog 4 (Drosophila)
chr2_+_20646824	0.082	ENST00000272233.4	RHOB	ras homolog family member B
chr14_+_64854958	0.082	ENST00000555709.2 ENST00000554739.1 ENST00000554768.1 ENST00000216605.8	MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr20_+_56884752	0.072	ENST00000244040.3	RAB22A	RAB22A, member RAS oncogene family
chr9_+_21802542	0.071	ENST00000380172.4	MTAP	methylthioadenosine phosphorylase
chr3_-_72496035	0.070	ENST00000477973.2	RYBP	RING1 and YY1 binding protein
chr11_+_32851487	0.065	ENST00000257836.3	PRRG4	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr2_+_36582857	0.063	ENST00000280527.2	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr20_+_62371206	0.062	ENST00000266077.2	SLC2A4RG	SLC2A4 regulator
chr1_+_64239657	0.061	ENST00000371080.1 ENST00000371079.1	ROR1	receptor tyrosine kinase-like orphan receptor 1
chr8_+_9413410	0.061	ENST00000520408.1 ENST00000310430.6 ENST00000522110.1	TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr2_-_64371546	0.060	ENST00000358912.4	PELI1	pellino E3 ubiquitin protein ligase 1
chr4_-_87281224	0.056	ENST00000395169.3 ENST00000395161.2	MAPK10	mitogen-activated protein kinase 10
chr9_-_34589700	0.055	ENST00000351266.4	CNTFR	ciliary neurotrophic factor receptor
chr8_+_75736761	0.055	ENST00000260113.2	PI15	peptidase inhibitor 15
chr2_+_70314579	0.054	ENST00000303577.5	PCBP1	poly(rC) binding protein 1
chr4_+_48018781	0.053	ENST00000295461.5	NIPAL1	NIPA-like domain containing 1
chr22_+_38302285	0.051	ENST00000215957.6	MICALL1	MICAL-like 1
chr17_-_32690239	0.050	ENST00000225842.3	CCL1	chemokine (C-C motif) ligand 1
chr17_-_33416231	0.049	ENST00000584655.1 ENST00000447669.2 ENST00000315249.7	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr1_+_2160134	0.048	ENST00000378536.4	SKI	v-ski avian sarcoma viral oncogene homolog
chr15_+_59063478	0.047	ENST00000559228.1 ENST00000450403.2	FAM63B	family with sequence similarity 63, member B
chr17_+_58755184	0.047	ENST00000589222.1 ENST00000407086.3 ENST00000390652.5	BCAS3	breast carcinoma amplified sequence 3
chr10_+_72164135	0.047	ENST00000373218.4	EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2
chrX_-_19140677	0.047	ENST00000357544.3 ENST00000379869.3 ENST00000360279.4 ENST00000379873.2 ENST00000379878.3 ENST00000354791.3 ENST00000379876.1	GPR64	G protein-coupled receptor 64
chr2_-_201936302	0.046	ENST00000453765.1 ENST00000452799.1 ENST00000446678.1 ENST00000418596.3	FAM126B	family with sequence similarity 126, member B
chr6_+_142468361	0.045	ENST00000367630.4	VTA1	vesicle (multivesicular body) trafficking 1
chr1_-_115053781	0.044	ENST00000358465.2 ENST00000369543.2	TRIM33	tripartite motif containing 33
chr5_-_32313019	0.040	ENST00000280285.5 ENST00000264934.5	MTMR12	myotubularin related protein 12
chr7_-_30029367	0.038	ENST00000242059.5	SCRN1	secernin 1
chr1_+_15853308	0.038	ENST00000375838.1 ENST00000375847.3 ENST00000375849.1	DNAJC16	DnaJ (Hsp40) homolog, subfamily C, member 16
chr10_+_76871454	0.037	ENST00000372687.4	SAMD8	sterile alpha motif domain containing 8
chr6_+_148663729	0.037	ENST00000367467.3	SASH1	SAM and SH3 domain containing 1
chr12_-_123011536	0.037	ENST00000331738.7 ENST00000354654.2	RSRC2	arginine/serine-rich coiled-coil 2
chr7_-_92463210	0.035	ENST00000265734.4	CDK6	cyclin-dependent kinase 6
chr5_+_139493665	0.032	ENST00000331327.3	PURA	purine-rich element binding protein A
chr16_+_12070567	0.032	ENST00000566228.1	SNX29	sorting nexin 29
chr8_-_57123815	0.031	ENST00000316981.3 ENST00000423799.2 ENST00000429357.2	PLAG1	pleiomorphic adenoma gene 1
chr10_-_119134918	0.028	ENST00000334464.5	PDZD8	PDZ domain containing 8
chr14_-_99737565	0.025	ENST00000357195.3	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)
chr4_-_103748880	0.025	ENST00000453744.2 ENST00000349311.8	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr10_-_3827417	0.025	ENST00000497571.1 ENST00000542957.1	KLF6	Kruppel-like factor 6
chr17_+_61627814	0.023	ENST00000310827.4 ENST00000431926.1 ENST00000415273.2	DCAF7	DDB1 and CUL4 associated factor 7
chr22_+_40573921	0.022	ENST00000454349.2 ENST00000335727.9	TNRC6B	trinucleotide repeat containing 6B
chr5_+_172483347	0.022	ENST00000522692.1 ENST00000296953.2 ENST00000540014.1 ENST00000520420.1	CREBRF	CREB3 regulatory factor
chr21_-_32931290	0.019	ENST00000286827.3	TIAM1	T-cell lymphoma invasion and metastasis 1
chr10_-_94003003	0.019	ENST00000412050.4	CPEB3	cytoplasmic polyadenylation element binding protein 3
chr4_+_99916765	0.019	ENST00000296411.6	METAP1	methionyl aminopeptidase 1
chr1_+_172628154	0.018	ENST00000340030.3 ENST00000367721.2	FASLG	Fas ligand (TNF superfamily, member 6)
chr12_-_42538657	0.017	ENST00000398675.3	GXYLT1	glucoside xylosyltransferase 1
chr7_-_83824169	0.017	ENST00000265362.4	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_-_69870835	0.017	ENST00000409085.4 ENST00000406297.3	AAK1	AP2 associated kinase 1
chr7_-_113559104	0.016	ENST00000284601.3	PPP1R3A	protein phosphatase 1, regulatory subunit 3A
chr3_+_159706537	0.016	ENST00000305579.2 ENST00000480787.1 ENST00000466512.1	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr2_+_70142189	0.011	ENST00000264444.2	MXD1	MAX dimerization protein 1
chr12_-_117319236	0.010	ENST00000257572.5	HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)
chr7_+_11013491	0.009	ENST00000403050.3 ENST00000445996.2	PHF14	PHD finger protein 14
chr11_+_120207787	0.009	ENST00000397843.2 ENST00000356641.3	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12
chr1_+_33005020	0.008	ENST00000373510.4 ENST00000316459.4	ZBTB8A	zinc finger and BTB domain containing 8A
chr16_-_20911641	0.008	ENST00000324344.4 ENST00000564349.1	DCUN1D3 ERI2	DCN1, defective in cullin neddylation 1, domain containing 3 ERI1 exoribonuclease family member 2
chr9_-_86595503	0.008	ENST00000376281.4 ENST00000376264.2	HNRNPK	heterogeneous nuclear ribonucleoprotein K
chr3_+_181429704	0.007	ENST00000431565.2 ENST00000325404.1	SOX2	SRY (sex determining region Y)-box 2
chr8_-_22550815	0.007	ENST00000317216.2	EGR3	early growth response 3
chr17_-_77813186	0.007	ENST00000448310.1 ENST00000269397.4	CBX4	chromobox homolog 4
chr1_+_113010056	0.006	ENST00000369686.5	WNT2B	wingless-type MMTV integration site family, member 2B
chr8_-_10588010	0.006	ENST00000304501.1	SOX7	SRY (sex determining region Y)-box 7
chr16_-_75498553	0.005	ENST00000569276.1 ENST00000357613.4 ENST00000561878.1 ENST00000566980.1 ENST00000567194.1	TMEM170A RP11-77K12.1	transmembrane protein 170A Uncharacterized protein
chr3_+_98451275	0.004	ENST00000265261.6 ENST00000497008.1	ST3GAL6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr12_+_5541267	0.004	ENST00000423158.3	NTF3	neurotrophin 3
chr7_+_138916231	0.003	ENST00000473989.3 ENST00000288561.8	UBN2	ubinuclein 2
chr19_+_1286097	0.003	ENST00000215368.2	EFNA2	ephrin-A2
chr4_-_111544254	0.003	ENST00000306732.3	PITX2	paired-like homeodomain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2	0.9	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2	0.6	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.1	0.8	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1	0.7	GO:0060242	contact inhibition(GO:0060242)
0.1	0.8	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.1	0.2	GO:0002514	B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1	0.2	GO:0060596	mammary placode formation(GO:0060596)
0.1	0.2	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927) Sertoli cell proliferation(GO:0060011)
0.0	0.4	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.2	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.4	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.1	GO:0002384	hepatic immune response(GO:0002384)
0.0	0.1	GO:0046495	nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.3	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.2	GO:0060123	female genitalia development(GO:0030540) regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	2.0	GO:0007162	negative regulation of cell adhesion(GO:0007162)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)

Gene overrepresentation in cellular_component category:

Total log-likelihood	Term	Description
0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0097651	phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	GO:0005955	calcineurin complex(GO:0005955)
0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
1.1	GO:0005604	basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0005112	Notch binding(GO:0005112)
0.1	0.6	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.2	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.1	1.0	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.1	0.2	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.1	0.2	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	2.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0019981	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0	0.7	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.2	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.6	GO:0008009	chemokine activity(GO:0008009)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.9	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.0	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)