Motif ID: AGGUAGU

Z-value: 1.311


Mature miRNA associated with seed AGGUAGU:

NamemiRBase Accession
hsa-miR-196a-5p MIMAT0000226
hsa-miR-196b-5p MIMAT0001080



Activity profile for motif AGGUAGU.

activity profile for motif AGGUAGU


Sorted Z-values histogram for motif AGGUAGU

Sorted Z-values for motif AGGUAGU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGGUAGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94023873 4.005 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr2_+_189839046 3.296 ENST00000304636.3
ENST00000317840.5
COL3A1

collagen, type III, alpha 1

chr17_-_46682321 2.007 ENST00000225648.3
ENST00000484302.2
HOXB6

homeobox B6

chr17_-_48278983 1.857 ENST00000225964.5
COL1A1
collagen, type I, alpha 1
chr1_+_164528866 1.712 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr9_-_16870704 1.669 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2



basonuclin 2



chr17_-_46688334 1.549 ENST00000239165.7
HOXB7
homeobox B7
chr17_+_68165657 1.496 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_+_159557637 1.449 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr3_+_158991025 1.325 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr12_-_25102252 1.319 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chrX_+_134166333 1.096 ENST00000257013.7
FAM127A
family with sequence similarity 127, member A
chr12_-_69326940 0.947 ENST00000549781.1
ENST00000548262.1
ENST00000551568.1
ENST00000548954.1
CPM



carboxypeptidase M



chr3_+_110790590 0.908 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr3_+_61547585 0.864 ENST00000295874.10
ENST00000474889.1
PTPRG

protein tyrosine phosphatase, receptor type, G

chr14_-_88459503 0.854 ENST00000393568.4
ENST00000261304.2
GALC

galactosylceramidase

chr9_+_132934835 0.804 ENST00000372398.3
NCS1
neuronal calcium sensor 1
chrX_-_134186144 0.793 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr7_-_27196267 0.751 ENST00000242159.3
HOXA7
homeobox A7
chr1_-_92351769 0.637 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr17_+_28705921 0.568 ENST00000225719.4
CPD
carboxypeptidase D
chr7_-_27183263 0.564 ENST00000222726.3
HOXA5
homeobox A5
chr2_+_5832799 0.563 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chr10_+_180987 0.561 ENST00000381591.1
ZMYND11
zinc finger, MYND-type containing 11
chr16_+_69221028 0.560 ENST00000336278.4
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr18_+_19749386 0.539 ENST00000269216.3
GATA6
GATA binding protein 6
chr2_-_39664405 0.502 ENST00000341681.5
ENST00000263881.3
MAP4K3

mitogen-activated protein kinase kinase kinase kinase 3

chr14_-_20020272 0.499 ENST00000551509.1
POTEM
POTE ankyrin domain family, member M
chr14_+_19553365 0.460 ENST00000409832.3
POTEG
POTE ankyrin domain family, member G
chr4_+_55095264 0.458 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr10_+_1095416 0.443 ENST00000358220.1
WDR37
WD repeat domain 37
chr7_-_75368248 0.435 ENST00000434438.2
ENST00000336926.6
HIP1

huntingtin interacting protein 1

chr14_+_90863327 0.407 ENST00000356978.4
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr8_+_59465728 0.401 ENST00000260130.4
ENST00000422546.2
ENST00000447182.2
ENST00000413219.2
ENST00000424270.2
ENST00000523483.1
ENST00000520168.1
SDCBP






syndecan binding protein (syntenin)






chr7_-_83824169 0.385 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr21_-_39870339 0.372 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG




v-ets avian erythroblastosis virus E26 oncogene homolog




chr14_+_58666824 0.372 ENST00000254286.4
ACTR10
actin-related protein 10 homolog (S. cerevisiae)
chr17_+_8213590 0.361 ENST00000361926.3
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr10_+_11206925 0.359 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2


CUGBP, Elav-like family member 2


chr12_-_58240470 0.346 ENST00000548823.1
ENST00000398073.2
CTDSP2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

chrX_+_95939711 0.343 ENST00000373049.4
ENST00000324765.8
DIAPH2

diaphanous-related formin 2

chr9_-_79520989 0.313 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2


prune homolog 2 (Drosophila)


chr5_+_178286925 0.263 ENST00000322434.3
ZNF354B
zinc finger protein 354B
chr3_-_28390581 0.256 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr15_+_66994561 0.247 ENST00000288840.5
SMAD6
SMAD family member 6
chr11_-_796197 0.234 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22


solute carrier family 25 (mitochondrial carrier: glutamate), member 22


chr1_+_193091080 0.231 ENST00000367435.3
CDC73
cell division cycle 73
chr21_+_42539701 0.225 ENST00000330333.6
ENST00000328735.6
ENST00000347667.5
BACE2


beta-site APP-cleaving enzyme 2


chr12_-_93323013 0.225 ENST00000322349.8
EEA1
early endosome antigen 1
chr7_-_120498357 0.222 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12


tetraspanin 12


chr9_+_133710453 0.219 ENST00000318560.5
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr12_-_110318263 0.203 ENST00000318348.4
GLTP
glycolipid transfer protein
chr16_+_447209 0.187 ENST00000382940.4
ENST00000219479.2
NME4

NME/NM23 nucleoside diphosphate kinase 4

chr8_-_82754427 0.187 ENST00000353788.4
ENST00000520618.1
ENST00000518183.1
ENST00000396330.2
ENST00000519119.1
ENST00000345957.4
SNX16





sorting nexin 16





chr7_-_27205136 0.177 ENST00000396345.1
ENST00000343483.6
HOXA9

homeobox A9

chr14_-_57735528 0.176 ENST00000340918.7
ENST00000413566.2
EXOC5

exocyst complex component 5

chr12_-_29534074 0.175 ENST00000546839.1
ENST00000360150.4
ENST00000552155.1
ENST00000550353.1
ENST00000548441.1
ENST00000552132.1
ERGIC2





ERGIC and golgi 2





chrX_-_77150985 0.175 ENST00000358075.6
MAGT1
magnesium transporter 1
chr9_+_99212403 0.163 ENST00000375251.3
ENST00000375249.4
HABP4

hyaluronan binding protein 4

chr19_+_47104493 0.162 ENST00000291295.9
ENST00000597743.1
CALM3

calmodulin 3 (phosphorylase kinase, delta)

chr22_+_50781723 0.161 ENST00000359139.3
ENST00000395741.3
ENST00000395744.3
PPP6R2


protein phosphatase 6, regulatory subunit 2


chr8_+_58907104 0.161 ENST00000361488.3
FAM110B
family with sequence similarity 110, member B
chr5_-_74326724 0.156 ENST00000322348.4
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr5_+_38846101 0.149 ENST00000274276.3
OSMR
oncostatin M receptor
chr18_+_21032781 0.141 ENST00000339486.3
RIOK3
RIO kinase 3
chr22_-_22221900 0.138 ENST00000215832.6
ENST00000398822.3
MAPK1

mitogen-activated protein kinase 1

chr12_-_76478686 0.137 ENST00000261182.8
NAP1L1
nucleosome assembly protein 1-like 1
chr8_-_23315190 0.132 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4


ectonucleoside triphosphate diphosphohydrolase 4


chr8_+_37594130 0.128 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2


ER lipid raft associated 2


chr20_+_49348081 0.115 ENST00000371610.2
PARD6B
par-6 family cell polarity regulator beta
chr12_+_62654119 0.114 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15


ubiquitin specific peptidase 15


chr18_+_6834472 0.113 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
ARHGAP28


Rho GTPase activating protein 28


chr4_+_71587669 0.110 ENST00000381006.3
ENST00000226328.4
RUFY3

RUN and FYVE domain containing 3

chr4_+_106473768 0.109 ENST00000265154.2
ENST00000420470.2
ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr16_+_29789561 0.105 ENST00000400752.4
ZG16
zymogen granule protein 16
chrX_+_135067576 0.099 ENST00000370701.1
ENST00000370698.3
ENST00000370695.4
SLC9A6


solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6


chr9_+_110045537 0.095 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr8_-_68255912 0.092 ENST00000262215.3
ENST00000519436.1
ARFGEF1

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

chr12_+_12764773 0.092 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr3_+_50712672 0.090 ENST00000266037.9
DOCK3
dedicator of cytokinesis 3
chr3_+_101504200 0.090 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr16_-_4166186 0.084 ENST00000294016.3
ADCY9
adenylate cyclase 9
chr9_-_135819987 0.082 ENST00000298552.3
ENST00000403810.1
TSC1

tuberous sclerosis 1

chr8_+_121137333 0.073 ENST00000309791.4
ENST00000297848.3
ENST00000247781.3
COL14A1


collagen, type XIV, alpha 1


chr15_-_50411412 0.073 ENST00000284509.6
ATP8B4
ATPase, class I, type 8B, member 4
chr9_+_128509624 0.071 ENST00000342287.5
ENST00000373487.4
PBX3

pre-B-cell leukemia homeobox 3

chrX_+_2746850 0.070 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2


glycogenin 2


chr6_+_34204642 0.069 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr1_-_115259337 0.064 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr12_-_112123726 0.063 ENST00000419234.4
BRAP
BRCA1 associated protein
chr1_-_200379180 0.056 ENST00000294740.3
ZNF281
zinc finger protein 281
chr9_+_115983808 0.054 ENST00000374210.6
ENST00000374212.4
SLC31A1

solute carrier family 31 (copper transporter), member 1

chr7_+_35840542 0.053 ENST00000435235.1
ENST00000399034.2
ENST00000350320.6
ENST00000469679.2
SEPT7



septin 7



chr21_-_30365136 0.044 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1


listerin E3 ubiquitin protein ligase 1


chr6_-_33267101 0.039 ENST00000497454.1
RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr11_-_110167352 0.037 ENST00000533991.1
ENST00000528498.1
ENST00000405097.1
ENST00000528900.1
ENST00000530301.1
ENST00000343115.4
RDX





radixin





chr9_-_111929560 0.035 ENST00000561981.2
FRRS1L
ferric-chelate reductase 1-like
chr1_-_179198702 0.033 ENST00000502732.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr8_+_81397876 0.030 ENST00000430430.1
ZBTB10
zinc finger and BTB domain containing 10
chr14_+_51706886 0.027 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr18_+_9475668 0.025 ENST00000383432.3
RALBP1
ralA binding protein 1
chr16_+_70332956 0.025 ENST00000288071.6
ENST00000393657.2
ENST00000355992.3
ENST00000567706.1
DDX19B


RP11-529K1.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B


Uncharacterized protein
chr16_+_70380732 0.025 ENST00000302243.7
DDX19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
chr6_-_35464727 0.021 ENST00000402886.3
TEAD3
TEA domain family member 3
chr2_-_50574856 0.020 ENST00000342183.5
NRXN1
neurexin 1
chr14_+_72399833 0.020 ENST00000553530.1
ENST00000556437.1
RGS6

regulator of G-protein signaling 6

chr12_-_123450986 0.017 ENST00000344275.7
ENST00000442833.2
ENST00000280560.8
ENST00000540285.1
ENST00000346530.5
ABCB9




ATP-binding cassette, sub-family B (MDR/TAP), member 9




chrX_+_49687216 0.013 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr12_+_123868320 0.011 ENST00000402868.3
ENST00000330479.4
SETD8

SET domain containing (lysine methyltransferase) 8

chr2_+_160568978 0.007 ENST00000409175.1
ENST00000539065.1
ENST00000259050.4
ENST00000421037.1
MARCH7



membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase



chr2_+_113239710 0.006 ENST00000233336.6
TTL
tubulin tyrosine ligase
chr6_+_133562472 0.001 ENST00000430974.2
ENST00000367895.5
ENST00000355167.3
ENST00000355286.6
EYA4



eyes absent homolog 4 (Drosophila)



chr1_+_153232160 0.001 ENST00000368742.3
LOR
loricrin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 3.3 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.3 0.8 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.2 1.3 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.2 0.9 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.2 0.6 GO:0060318 definitive erythrocyte differentiation(GO:0060318)
0.2 2.0 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.2 1.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.2 0.6 GO:0060574 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536) intestinal epithelial cell maturation(GO:0060574) intestinal epithelial cell development(GO:0060576)
0.2 0.5 GO:0071635 intestinal epithelial cell differentiation(GO:0060575) negative regulation of transforming growth factor beta production(GO:0071635)
0.1 0.6 GO:0070669 response to interleukin-2(GO:0070669)
0.1 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.1 0.2 GO:0060394 obsolete positive regulation of S phase of mitotic cell cycle(GO:0045750) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 0.8 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:1903019 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of glycoprotein metabolic process(GO:1903019)
0.0 0.2 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.6 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 1.3 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.2 GO:0046051 GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0 0.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.2 GO:0033523 histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523)
0.0 0.4 GO:0050807 regulation of synapse organization(GO:0050807)
0.0 1.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.9 GO:0034332 adherens junction organization(GO:0034332)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 0.6 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.4 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.6 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.2 GO:0031997 N-terminal myristoylation domain binding(GO:0031997)
0.1 0.2 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713) transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 5.6 GO:0030528 obsolete transcription regulator activity(GO:0030528)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)