ISMARA results: ATF4

Motif ID: ATF4

Z-value: 1.476

Transcription factors associated with ATF4:

Gene Symbol	Entrez ID	Gene Name
ATF4	ENSG00000128272.10	ATF4

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_1665253	3.572	ENST00000254722.4	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665345	3.082	ENST00000576406.1 ENST00000571149.1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_79895097	2.148	ENST00000402252.2 ENST00000583564.1 ENST00000585244.1 ENST00000337943.5 ENST00000579698.1	PYCR1	pyrroline-5-carboxylate reductase 1
chr17_-_79895154	2.146	ENST00000405481.4 ENST00000585215.1 ENST00000577624.1 ENST00000403172.4	PYCR1	pyrroline-5-carboxylate reductase 1
chr8_-_38008783	2.143	ENST00000276449.4	STAR	steroidogenic acute regulatory protein
chr12_+_57849048	1.968	ENST00000266646.2	INHBE	inhibin, beta E
chrX_+_9431324	1.834	ENST00000407597.2 ENST00000424279.1 ENST00000536365.1 ENST00000441088.1 ENST00000380961.1 ENST00000415293.1	TBL1X	transducin (beta)-like 1X-linked
chr21_-_44495919	1.686	ENST00000398158.1	CBS	cystathionine-beta-synthase
chr21_-_44495964	1.677	ENST00000398168.1 ENST00000398165.3	CBS	cystathionine-beta-synthase
chr9_-_99381660	1.645	ENST00000375240.3 ENST00000463569.1	CDC14B	cell division cycle 14B
chr12_+_93963590	1.561	ENST00000340600.2	SOCS2	suppressor of cytokine signaling 2
chr12_+_57624085	1.340	ENST00000553474.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr14_+_24563510	1.327	ENST00000545054.2 ENST00000561286.1 ENST00000558096.1	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr19_-_47288162	1.218	ENST00000594991.1	SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5
chr14_+_24563262	1.203	ENST00000559250.1 ENST00000216780.4 ENST00000560736.1 ENST00000396973.4 ENST00000559837.1	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_-_38412683	1.111	ENST00000373024.3 ENST00000373023.2	INPP5B	inositol polyphosphate-5-phosphatase, 75kDa
chr19_-_47287990	1.049	ENST00000593713.1 ENST00000598022.1 ENST00000434726.2	SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5
chr12_-_57914275	1.031	ENST00000547303.1 ENST00000552740.1 ENST00000547526.1 ENST00000551116.1 ENST00000346473.3	DDIT3	DNA-damage-inducible transcript 3
chr19_+_11350278	0.941	ENST00000252453.8	C19orf80	chromosome 19 open reading frame 80
chr1_+_212782012	0.894	ENST00000341491.4 ENST00000366985.1	ATF3	activating transcription factor 3
chr12_+_57624119	0.888	ENST00000555773.1 ENST00000554975.1 ENST00000449049.3 ENST00000393827.4	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_46703826	0.875	ENST00000550387.1 ENST00000311177.5	HOXB9	homeobox B9
chr12_+_57623477	0.868	ENST00000557487.1 ENST00000555634.1 ENST00000556689.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57623869	0.831	ENST00000414700.3 ENST00000557703.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_149832704	0.820	ENST00000392933.1 ENST00000369157.2 ENST00000392932.4	HIST2H4B	histone cluster 2, H4b
chr10_-_101190202	0.795	ENST00000543866.1 ENST00000370508.5	GOT1	glutamic-oxaloacetic transaminase 1, soluble
chr16_-_70323422	0.774	ENST00000261772.8	AARS	alanyl-tRNA synthetase
chr9_+_100745615	0.724	ENST00000339399.4	ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_149804218	0.714	ENST00000610125.1	HIST2H4A	histone cluster 2, H4a
chr9_+_80912059	0.709	ENST00000347159.2 ENST00000376588.3	PSAT1	phosphoserine aminotransferase 1
chr14_-_92413727	0.649	ENST00000267620.10	FBLN5	fibulin 5
chr12_-_25101920	0.645	ENST00000539780.1 ENST00000546285.1 ENST00000342945.5	BCAT1	branched chain amino-acid transaminase 1, cytosolic
chr11_+_118955583	0.614	ENST00000278715.3 ENST00000536813.1 ENST00000537841.1 ENST00000542729.1 ENST00000546302.1 ENST00000442944.2 ENST00000544387.1 ENST00000543090.1	HMBS	hydroxymethylbilane synthase
chr14_-_92413353	0.604	ENST00000556154.1	FBLN5	fibulin 5
chr16_-_18908196	0.592	ENST00000565324.1 ENST00000561947.1	SMG1	SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_77813186	0.558	ENST00000448310.1 ENST00000269397.4	CBX4	chromobox homolog 4
chr1_+_33283043	0.548	ENST00000373476.1 ENST00000373475.5 ENST00000529027.1 ENST00000398243.3	S100PBP	S100P binding protein
chr1_-_220219775	0.538	ENST00000609181.1	EPRS	glutamyl-prolyl-tRNA synthetase
chr12_-_25102252	0.472	ENST00000261192.7	BCAT1	branched chain amino-acid transaminase 1, cytosolic
chr5_-_145562147	0.436	ENST00000545646.1 ENST00000274562.9 ENST00000510191.1 ENST00000394434.2	LARS	leucyl-tRNA synthetase
chr1_-_220220000	0.429	ENST00000366923.3	EPRS	glutamyl-prolyl-tRNA synthetase
chr11_-_33913708	0.413	ENST00000257818.2	LMO2	LIM domain only 2 (rhombotin-like 1)
chr17_-_76836963	0.404	ENST00000312010.6	USP36	ubiquitin specific peptidase 36
chr3_+_148415571	0.374	ENST00000497524.1 ENST00000349243.3 ENST00000542281.1 ENST00000418473.2 ENST00000404754.2	AGTR1	angiotensin II receptor, type 1
chr5_+_33441053	0.354	ENST00000541634.1 ENST00000455217.2 ENST00000414361.2	TARS	threonyl-tRNA synthetase
chr22_+_50919995	0.346	ENST00000362068.2 ENST00000395737.1	ADM2	adrenomedullin 2
chr22_+_42229100	0.342	ENST00000361204.4	SREBF2	sterol regulatory element binding transcription factor 2
chr5_+_44809027	0.341	ENST00000507110.1	MRPS30	mitochondrial ribosomal protein S30
chr22_+_50919944	0.334	ENST00000395738.2	ADM2	adrenomedullin 2
chr3_-_33686743	0.332	ENST00000333778.6 ENST00000539981.1	CLASP2	cytoplasmic linker associated protein 2
chr12_-_10324716	0.323	ENST00000545927.1 ENST00000432556.2 ENST00000309539.3 ENST00000544577.1	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1
chr20_+_8112824	0.319	ENST00000378641.3	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)
chr7_-_50860565	0.315	ENST00000403097.1	GRB10	growth factor receptor-bound protein 10
chrX_+_24072833	0.315	ENST00000253039.4	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr7_+_30634297	0.307	ENST00000389266.3	GARS	glycyl-tRNA synthetase
chr5_+_33440802	0.291	ENST00000502553.1 ENST00000514259.1 ENST00000265112.3	TARS	threonyl-tRNA synthetase
chr1_+_228353495	0.289	ENST00000366711.3	IBA57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr17_+_56315936	0.261	ENST00000543544.1	LPO	lactoperoxidase
chr1_+_154244987	0.244	ENST00000328703.7 ENST00000457918.2 ENST00000483970.2 ENST00000435087.1 ENST00000532105.1	HAX1	HCLS1 associated protein X-1
chr14_-_25045446	0.225	ENST00000216336.2	CTSG	cathepsin G
chr7_+_99006232	0.208	ENST00000403633.2	BUD31	BUD31 homolog (S. cerevisiae)
chr10_+_111765562	0.203	ENST00000360162.3	ADD3	adducin 3 (gamma)
chr11_-_8680383	0.197	ENST00000299550.6	TRIM66	tripartite motif containing 66
chr17_-_76836729	0.178	ENST00000587783.1 ENST00000542802.3 ENST00000586531.1 ENST00000589424.1 ENST00000590546.2	USP36	ubiquitin specific peptidase 36
chr1_+_162602244	0.163	ENST00000367922.3 ENST00000367921.3	DDR2	discoidin domain receptor tyrosine kinase 2
chr10_+_63661053	0.150	ENST00000279873.7	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr12_-_50298000	0.144	ENST00000550635.2	FAIM2	Fas apoptotic inhibitory molecule 2
chr16_+_67694849	0.112	ENST00000602551.1 ENST00000458121.2 ENST00000219255.3	PARD6A	par-6 family cell polarity regulator alpha
chr1_-_44497118	0.108	ENST00000537678.1 ENST00000466926.1	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_167883327	0.102	ENST00000476818.2 ENST00000367851.4 ENST00000367848.1	ADCY10	adenylate cyclase 10 (soluble)
chr1_-_167883353	0.066	ENST00000545172.1	ADCY10	adenylate cyclase 10 (soluble)
chr4_+_77870856	0.051	ENST00000264893.6 ENST00000502584.1 ENST00000510641.1	SEPT11	septin 11
chr12_-_50297638	0.046	ENST00000320634.3	FAIM2	Fas apoptotic inhibitory molecule 2
chr7_+_99006550	0.022	ENST00000222969.5	BUD31	BUD31 homolog (S. cerevisiae)
chr16_-_67694597	0.021	ENST00000393919.4 ENST00000219251.8	ACD	adrenocortical dysplasia homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	6.7	GO:0007614	short-term memory(GO:0007614)
1.1	3.4	GO:0043418	cysteine biosynthetic process from serine(GO:0006535) homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) transsulfuration(GO:0019346) homocysteine catabolic process(GO:0043418)
0.6	3.9	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
0.5	4.3	GO:0006561	proline biosynthetic process(GO:0006561)
0.4	1.3	GO:2000121	regulation of removal of superoxide radicals(GO:2000121)
0.3	1.0	GO:0048263	determination of dorsal identity(GO:0048263)
0.3	0.8	GO:0006106	fumarate metabolic process(GO:0006106)
0.3	0.8	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.2	2.5	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.2	0.6	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.2	0.6	GO:0097237	response to cobalt ion(GO:0032025) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2	1.1	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082)
0.2	0.7	GO:0042816	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2	0.3	GO:0070672	response to interleukin-15(GO:0070672)
0.1	2.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.1	0.3	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.1	0.3	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	0.4	GO:2000858	renin-angiotensin regulation of aldosterone production(GO:0002018) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) positive regulation of NAD(P)H oxidase activity(GO:0033864) mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858)
0.1	1.5	GO:0071378	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1	0.2	GO:0070942	neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.1	0.4	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.3	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1	1.7	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.1	1.6	GO:0031572	G2 DNA damage checkpoint(GO:0031572)
0.0	0.6	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.3	GO:0007020	microtubule nucleation(GO:0007020)
0.0	1.8	GO:0007605	sensory perception of sound(GO:0007605)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.3	GO:0071953	elastic fiber(GO:0071953)
0.1	6.1	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	8.5	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	2.2	GO:0005876	spindle microtubule(GO:0005876)
0.0	7.1	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	0.2	GO:0010369	chromocenter(GO:0010369)
0.0	0.8	GO:0043679	axon terminus(GO:0043679)
0.0	0.3	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.4	GO:0004122	cystathionine beta-synthase activity(GO:0004122)
0.9	4.3	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.8	2.5	GO:0004613	phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.6	3.9	GO:0008732	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3	0.8	GO:0004609	phosphatidylserine decarboxylase activity(GO:0004609)
0.3	1.6	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.3	0.8	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.2	0.6	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.2	1.1	GO:0052654	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2	1.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.2	0.6	GO:0004852	uroporphyrinogen-III synthase activity(GO:0004852)
0.1	2.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.1	0.4	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.1	2.3	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.1	0.3	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.1	6.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.2	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.7	GO:0008483	transaminase activity(GO:0008483)
0.0	1.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	1.8	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187) glycine:sodium symporter activity(GO:0015375)
0.0	0.2	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	2.6	GO:0005179	hormone activity(GO:0005179)
0.0	0.3	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.6	GO:0016875	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.5	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	1.3	GO:0005178	integrin binding(GO:0005178)
0.0	0.5	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)