Motif ID: AUGUGCC

Z-value: 0.488


Mature miRNA associated with seed AUGUGCC:

NamemiRBase Accession
hsa-miR-455-5p MIMAT0003150



Activity profile for motif AUGUGCC.

activity profile for motif AUGUGCC


Sorted Z-values histogram for motif AUGUGCC

Sorted Z-values for motif AUGUGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AUGUGCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_101702417 0.516 ENST00000305352.6
 S1PR1
sphingosine-1-phosphate receptor 1
chr12_+_12870055 0.368 ENST00000228872.4
 CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr18_-_74207146 0.273 ENST00000443185.2
 ZNF516
zinc finger protein 516
chr18_+_13218769 0.268 ENST00000399848.3
ENST00000361205.4
 LDLRAD4

low density lipoprotein receptor class A domain containing 4

chr7_+_102715315 0.262 ENST00000428183.2
ENST00000323716.3
ENST00000441711.2
ENST00000454559.1
ENST00000425331.1
ENST00000541300.1
 ARMC10





armadillo repeat containing 10





chr12_+_104458235 0.260 ENST00000229330.4
 HCFC2
host cell factor C2
chr6_+_89790490 0.228 ENST00000336032.3
 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_+_30264014 0.225 ENST00000322652.5
ENST00000580398.1
 SUZ12

SUZ12 polycomb repressive complex 2 subunit

chr5_+_118407053 0.199 ENST00000311085.8
ENST00000539542.1
 DMXL1

Dmx-like 1

chr1_-_70671216 0.188 ENST00000370952.3
 LRRC40
leucine rich repeat containing 40
chr22_+_40573921 0.164 ENST00000454349.2
ENST00000335727.9
 TNRC6B

trinucleotide repeat containing 6B

chr10_-_94003003 0.158 ENST00000412050.4
 CPEB3
cytoplasmic polyadenylation element binding protein 3
chrX_+_46433193 0.153 ENST00000276055.3
 CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr8_+_106330920 0.152 ENST00000407775.2
 ZFPM2
zinc finger protein, FOG family member 2
chr15_+_63796779 0.149 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
 USP3






ubiquitin specific peptidase 3






chr7_-_155604967 0.148 ENST00000297261.2
 SHH
sonic hedgehog
chr5_-_175964366 0.147 ENST00000274811.4
 RNF44
ring finger protein 44
chr14_-_90085458 0.147 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
 FOXN3


forkhead box N3


chr5_+_102455853 0.142 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
 PPIP5K2


diphosphoinositol pentakisphosphate kinase 2


chr3_-_176914238 0.138 ENST00000430069.1
ENST00000428970.1
 TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr12_+_62654119 0.134 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
 USP15


ubiquitin specific peptidase 15


chr5_-_76788317 0.130 ENST00000296679.4
 WDR41
WD repeat domain 41
chr7_+_39989611 0.126 ENST00000181839.4
 CDK13
cyclin-dependent kinase 13
chr4_-_185395672 0.123 ENST00000393593.3
 IRF2
interferon regulatory factor 2
chr5_-_160973649 0.122 ENST00000393959.1
ENST00000517547.1
 GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr12_+_2162447 0.115 ENST00000335762.5
ENST00000399655.1
 CACNA1C

calcium channel, voltage-dependent, L type, alpha 1C subunit

chr6_+_87865262 0.114 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
 ZNF292



zinc finger protein 292



chr17_-_76356148 0.111 ENST00000587578.1
ENST00000330871.2
 SOCS3

suppressor of cytokine signaling 3

chrX_+_41192595 0.107 ENST00000399959.2
 DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr8_-_82024290 0.106 ENST00000220597.4
 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr12_+_94542459 0.105 ENST00000258526.4
 PLXNC1
plexin C1
chr1_+_27022485 0.105 ENST00000324856.7
 ARID1A
AT rich interactive domain 1A (SWI-like)
chr20_-_60640866 0.104 ENST00000252996.4
 TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr1_+_36771946 0.092 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
 SH3D21


SH3 domain containing 21


chr5_-_132073210 0.089 ENST00000378735.1
ENST00000378746.4
 KIF3A

kinesin family member 3A

chr10_-_15762124 0.088 ENST00000378076.3
 ITGA8
integrin, alpha 8
chr8_-_8751068 0.088 ENST00000276282.6
 MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr1_+_212458834 0.083 ENST00000261461.2
 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr7_-_11871815 0.083 ENST00000423059.4
 THSD7A
thrombospondin, type I, domain containing 7A
chr2_+_85198216 0.082 ENST00000456682.1
ENST00000409785.4
 KCMF1

potassium channel modulatory factor 1

chr22_+_39077947 0.075 ENST00000216034.4
 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr1_+_193091080 0.074 ENST00000367435.3
 CDC73
cell division cycle 73
chr10_+_112679301 0.067 ENST00000265277.5
ENST00000369452.4
 SHOC2

soc-2 suppressor of clear homolog (C. elegans)

chr4_+_39699664 0.065 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
 UBE2K


ubiquitin-conjugating enzyme E2K


chr14_-_21737610 0.065 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
 HNRNPC


heterogeneous nuclear ribonucleoprotein C (C1/C2)


chr20_+_34894247 0.062 ENST00000373913.3
 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr2_-_152955537 0.058 ENST00000201943.5
ENST00000539935.1
 CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr10_-_15210666 0.057 ENST00000378165.4
 NMT2
N-myristoyltransferase 2
chr19_-_33166045 0.057 ENST00000586693.3
ENST00000587352.1
ENST00000586463.1
ENST00000306065.4
 ANKRD27



ankyrin repeat domain 27 (VPS9 domain)



chr11_-_128392085 0.056 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
 ETS1




v-ets avian erythroblastosis virus E26 oncogene homolog 1




chr14_+_33408449 0.054 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
 NPAS3




neuronal PAS domain protein 3




chr1_-_115053781 0.052 ENST00000358465.2
ENST00000369543.2
 TRIM33

tripartite motif containing 33

chr20_-_48770174 0.052 ENST00000341698.2
 TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr9_-_74980113 0.046 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
 ZFAND5


zinc finger, AN1-type domain 5


chr1_-_217262969 0.044 ENST00000361525.3
 ESRRG
estrogen-related receptor gamma
chr15_+_59279851 0.041 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111


ring finger protein 111


chr12_-_100536608 0.040 ENST00000356828.3
ENST00000279907.7
 UHRF1BP1L

UHRF1 binding protein 1-like

chr9_-_91793675 0.040 ENST00000375835.4
ENST00000375830.1
 SHC3

SHC (Src homology 2 domain containing) transforming protein 3

chr3_-_12705600 0.032 ENST00000542177.1
ENST00000442415.2
ENST00000251849.4
 RAF1


v-raf-1 murine leukemia viral oncogene homolog 1


chr6_+_45389893 0.031 ENST00000371432.3
 RUNX2
runt-related transcription factor 2
chr20_-_48770244 0.029 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
 TMEM189


transmembrane protein 189


chr12_-_49449107 0.027 ENST00000301067.7
 KMT2D
lysine (K)-specific methyltransferase 2D
chr2_-_157189180 0.020 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
 NR4A2




nuclear receptor subfamily 4, group A, member 2




chr8_+_61429416 0.020 ENST00000262646.7
ENST00000531289.1
 RAB2A

RAB2A, member RAS oncogene family

chr13_-_52027134 0.019 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
 INTS6




integrator complex subunit 6




chr2_-_38978492 0.015 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
 SRSF7


serine/arginine-rich splicing factor 7


chr4_+_62066941 0.015 ENST00000512091.2
 LPHN3
latrophilin 3
chrX_+_40944871 0.014 ENST00000378308.2
ENST00000324545.8
 USP9X

ubiquitin specific peptidase 9, X-linked

chr17_+_48796905 0.014 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
 LUC7L3






LUC7-like 3 (S. cerevisiae)






chrX_+_44732757 0.014 ENST00000377967.4
ENST00000536777.1
ENST00000382899.4
ENST00000543216.1
 KDM6A



lysine (K)-specific demethylase 6A



chr1_-_204329013 0.010 ENST00000272203.3
ENST00000414478.1
 PLEKHA6

pleckstrin homology domain containing, family A member 6

chr18_+_43914159 0.009 ENST00000588679.1
ENST00000269439.7
ENST00000543885.1
 RNF165


ring finger protein 165


chr2_-_50574856 0.009 ENST00000342183.5
 NRXN1
neurexin 1
chr1_-_10856694 0.005 ENST00000377022.3
ENST00000344008.5
 CASZ1

castor zinc finger 1

chr12_-_81331697 0.004 ENST00000552864.1
 LIN7A
lin-7 homolog A (C. elegans)
chr4_-_149365827 0.004 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr20_-_48729670 0.003 ENST00000371657.5
 UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr12_-_94853716 0.002 ENST00000339839.5
ENST00000397809.5
ENST00000547575.1
 CCDC41


coiled-coil domain containing 41


chr12_+_113659234 0.002 ENST00000551096.1
ENST00000551099.1
ENST00000335509.6
ENST00000552897.1
ENST00000550785.1
ENST00000549279.1
 TPCN1





two pore segment channel 1






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097237 autophagic cell death(GO:0048102) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.1 GO:0070445 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) regulation of photoreceptor cell differentiation(GO:0046532) male genitalia morphogenesis(GO:0048808) formation of anatomical boundary(GO:0048859) negative regulation of smooth muscle cell differentiation(GO:0051151) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) kidney mesenchymal cell proliferation(GO:0072135) metanephric mesenchymal cell proliferation involved in metanephros development(GO:0072136) male anatomical structure morphogenesis(GO:0090598)
0.0 0.5 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0018377 N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0030578 nuclear body organization(GO:0030575) PML body organization(GO:0030578)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.5 GO:0046625 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) sphingolipid binding(GO:0046625)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.