Motif ID: BHLHE22_BHLHA15_BHLHE23

Z-value: 0.898

Transcription factors associated with BHLHE22_BHLHA15_BHLHE23:

Gene SymbolEntrez IDGene Name
BHLHA15 ENSG00000180535.3 BHLHA15
BHLHE22 ENSG00000180828.1 BHLHE22
BHLHE23 ENSG00000125533.4 BHLHE23






Network of associatons between targets according to the STRING database.



First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_111312622 2.915 ENST00000395634.3
NREP
neuronal regeneration related protein
chr3_-_121379739 2.650 ENST00000428394.2
ENST00000314583.3
HCLS1

hematopoietic cell-specific Lyn substrate 1

chr3_-_114477962 1.936 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_114477787 1.876 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_188378368 1.651 ENST00000392365.1
ENST00000435414.1
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr7_-_27205136 1.250 ENST00000396345.1
ENST00000343483.6
HOXA9

homeobox A9

chr1_+_244214577 0.711 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr6_-_112115074 0.702 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr11_+_65405556 0.627 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
SIPA1


signal-induced proliferation-associated 1


chr18_-_52989525 0.603 ENST00000457482.3
TCF4
transcription factor 4
chrX_+_128913906 0.587 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr4_-_159094194 0.586 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B


family with sequence similarity 198, member B


chr7_+_116502605 0.539 ENST00000458284.2
ENST00000490693.1
CAPZA2

capping protein (actin filament) muscle Z-line, alpha 2

chr15_-_55700522 0.475 ENST00000564092.1
ENST00000310958.6
CCPG1

cell cycle progression 1

chr16_+_31119615 0.447 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
BCKDK



branched chain ketoacid dehydrogenase kinase



chr4_-_41216619 0.400 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr15_-_55700216 0.371 ENST00000569205.1
CCPG1
cell cycle progression 1
chr10_-_75415825 0.273 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr3_+_62304648 0.270 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14


chromosome 3 open reading frame 14


chr15_-_55700457 0.267 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1


cell cycle progression 1


chr7_+_116502527 0.263 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr15_-_63448973 0.259 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr12_-_91573249 0.253 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN


decorin


chr15_+_63354769 0.245 ENST00000558910.1
TPM1
tropomyosin 1 (alpha)
chr12_-_91573316 0.245 ENST00000393155.1
DCN
decorin
chr12_-_91573132 0.245 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chrX_+_107334895 0.242 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A


autophagy related 4A, cysteine peptidase


chr14_-_69864993 0.216 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr17_+_60758814 0.202 ENST00000579432.1
ENST00000446119.2
MRC2

mannose receptor, C type 2

chr11_-_107582775 0.171 ENST00000305991.2
SLN
sarcolipin
chr8_-_23315190 0.171 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4


ectonucleoside triphosphate diphosphohydrolase 4


chr9_-_130635741 0.170 ENST00000223836.10
AK1
adenylate kinase 1
chr9_+_2158443 0.150 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2



SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2



chr9_+_2158485 0.149 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2


chr3_+_113251143 0.144 ENST00000264852.4
ENST00000393830.3
SIDT1

SID1 transmembrane family, member 1

chr12_-_108714412 0.135 ENST00000412676.1
ENST00000550573.1
CMKLR1

chemokine-like receptor 1

chr2_-_163099885 0.127 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr7_-_55930443 0.125 ENST00000388975.3
SEPT14
septin 14
chr11_-_26743546 0.120 ENST00000280467.6
ENST00000396005.3
SLC5A12

solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

chr4_+_2814011 0.116 ENST00000502260.1
ENST00000435136.2
SH3BP2

SH3-domain binding protein 2

chr3_+_171758344 0.115 ENST00000336824.4
ENST00000423424.1
FNDC3B

fibronectin type III domain containing 3B

chr7_-_38403077 0.105 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr10_+_18629628 0.105 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr10_-_94257512 0.097 ENST00000371581.5
IDE
insulin-degrading enzyme
chr4_+_2813946 0.097 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr19_-_11450249 0.094 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr12_-_102872317 0.092 ENST00000424202.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_-_44972476 0.084 ENST00000527685.1
ENST00000308212.5
TP53I11

tumor protein p53 inducible protein 11

chr6_+_163148161 0.084 ENST00000337019.3
ENST00000366889.2
PACRG

PARK2 co-regulated

chr4_+_144354644 0.083 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr14_+_69865401 0.082 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
SLC39A9


solute carrier family 39, member 9


chrX_-_13835147 0.081 ENST00000493677.1
ENST00000355135.2
GPM6B

glycoprotein M6B

chr2_+_219110149 0.080 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr11_+_66008698 0.077 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr15_-_65503801 0.072 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_+_104293028 0.064 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr2_-_163100045 0.061 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chrX_+_107288239 0.049 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr19_+_57874835 0.048 ENST00000282282.3
ENST00000543226.1
ENST00000596755.1
ENST00000597658.1
ZNF547
TRAPPC2P1

AC003002.4
zinc finger protein 547
trafficking protein particle complex 2 pseudogene 1

Uncharacterized protein
chr6_+_73076432 0.045 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_58166370 0.039 ENST00000300209.8
METTL21B
methyltransferase like 21B
chr8_-_67976509 0.028 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr7_+_107531580 0.027 ENST00000537148.1
ENST00000440410.1
ENST00000437604.2
DLD


dihydrolipoamide dehydrogenase


chrX_+_107288197 0.026 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr10_-_74114714 0.026 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12


DnaJ (Hsp40) homolog, subfamily B, member 12


chr5_-_171433819 0.024 ENST00000296933.6
FBXW11
F-box and WD repeat domain containing 11
chrX_-_15402498 0.024 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr2_+_210444748 0.022 ENST00000392194.1
MAP2
microtubule-associated protein 2
chr1_-_44818599 0.022 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr5_-_171433579 0.022 ENST00000265094.5
ENST00000393802.2
FBXW11

F-box and WD repeat domain containing 11

chr11_-_44972418 0.022 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11


tumor protein p53 inducible protein 11


chr22_+_36113919 0.021 ENST00000249044.2
APOL5
apolipoprotein L, 5
chr19_-_52227221 0.019 ENST00000222115.1
ENST00000540069.2
HAS1

hyaluronan synthase 1

chr12_+_58166431 0.018 ENST00000333012.5
METTL21B
methyltransferase like 21B
chrX_+_69509927 0.018 ENST00000374403.3
KIF4A
kinesin family member 4A
chr1_+_186344883 0.013 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr16_-_4896205 0.013 ENST00000589389.1
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr3_+_119298429 0.012 ENST00000478927.1
ADPRH
ADP-ribosylarginine hydrolase
chr5_-_169725231 0.012 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_-_107283278 0.002 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 1.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.4 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.1 0.6 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.1 2.7 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.2 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.2 GO:0003065 regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.8 GO:0051693 actin filament capping(GO:0051693)
0.0 0.4 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.7 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0 0.2 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035) nucleotide diphosphatase activity(GO:0004551)