Motif ID: BHLHE40
Z-value: 1.042
Transcription factors associated with BHLHE40:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| BHLHE40 | ENSG00000134107.4 | BHLHE40 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.4 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.3 | 3.8 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.3 | 1.5 | GO:0070561 | hormone-mediated apoptotic signaling pathway(GO:0008628) vitamin D receptor signaling pathway(GO:0070561) |
| 0.3 | 1.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.2 | 1.4 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.2 | 1.6 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 0.4 | GO:0071529 | cementum mineralization(GO:0071529) |
| 0.1 | 1.3 | GO:0010799 | regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.1 | 0.3 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.1 | 0.6 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.1 | 0.8 | GO:0034661 | ncRNA catabolic process(GO:0034661) |
| 0.1 | 0.4 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.1 | 1.0 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
| 0.0 | 0.1 | GO:0031558 | obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) determination of dorsal identity(GO:0048263) |
| 0.0 | 0.6 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.0 | 0.1 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.0 | 0.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.0 | 0.1 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470) |
| 0.0 | 0.1 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.0 | 0.6 | GO:0010833 | telomere maintenance via telomere lengthening(GO:0010833) |
| 0.0 | 0.1 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.0 | 0.3 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 1.1 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 0.3 | GO:0070670 | response to interleukin-4(GO:0070670) |
| 0.0 | 0.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.1 | GO:0000491 | small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492) |
| 0.0 | 0.0 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.0 | 2.2 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.0 | 1.6 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 1.4 | GO:0007163 | establishment or maintenance of cell polarity(GO:0007163) |
| 0.0 | 0.1 | GO:0019614 | phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) dopamine catabolic process(GO:0042420) catecholamine catabolic process(GO:0042424) |
| 0.0 | 0.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.3 | GO:0008334 | histone mRNA metabolic process(GO:0008334) |
| 0.0 | 1.1 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0070188 | obsolete Stn1-Ten1 complex(GO:0070188) |
| 0.1 | 1.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.3 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.1 | 1.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.8 | GO:0030681 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
| 0.1 | 0.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.6 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.1 | 1.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.3 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.0 | 0.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.4 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.3 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.4 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.0 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.0 | 0.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 3.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.3 | 2.7 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.2 | 0.6 | GO:0098847 | single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847) |
| 0.1 | 1.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 1.3 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 1.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 3.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 0.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 0.4 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.8 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.1 | 1.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.4 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.0 | 0.6 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 1.4 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.2 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.1 | GO:0004461 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.0 | 0.4 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.0 | 0.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.1 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.0 | 0.4 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.0 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.0 | 0.1 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.4 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
