Motif ID: BRCA1

Z-value: 0.944


Transcription factors associated with BRCA1:

Gene SymbolEntrez IDGene Name
BRCA1 ENSG00000012048.15 BRCA1



Activity profile for motif BRCA1.

activity profile for motif BRCA1


Sorted Z-values histogram for motif BRCA1

Sorted Z-values for motif BRCA1



Network of associatons between targets according to the STRING database.



First level regulatory network of BRCA1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_69597810 1.469 ENST00000483798.2
 DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr17_+_74372662 1.428 ENST00000591651.1
ENST00000545180.1
 SPHK1

sphingosine kinase 1

chr15_-_58358607 1.308 ENST00000249750.4
 ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr14_+_103058948 1.030 ENST00000262241.6
 RCOR1
REST corepressor 1
chr7_-_23510086 0.960 ENST00000258729.3
 IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr6_+_16129308 0.867 ENST00000356840.3
ENST00000349606.4
 MYLIP

myosin regulatory light chain interacting protein

chr3_+_193853927 0.850 ENST00000232424.3
 HES1
hes family bHLH transcription factor 1
chr18_+_55888767 0.695 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr17_-_56296580 0.687 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
 MKS1



Meckel syndrome, type 1



chr4_-_140005443 0.563 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
 ELF2


E74-like factor 2 (ets domain transcription factor)


chr6_+_33172407 0.517 ENST00000374662.3
 HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_+_10271674 0.504 ENST00000377086.1
 KIF1B
kinesin family member 1B
chr10_-_36813162 0.496 ENST00000440465.1
 NAMPTL
nicotinamide phosphoribosyltransferase-like
chr6_+_42981922 0.490 ENST00000326974.4
ENST00000244670.8
 KLHDC3

kelch domain containing 3

chr11_+_117947724 0.475 ENST00000534111.1
 TMPRSS4
transmembrane protease, serine 4
chr17_-_7082861 0.452 ENST00000269299.3
 ASGR1
asialoglycoprotein receptor 1
chr11_+_117947782 0.411 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
 TMPRSS4




transmembrane protease, serine 4




chr10_+_28822636 0.411 ENST00000442148.1
ENST00000448193.1
 WAC

WW domain containing adaptor with coiled-coil

chr3_+_185303962 0.407 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr3_-_176914238 0.388 ENST00000430069.1
ENST00000428970.1
 TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr7_+_73868439 0.359 ENST00000424337.2
 GTF2IRD1
GTF2I repeat domain containing 1
chr20_-_48530230 0.353 ENST00000422556.1
 SPATA2
spermatogenesis associated 2
chr20_+_52105495 0.331 ENST00000439873.2
 AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr8_+_22022800 0.331 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr12_-_12491608 0.326 ENST00000545735.1
 MANSC1
MANSC domain containing 1
chr1_+_159141397 0.321 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
 CADM3


cell adhesion molecule 3


chr17_-_41738931 0.316 ENST00000329168.3
ENST00000549132.1
 MEOX1

mesenchyme homeobox 1

chr17_-_60142609 0.315 ENST00000397786.2
 MED13
mediator complex subunit 13
chr11_+_47291645 0.307 ENST00000395336.3
ENST00000402192.2
 MADD

MAP-kinase activating death domain

chr6_+_123100620 0.295 ENST00000368444.3
 FABP7
fatty acid binding protein 7, brain
chr5_-_68665084 0.283 ENST00000509462.1
 TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr8_-_81083341 0.281 ENST00000519303.2
 TPD52
tumor protein D52
chr11_-_6817128 0.279 ENST00000332601.3
 OR6A2
olfactory receptor, family 6, subfamily A, member 2
chrX_+_49644470 0.273 ENST00000508866.2
 USP27X
ubiquitin specific peptidase 27, X-linked
chr17_-_41739283 0.267 ENST00000393661.2
ENST00000318579.4
 MEOX1

mesenchyme homeobox 1

chr10_-_61900762 0.264 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_-_48389651 0.263 ENST00000222002.3
 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr5_-_68665296 0.250 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
 TAF9



TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa



chr13_-_31038370 0.249 ENST00000399489.1
ENST00000339872.4
 HMGB1

high mobility group box 1

chr19_+_46850320 0.247 ENST00000391919.1
 PPP5C
protein phosphatase 5, catalytic subunit
chr1_-_173020056 0.245 ENST00000239468.2
ENST00000404377.3
 TNFSF18

tumor necrosis factor (ligand) superfamily, member 18

chr2_-_152118352 0.228 ENST00000331426.5
 RBM43
RNA binding motif protein 43
chr19_+_46850251 0.222 ENST00000012443.4
 PPP5C
protein phosphatase 5, catalytic subunit
chr18_-_23671139 0.206 ENST00000579061.1
ENST00000542420.2
 SS18

synovial sarcoma translocation, chromosome 18

chr1_-_217250231 0.204 ENST00000493748.1
ENST00000463665.1
 ESRRG

estrogen-related receptor gamma

chr15_-_88799948 0.197 ENST00000394480.2
 NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr11_+_47291193 0.193 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
 MADD







MAP-kinase activating death domain







chr14_-_69261310 0.189 ENST00000336440.3
 ZFP36L1
ZFP36 ring finger protein-like 1
chr5_+_139493665 0.184 ENST00000331327.3
 PURA
purine-rich element binding protein A
chr1_-_227505289 0.183 ENST00000366765.3
 CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr6_-_170862322 0.173 ENST00000262193.6
 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr12_-_67072714 0.171 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
 GRIP1




glutamate receptor interacting protein 1




chr5_-_68665469 0.161 ENST00000217893.5
 TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr9_-_86593238 0.145 ENST00000351839.3
 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr1_-_160232312 0.132 ENST00000440682.1
 DCAF8
DDB1 and CUL4 associated factor 8
chr11_-_119234876 0.132 ENST00000525735.1
 USP2
ubiquitin specific peptidase 2
chr2_+_203879568 0.124 ENST00000449802.1
 NBEAL1
neurobeachin-like 1
chr4_+_619386 0.124 ENST00000496514.1
 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr14_-_60097297 0.111 ENST00000395090.1
 RTN1
reticulon 1
chr12_-_117319236 0.111 ENST00000257572.5
 HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr10_+_92631709 0.109 ENST00000413330.1
ENST00000277882.3
 RPP30

ribonuclease P/MRP 30kDa subunit

chr14_+_32030582 0.108 ENST00000550649.1
ENST00000281081.7
 NUBPL

nucleotide binding protein-like

chr11_-_71823266 0.103 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15


anaphase promoting complex subunit 15


chr19_+_45394477 0.082 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
 TOMM40




translocase of outer mitochondrial membrane 40 homolog (yeast)




chr6_-_25832254 0.076 ENST00000476801.1
ENST00000244527.4
ENST00000427328.1
 SLC17A1


solute carrier family 17 (organic anion transporter), member 1


chr8_-_16859690 0.076 ENST00000180166.5
 FGF20
fibroblast growth factor 20
chr19_-_40324767 0.064 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
 DYRK1B



dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B



chr4_+_619347 0.047 ENST00000255622.6
 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr16_-_790982 0.044 ENST00000301694.5
ENST00000251588.2
 NARFL

nuclear prelamin A recognition factor-like

chr19_+_45971246 0.043 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
 FOSB





FBJ murine osteosarcoma viral oncogene homolog B





chr5_+_140186647 0.038 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr12_-_49418407 0.029 ENST00000526209.1
 KMT2D
lysine (K)-specific methyltransferase 2D
chr1_-_160232197 0.028 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
 DCAF8





DDB1 and CUL4 associated factor 8





chr13_+_30002741 0.022 ENST00000380808.2
 MTUS2
microtubule associated tumor suppressor candidate 2
chr6_-_42981651 0.021 ENST00000244711.3
 MEA1
male-enhanced antigen 1
chr14_-_60097524 0.018 ENST00000342503.4
 RTN1
reticulon 1
chr17_+_36908984 0.012 ENST00000225426.4
ENST00000579088.1
 PSMB3

proteasome (prosome, macropain) subunit, beta type, 3

chr1_+_161736072 0.007 ENST00000367942.3
 ATF6
activating transcription factor 6
chrX_+_10124977 0.002 ENST00000380833.4
 CLCN4
chloride channel, voltage-sensitive 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 0.9 GO:2000644 negative regulation of low-density lipoprotein particle clearance(GO:0010989) low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.3 0.9 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 0.6 GO:0001757 somite specification(GO:0001757)
0.2 0.5 GO:0019521 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.1 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.4 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.7 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.2 GO:0019056 modulation by virus of host transcription(GO:0019056) regulation of sprouting of injured axon(GO:0048686) positive regulation of sprouting of injured axon(GO:0048687) regulation of axon extension involved in regeneration(GO:0048690) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.1 GO:0010988 regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0 0.7 GO:0060760 positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.5 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.7 GO:0042384 cilium assembly(GO:0042384)
0.0 0.2 GO:0046037 phototransduction, visible light(GO:0007603) GMP metabolic process(GO:0046037)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0006706 steroid catabolic process(GO:0006706) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) sulfation(GO:0051923)
0.0 1.0 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.7 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 0.9 GO:0043398 HLH domain binding(GO:0043398)
0.2 1.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.5 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 1.5 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)