Motif ID: CACAGUG
Z-value: 0.980
Mature miRNA associated with seed CACAGUG:
| Name | miRBase Accession |
|---|---|
| hsa-miR-128-3p | MIMAT0000424 |
| hsa-miR-216a-3p | MIMAT0022844 |
| hsa-miR-3681-3p | MIMAT0018109 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.4 | 0.7 | GO:0071504 | response to heparin(GO:0071503) cellular response to heparin(GO:0071504) |
| 0.3 | 1.1 | GO:0002689 | negative regulation of leukocyte chemotaxis(GO:0002689) |
| 0.2 | 2.1 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.2 | 1.6 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.2 | 0.7 | GO:0043276 | anoikis(GO:0043276) |
| 0.2 | 0.6 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.2 | 1.6 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.2 | 0.6 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) Sertoli cell proliferation(GO:0060011) |
| 0.2 | 0.8 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.2 | 0.5 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) |
| 0.2 | 0.2 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.2 | 0.5 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.2 | 0.5 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.1 | 1.3 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.1 | 0.4 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) intestinal epithelial cell development(GO:0060576) |
| 0.1 | 1.0 | GO:0097531 | mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531) |
| 0.1 | 0.4 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.1 | 0.3 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.1 | 0.5 | GO:0070669 | response to interleukin-2(GO:0070669) |
| 0.1 | 1.5 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.1 | 0.8 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 0.3 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 0.6 | GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) |
| 0.1 | 0.2 | GO:0033025 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 0.1 | 0.2 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.1 | 0.5 | GO:0006562 | proline catabolic process(GO:0006562) |
| 0.1 | 0.6 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 0.2 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.1 | 0.4 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 0.2 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
| 0.1 | 0.4 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.1 | 1.3 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.1 | 0.2 | GO:0021592 | fourth ventricle development(GO:0021592) |
| 0.1 | 0.3 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.1 | 0.6 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
| 0.1 | 0.2 | GO:0034204 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 0.3 | GO:0046836 | glycolipid transport(GO:0046836) |
| 0.1 | 0.4 | GO:0046349 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349) |
| 0.1 | 0.3 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 0.2 | GO:0030812 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) negative regulation of nucleotide catabolic process(GO:0030812) |
| 0.1 | 0.6 | GO:0034405 | response to fluid shear stress(GO:0034405) |
| 0.0 | 0.1 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 0.4 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 0.1 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.0 | 0.1 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.0 | 0.1 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.0 | 0.1 | GO:0060318 | definitive erythrocyte differentiation(GO:0060318) |
| 0.0 | 0.2 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.0 | 0.3 | GO:0044273 | sulfur compound catabolic process(GO:0044273) |
| 0.0 | 0.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.3 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.1 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.0 | 0.6 | GO:0008214 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.0 | 1.2 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.1 | GO:0071428 | rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428) |
| 0.0 | 0.4 | GO:0045047 | protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.0 | 0.2 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 0.1 | GO:0032736 | positive regulation of interleukin-13 production(GO:0032736) |
| 0.0 | 0.3 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.1 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.0 | 0.3 | GO:0001945 | lymph vessel development(GO:0001945) |
| 0.0 | 0.5 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 0.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.0 | 1.1 | GO:0001843 | neural tube closure(GO:0001843) tube closure(GO:0060606) |
| 0.0 | 0.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:0034959 | neuropeptide catabolic process(GO:0010813) substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 0.5 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 0.4 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.0 | 0.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.0 | 0.0 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) |
| 0.0 | 0.1 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 1.1 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.2 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.1 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.1 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.0 | 0.1 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.1 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.2 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 0.0 | GO:0015791 | polyol transport(GO:0015791) |
| 0.0 | 0.4 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 0.4 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.1 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.0 | 0.0 | GO:0060744 | thelarche(GO:0042695) development of secondary female sexual characteristics(GO:0046543) mammary gland branching involved in thelarche(GO:0060744) |
| 0.0 | 0.2 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.3 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.2 | 0.8 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.2 | 0.7 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 0.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 0.3 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 0.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.2 | GO:0044462 | external encapsulating structure part(GO:0044462) |
| 0.0 | 0.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 1.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.0 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 0.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.2 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.1 | GO:0031310 | intrinsic component of endosome membrane(GO:0031302) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.0 | 0.4 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 1.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 4.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 2.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.8 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.0 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.4 | 2.2 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.3 | 1.5 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.3 | 0.8 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 0.6 | GO:0050816 | beta-2 adrenergic receptor binding(GO:0031698) phosphothreonine binding(GO:0050816) |
| 0.2 | 0.6 | GO:0016362 | activin receptor activity, type II(GO:0016362) |
| 0.2 | 0.7 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 0.5 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 0.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.4 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.1 | 1.1 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 0.6 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 0.4 | GO:0070548 | L-glutamine aminotransferase activity(GO:0070548) |
| 0.1 | 0.3 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 0.6 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.6 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.5 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
| 0.1 | 1.2 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 0.9 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 0.3 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.1 | 0.2 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.1 | 0.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.2 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 0.1 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.5 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 0.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 0.2 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.1 | 0.3 | GO:0017089 | glycolipid transporter activity(GO:0017089) |
| 0.1 | 0.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.1 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.3 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.5 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.0 | 0.4 | GO:0016944 | obsolete RNA polymerase II transcription elongation factor activity(GO:0016944) |
| 0.0 | 0.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.4 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 0.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.9 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 0.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.5 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.1 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.2 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 1.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 0.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.0 | 0.2 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.5 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.1 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 1.1 | GO:0004702 | receptor signaling protein serine/threonine kinase activity(GO:0004702) |
| 0.0 | 0.1 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 1.0 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.0 | 0.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.2 | GO:0043498 | obsolete cell surface binding(GO:0043498) |
| 0.0 | 1.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.2 | GO:0032129 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.0 | 0.6 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 0.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.8 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.2 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.8 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 1.0 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.1 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
