Motif ID: CBFB

Z-value: 0.929


Transcription factors associated with CBFB:

Gene SymbolEntrez IDGene Name
CBFB ENSG00000067955.9 CBFB



Activity profile for motif CBFB.

activity profile for motif CBFB


Sorted Z-values histogram for motif CBFB

Sorted Z-values for motif CBFB



Network of associatons between targets according to the STRING database.



First level regulatory network of CBFB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_157154578 2.490 ENST00000295927.3
 PTX3
pentraxin 3, long
chr11_+_114310237 1.830 ENST00000539119.1
 REXO2
RNA exonuclease 2
chr3_-_99569821 1.830 ENST00000487087.1
 FILIP1L
filamin A interacting protein 1-like
chr11_+_114310102 1.777 ENST00000265881.5
 REXO2
RNA exonuclease 2
chr5_+_35856951 1.752 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
 IL7R



interleukin 7 receptor



chr11_+_114310164 1.737 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
 REXO2


RNA exonuclease 2


chr14_+_85996471 1.597 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_196621002 1.086 ENST00000367429.4
ENST00000439155.2
 CFH

complement factor H

chr1_+_196621156 0.874 ENST00000359637.2
 CFH
complement factor H
chr14_+_85996507 0.868 ENST00000554746.1
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_+_32582293 0.846 ENST00000580907.1
ENST00000225831.4
 CCL2

chemokine (C-C motif) ligand 2

chr14_-_61116168 0.645 ENST00000247182.6
 SIX1
SIX homeobox 1
chr1_-_240775447 0.632 ENST00000318160.4
 GREM2
gremlin 2, DAN family BMP antagonist
chr4_-_156297949 0.601 ENST00000515654.1
 MAP9
microtubule-associated protein 9
chr20_+_43343886 0.584 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr18_-_53089723 0.511 ENST00000561992.1
ENST00000562512.2
 TCF4

transcription factor 4

chr3_-_189840223 0.475 ENST00000427335.2
 LEPREL1
leprecan-like 1
chr21_-_36421535 0.474 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
 RUNX1


runt-related transcription factor 1


chr21_-_36421626 0.472 ENST00000300305.3
 RUNX1
runt-related transcription factor 1
chr11_+_18343800 0.466 ENST00000453096.2
 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr5_-_137878887 0.434 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1



eukaryotic translation termination factor 1



chr11_-_58343319 0.433 ENST00000395074.2
 LPXN
leupaxin
chr4_+_74347400 0.418 ENST00000226355.3
 AFM
afamin
chr10_-_29811456 0.392 ENST00000535393.1
 SVIL
supervillin
chr12_-_68553512 0.336 ENST00000229135.3
 IFNG
interferon, gamma
chr1_+_209859510 0.315 ENST00000367028.2
ENST00000261465.1
 HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr2_-_87248975 0.294 ENST00000409310.2
ENST00000355705.3
 PLGLB1

plasminogen-like B1

chr20_+_54987168 0.289 ENST00000360314.3
 CASS4
Cas scaffolding protein family member 4
chr15_+_49715293 0.256 ENST00000267843.4
ENST00000560270.1
 FGF7

fibroblast growth factor 7

chr7_+_120628731 0.242 ENST00000310396.5
 CPED1
cadherin-like and PC-esterase domain containing 1
chr20_+_54987305 0.232 ENST00000371336.3
ENST00000434344.1
 CASS4

Cas scaffolding protein family member 4

chr21_-_36421401 0.217 ENST00000486278.2
 RUNX1
runt-related transcription factor 1
chr12_-_14849470 0.207 ENST00000261170.3
 GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr9_+_15422702 0.184 ENST00000380821.3
ENST00000421710.1
 SNAPC3

small nuclear RNA activating complex, polypeptide 3, 50kDa

chr11_-_66103867 0.178 ENST00000424433.2
 RIN1
Ras and Rab interactor 1
chr1_-_184723942 0.158 ENST00000318130.8
 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr16_+_53088885 0.146 ENST00000566029.1
ENST00000447540.1
 CHD9

chromodomain helicase DNA binding protein 9

chr5_+_131409476 0.132 ENST00000296871.2
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr9_-_35080013 0.128 ENST00000378643.3
 FANCG
Fanconi anemia, complementation group G
chrX_-_153718988 0.117 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
 SLC10A3


solute carrier family 10, member 3


chrX_+_68048803 0.104 ENST00000204961.4
 EFNB1
ephrin-B1
chr5_+_131396222 0.097 ENST00000296870.2
 IL3
interleukin 3 (colony-stimulating factor, multiple)
chr11_-_18343669 0.085 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
 HPS5


Hermansky-Pudlak syndrome 5


chr8_-_60031762 0.083 ENST00000361421.1
 TOX
thymocyte selection-associated high mobility group box
chr11_-_64885111 0.078 ENST00000528598.1
ENST00000310597.4
 ZNHIT2

zinc finger, HIT-type containing 2

chr2_+_207024306 0.067 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
 EEF1B2



eukaryotic translation elongation factor 1 beta 2



chr1_-_179112189 0.056 ENST00000512653.1
ENST00000344730.3
 ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr14_+_22919081 0.052 ENST00000390473.1
 TRDJ1
T cell receptor delta joining 1
chr6_+_27925019 0.045 ENST00000244623.1
 OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr15_+_64386261 0.041 ENST00000560829.1
 SNX1
sorting nexin 1
chr14_-_24977457 0.029 ENST00000250378.3
ENST00000206446.4
 CMA1

chymase 1, mast cell

chr6_+_29068386 0.026 ENST00000377171.3
 OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr9_-_123342415 0.015 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
 CDK5RAP2



CDK5 regulatory subunit associated protein 2



chr13_-_28674693 0.004 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
 FLT3


fms-related tyrosine kinase 3


chr1_+_89246647 0.001 ENST00000544045.1
 PKN2
protein kinase N2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0008228 opsonization(GO:0008228)
0.3 1.8 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911) negative regulation of T cell mediated immunity(GO:0002710)
0.2 0.6 GO:0051451 myoblast migration(GO:0051451)
0.1 0.1 GO:0071801 podosome assembly(GO:0071800) regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.1 0.8 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.3 GO:0060557 serine phosphorylation of STAT protein(GO:0042501) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) tumor necrosis factor (ligand) superfamily member 11 production(GO:0072535) regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000307) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.1 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.3 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.1 1.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.4 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.5 GO:0044349 nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349)
0.0 0.0 GO:0034498 early endosome to Golgi transport(GO:0034498)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0071437 podosome(GO:0002102) invadopodium(GO:0071437)
0.0 0.5 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.2 0.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 2.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 5.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 0.5 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.0 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 2.5 GO:0005057 receptor signaling protein activity(GO:0005057)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.