Motif ID: CREB3L1_CREB3
Z-value: 1.132
Transcription factors associated with CREB3L1_CREB3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| CREB3 | ENSG00000107175.6 | CREB3 |
| CREB3L1 | ENSG00000157613.6 | CREB3L1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.5 | 2.1 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 0.5 | 1.4 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.5 | 1.9 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.4 | 4.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.4 | 1.8 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
| 0.3 | 0.8 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.2 | 0.8 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.2 | 0.7 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.2 | 0.5 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.2 | 1.6 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 0.4 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.1 | 0.5 | GO:0002063 | chondrocyte development(GO:0002063) |
| 0.1 | 1.0 | GO:0007220 | Notch receptor processing(GO:0007220) membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.1 | 0.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 1.2 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 0.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 0.2 | GO:0051665 | membrane raft localization(GO:0051665) |
| 0.0 | 1.9 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.0 | 0.3 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.0 | 0.2 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.0 | 0.3 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 0.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.4 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.0 | 0.5 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.0 | 0.6 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 0.2 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 0.1 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, monounsaturated fatty acid(GO:0034625) |
| 0.0 | 0.3 | GO:1901984 | negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
| 0.0 | 0.8 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.1 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 0.3 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 0.2 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.0 | 0.2 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.0 | 0.2 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 3.7 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.1 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.0 | 0.4 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.0 | 0.1 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 0.5 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.2 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.9 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 1.1 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.3 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.1 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 0.1 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.2 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.3 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 0.6 | GO:0006914 | autophagy(GO:0006914) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 1.0 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.2 | 1.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 2.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 3.3 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 0.2 | GO:0031083 | BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083) |
| 0.0 | 0.5 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.5 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 3.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.6 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.5 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.6 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.2 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.1 | GO:0016461 | unconventional myosin complex(GO:0016461) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.4 | 1.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.2 | 1.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 1.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.5 | GO:0008934 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.1 | 1.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 2.1 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 0.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.5 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 0.3 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 0.2 | GO:0031755 | endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755) |
| 0.1 | 0.2 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 1.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.6 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.1 | 0.4 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.2 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.0 | 0.3 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 1.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.4 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.3 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.0 | 0.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.6 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.1 | GO:0004461 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.3 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.0 | 0.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.7 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.1 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
| 0.0 | 0.4 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.0 | 0.2 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.1 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.0 | 1.8 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.2 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.1 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.3 | GO:0005048 | signal sequence binding(GO:0005048) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 2.8 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.1 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
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