Motif ID: CREB3L2
Z-value: 1.388
Transcription factors associated with CREB3L2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| CREB3L2 | ENSG00000182158.10 | CREB3L2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.6 | 1.8 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.5 | 5.4 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.4 | 1.3 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.3 | 1.0 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) DNA dealkylation(GO:0035510) |
| 0.3 | 0.9 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.3 | 1.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 1.7 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.2 | 0.9 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.2 | 0.7 | GO:0003011 | diaphragm contraction(GO:0002086) involuntary skeletal muscle contraction(GO:0003011) |
| 0.2 | 2.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.2 | 0.6 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 0.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 1.2 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.1 | 1.3 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 2.2 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.1 | 1.4 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.1 | 0.3 | GO:0019853 | L-ascorbic acid biosynthetic process(GO:0019853) |
| 0.1 | 3.0 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.1 | 1.9 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.1 | 0.5 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.1 | 1.6 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.1 | 0.4 | GO:0046349 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349) |
| 0.1 | 1.0 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 0.2 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.0 | 0.1 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.6 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.0 | 0.1 | GO:0035623 | renal glucose absorption(GO:0035623) |
| 0.0 | 1.5 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.0 | 0.2 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860) |
| 0.0 | 0.7 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.5 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.0 | 0.2 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.4 | GO:0006386 | transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386) |
| 0.0 | 0.7 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.4 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.0 | 0.3 | GO:0009650 | UV protection(GO:0009650) |
| 0.0 | 1.3 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.0 | 0.2 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.9 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 1.0 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
| 0.0 | 0.6 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.0 | 2.4 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403) |
| 0.0 | 0.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 1.1 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.0 | 0.3 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.0 | 0.9 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) |
| 0.0 | 0.3 | GO:0010226 | response to lithium ion(GO:0010226) |
| 0.0 | 1.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.2 | GO:0051927 | obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927) |
| 0.0 | 0.2 | GO:0048514 | angiogenesis(GO:0001525) blood vessel morphogenesis(GO:0048514) |
| 0.0 | 1.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.8 | GO:0034976 | response to endoplasmic reticulum stress(GO:0034976) |
| 0.0 | 0.2 | GO:0071230 | positive regulation of TOR signaling(GO:0032008) cellular response to amino acid stimulus(GO:0071230) |
| 0.0 | 0.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.3 | GO:0045806 | negative regulation of endocytosis(GO:0045806) |
| 0.0 | 3.4 | GO:0006887 | exocytosis(GO:0006887) |
| 0.0 | 1.3 | GO:0007018 | microtubule-based movement(GO:0007018) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 2.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 2.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 3.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.4 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.9 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 6.8 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 1.4 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 1.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.3 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 0.2 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500) |
| 0.0 | 3.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.3 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.5 | GO:0019861 | obsolete flagellum(GO:0019861) |
| 0.0 | 0.2 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.2 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 5.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 2.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.5 | 1.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.4 | 1.3 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.3 | 2.4 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.3 | 1.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.3 | 1.3 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.2 | 1.0 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.2 | 1.0 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.2 | 0.9 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.2 | 0.6 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) exoribonuclease II activity(GO:0008859) |
| 0.2 | 0.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 0.9 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.2 | 0.7 | GO:0032450 | maltose alpha-glucosidase activity(GO:0032450) |
| 0.2 | 1.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 1.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.1 | 1.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 3.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.5 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.1 | 0.7 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 1.0 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
| 0.1 | 1.3 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.1 | 3.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.3 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 1.3 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.1 | 0.4 | GO:0070548 | L-glutamine aminotransferase activity(GO:0070548) |
| 0.1 | 0.4 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.5 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.1 | 1.8 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 0.4 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 2.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.8 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.1 | 0.6 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 1.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.3 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 0.2 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.1 | 0.9 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.6 | GO:0001619 | obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) |
| 0.0 | 1.0 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.7 | GO:0004673 | phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673) |
| 0.0 | 0.3 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 1.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.5 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0008312 | 7S RNA binding(GO:0008312) |
| 0.0 | 0.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.2 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.0 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) |
| 0.0 | 0.2 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.4 | GO:0015179 | L-amino acid transmembrane transporter activity(GO:0015179) |
| 0.0 | 0.0 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.0 | 0.3 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.0 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.7 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
