Motif ID: CUX1
Z-value: 2.008
Transcription factors associated with CUX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| CUX1 | ENSG00000257923.5 | CUX1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0071639 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.6 | 4.4 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.6 | 3.9 | GO:0090025 | regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.4 | 1.2 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.3 | 1.7 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.3 | 1.0 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.3 | 0.8 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.2 | 1.3 | GO:0060263 | regulation of respiratory burst(GO:0060263) |
| 0.2 | 1.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.2 | 0.6 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.2 | 0.4 | GO:0046060 | dATP metabolic process(GO:0046060) |
| 0.2 | 0.9 | GO:0072207 | metanephric tubule development(GO:0072170) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
| 0.2 | 4.5 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.2 | 1.1 | GO:0006658 | phosphatidylserine metabolic process(GO:0006658) |
| 0.2 | 1.2 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
| 0.2 | 0.2 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.2 | 0.5 | GO:0042560 | 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.1 | 1.6 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 1.3 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 0.7 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.1 | 1.6 | GO:0098927 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
| 0.1 | 0.6 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 0.1 | 0.6 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 0.1 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.1 | 0.4 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.1 | 0.4 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.1 | 0.4 | GO:0019056 | modulation by virus of host transcription(GO:0019056) regulation of sprouting of injured axon(GO:0048686) positive regulation of sprouting of injured axon(GO:0048687) regulation of axon extension involved in regeneration(GO:0048690) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
| 0.1 | 0.4 | GO:0034635 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.1 | 0.4 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 2.0 | GO:0045885 | obsolete positive regulation of survival gene product expression(GO:0045885) |
| 0.1 | 0.7 | GO:0000089 | mitotic metaphase(GO:0000089) |
| 0.1 | 3.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.0 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 0.5 | GO:0045767 | obsolete regulation of anti-apoptosis(GO:0045767) |
| 0.1 | 0.5 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.1 | 0.3 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.1 | 0.3 | GO:0009103 | lipopolysaccharide biosynthetic process(GO:0009103) |
| 0.1 | 0.4 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 0.1 | 1.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 1.9 | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) |
| 0.1 | 0.3 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
| 0.1 | 0.3 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.1 | 0.3 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.1 | 0.2 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 0.6 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.1 | 0.3 | GO:0010572 | regulation of cellular extravasation(GO:0002691) positive regulation of platelet activation(GO:0010572) |
| 0.1 | 1.8 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.1 | 0.2 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.1 | 0.3 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.2 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.1 | 0.4 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 0.9 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.5 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.1 | 0.3 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.1 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.1 | 0.3 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.1 | 1.8 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 0.3 | GO:0060406 | positive regulation of penile erection(GO:0060406) |
| 0.1 | 0.1 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.1 | 0.3 | GO:0042635 | positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798) |
| 0.0 | 0.7 | GO:0045815 | positive regulation of gene expression, epigenetic(GO:0045815) |
| 0.0 | 0.6 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.0 | 1.2 | GO:0030101 | natural killer cell activation(GO:0030101) |
| 0.0 | 0.5 | GO:0042640 | anagen(GO:0042640) |
| 0.0 | 0.3 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.0 | 0.6 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.4 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.0 | 0.4 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.2 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.0 | 0.5 | GO:0031498 | nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986) |
| 0.0 | 1.2 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.0 | 0.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 1.4 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
| 0.0 | 0.2 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.0 | 0.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.4 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.0 | 0.2 | GO:0033522 | histone H2A ubiquitination(GO:0033522) |
| 0.0 | 0.3 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.0 | 0.4 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.3 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.0 | 0.6 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.7 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.0 | 0.2 | GO:0036037 | CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.1 | GO:0018352 | glutamate decarboxylation to succinate(GO:0006540) protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.0 | 0.4 | GO:0014009 | glial cell proliferation(GO:0014009) activation of Janus kinase activity(GO:0042976) |
| 0.0 | 0.6 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.0 | 0.5 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.0 | 0.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.5 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.0 | 0.2 | GO:0045059 | positive T cell selection(GO:0043368) positive thymic T cell selection(GO:0045059) |
| 0.0 | 0.3 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
| 0.0 | 0.7 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.2 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.2 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.0 | 1.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.9 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.7 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
| 0.0 | 1.8 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 0.2 | GO:0043497 | regulation of protein heterodimerization activity(GO:0043497) |
| 0.0 | 0.1 | GO:0014820 | tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824) |
| 0.0 | 0.1 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.0 | 0.4 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.4 | GO:0000303 | response to superoxide(GO:0000303) |
| 0.0 | 0.1 | GO:0001999 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) |
| 0.0 | 0.8 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 0.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.1 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
| 0.0 | 0.2 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.4 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.0 | 0.1 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
| 0.0 | 0.3 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 0.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.0 | 0.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.0 | 0.3 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.4 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 0.0 | 0.2 | GO:0098534 | centriole replication(GO:0007099) centriole assembly(GO:0098534) |
| 0.0 | 0.3 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 0.1 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
| 0.0 | 0.2 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.2 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.6 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.0 | 0.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.0 | 0.5 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.0 | 0.2 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473) |
| 0.0 | 1.1 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.3 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.0 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling(GO:0007249) |
| 0.0 | 0.3 | GO:0030811 | regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of ATP metabolic process(GO:1903578) |
| 0.0 | 0.5 | GO:0001892 | embryonic placenta development(GO:0001892) |
| 0.0 | 0.0 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.0 | 0.5 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.9 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 0.1 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.0 | 0.2 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.0 | 0.5 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.3 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.1 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.0 | 0.9 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.3 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.1 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.2 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.0 | 0.3 | GO:0007492 | endoderm development(GO:0007492) |
| 0.0 | 0.1 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
| 0.0 | 0.4 | GO:0046847 | filopodium assembly(GO:0046847) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 1.6 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
| 0.2 | 0.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 0.6 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.2 | 4.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 1.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 3.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 2.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.6 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 0.6 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 0.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.3 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 2.0 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.9 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.9 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.1 | 0.6 | GO:0005678 | obsolete chromatin assembly complex(GO:0005678) |
| 0.1 | 2.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.8 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.3 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.3 | GO:0005954 | calcium- and calmodulin-dependent protein kinase complex(GO:0005954) |
| 0.0 | 0.9 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 0.2 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 0.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.2 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 0.4 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.1 | GO:0033011 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
| 0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.9 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.2 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 2.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.2 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 1.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 1.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.5 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.1 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.3 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.3 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 1.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.2 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.0 | 0.0 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 0.6 | GO:0030532 | small nuclear ribonucleoprotein complex(GO:0030532) |
| 0.0 | 0.1 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.0 | 5.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.3 | GO:0042645 | mitochondrial nucleoid(GO:0042645) |
| 0.0 | 2.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0019976 | interleukin-2 binding(GO:0019976) |
| 0.4 | 1.2 | GO:0050473 | arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.4 | 1.9 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.3 | 1.0 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.3 | 4.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.3 | 1.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 1.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 0.8 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.2 | 2.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 0.7 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.2 | 2.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 0.5 | GO:0031177 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) phosphopantetheine binding(GO:0031177) |
| 0.2 | 0.9 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 1.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.4 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.1 | 0.7 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 0.4 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.1 | 1.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.1 | 0.6 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 1.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.0 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 0.3 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 0.4 | GO:0042156 | obsolete zinc-mediated transcriptional activator activity(GO:0042156) |
| 0.1 | 0.3 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.1 | 0.4 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.1 | 0.6 | GO:0015651 | quaternary ammonium group transmembrane transporter activity(GO:0015651) |
| 0.1 | 0.2 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 1.0 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.2 | GO:0016418 | S-acetyltransferase activity(GO:0016418) |
| 0.1 | 1.2 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 4.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 3.9 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.1 | 2.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.2 | GO:0042806 | fucose binding(GO:0042806) |
| 0.1 | 0.2 | GO:0004946 | bombesin receptor activity(GO:0004946) |
| 0.1 | 0.2 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.1 | 0.4 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.1 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 0.5 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.1 | 0.2 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.1 | 0.2 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.0 | 1.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.1 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 0.3 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.0 | 0.3 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 0.3 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.0 | 0.4 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.0 | 0.4 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 0.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.7 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.3 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.0 | 0.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.8 | GO:0008200 | ion channel inhibitor activity(GO:0008200) |
| 0.0 | 0.2 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.3 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.2 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 1.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.6 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.0 | 0.3 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 0.4 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.0 | 0.2 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.1 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.0 | 0.6 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.6 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.1 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.0 | 0.1 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.0 | 0.4 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.0 | 1.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.3 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.1 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 0.2 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.0 | 0.2 | GO:0051637 | obsolete Gram-positive bacterial cell surface binding(GO:0051637) |
| 0.0 | 0.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.2 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 0.1 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 0.0 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 0.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.2 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.4 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.0 | 0.1 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.2 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.0 | 0.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.1 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 0.7 | GO:1901505 | carbohydrate derivative transporter activity(GO:1901505) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 0.1 | GO:0000827 | inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 0.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.1 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.0 | 0.1 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 0.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917) |
| 0.0 | 0.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.2 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 0.8 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 0.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.2 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.1 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 1.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.1 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.0 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.1 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 0.2 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.0 | 0.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 1.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.9 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 0.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.8 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.4 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.6 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
